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6509362 N-phenylamide and N-pyridylamide derivatives, method of preparing them and pharmaceutical compositions containing them  
The present invention relates to the compounds of formula (I) in which X, R1, R2 and R3 are as defined in claim 1. These compounds are cholesteryl acyl transferase (ACAT) inhibitors.
6500849 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino 1,3-propanediols and related compounds  
Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and...
6498172 Prostaglandin agonists and their use to treat bone disorders  
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
6495576 Aminal diones as potassium channel openers  
Compounds of formula (I) may be useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of...
6495568 Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors  
Compounds of formula (I): or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line represents...
6495550 Pyridine-substituted benzanilides as potassium ion channel openers  
The present invention provides a genus of pyridine-substituted benzanilides that are useful as openers of potassium ion channels. The compounds of the invention are of use in both therapeutic and...
6492416 4,5-diaryl-3(2H)-furanone derivatives as cyclooxygenase-2 inhibitors  
The present invention provides a novel class of 4,5-diaryl-3(2H)-furanone derivatives, which inhibit strongly and selectively COX-2 over COX-1. They are useful to treat inflammation,...
6489354 3-alkyl substituted pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor...
6472350 Utilization of 3-phenyl-pyrones for pest control  
3-Phenyl-pyrones of the formula in whichx represents pyrid-2-yl andY represents fluorine,orx represents 4-fluoro-phenyl andY represents chlorine,are highly suitable for use as pesticides,...
6472406 Sulfonamidomethyl phosphonate inhibitors of beta-lactamase  
The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel β-lactamase...
6465471 Cinnamic acid derivatives  
Compounds of formula (1) are described: in which Het is a heteroaromatic group, Alk1 is an optionally substituted aliphatic or heteroaliphatic chain and R is a carboxylic acid or a derivative...
6465491 6-phenylpyridyl-2-amine derivatives  
The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and...
6458789 2-aminopyridine derivatives and combinatorial libraries thereof  
The present invention relates to novel 2-aminopyridine derivative compounds of the following formula: wherein R1 to R5 have the meanings provided herein. The invention further relates to...
6458813 Substituted pyridine compounds and methods of use  
Selected novel substituted pyridine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain...
6441030 3-phenyl-pyrones  
Novel 3-phenyl-pyrones of the formula in whichA, D, X and Y are each as defined in the description,a process for preparing these substances and their use as pesticides, fungicides and herbicides.
6441003 Process for the application of systemic pesticides to asexual plant propagules  
The field of this invention is the application of systemic pesticides. More particularly, this invention pertains to an improved process for the internal placement of systemic insecticides,...
6436963 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamides with (derivatised) hydroxyalkyl derivatives on the pyridine ring  
The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl)phenyl acetamide compounds with (derivatised) hydroxyalkyl substituents on the pyridine ring, their use as fungicidal...
6420392 Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders  
2,5-Diaryl tetrahydrofurans, 2,5-diaryl tetrahydrothiophenes, 1,3-diaryl cyclopentanes are disclosed that reduce the chemotaxis and respiratory burst leading to the formation of damaging oxygen...
6420375 Fused ring compounds, process for producing the same and use thereof  
To provide a novel compound of the formula: [wherein A1 ix a 5 or 6-membered ring which may be substituted by a group not containing a cyclic group, A2 is an aromatic ring which may be...
6420385 Substituted pyrimidinone and pyridone compounds and methods of use  
Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other...
6413990 Arylsulphonamide-substituted benzimidazoles having tryptase-inhibiting activity  
Bezimidazole derivatives of general formula (I) having tryptase-inhibitory activity. Exemplary are:N-{2-[2-(4-amidinophenyl)-ethyl]-1-methyl-benzimidazol-5 -yl}-N-diethylaminoethyl-(4-ethoxycarbony...
6399606 Neuroprotective agents and methods related thereto  
Neuroprotective agents are disclosed having the following structure: wherein R1, R2, R3, R4 and R5 are as defined herein. Such compounds have utility in the treatment of conditions which benefit...
6391327 Pesticidal composition  
A pesticidal composition comprising prallethrin and a neonicotinoid compound given in the following formula (1), (2) or (3), as an active ingredient wherein, A represents a 6-chloro-3-pyridyl,...
6384060 2,4,6-trisbstituted pyridines with estrogenic activity and methods for the solid phase synthesis thereof  
The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their...
6384058 2,4,6-trisubstituted pryridines with estrogenic activity and methods for the solid phase synthesis thereof  
The present invention relates to novel substituted pyridine compounds of Formula (I) wherein the moiety Z, R1, R2 and R3 are as herein defined, having estrogenic activity, to processes for their...
6376502 Osteoporosis compounds  
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
6372764 Pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor...
6372765 Parasiticidal formulations that can be applied dermally  
The present invention relates to formulations for the dermal control of parasitic insects of animals, having the following composition agonists or antagonists of the nicotinergic acetylcholine...
6369083 2-methoxyimino-2 (pyrinyloxymethyl) phenyl acetamides with polyether derivatives on the pyridine ring  
The present invention provides novel 2-methoxyimino-2-(pyridinyloxymethyl) phenyl acetamide compounds with polyether substituents on the pyridine ring, their use as fungicidal compounds, and their...
6369084 Carboxylic acids and acylsulfonamides, compositions containing such compounds and methods of treatment  
This invention encompasses the novel compounds of formula A, which are useful in the treatment of prostaglandin mediated diseases, or a pharmaceutically acceptable salt, hydrate or ester thereof....
6369100 Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids  
Retinoid compounds which repress expression of the gene promoted by AP1 protein but which do not significantly activate expression of the genes having RA-responsive elements in their promoter...
6365608 Fungicide mixtures based on pyridine carboxamides  
Fungicidal mixtures comprise as active components a) an amide compound of the formula IA—CO—NR1R2 I in whichA is an aryl group or an aromatic or non-aromatic, 5- or 6-membered heterocycle which...
6365584 Arylysulphonamide-substituted benzimidazoles having tryptase-inhibiting activity  
Arylsulphonamide-substituted benzimidazole derivatives of formula (I) having tryptase-inhibiting activity. Exemplary...
6362201 3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity  
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4f are defined herein) which are useful as modulators of chemokine receptor...
6358944 Methods and compositions for treating generalized anxiety disorder  
The present invention relates to methods and compositions comprising a very low dose of cyclobenzaprine or metabolite thereof for preventing and treating Generalized Anxiety Disorder. The present...
6355672 Benzothiepin derivatives, process for the preparation of the same and uses thereof  
The invention provides compounds of the formula: wherein the ring A is an optionally substituted benzene ring; R1 is an optionally substituted non-aromatic heterocyclic group; R2 and R3 are...
6350762 Dihydropyridine derivative  
Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel....
6331531 Method for controlling harmful organisms in crops of useful plants  
Method for controlling harmful organisms in genetically modified cotton plants which contain a gene derived from Bacillus thuringiensis which encodes and expresses an insecticidally active...
6329400 Formamide compounds as therapeutic agents  
A family of compounds having the general structural formula ##STR1##where W is a reverse hydroxamic acid group, and R1, R2, R3, R4, R5 and R6 are as described in the specification, or a...
6329418 Substituted pyrrolidine hydroxamate metalloprotease inhibitors  
The invention provides compounds which are potent inhibitors of metalloproteases and which are effective in treating conditions characterized by excess activity of these enzymes. In particular,...
6326385 Methods for treating or preventing pain  
The present invention relates to a novel method of treating of pain, using compounds that modulate KCNQ potassium channels and currents.
6326372 Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists  
Lactam and cyclic urea derivatives and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also...
6323222 1-aza-2-alkyl-6-aryl-cycloalkane compounds  
Compound of formula (I): ##STR1##wherein: {character pullout} n represents 0 or 1, {character pullout} R1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or...
6319894 Complexes and combinations of fetuin with therapeutic agents  
There is disclosed a complex and a combination of the glycosylated polypeptide fetuin and a therapeutically active small molecule compound having a net positive charge at physiological pH. The...
6316473 Two surfactant-containing medicinal composition  
Provided is a medicinal composition having a very satisfactory drug release profile and a very satisfactory drug absorption profile after oral administration characterized by its comprising an...
6313164 Dithiolin derivatives, their preparation and their therapeutic effect  
Compounds of the formula (I): ##STR1##wherein one of m and n is 0, and the other is 0, 1 or 2; k is 0 or 1 to 12; R1 is hydrogen, a substituent which is an aryl or a heterocyclic, or an optionally...
6313146 Calcium receptor-active molecules  
The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more...
6300348 Pesticide for parasitic insects and acarids on humans  
The present invention relates to formulations for the dermal control of parasitic insects on humans, having the following composition agonists or antagonists of the nicotinergic acetylcholine...
6300346 Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions  
Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.
6288091 Antiherpes virus compounds and methods for their preparation and use  
This invention relates to methods for inhibiting herpes replication and for treating herpes infection in a mammal by inhibiting the herpes helicase-primase enzyme complex. This invention also...