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7432247 Methods of cardioprotection using dichloroacetate in combination with an inotrope  
The present invention provides compositions and methods for maintaining cardiac function by administering dichloroacetate (DCA) in combination with an inotrope.
7432289 5-Acylamino-1,1′-biphenyl-4-carboxamide derivatives and their use as P38 kinase inhibitors  
Compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
7432286 Pharmaceutically active sulfonyl hydrazide derivatives  
The present invention is related to sulfonyl hydrazide derivatives for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonyl hydrazide...
7429604 Six-membered heterocycles useful as serine protease inhibitors  
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, X1, X2, X3, X4, and X5 are as...
7423051 2,6-diaminopyridine derivatives  
Novel 2,6-diaminopyridine derivatives of formula wherein R1 and R2 are as defined below, are disclosed. These compounds inhibit cyclin-dependent kinases. These compounds and their pharmaceutically...
7414064 4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives  
Compounds of formula whereinA1, A2 and A3 are each independently of the others a bond or a C1-C6alkylene bridge;A4 is a C1-C6alkylene bridge;D is CH or N;W is, for example, O, NR7 or S;T is, for...
7414060 Pyridine-2-carboxyamide derivatives  
The invention relates to compounds of formula I: wherein R1 to R3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them, and to...
7399775 β-amyloid protein production/secretion inhibitor  
Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of...
7393865 Sleep inducing compounds and methods relating thereto  
Compounds having the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R1, R2, R3a, R3b, L1, L2 and n are as...
7384961 Saturated and unsaturated heteroarylcycloalkylmethyl amines as anti-depressants  
Saturated and unsaturated heteroarylcycloalkylmethyl-amine compounds corresponding to formula I, processes for their preparation, pharmaceutical formulations comprising these compounds and the use...
7375118 Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation  
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
7375122 Compounds useful as pesticides  
Compounds useful to control pests are provided.
7365068 Substituted aryl acylthioureas and related compounds; inhibitors of viral replication  
The invention provides compounds and pharmaceutically acceptable salts of Formula I wherein the variables A1, A2, R1, R2, V, W, X, Y, and Z are defined herein. Certain compounds of Formula I...
7354936 2-phenylpyran-4-one derivatives  
The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula processes for their preparation, pharmaceutical compositions containing them, and their medical uses.
RE40155 Methods for treatment of benign and malignant tumors, including lymphomas, leukemias, and leiomyomas  
In a preferred embodiment, drugs having chemotherapeutic properties which are useful against certain neoplastic disorders with wide safety margins as evidenced by their low toxicity, and molecular...
7332504 Heterocyclic substituted aminoazacycles useful as central nervous system agents  
Heterocyclic substituted aminoazacyclic compounds of formula I Z-R3I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds,...
7332509 Heterocyclic amides, a process for their preparation, compositions comprising them and their use  
What is described are amides of the formula (I) and salts thereof, where the symbols and indices are as defined below: X is CH or N; Y is O or S;n is 0 or 1; R1 is (C1-C4)-haloalkyl;R2, R3...
7317010 Thieno-pyrrole compounds as antagonists of gonadotropin releasing hormone  
The invention relates to a group of novel thieno-pyrrole compounds of Formula (I), wherein: R1, R2, R4, R5, R6, R6a, R7, R8, A and B are as defined in the specification, which are useful as...
RE39991 Fungicidal heterocyclic aromatic amides and their compositions, methods of use and preparation  
A compound having the following formula: wherein R3 and M are defined herein, and processes therewith.
7312236 Substituted (4-aminocyclohexen-1-yl)phenyl and (4-aminocyclohexen-1-yl)pyridinyl compounds as 5-HT1F agonists  
The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, where; X is —C(R4)═ or —N═;Ar is phenyl, substituted phenyl, heterocycle, or...
7312235 Benzamide inhibitors of factor Xa  
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
7297693 Nitrogen-containing heterocyclic compounds and their use as Raf inhibitors  
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
7291631 CXCR4 chemokine receptor binding compounds  
The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to...
7282514 Reactive probes for two-photon fluorescent imaging and sensing  
Fluorescent dyes and probes are key components in multiphoton based fluorescence microscopy imaging of biological samples. In order to address the demand for better performing dyes for two-photon...
7279476 Pyrazole-derived kinase inhibitors and uses thereof  
Described herein are compounds that are useful as protein kinase inhibitors having the formula: where B, R1, n, R3, Q, and R4 are described in the specification. The compounds are useful for...
7271181 Inhibitors of p38  
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
7259166 Substituted-cycloalkyl and oxygenated-cycloalkyl glucokinase activators  
2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being...
7259157 N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists  
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
7256203 Dicationic 2,5-diarylfuran aza-analogs as anti-protozoan agents  
A compound of Formula (I): wherein: X is selected from the group consisting of O, S, and NR17, where R17 is hydrogen or lower alkyl;A and Y are CH, N, NR17, O, or S;C1 and C2 are each C or N,...
7253188 Aminobenzamide derivative  
This invention relates to a novel compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, whereinR1 is —S(O)p-A, —S—(O)q-B or —O-D, wherein p and q, which are the...
7253191 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry  
The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3 and R4 are as defined in the description. The compounds according to the...
7253187 Heterocyclic inhibitors of ERK2 and uses thereof  
Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as...
7244763 Compounds that modulate PPAR activity and methods of preparation  
This invention relates to compounds that alter PPAR activity. The invention also relates to pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising...
7244752 Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors  
The present invention concerns the compounds having the formula N-oxides, salts, stereoisomeric forms, racemic mixtures, prodrugs, esters and metabolites thereof, wherein R1 and R8 each are H,...
7241758 Compounds useful as anti-inflammatory agents  
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
7238717 CCR9 inhibitors and methods of use thereof  
The invention relates to compounds represented by Structural Formula I, which can bind to CCR9 receptors and block the binding of a ligand (e.g., TECK) to the receptors. The invention also relates...
7214701 Active substance combinations having insecticidal and acaricdal properties  
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) in which W, X, Y, Z, A, B, D and G are each as defined in...
7211595 Farnesyltransferase inhibitors  
Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting...
7196089 EP4 receptor antagonists  
Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected...
7196106 Cyanothiophene derivatives, compositions containing such compounds and methods of use  
The present invention addresses substituted cyanothiophene derivatives of the formula I: as well as compositions containing such compounds and methods of treatment. The compounds in the present...
7192967 Cyclic imide-substituted pyridylalkane, alkene, alkine carboxamides useful as cytostatic and immunosuppressive agents  
The invention relates to new pyridylalkane, alkene, and alkine carboxamides substituted with an imide with a saturated or one or several-fold unsaturated hydrocarbon residue in the carboxylic acid...
7186709 Dihydropyrancarboxamides and uses thereof  
The present invention provides novel dihydropyrancarboxamide compounds of formula (I): and collections of these compounds, and provides methods for the synthesis of these compounds; wherein R1–R6...
7186719 Antibacterial agents  
Compounds of formula (II) are antibacterial agents wherein Q represents a radical of the formula: —N(OH)CH(═O) or the formula: —C(═O)NH(OH); R1 represents hydrogen, C1–C6 alkyl or C1–C6 alkyl...
7166637 Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them  
The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of...
7163951 N-biarylmethyl aminocycloalkanecarboxamide derivatives  
N-Biarylmethylaminocycloalkanecarboxamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated...
7160903 Sulfonylaminocarboxylic acids  
Compounds of formula (I) are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading...
7157078 Devices and methods for eliminating termite colonies  
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing a) a termiticide selected such...
7153870 Nicotinamide derivatives useful as PDE4 inhibitors  
This invention relates to nicotinamide derivatives of general formula (I): in which R1, R2 and R3 have the meanings defined herein, and to processes for the preparation of, intermediates used in...
7141586 Nicotinamide derivatives useful as PDE4 inhibitors  
This invention relates to nicotinamide derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, pharmaceutical compositions containing, and the...
7132420 Aspartic protease inhibitors  
The present invention provides an aspartic proteinase-inhibiting compound of the formula: wherein a, b, c, d, and e, can be the same or different and each are R7, OR7, SR7, NR7R8, NHCOR7, CO2R7,...