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7718676 2-aminoaryloxazole compounds as tyrosine kinase inhibitors  
The present invention relates to novel compounds selected from 2-aminoaryloxazoles of formula I that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native...
7700628 Aromatic ether derivatives useful as thrombin inhibitors  
This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use...
7700620 C-linked cyclic antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions  
The present invention provides novel C-linked cyclic compounds and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the...
7691883 Cinnamoyl compound and use of the same  
The present invention relates to a cinnamoyl compound represented by the formula (I):
7691884 Heterocyclic sulfonamide inhibitors of β amyloid production  
Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof....
7687067 2-pyridinylcycloalkylcarboxamide derivatives useful as fungicides  
A compound of general formula (I): A process for preparing this compound.An intermediate of general formula (II) for the preparation of a compound of general formula (I). A fungicidal composition...
7687500 Substituted oxetanes, method of making, and method of use thereof  
Oxetane-containing nucleosides, particularly non-reducing psiconucleoside oxetanes are described herein. Therapeutic application of these oxetane compounds toward the treatment of nucleoside...
7683065 Pyridines useful as modulators of ion channels  
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
7674801 Alkyl urea substituted pyridines  
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their...
7652041 Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity  
The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention...
7652023 Heterocyclic CETP inhibitors  
Compounds of formula Ia and Ib wherein A, B, C and R1 are described herein.
7652021 Compounds useful for DPP-IV enzyme inhibition  
The present invention relates to the novel compounds of the general formula (I) possessing dipeptidyl peptidase IV enzyme inhibitory activity, pharmaceutical compositions thereof, methods of using...
7649004 Pyridine derivatives  
The present invention relates to compounds of the formula (I) and pharmaceutically acceptable salts and solvates thereof, to processes for the preparation of, intermediates used in the preparation...
7638538 Pharmaceutically active sulfonyl amino acid derivatives  
The present invention is related to sulfonyl amino acid derivatives of formula (I), notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such...
7629363 Diaryl substituted pyridinones  
Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3/R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions...
7625944 Inhibitors of plasma kallikrein  
The present invention provides compounds that inhibit the activity of plasma kallikrein (PK) and methods of preventing and treating the formation of thrombin during or after a PK dependent disease...
7618988 Use of substituted aminomethyl chromans  
Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement...
7592337 Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5  
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
7589085 Tetrahydropyran heterocyclic cyclopentyl heteroaryl modulators of chemokine receptor activity  
The present invention is further directed to compounds of the formulas: (I) (II) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24 and R25 are as defined herein) which...
7582676 2-phenylpyran-4-one derivatives as selective COX-2 inhibitors  
The present invention relates to 2-phenylpyran-4-derivatives of general formula (I), processes for their preparation, pharmaceutical compositions containing them, and their medical uses.
7582632 Tri(cyclo) substituted amide compounds  
Compounds of Formula (I): or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes.
7579347 Vanilloid receptor ligands and their use in treatments  
Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache,...
7576110 Benzothiazole cyclobutyl amine derivatives  
Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the...
7572816 Therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders  
The present invention is directed to compounds having the structure wherein R1, R2, R3, R4, R5 and m are as defined herein. The compounds of this invention are novel therapeutic agents for the...
7569590 Use of thianecarboxamides as dgat inhibitors  
The present application describes methods of treating obesity using DGAT-1 inhibitors according to Formula I: including all prodrugs, solvates, pharmaceutically acceptable salts and stereoisomers,...
7563811 1,2-dihydropyridine compounds, manufacturing method thereof and use thereof  
The present invention provides a novel compound having an excellent AMPA receptor inhibitory action and/or kainate inhibitory action. A compound represented by the following formula, a salt...
7547693 Piperidine derivative  
Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty...
7544702 Bisaryl-sulfonamides  
Bisaryl-sulfonamide compounds having the formula wherein Ar, R1, R2, L, B, W, X, Y, and Z, compositions and methods are provided that are useful in the treatment or prevention of a condition or...
7538138 Amines as histamine-3 receptor ligands and their therapeutic applications  
Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the...
7531556 Compositions useful as inhibitors of rock and other protein kinases  
The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
7528157 EP4 receptor antagonists  
Compounds of formula (I): wherein: R2 is H or an optionally substituted C1-4 alkyl group; Y is either —(CH2)n—X—, where n is 1 or 2 and X is O, S, S(═O), S(═O)2, or NRN1, where RN1 is selected...
7524870 Biaryloxymethylarenecarboxylic acids as glycogen synthase activators  
The present invention relates to compounds of formula (I) wherein Ar, Ar2, R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The...
7517893 Bichalcophenes and their prodrugs as antiprotozoal agents  
Novel dicationic bichalcophene compounds are described. The presently disclosed novel dicationic bichalcophene compounds exhibit in vitro activity versus Trypanosoma brucei rhodesiense, Plasmodium...
7514452 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same  
The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof:...
7504420 Compounds which inhibit beta-secretase activity and methods of use  
The present invention provides novel beta-secretase inhibitors and methods for their use, including methods of treating Alzheimer's disease.
7501445 Imidazolidinone compounds  
This invention relates to compounds of the following formula: in which R1, R2, A1, A2, X, Y, m, n, p, x and y are as defined herein, pharmaceutical compositions comprising the compounds and use of...
7494997 Amide derivative  
The present invention provides an amide derivative represented by the following general formula (1): wherein R1 represents a saturated cyclic amino group, R2 represents alkyl, halogen or...
7488734 Methods of treating hormone-related conditions using thio-oxindole derivatives  
The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which...
7485653 1,4-dihydropyridine compounds, pharmaceutical compositions, and methods for the treatment of cardiovascular disease  
The present invention provides certain substituted 1,4-dihydropyridine compounds, including pure enantiomeric forms and pharmaceutical formulations thereof. These compounds provide for elevation...
7482366 Modulators of LXR  
Compounds of the invention, such as compounds of formula (I): where n, m, A, B, R1, R2, R3, R4 and R5 are defined herein, are useful as modulators of the activity of liver X receptors....
7468360 Therapeutic amides and related compounds  
Disclosed herein is a compound having a structure: Therapeutic methods, compositions, and medicaments relating thereto are also disclosed.
7465736 Azole methylidene cyanide derivatives and their use as protein kinase modulators  
An azole derivative of formula (I) a medicament that contains the azole derivative of formula (I), a method of treating a disease with the azole derivative of formula (I), and a method of...
7465748 Amide derivative  
There is provided a pharmaceutical drug, particularly a novel compound useful for prophylaxis or a therapeutic treatment of various diseases involving infections with viruses of the herpesvirus...
7456164 3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands  
The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions...
7452906 Pyridine derivatives as Raf kinase inhibitors  
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
7446106 Pyridylfurans and pyrroles as Raf kinase inhibitors  
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
7442713 2-thio-substituted imidazole derivatives and their use in pharmaceutics  
The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R1, R2, R3, R4 and p are as defined in the description. The compounds according to the...
7442702 Prostaglandin agonists  
This invention relates to prostaglandin agonists, methods of using such prostaglandin agonists, pharmaceutical compositions containing such prostaglandin agonists and kits containing such...
7439260 7-(1,3-thiazol-2-YL)thio-coumarin derivatives and their use as leukotriene biosynthesis inhibitors  
The instant invention provides compounds of Formula (I) which are leukotriene biosynthesis inhibitors. Compounds of formula (I) are useful as anti-asthmatic, anti-allergic, anti-inflammatory,...
7435743 Pyridine derivatives  
Pyrimidine compounds of general formula: wherein —R1 represents in which R11 is hydrogen, C1-6 alkyl, halogen, hydroxy, C1-12 alkoxy, nitro, amino, C1-6 alkylsulfonylamino, C1-6 alkoxycarbonyl,...