Match Document Document Title
4898868 3-demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and intermediates  
3-Demethyl-4-fluoromevalonic acid derivatives, a process for the preparation thereof, pharmaceutical products based on these compounds, the use thereof, and...
4889865 10-aryl-1,8-dihydroxy-9- anthrones and their esters  
Mono, di and tri-esters of 1,8-dihydroxy-10-phenyl-9-anthrone or -9-anthranol have the formula ##STR1## wherein p is 0 or 1, (a) when p=0, t=1 and R2 represents hydrogen or --COR3, (b) when p=1,...
4888338 5-Methoxy alkyl ammonium tetrahydrofurans and tetrahydrothiophenes as anti-PAF agents  
This invention relates to new tetrahydrofurans and tetrahydrothiophenes of the general formula: ##STR1## wherein X stands for O or S, m is an integer from 1 to 12 and A is a pyridinium or an...
4888337 5-oxy derivatives of tetrahydrofuran  
This invention relates to: (a) new tetrahydrofuran derivatives having the general formula I: ##STR1## wherein either each of R and R' independently represents a hydrogen atom or various...
4885292 N-heterocyclic alcohol renin inhibitors  
Compounds of the formula ##STR1## are disclosed wherein R1 is N-heterocyclic moiety. These compounds intervene in the conversion of angiotensin to angiotensin II by inhibiting renin and thus are...
4885303 Circulation-active tetrahydropyridine-3-carbonitrile derivatives  
Circulation active tetrahydropyridines of the formula ##STR1## in which R1 represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical which has up to 20 carbon...
RE33125 3- and 5-[3-(1-arylureido)]-1,2,4-triazoles  
4882341 Amino substituted propenoates and their use as fungicides  
The invention relates to amino substituted propenoates and their use against fungi.
4871737 3-Amino-5-methyl-1H-pyrazole-4-carboxylic acids and esters thereof as anticonvulsants muscle relaxants and anxiolytics  
A novel method of controlling epilepsy, muscle tension, muscular spasticity, and anxiety in living animal bodies by administering compounds of the formula: ##STR1## wherein: R1 is hydrogen,...
4870087 Indole containing, 2-thienyl-1,2,3,6-tetrahydropyridyls and their pharmaceutical use  
Indole derivatives of the general formula I ##STR1## in which Ind is a 3-indolyl radical which can be substituted once or twice by alkyl, O-alky, S-alkyl, SO-alkyl, SO2 -alkyl, OH, F, Cl, Br, CF3...
4868193 Styryl tetrazoles and anti-allergic use thereof  
Compounds of the formula: ##STR1## and salts thereof, wherein, Ar1 is phenyl, naphthyl or heterocyclic ring selected from the group consisting of quinolinyl, isoquinolinyl, pyridinyl,...
4863938 Pyridine derivatives and their use as nootropic agents  
Pyridine derivatives of the formula ##STR1## their tautomers and their salts, in which R1, R2, R3, R4, R5 and n have the meanings given in the claims, can be used as active ingredients in...
4859687 Substituted 1,3-dioxolane compounds and their use as fungicides  
The described novel pyridine derivatives are those of the general formula I ##STR1## wherein R is hydrogen, C1 -C6 -alkyl, C3 -C6 -cycloalkyl, phenyl, benzyl, phenyl substituted by C1 -C4 -alkyl,...
4859699 Substituted N-benzoyl-N'-thienylureas  
Substituted N-benzoyl-N'-thienylureas, processes for making these compounds, intermediates therefor and the use of the compounds for the control of pests, and in particular for the control of...
4853395 Certain 3-carboxylate or 3-carbamyl-5-acyl-2-(1H)-pyridinones having cardiotonic properties  
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic...
4851413 Certain benzoquinones, naphthoquinones, corresponding hydroquinones which exhibit thromboxane A2 synthetase inhibition or receptor antagonism and the like  
Quinone derivatives represented by the general formula ##STR1## (wherein, R1 and R2, the same or different, refer to a hydrogen atom, methyl or methoxymethyl group, or R1 and R2 bind together to...
4847271 Antihypercholesterolemic β-lactones  
The compounds of the following general structural formula (I) ##STR1## are 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) synthase inhibitors and useful as antihypercholesterolemic agents for the...
4845113 2-substituted -1,4-dihydropyridines and pharmaceutical compositions containing them  
Compounds of formula I ##STR1## wherein R is hydrogen or lower alkyl; R1 is acetyl, benzoyl, cyano, nitro, carboxy, alkoxycarbonyl or aminocarbonyl groups; R2 is an optionally substituted aryl or...
4829076 Novel dihydropyridines having calcium antagonistic and antihypertensive activity  
The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R1 and R6 are as defined herein after, the racemic and optically active variants...
4824858 1,3-Dioxolane-5-yl-hexenoic acid derivatives  
The invention describes novel (2-styryl-, 2-naphthyl- and 2-phenethyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)alkenoic acids and related tetrazoles and sulphonamides, of the formula I wherein Q...
4824837 Novel 1,4-dihydropyridine derivatives, process for preparing the same, and agents for treating disorders of circulatory system  
1,4-Dihydropyridine derivatives of the formula (1): ##STR1## wherein X is a halogen; R1 is a straight, branched or cyclic alkyl group having 1 to 10 carbon atoms, the group --(CH2)n -Y [where n is...
4820718 N-alkyl-(2- or 5-substituted-2-methoxycarbonyl aminoalkyl furanyl)-substituted cyclimmonium salts and use thereof in PAF inhibition  
The invention discloses certain N-alkyl-(2- or 5-substituted-2-methoxycarbonyl aminoalkyl furanyl)-substituted cyclimmonium salts useful as PAF inhibitors, pharmaceutical compositions containing...
4816475 1,3,5-trithian derivatives and pharmaceutical compositions  
An anti-arteriosclerotic or anti-hyperlipemic 1,3,5-trithiane derivative according to the formula (I): ##STR1## a pharmaceutical composition containing the same, and a process for producing the same.
4808762 Insecticidal cyclopropyl-substituted di(aryl) compounds  
Compounds of the formula ##STR1## in which Ar is substituted or unsubstituted phenyl, naphthyl, or thienyl; Z is oxygen, sulfur, or methylene; and Ar' is 2-methyl[1,1'-biphenyl]-3-yl,...
4806553 Pyridyl alkylenediamine compounds insecticidal  
There are provided insecticidally active alkylenediamines of the formula ##STR1## wherein W1 stands for a 5- or 6-membered heterocyclic group which may be substituted, containing at least one...
4804762 N-cyanoalkylisonicotinamide derivatives  
Disclosed herein is a compound of the formula: ##STR1## wherein X is halogen, lower alkoxy or lower alkylthio, Y is hydrogen or chloro, R1 is hydrogen, lower alkyl, cyanomethyl, phenyl or benzyl,...
4797407 Fungicidal pyridyl carbamates  
Novel fungicidal pyridyl carbamates having the formula ##STR1## wherein R is selected from the group consisting of halogen such as chlorine, fluorine and bromine, C1 -C3 alkoxy such as propoxy,...
4786641 Dihydropyridine compounds and their use in reducing blood sugar  
Blood-sugar-lowering dihydropyridines of the formula ##STR1## in which R1 represents phenyl, naphthyl, thienyl, pyridyl, chromenyl or thiochromenyl, it being possible for the radicals mentioned...
4774250 Composition and method for treating differentiated carcinoma or melanoma cells with thiapyrylium dyes  
There are described an anti-cancer composition and a method of treating differentiated carcinomas or melanoma, Featuring a suitable carrier and particular 2,4,6-tri(aryl or heteroaryl)...
4772612 Circulation-active 1,4-dihydropyridines  
Novel circulation active dihydropyridines of the formula ##STR1## in which X is CO, SO2 or CONH, R4 is H, OH, alkyl, halogen, acyloxy, alkoxyalkoxy, aralkyloxy, or together with R5 forms a...
4767757 Acyloxythiophene-carboxamide fungicides, compositions and use  
Novel fungicidally active acyloxythiophene-carboxamides of the formula ##STR1##
4762847 Method of treating acne  
A topical composition for application to skin affected by acne containing from 0.05 to 2% by weight of Octopirox together with a non-irritant topically acceptable carrier. The composition is...
4761420 Antihypertensive dihydropyridine derivatives  
Compound of formula 1 are calcium entry antagonists useful for treating hypertension, congestive heart failure, angina, and vasospastic disorders: ##STR1## wherein n is an integer from 1 to 4; R1...
4760068 Certain pyridyl alkenoic acid derivatives which inhibit the action of thromboxane A2 synthetase  
Novel compound of the formula: ##STR1## wherein R1 is pyridyl group, R2 is a phenyl group, a thienyl group, a furyl group, a naphthyl group, a benzothienyl group or pyridyl group, which may...
4757071 1,4-dihydropyridine derivatives, and pharmaceutical compositions containing same, useful for treating cardiovascular diseases  
2,6-Dimethyl-4-(2- or 3-substituted phenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diesters, having vasodilating and blood pressure lowering effects, in the ester moiety at the 3-position of...
4751234 Certain N-alkyl-2-[(quinolin-3-yl)-tetrahydro-pyran or furan]-2-carbothiamide 1-oxide derivatives useful for treating hypertension  
Thioformamide derivatives of the formula: ##STR1## wherein R is hydrogen or alkyl (1 to 4 C), Het is pyridin-3-yl[optionally substituted by alkyl (1 to 4 C) or a halogen], quinolin-3-yl,...
4749712 Antiinflammatory and/or analgesic 5-alkylthiophenes  
5-Alkyl-2,3-diarylthiophenes, such as 5-(1,1-dimethylethyl)-2,3-bis(4-methoxyphenyl)thiophene, 5-(1-methylpropyl)-2,3-bis(4-methoxyphenyl)thiophene and...
4749700 Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same  
Invention relates to nasal administration of physiologically active therapeutic agents and dosage forms useful for such administration.
4746671 Pharmaceutical use of [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters  
Novel [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters, compositions containing the same, and methods of treating clinical conditions related with the production of thromboxane A2,...
4745120 3-pyridyl compounds and use as thromboxane synthetase inhibitors  
The present invention relates to new pyridines substituted in the 3-position, of the formula ##STR1## and to a process for their preparation. The compounds bring about specific inhibition of...
4738969 Substituted aminopyridones and aminoquinolones having histamine H2 -receptor blocking activity  
This invention relates to 2-substituted aminopyridone compounds which have histamine H2 -antagonist activity.
4738977 2-pyridylacetic acid derivatives, pharmaceutical composition containing the same and their use in treating ulcers  
A 2-pyridylacetic acid derivative having the formula (I): ##STR1## wherein R1 represents an alkyl having 1 to 15 carbon atoms, an alkenyl having 5 to 20 carbon atoms or an aralkyl having 7 to 15...
4735959 Carboxylic acid amides and pharmaceutical compositions containing them  
There are described novel carboxylic acid derivatives of the formula ##STR1## and derivatives of the formula ##STR2## and the addition salts thereof, which exhibit an effect on the intermediary...
4731371 Certain 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles which are useful as cardiotonic agents  
Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic...
4722930 3-benzoyl-1-[(oxo or thioheteroaryl-ylalkyl)-piperid-4-yl]ureas and derivatives  
The invention concerns the preparation of compounds of formula ##STR1## and acid addition and quaternary ammonium salts thereof, wherein the dotted line represents an optional bond, Ar represents...
4719221 2-acetylpyrimidine-5-[(dimethylamino)thiocarbonyl]thiocarbonohydrazone and salts thereof  
A class of novel thiosemiarbazones has been found to be active against a number of protozoa which cause serious diseases, mainly in the tropical areas of the world.
4714710 Insecticidal and acaricidal oxetane and thietane derivatives, compositions, and method of use therefor  
There are described new compounds of general formula I ##STR1## in which R1 is aryl or aryl substituted by C1-4 -alkyl, halo-C1-4 -alkyl, phenyl-C1-4 -alkyl, C2-4 -alkenyl, halo-C2-4 -alkenyl,...
4711892 Certain 5-nitro-2-furyl derivatives of pyridylpropenoic acid hydrazides which are useful in treating bacterial, fungal, protozoal, parasitic and intestinal infections  
Nitrofuran derivatives corresponding to the formula (I). ##STR1## in which m is 0 or 1 R is H or (C1-4)alkoxy are useful in treating bacterial, fungal, parasitic or protozan infections.
4710505 Asymmetric heterocyclic ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids  
The present invention relates to new asymmetric heterocyclic ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acids of the formula: ##STR1## wherein R1 is a C1 -C4 -alkyl group; X and Y,...
4710498 Pyridyloxy derivatives  
Pyridyloxy derivatives represented by the general formula: ##STR1## wherein the substituted group Z is either one of the following groups: ##STR2## were prepared. These derivatives exert...