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5061726 Alkynylphenyl-substituted 1,3-oxathione compounds with pesticidal activity  
Pesticidally-active alkynylphenyl-substituted 1,3-oxathianes and related substituted compounds of the formula: ##STR1## and their use in controlling pests such as arthropods and helminths are...
5061716 Fungicidal 3,3-bisthioalkyl-2-pyridylacrylic acid compounds  
Compounds having the structure ##STR1## wherein: R and R1 are each independently members selected from the group consisting of C1 -C10 alkyl, C1 -C10 cyanoalkyl, C7 -C13 arylalkyl, C2 -C9 alkenyl,...
5059611 Anti-inflammatory 5-hydroxy-2-furanones  
New 5-hydroxy-2-furanone compounds have anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.
5055454 13-epi-avermectin derivatives useful as antiparasitic agents  
There are disclosed avermectin derivatives in which position 13 of the avermectins has been inverted from the normal (alpha) stereoschemistry to the epimeric 13-beta stereochemistry. The synthetic...
5053073 Thiophene derivatives useful as fungicidal, insecticidal or plant growth regulating agents  
Compounds of formula (I): ##STR1## and stereoisomers thereof, wherein W is R1 O2 C--CCH--ZR2, wherein R1 and R2, which are the same or different, are alkyl or fluoroalkyl groups, and Z is either...
5053415 Pyridine derivatives  
The invention concerns novel, pharmaceutically useful 1,3-dioxane alkenoic acid derivatives of the formula I containing a pyridyl moiety at position 4 of the dioxane ring and in which the groups...
5049569 Method for the protection of plants against diseases  
Novel acylated urea derivatives of the general formula ##STR1## in which: X is hydrogen or halogen; Y is halogen; R1, R2 independently of one another are hydrogen, C1 -C6 alkyl or C1 -C6 alkyl...
5047406 Substituted cyclohexanols as central nervous system agents  
Substituted cyclohexanols and cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central...
5047414 2-(aminoalkylthio)methyl-1,4-dihydropyridine, a method for the preparation thereof and pharmaceutical compositions containing them  
Compounds of formula I, and pharmaceutical compositions containing compounds of formula I ##STR1## wherein: R1 is: (a) COCH3, COC6 H5, CN or NO2 ; (b) COORa wherein Ra is hydrogen, or optionally...
5036081 Calcium absorption promoter  
Alpha-glucosidase inhibitor is provided as a promoter of calcium absorption in mammals. The examples of the inhibitor are shown by the formula; ##STR1## wherein A stands for a C1 -C10 acyclic...
5034395 Novel dihydropyridine derivatives  
Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory...
5032602 Inhibiting HMG-CoA reductase with novel substituted 2-pyridones and pyrid-2-thiones  
For inhibiting HMG-CoA reductase and cholesterol synthesis, the novel 2-pyridones and pyrid-2-thiones of the formula ##STR1## in which A is optionally substituted aryl or heterocyclic, B is...
5026716 Method of treatment of anxiety and anxio-depressive disorders  
A method of treatment of anxiety and depression in mammals is described which comprises administering to a mammal in need thereof an effective amount of a trifluoromethylphenyl-tetrahydropyridine...
5017588 5-(ω-ammonio acyloxy methylene) tetrahydrofurans and tetrahydrothiophenes and a therapeutic composition containing same  
This invention relates to new tetrahydrofurans and tetrahydrothiophenes of the general formula ##STR1## wherein X stands for O or S, η is an integer from 1 to 6, R stands for various hydrocarbon...
5017586 5-dialkylaminomethyl-2-furanomethanol derivatives having anti-hypertensive properties  
Derivatives of 5-aminomethyl-2-furanomethanol represented by formula (I), or pharmaceutically acceptable salts thereof, which possess calcium-antagonistic activity and are effective in lowering...
5013734 Novel esters of phenylalkanoic acid  
The esters of phenylalkanoic acid of the formula: ##STR1## wherein R1 is 4-10 membered, saturated or unsaturated, mono- or bi-cyclic hetero ring containing as hetero atoms: (i) one or two...
5008275 Pesticidal pyridyl-substituted acrylic ester compounds  
Fungicidal pyridyl-substituted acrylic esters of the formula ##STR1## in which R1 represents alkyl or represents optionally substituted aralkyl, R2 represents dialkylamino or represents a radical...
5002957 Azaneophyl sulfides, and their use as pesticides  
Azaneophyl and silazaneophyl sulfides, processes for their preparation, agents containing them, and their use as pesticides.Compounds of the formula I, their optical isomers and mixtures thereof...
5000778 2-aryl-2-(3-pyridyl)-1,3-dioxalanes, dithiolanes and -oxa-thiolanes having herbicidal and pesticidal activity  
Fungicidal and herbicidal novel 3-substituted pyridines of the formula ##STR1## wherein A represents oxygen or sulfur, B represents oxygen, sulfur or sulfinyl, R1 represents hydrogen, halogen,...
5001137 Pyridine compounds and pharmaceutical use thereof  
A novel pyridine compound of the formula ##STR1## wherein each symbol is as defined in the specification, or a salt thereof which exhibit inhibitory activity or prolylendopeptidase and a...
5001136 Leukotriene-synthesis-inhibiting 2-substitutedmethylamino-5-(hydroxy or alkoxy)pyridines  
2-substitutedmethylamino-amino 5-(hydroxy or alkoxy) pyridines and derivatives thereof are disclosed. The compounds are inhibitors of leukotriene synthesis and are therefore useful for the...
4997843 2,4-disubstituted derivatives of tetrahydrofuran useful for the treatment of PAF mediated illnesses  
The present invention describes novel 2,4-disubstituted derivatives of tetrahydrofuran, having the formula I ##STR1## wherein: -X- is either an oxygen atom or a covalent single bond; --CH2 XR1...
4997837 6-(((substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis  
Certain trans-6-[[(substituted)pyridin-3-yl]-alkyl- and alkenyl]tetrahydro-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom are potent inhibitors of the enzyme...
4994476 Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties  
A series of compounds useful in treating cardiovascular disorders due to the combined expression of both β-block and calcium-block activity by these agents. This useful combination of actions is...
4994465 Antihyperlipidemic and antiatherosclerotic trisubstituted urea compounds  
Certain trisubstituted urea compounds as potent inhibitors of the enzyme acyl-CoA:cholesterol acyltransferase, their method of manufacture, pharmaceutical compositions containing such compounds as...
4994473 Pyridyl containing insecticides  
Insecticides of the general formula ##STR1## wherein R1 is an optionally substituted 5- to 10-member heterocyclic moiety; R2 is an optionally substituted alkyl, cycloalkyl or alkenyl moiety; X is...
4987146 N-hetaryl imidazole derivatives  
N-hetaryl imidazole derivatives of general Formula I ##STR1##are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R3 represents hydrogen, a...
4980362 4-substituted-2-alkoxytetrahydrofuran derivatives  
The present invention describes a process to obtain 4-substituted 2-alkoxytetrahydrofuran derivatives of formula I, ##STR1## wherein, --R1 represents an alkyl or phenylalkyl radical; --R2 is...
4975443 Fungicidal pyridyl iminocarbonates  
Novel fungicidal pyridyl iminocarbonates having the general structural formula ##STR1## wherein R is selected from the group consisting of C1 -C16 alkyl, C3 -C8 cycloalkyl, C2 -C8 alkenyl, C2 -C8...
4975426 Cough/cold mixtures comprising non-sedating antihistamine drugs  
Pharmaceutical compositions and methods of using same comprising aspirin, sodium salicylate, salicylamide or acetaminophen, in combination with a non-sedating antihistamine and optionally one or...
4971981 Substituted dioxolan and dioxan derivatives useful as pesticides  
Novel substituted 1,3-dioxolan and 1,4-dioxan derivatives of formula I ##STR1## in which R1, R2, R3, R4, R5 and R6 each independently of the others represents hydrogen or C1 -C4 -alkyl or, if n=1,...
4971985 Pyridylketoxime ether compound and pharmaceutical composition containing it  
A pyridylketoxime ether compound of the formula: ##STR1## wherein Ar is a phenyl, naphthyl, or heterocyclic group unsubstituted or substituted by a C1 -C8 alkyl group, a C1 -C8 alkylamino group, a...
4966908 Isonicotinic acid amides for protecting plants against disease  
Novel substituted isonicotinic acid amides and isonicotinic acid hydrazides of the general formula ##STR1## in which Hal, each independently of the other, is fluorine, chlorine, bromine or iodine,...
4963573 [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters  
Novel [[[(3-pyridinyl)methylen]amino]oxy]alkanoic acids and esters, compositions containing the same, and methods of treating clinical conditions related with the production of thromboxane A2,...
4959362 Pharmaceutical compositions containing certain ascorbic acid derivatives useful in the prophylaxis and treatment of disorders of the circulatory system  
An ascorbic acid derivative of the formula: ##STR1## wherein R1 is organic residue having molecular weight of from 15 to 700, R2 is hydrogen or hydroxyl, R3 is hydrogen, acyl, optionally...
4956369 2-dithioalkyl-dihydropyridines and pharmaceutical compositions containing them  
Compounds of formula I ##STR1## wherein R1 and R3, which are the same or different, are alkoxycarbonyl, acetyl, cyano, nitro, benzoyl or amino-carbonyl groups, R2 is differently substituted aryl...
4950675 Pyridine di-mevalono-lactones as inhibitors of cholesterol biosynthesis  
Certain trans-6,6'-[[(substituted)pyridin-3,5-diyl]-dialkane- and dialkene-diyl]bis [tetrahydro-4-hydroxypyran]-2-ones and the corresponding ring-opened acids derived therefrom are potent...
4946852 4(R)-substituted 6(S)-phenoxymethyl-, 6(S)-β-phenylethyl- and 6(S)-β-styryl-tetrahydropyran-2-ones, a highly stereoselective process for their preparation, pharmaceutical products based on these compounds, and their use  
4(R)-Substituted 6(S)-phenyloxymethyl-, 6(S)-β-phenylethyl- and 6(S)-β-styryl-tetrahydropyran-2-ones of the general formula V ##STR1## in which R7, R8 and A have the meanings given, and the...
4940706 2,4-disubstituted 1,3-dioxolanes and pharmaceutical use  
The present invention describes novel 2,4-disubstituted 1,3-dioxolanes having the formula I ##STR1## wherein R1 represents a long chain alkyl group; X is a covalent single bond, a carbonyl group,...
4940483 Fungicidal 2-(-3-pyridyl)-1,3-dioxanes  
Fungicidal and herbicidal novel 3-substituted pyridines of the formula ##STR1## wherein A represents oxygen or sulfur, B represents oxygen, sulfur or sulfinyl, R1 represents hydrogen, halogen,...
4939160 Hydropyridine derivatives  
Hydropyridine derivatives of the formula ##STR1## in which R1 represents carboxy, lower alkoxycarbonyl, carbamoyl, N-lower alkylcarbamoyl or N,N-di-lower alkylcarbamoyl, R2 represents hydrogen, an...
4933352 Bi-functional carbamates of 2-ureado-pyridine compounds  
Novel carbamates of 2-ureado-6-hydroxy-pyridines have the structural formula ##STR1## wherein n is 0 to 20; R1 is hydrogen, alkyl which may be substituted, aryl which may be substituted; R2 is...
4929637 Substituted thiophene-2-sulfonamide antiglaucoma agents  
Thiophene-2-sulfonamides with an alkyl or substituted-alkyl and an alkyl-S(O)n -substituent are carbonic anhydrase inhibitors useful in the treatment of elevated intraocular pressure.
4925852 3-demethylmevalonic acid derivatives, and pharmaceutical products based on these compounds  
3-Demethylmevalonic acid derivatives of the formula I (δ-lactone) and II (corresponding dihydroxy carboxylic acid derivative) ##STR1## in which A--B, Z, R1, R2, R3 and R4 have the indicated...
4923882 Novel amine derivatives, salts thereof and an anti-ulcer agent containing the same  
This invention relates to amine derivatives and salts thereof. These compounds have an anti-ulcer activity which is effective to human beings and animals. This disclosure relates to such compound,...
4921866 1,3-dioxanes  
The invention concerns novel, pharmaceutically useful 1,3-dioxane alkanoic and alkenoic acid derivatives of the formula I in which the groups at positions 2, 4 and 5 of the 1,3-dioxane ring have...
4921865 Aminoacylates of glycerol acetal  
The invention relates to new aminoacylates of glycerol acetal of the general formula I ##STR1## wherein R1 represents a substituted phenyl group or a group of the formula Cm H2m+1, m being an...
4906454 Deodorant compositions containing specific piroctone salts and perfumes  
Deodorant compositions comprising piroctone acid, its nonprimary olamine salts, metal salts and combination thereof; and a perfume which contains high concentrations of aldehydes and/or ketones...
4902710 Serotonin and norepinephrine uptake inhibitors  
The present invention provides propanamines, substituted at the 3-position of the propanamine chain with a thio, sulfinyl or sulfonyl moiety, which are capable of selectively inhibiting the uptake...
4900727 4H-1-benzopyran-4-one compounds which have anti-inflamatory or immunodulating action  
The present invention relates to novel 4H-1-benzopyran-4-one derivatives, to processes for the preparation thereof and to their use as anti-inflammatory, analgesic, immuno-suppressive and...