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5567717 Heterocycle substituted phenoxyalkylheterocycles and their use as antiviral agents  
A compound of the formula ##STR1## wherein Y, R1, R2, R3, R4 and R5 are as defined in the specification.
5559134 Leukotriene-B4 antagonists, process for their production and their use as pharmaceutical agents  
The invention relates to leukotriene-B4 antagonists of formula I ##STR1## in which n represents a whole number from 2 to 5, X represents a direct bond, 1 to 6 methylene units, an ortho-, meta- or...
5541163 Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives  
Disclosed herein are compounds of the formula: A--N(R1)C(O)CH2 CHR2 C(O)--Bwherein A is R3 R4 NC(O)CH2 wherein, for example, R3 is hydrogen or alkyl and R4 is hydrogen, alkyl or a substituted...
5541202 New leukotriene-B4 Antagonists and their use as pharmaceutical agents  
1. Leukotriene-B4 antagonists of formula I, ##STR1## are described, in whichX represents C1 -C4 -alkoxy or --S(O)p --(C1 -C4)-alkyl,p represents 0, 1 or 2Y represents a hydrogen atom or the...
5536734 Dihydropyran derivatives and crop protection agents containing them  
Crop protection agents contain dihydropyrans of the formula ##STR1## wherein the variable substituents are defined in the specification.
5527827 Bisarylcarbinol cinnamic acids as inhibitors of leukotriene biosynthesis  
Compounds having the Formula I: R1 R2 C(OR3)--Ar1 --X--Ar2 --C(Ar3)CHCO2 H Iare inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic,...
5523312 Antipicornaviral agents  
Disclosed herein are compounds and pharmaceutical compositions useful for combating picornaviruses and preventing or treating picornaviral infections. The compounds have the formula: ##STR1##...
5506242 Arylsufonamido-substituted hydroxamic acids  
The invention relates to a method of inhibiting metalloellastase activity, of inhibiting the degradation of elastin, or of treating macrophage metalloelastase dependent conditions in mammals which...
5506259 β-mercapto-propanamide derivatives useful in the treatment of cardiovascular diseases  
Compounds of formula ##STR1## wherein R, R1, R2, Het and n have the meanings reported in the description, processes for their preparation and pharmaceutical compositions which contain them as...
5504106 Phenyl amidine alkanoic acids and lactones useful as platelet aggregation inhibitors  
This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet...
5502064 4-heterocyclyl-substituted dihydropyridines  
4-Heterocyclyl-substituted dihydropyridines are prepared by reacting appropriate aldehydes with β-keto esters and aminocrotonic acid esters, or by esterifying 4-hetero-cyclyl-substituted...
5492908 Diaminotrifluoromethylpyridine derivatives, process for their production and phospholipase A2 inhibitor containing them  
A method of treating rheumatoid arthritis using a diaminotrifluoromethylpyridine derivative of the formula (I) or its salt: ##STR1## wherein X is --CW1 R1, --COCOR2, --CW1 NHCOR2, --C(W1)W2 R3 or...
5491152 Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis  
The present invention provides compounds of Formula I, ##STR1## or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT),...
5482966 Oxime derivatives  
The invention concerns oxime derivatives of the formula I ##STR1## wherein R4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and...
5482942 (3,4-dioxocyclobuten-1-yl)chromene, indene, and dihydronaphthalenone derivatives as smooth muscle relaxants  
This invention relates to novel 4-(3,4-dioxocyclobuten-1-yl)chromenes and dihydronaphthalenones and 3-(3,4-dioxocyclobuten-1-yl)indenes and salts thereof having smooth muscle relaxing activity, to...
5468746 Compounds active on the cardiovascular system  
Compounds of the formula ##STR1## (wherein Ar, R, R1, R2, R3, R4, R5, m and n have the meanings given in the description), their preparation and pharmaceutical compositions containing them.The...
5457118 Pyridine derived agents for cardiovascular diseases  
PCT No. PCT/EP92/00591 Sec. 371 Date Apr. 20, 1994 Sec. 102(e) Date Apr. 20, 1994 PCT Filed Mar. 17, 1992 PCT Pub. No. WO92/17451 PCT Pub. Date Oct. 15, 1992. (I) Compounds of formula (I) or a...
5457125 Oxime derivatives  
The invention concerns oxime derivatives of the formula I ##STR1## wherein R4 is hydrogen, (1-4C)alkyl, halogeno-(2-4C)alkyl, hydroxy-(2-4C)alkyl, cyano-(1-4C)alkyl, phenyl or phenyl-(1-4C)alkyl;...
5447942 N-derivatives of (phenylethyl-β-ol) amine, a process for their preparation and pharamaceutical compositions containing the same  
The invention relates to a N-(2,4- or 2,5-disubstituted tetrahydrofuryl alkyl)-N-(phenylethyl-β-ol)amine derivative, under a racemic or enantiomer form, of general formula I ##STR1## wherein R...
5428039 Method for electively achieving reversible hyperpolarized cardiac arrest  
While performing cardiopulmonary bypass, the aorta is cross-clamped and the beating heart is stopped by introducing of an ATP-dependent potassium channel opening agent. The infusion into the...
5426109 Phenylnaphthalene hydroxy acids  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5426117 N-methyl-2-(3-pyridyl)-tetrahydrothio-pyran-2-carbothioamide 1-oxide to the preparation of medicinal products intended for treatment of coronary insufficiency  
Application of N-Methyl-2-(3-pyridyl)tetrahydrothiopyran-2-carbothioamide 1-oxide, in the form of a racemic mixture of the 1S,2S and 1R,2R isomers or in the form of the 1R,2R isomer, to the...
5426119 Arylsulphonamides, pharmaceutical compositions containing these compounds  
The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R1 to R6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R4 and R5...
5424309 N-substituted acylamino acid compounds, process for their production and their use  
The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
5413997 Triphenylmethane derivatives  
A triphenylmethane derivative represented by the following general formula: ##STR1## exhibits bone absorption inhibiting effects and is useful as a medicament for treating osteoporosis.
5409910 Substituted pyridines  
New substituted pyridines are prepared by reducing suitably substituted pyridine derivatives. The new substituted pyridines are suitable as active compounds in pharmaceuticals, in particular for...
5403845 Muscarinic agonists  
Substituted 1,4,5,6 -tetrahydropyrimidine compositions, substituted 1,2,3,6 -tetrahydropyrimidine compositions and substituted 3,4,5,6 -tetrahydropyridine compositions are disclosed. They are...
5393762 Pharmaceutical agents for treatment of emesis  
The present invention relates to a method of treating or preventing emesis in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives...
5389649 Oxathiane derivatives  
Oxathiane derivatives of formula ##STR1## in which R represents alkyl and A represents optionally substituted phenyl or a heteroaromatic group containing 1 or 2 nitrogen atoms optionally...
5389644 1,4-dihydropyridine compounds  
The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to...
5371096 (3-pyridyl)tetrafuran-2-yl substituted carboxylic acids  
Disclosed are compounds of formula ##STR1## wherein R is OR' and R' is aryl-lower alkyl, biaryl-lower alkyl, lower alkyl or cycloalkyl-lower alkyl; or R is arylsulfonylamido; n is 1, 2 or 3; m is...
5369107 Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same  
Compounds of the formula: ##STR1## wherein A is S, SO, or SO2, R1 is H or acyl, R2 is H, alkyl, hydroxyalkyl, halogen or carboxy, and R3 is pyridyl are claimed. The compounds are useful as...
5364873 Pyridine-2,4- and dicarboxylic acid derivatives, the use thereof and pharmaceutical composition based on these compounds  
The invention relates to pyridine-2,4- and -2,5-dicarboxylic acid derivatives of the formula I ##STR1## in which R1, R2 and X have the meanings given, a process for the preparation of these...
5364853 Thioformamide derivatives  
Thioformamide compounds of formula (I) are disclosed in which R is alkyl, Y is methylene, ethylene or a direct bond, A is optionally substituted phenyl or pyridyl, R1 is hydrogen and R2 is...
5356909 Substituted pyridine-2,4-dicarboxylic acid compounds and the use thereof and medicaments  
The invention relates to substituted pyridine-2,4-dicarboxylic acid derivatives of the formula I ##STR1## in which R1 and R2 have the meanings given. The invention also relates to a process for...
5356915 Tetralones with pharmacological activity, compositions containing them  
The present invention relates to new tetralones having formula I: ##STR1## wherein R1 to R7 are as defined in claim 1. The invention also relates to processes for their preparation, to...
5344843 Cat-1 inhibitors, pharmaceutical compositions and methods of use  
The invention relates to compounds of the formula ##STR1## wherein R1, R2, R2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate,...
5342848 Thioformamide derivatives  
Thioformamide derivatives of formula (I): ##STR1## wherein R represents alkyl; A represents optionally substituted pyrid-4-yl; Y represents ethylene or methylene or a direct bond and X represents...
5340579 Method of treating dermatological conditions  
A method is provided for treating dermatological conditions by binding and blocking 5-a-dihydrotestosterone receptors comprising applying to the skin an effective amount of composition comprising:...
5336686 17 Methylene lactones of steroids  
A compound selected from the group consisting of a compound of the formula ##STR1## wherein the substituents are defined as in the application having antiglucocorticoid and antiprogestomimetic...
5334614 Hydroxylamine derivatives  
The invention concerns hydroxylamine derivatives of the formula I ##STR1## wherein R4 is hydrogen, carbamoyl, (1-4C)alkyl, cyclopentyl, cyclohexyl, tetrahydrofuran-3-yl, tetrahydropyran-4-yl,...
5317029 Pharmaceutical composition of benzopyranes for the inhibition of bone resorption  
Pharmaceutical compositions for the inhibition of bone resorption comprising a pharmaceutical carrier and a therapeutically effective amount of a benzopyran derivative represented by the general...
5314891 Benzenesulphonamide derivatives  
The invention concerns benzenesulphonamide derivatives of the formula I ##STR1## wherein R1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; R2 and R3 together form --A2 --X2 --A3 -- which defines...
5308852 Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis  
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
5308853 Substituted-5-methylidene hydantoins with AT1 receptor antagonist properties  
Substituted 1-benzylimidazole-5-methylidene hydantoins are disclosed as well as methods of preparing them, pharmaceutical compositions containing them, and method of using them. Intermediates...
5302603 Heterocyclic cyclic ethers  
The invention concerns a heterocyclic cyclic ether of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one...
5300499 5-substituted 3-thiophene sulfonamides as antiglaucoma agents  
The present invention provides novel carbonic anhyrase inhibitors represented by the structural formula: ##STR1## wherein R1 and R2 are, for example, independently (a) hydrogen; or (b) OR4,...
5286736 Pyridyl compounds and pharmaceutical compositions containing these compounds  
New pyridyl derivatives of the formula ##STR1## wherein R1 to R6, A, X and n are as defined herein, the enantiomers thereof, the cis- and trans-isomers thereof if R4 and R5 together represent a...
5276037 Heterocyclic 5-lipoxygenase inhibitors  
The invention concerns an aryl derivative of the formula I, ##STR1## wherein Ar1 is optionally substituted phenyl, naphthyl or a heterocyclic moiety, and X1 is oxy, thio, sulphinyl, sulphonyl,...
5270301 Fluoro-amide derivatives  
The present invention relates to certain fluoro-amide derivatives, as described herein, which are human leukocyte elastase (HLE) inhibitors making them useful whenever such inhibition is desired,...