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7622486 |
Pyridine compounds, process for their preparation and compositions containing them
The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a...
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7618988 |
Use of substituted aminomethyl chromans
Compounds of formula I in which R has a meaning as indicated in claim 1 , or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement...
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7612097 |
Method for producing bactericidal pyridine compound and bactericidal pyridine compound
Provided are novel pyridine compounds represented by the following formula (7):
wherein R 1 and R 4 may be the same or different and are each a linear or branched alkyl group having 1 to 4...
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7572815 |
Amide derivative
Amide derivatives represented by the formula (I):
wherein:
A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m-,...
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7560553 |
Use of fuse nicotinamides to promote neurogenesis
The present invention provides a group of compounds found to increase the number of neurons derived from stem cells for use as a therapeutic agent in neurological conditions or diseases. In one...
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7534802 |
Compounds having 4-pyridylalkylthio group as substituent
A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a...
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7501413 |
Dicarboxamide derivatives
The invention is concerned with novel dicarboxamide derivatives of formula (I)
wherein A, B, R c , D and E are as defined in the description and in the claims, as well as physiologically...
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7417041 |
Imidazopyrimidines as transforming growth factor (TGF) inhibitors
Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described....
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7414060 |
Pyridine-2-carboxyamide derivatives
The invention relates to compounds of formula I:
wherein R 1 to R 3 are as defined in the specification, to processes for their preparation, to pharmaceutical compositions containing them,...
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7410979 |
Synergistically effective combinations of dihaloacetamide compounds and interferon or ribavirin against HCV infections
The present invention relates to anti-HCV dihaloacetamide compounds in synergistic combination with an interferon and/or ribavirin and pharmaceutical compositions thereof for inhibition of the...
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7407972 |
Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
The present invention provides compounds of Formula (I):
wherein A, B, C, G, and W 1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
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7402683 |
Cinnamic acid amides
The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis in illnesses in...
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7388021 |
Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions
The present invention provides novel pyridyl or phenyl ureas and analogues thereof, which are selective inhibitors of the human P2Y 1 receptor. The invention also provides for various...
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7371766 |
Curcumin analogs with anti-tumor and anti-angiogenic properties
The present invention is directed to curcumin analogs exhibiting anti-tumor and anti-angiogenic properties, pharmaceutical formulations including such compounds and methods of using such compounds.
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7371763 |
Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in...
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7351722 |
Use of Mangafodipir for treating oxidative stress effects
The invention concerns the use of Mangafodipir to obtain a medicine for preventive or curative treatment of hepatocellular deficiencies.
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7338950 |
Amide compounds as ion channel ligands and uses thereof
Compounds are disclosed that have a formula represented by the following:
The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a...
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7326723 |
Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same
The present invention relates to compounds of formula (I):
in which
X represents N or CH; R 1 represents a hydrogen or halogen atom or a CF 3 group; n is an integer from 1 to 5; A...
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7312235 |
Benzamide inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
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7304066 |
Pyridyl cyanoguanidine compounds
Compounds according to formula (I)
wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C 1-6 hydrocarbon radical, optionally substituted with...
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7291631 |
CXCR4 chemokine receptor binding compounds
The present invention relates to compounds that bind to chemokine receptors, and having the formula
wherein each A, X, Y, R 1 , R 2 and R 3 are substituents. The present invention also...
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7262210 |
Fluorinated pyridine N-oxide thrombin modulators and process for N-oxidation of nitrogen containing heteroaryls
The present invention describes compounds of Formula I
or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to thrombin activity...
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7262209 |
Carbonyloxy-cyanomethyl compounds as antiparasitic agents
The invention relates to compounds of the general formula
wherein Ar 1 , Ar 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, a and b have the significances given in the specification, and optionally the...
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7241758 |
Compounds useful as anti-inflammatory agents
Disclosed are novel aromatic compounds of the formula (I) wherein G, X, Ar, L and Q are defined herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological...
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7241745 |
Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives
The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I)
as well as methods for their production, medicaments containing these compounds...
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7238715 |
Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
A method of treating a patient suffering from pancreatitis comprising treating said patient with a therapeutically effective amount of a cholinergic agonist selective for an α7 nicotinic receptor...
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7238714 |
Aryl or heteroaryl amide compounds
This invention provides a compound of the formula (I):
wherein A represents a phenyl group or the like: B represents an aryl or the like: E represents a 1,4-phenylene group; R 1 and R 2 ...
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7214701 |
Active substance combinations having insecticidal and acaricdal properties
The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising
(a) compounds of the formula (I)
in which W, X, Y, Z, A, B, D and G...
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7211578 |
Nitrogenous tetrahydropyridyl-alkyl-heterocycles with TNF activity
This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the...
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RE39575 |
Substituted thioacetamides
The present invention is directed to chemical compositions of substituted thioacetamides, processes for the preparation thereof and uses of the compositions in the treatment of diseases.
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7202260 |
VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones
Novel VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridones and their use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are selected.
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7196101 |
Bis(5-aryl-2-pyridyl) derivatives
A bis(5-aryl-2-pyridyl) compound represented by formula (1) or a salt thereof:
wherein A is a substituted or unsubstituted aromatic hydrocarbyl group or a substituted or unsubstituted aromatic...
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7173046 |
CD40:CD154 binding interrupter compounds and use thereof to treat immunological complications
The present invention relates to novel CD40:CD154 binding interrupter compounds and use of these compounds and pharmaceutical compositions comprising them, to treat conditions associated with...
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7173041 |
Polyglutamic acid-camptothecin conjugates and methods of preparation
The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.
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7153864 |
Polyglutamic acid-camptothecin conjugates and methods of preparation
The invention provides polyglutamic acid-therapeutic agent conjugates and methods for their preparation and use.
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7138406 |
Modulators of the glucocorticoid receptor
The present invention provides compounds of the formula
wherein A is of the formula
and X, Y, n, R 1 –R 25 are as described in the specification which are modulators of the...
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7129252 |
Six membered amino-amide derivatives an angiogenisis inhibitors
The present invention relates to six membered amino-amide derivatives, processes for their preparation, pharmaceutical compositions containing them as active ingredient, methods for the treatment...
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7129235 |
Amides useful for treating pain
The present invention relates to compounds of formula (I-VII)
or a pharmaceutically acceptable salt or prodrug thereof, in which A, L, R 6 , R 7 and R 8 are defined herein. The present...
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7122543 |
Substituted benzoic acid derivatives having NF-κB inhibiting action
A substituted benzoic acid derivative which is represented by the following formula (I) and has an NF-κB inhibiting action (in the formula, R 3 , R 4 and R 5 each independently represents a...
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7115637 |
Inhibitors of p38
The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
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7109220 |
Amino substituted pyridinyl methanone compounds useful in treating kinase disorders
The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are...
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7109218 |
Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same
Compounds of the formula (I)
a process for their preparation and their use as medicaments are described.
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7109208 |
Visual function disorder improving agents
The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly...
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7098223 |
Arylsulfanyl and heteroarylsulfanyl derivatives for treating pain
According to the invention there is provided a compound the formula I;
wherein A, X, B, R 1 , R 2 , R 3 and R 4 are as defined in the specification.
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7091210 |
Substituted 2-aminoacetamides and the use thereof
The invention is directed to substituted 2-aminoacetamides represented by formula (II):
and to pharmaceutically acceptable salts thereof, wherein the substituents are defined herein, for use in...
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7087106 |
Materials and methods for inhibiting fouling of surfaces exposed to aquatic environments
The subject invention provides materials and methods for inhibiting the biofouling of surfaces exposed to aquatic environments. In one embodiment, the subject invention provides additives for...
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7084159 |
Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
The present invention provides compounds of formula I:
or a pharmaceutically acceptable derivative o thereof, wherein A, B, R a , R 1 , R 2 , R 3 , and R 4 are as described in the...
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7060714 |
Fungal strain acremonium sp.MT70646(KCTC 0916BP), novel compounds produced by this strain and their use
The invention is aimed at discovering a new type of anti-cancer compound which can exert an excellent inhibitory activity against the heparanase. A fungal strain Acremonium sp. MT70646 (KCTC...
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7045536 |
Compound having anti-viral activity
The present invention discloses an organic ionic compound having anti-viral activity and the method for antagonizing virus in vitro by putting the compounds in contact with the virus.
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7008903 |
Pesticide
The present invention provides a composition comprising synergistic amounts of a compound of the formula (I)
wherein X, E, R, A and Z are as defined herein, and at least one fungicidal active...
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