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9028873 Nanoparticles for drug delivery to the central nervous system  
The present disclosure relates to compositions and methods for producing nanoparticles to provide relatively more rapid delivery of such particles across the blood-brain barrier. The nanoparticles...
9017735 Modulation of KCNQ potassium channel activity for treatment of psychiatric disorders and the symptoms thereof  
Disclosed herein are compositions and methods for treating a psychiatric disorder or symptoms thereof in a patient. The compositions comprise a compound that modulates KCNQ (Kv7) potassium channel...
9018233 Diaminoaryl derivatives substituted by carbamate and pesticidal composition containing same  
The invention relates to diaminoaryl derivatives substituted by carbamate, salts thereof and a pesticidal composition containing the same, which exhibit superior pest control effects against...
9006269 Azetidine derivatives  
Compounds of formula (I) are inhibitors of fatty acid amide hydrolase, (FAAH), and which are useful in the treatment of diseases or medical conditions which benefit from inhibition of FAAH...
8980925 Antimicrobial amphiphiles and methods for their use  
The present invention is directed to compositions useful for antimicrobial applications. These compositions comprise amphiphilic compounds.
8956589 Imaging diagnostic agent and extracorporeal diagnostic agent for incurable neurological diseases  
Disclosed are a curcumin derivative or a salt thereof, which contains a fluorine atom, represented by formula (I): (wherein R1a and R1b are each independently a hydrogen atom, alkyl, acetyl, or...
8946263 Compositions and methods for modulating circadian synchronization  
The present invention relates to a modulator of glucocorticoid biosynthesis, degradation and/or receptor activation for use in preventing or treating symptoms and/or diseases associated with jet...
8940324 Octenidine composition  
The invention relates to octenidine or a pharmaceutical salt thereof, in particular octenidine dihydrochloride, which is intended for mutual therapeutic administration of the octenidine in...
8933104 Glucagon receptor modulators  
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds...
8933103 Pyridone derivatives  
Novel compounds or salts thereof, or crystals thereof, which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or...
8927580 Thiosemicarbazone compounds and use in the treatment of cancer  
The present invention relates to dipyridyl thiosemicarbazone compounds of formula (I): wherein R1 is cyclohexyl or ethyl; as well as pharmaceutical compositions containing those compounds, and the...
8921370 Bicyclo[3.2.1]octyl amide derivatives and uses of same  
The present invention provides bicyclo[3.2.1]octyl amide derivatives of formula (I): wherein L, R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical...
8916590 2,6-diaminopyridine compounds suitable for treating diseases associated with amyloid or amyloid-like proteins or for treating or preventing ocular diseases or conditions associated with a pathological abnormality/change in the tissue of the visual system  
The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or...
8916589 Bradykinin B1-antagonists  
The present invention relates to compounds of general formula I wherein n, R1, R2, R3, R4, R5, R6, R7 and R8 are defined as stated hereinafter, the enantiomers, the diastereomers, the mixtures...
8912184 Therapeutic and diagnostic methods  
The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase (Nampt); it also relates to...
8906408 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Octenidine composition
 
The invention relates to octenidine or a pharmaceutical salt thereof, in particular octenidine dihydrochloride, which is intended for mutual therapeutic administration of the octenidine in...
8895585 Nicotinamide derivative or salt thereof  
An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide...
8841326 Therapeutic curcumin derivatives  
Curcumin analogs and methods are provided for treatment of disease.
8815912 Wound and mucosa antiseptic based on bispyridiniumalkanes  
The invention relates to an antimicrobially effective composition which comprises a) 0.001 to 1% by weight of bispyridiniumalkane, b) humectant and c) water. The composition has an osmolality of...
8809342 Glucagon receptor modulators  
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds...
8809371 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Nicotinamide derivative or salt thereof
 
An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide...
8772320 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Nicotinamide derivative or salt thereof
 
An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide...
8741931 Kinase inhibitors  
The present invention relates to compounds having formula: which are useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said...
8735416 Antiviral therapies  
The field of the invention relates to the use of carbohydrate binding compounds as a medicine, their use to treat or prevent viral infections, their use to manufacture a medicine to treat or...
8722706 Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts  
The present invention relates to two phase systems of a bioactive ingredient in particle form that has limited or no solubility in a liquid medium, which provides stability to the bioactive...
8716284 Adamantyl diamide derivatives and uses of same  
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions...
8697733 Pyridine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8697729 Small molecules modulator of epigenetic regulation and their therapeutic applications  
Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to...
8673940 Compounds for the treatment of diseases associated with amyloid or amyloid-like proteins  
The present invention relates to novel compounds of formula (II) that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as...
8664247 Acyclic organonitro compounds for use in treating cancer  
The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating...
8629163 Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors  
Provided are tetrakis-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a...
8629164 Inhibitors of NF-κB  
The invention relates to compounds of formulae (1) and (2): and pharmaceutically acceptable salts thereof for the treatment of cancer, inflammation, auto-immune diseases, diabetes and diabetic...
8609697 Stabilized, antimicrobially effective composition with a content of bispyridinium alkane  
An aqueous-based composition which includes a) at least one bispyridinium alkane (for example octenidine) and b) at least one stabilizer selected from antioxidants, complexing agents, reducing...
8597876 Method of treating HIV infection  
Disclosed is a method of treating human immunodeficiency virus (HIV) infection in an antiretroviral treatment-experienced mammal, which involves administering to the mammal an effective amount of...
8586613 Pyridinium and quinolinium derivatives  
The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by...
8575165 Methods for treating inflammatory disorders using 2,4-pyrimidinediamine compounds  
Methods for treating an inflammatory disorder and for inhibiting the production of IL-23 using 2,4-pyrimidinediamine compounds represented by formula (I):
8569345 Compounds and compositions as LXR modulators  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity...
8541454 Antiseptic based on bispyridinium alkanes  
An antimicrobially effective composition includes a) at least 0.15% by weight of bispyridinium alkane, b) at least 3.5% by weight of humectant and c) water. Upon dilution with water, the...
8536200 Pyridinone compounds  
The invention is directed to pyridinone compounds useful for modulating Met kinase, having the following structure: and is further directed to pharmaceutical compositions comprising the compound;...
8536176 GPR119 agonist  
A cyclic amine derivative represented by the formula (II) is a GPR119 agonist, and is used as an agent for treating diabetes. wherein Ar0 is phenyl or phenyl having a substituent such as C1-8...
8536199 Oral combination of vitamins  
This invention provides compositions for treating and preventing nausea and other disorders, the compositions comprising vitamins as active ingredients, including vitamin B6, vitamin K, and...
8518948 Inhibitors of protein kinases  
Compounds of general Formula (I): wherein R1, R2, R3, Ra, A, B and x are as defined herein are inhibitors of protein kinases in particular members of the cyclin-dependent kinase family and/or the...
8513286 Iminipyridine derivatives and their uses as microbiocides  
Compounds of the formula (I) in which the substituents are as defined in claim 1 are suitable for use as microbiocides.
8492410 Pyridine derivatives as sphingosine 1-phosphate (S1P) receptor modulators  
The present invention relates to novel pyridine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
8476197 Aminopropenoates as fungicides  
The present invention relates to aminopropenoate derivatives, the process of their preparation, intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide...
8465725 Process for production of heterodimers of glutamic acid  
A manufacturing process for the preparation of radiolabeled compounds of formula (I) includes reacting compounds of formula (II) with a source of radionuclide of a halogen in the presence of an...
8455501 N-(5-cycloalkyl)-pyridin-3-yl carboxamides  
The present invention relates to compounds of the formula wherein R1 to R3 are defined in the description, and to pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical...
8450348 Derivatives of squaric acid with anti-proliferative activity  
The present invention provides derivatives of squaric acid, in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione and tautomers and isomers thereof, as a single stereoisomer or a...
8450346 Azetidine derivatives as FAAH inhibitors  
Compounds of formula (I) are inhibitors of fatty acid amide hydrolase, (FAAH), and which are useful in the treatment of diseases or medical conditions which benefit from inhibition of FAAH...
8426446 Acrylamide derivative and use thereof in manufacture of medicament  
An acrylamide derivative represented by formula (I), pharmaceutically acceptable salts and solvates thereof, as well as a medicament containing said acrylamide derivative or its pharmaceutically...