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7592359 |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
This invention generally relates to derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment...
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7576105 |
Benzyl substituted (piperidin-4-yl)aminobenzamido derivatives
The present invention is directed to N-benzyl substituted (piperidin-4-yl)aminobenzamido derivatives which are delta-opioid receptor modulators.
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7569579 |
Cyclopropyl compounds as ccr5 antagonists
The present invention relates to compounds of formula (I), or pharmaceutically acceptable derivatives thereof, useful in the treatment of CCR5-related diseases and disorders, for example, useful in...
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7550485 |
Substituted N-heterocycle derivatives and methods of their use
The present invention is directed to substituted N-heterocycle derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions...
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7538124 |
Biphenylcarboxamides useful as lipid lowering agents
Biphenylcarboxamide compounds of formula (I)
methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for...
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7528250 |
Chroman derivatives and uses thereof
Compounds of the formula I:
or pharmaceutically acceptable salts thereof,
wherein m, p, q, Ar, R 1 , R 2 , R 3 and R 4 are as defined herein. Also provided are methods for preparing,...
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7528156 |
Compounds
The invention provides compounds of general formula (D wherein m, n, Q, Z1, Z2, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification, processes for their preparation,...
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7507753 |
Biaryl compound and use thereof
The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I):
wherein...
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7488741 |
4-Aminopiperidine derivatives, processes for their preparation and their use as medicaments
4-Aminopiperidine derivatives, pharmaceutical compositions containing the same, and methods for their preparation are provided herein for the treatment of disorders of the central and/or peripheral...
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7473692 |
Sulfonamide derivatives as D3-receptor ligands
The present invention relates to new D 3 dopamine receptor subtype selectice ligands of formula (I) to pharmacological compositions containing the same and to their use in therapy and/or...
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7432280 |
3-aminopiperidines and 3-aminoquinuclidines as inhibitors of monoamine uptake
The present invention provides compounds of formula (I)
and pharmaceutically acceptable salts thereof, which are useful for the inhibition of the uptake of one or more physiologically active...
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7405229 |
Cathepsin cysteine protease inhibitors
This invention relates to a class of compounds having the general formula (I) which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These...
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7390823 |
Use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal products that are useful in the treatment or prevention of all mood disorders, adaptation disorders or mixed anxiety-depression disorders
The present invention relates to the use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal products that are useful in the treatment or prevention of all...
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7388018 |
4-Piridinylmethylsulphonamide derivatives as fungicidal plant protein agents
Sulfonamides of the formula I
where the substituents are as follows:
R 1 is hydrogen, alkyl, alkoxy, alkenyl or alkynyl; and R 2 , R 3 , R 4 , R 5 are hydrogen, halogen, alkyl, alkoxy or...
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7381735 |
Ultrashort-acting opioids for transdermal application
The subject invention concerns analogs of fentanyl opioids. The subject invention also concerns methods for synthesizing the compounds of the invention. The invention also concerns methods for...
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7381721 |
Substituted piperidine compounds
3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are...
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7368443 |
2,6-disubstituted piperidines and piperazine compounds
The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula:
which are used to treat diseases of the central nervous system,...
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7361666 |
Heterocyclic analgesic compounds and methods of use thereof
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
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7342028 |
Medical use for tachykinin antagonists
The present invention relates to the use of tachykinin antagonists, including substance P antagonists and other neurokinin antagonists, in the treatment of emesis. Also described are novel...
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7223788 |
Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
The invention relates to substituted N-aryl heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof. Compounds of the formula I
in which the...
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7223780 |
Triazole-derivatives as blood clotting enzyme factor Xa inhibitors
The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions...
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7183277 |
Carboxylic acid amides
Novel compounds of the formula I
in which
D, W, X, Y, T and R 1 are as defined in Patent Claim 1,
are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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7176201 |
Modulation of anxiety through blockade of anandamide hydrolysis
Fatty acid amide hydrolase inhibitors of the Formula:
are provided wherein X is NH, CH 2 , O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7148223 |
4′-thio-L-xylo furanosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z is...
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7109208 |
Visual function disorder improving agents
The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly...
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7090866 |
Opioid agonist in a fast dispersing dosage form
This invention relates to a pharmaceutical composition for oral administration comprising a carrier and, as active ingredient, an opioid (μ receptor) agonist, such as fentanyl, or a salt thereof,...
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7089053 |
Compositions for drug administration by electroporation
The present invention relates to compositions for electroporation which are useful in elevating a percutaneous absorbability of drugs, etc. By adding polyhydric alcohols to compositions for...
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7084144 |
Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction
A compound having the general formula (I):
wherein: X is N or C; R 0 is H, a lower alkyl group, a lower O-alkyl group,
lower alkyl group, a benzyl group, a phenyl group, a heterocyclic...
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7084140 |
Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds
The invention relates to new arylglycinamide derivatives of general formula I
and the pharmaceutically acceptable salts thereof, wherein R 1 and R 2 together with the N to which they are...
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7067535 |
5-Phenylbenzylamine compounds, process for their production and intermediates for their synthesis
The present invention relates to a 5-phenylbenzylamine compound represented by the formula [1]:
wherein Ring A represents a phenyl group having a substituent(s), R a , R b1 and R b2 each...
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7049326 |
Method and compositions for temporarily incapacitating subjects
A method for modifying at least one non-ester-containing parent compound, and the compounds produced using such method, which compounds are deployed to temporarily incapacitate at least one subject...
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7030147 |
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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7022716 |
Cyclic amine phenyl beta-3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure
wherein,
R 1 , R 2 , R 3 , R 4 , R 5 , T, T 1 , T 2 , and X are as defined hereinbefore, or a pharmaceutically...
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7001905 |
Substituted diarylamines as MEK inhibitors
Diarylamines, such as 5-amide substituted diarylamines of formula (I) or formula (II) wherein A is hydroxy, C 1-6 alkoxy, or NR 6 OR 7 ; X is OR 12 , NR 13 R 12 , or NR 14 ; inhibitors of MEK and...
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6982263 |
Nitriles useful as reversible inhibitors of cysteine proteases
Disclosed are novel nitrile compounds of formula (I) further defined herein, which compounds are useful as reversible inhibitors of cysteine proteases such as cathepsin K, S, F, L and B. These...
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6974825 |
Compounds with analgesic effect
Compounds of general formula (I)
wherein m is 0 or 1, and n is 1 or 2;
are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts, pharmaceutical...
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6974590 |
Sublingual buccal effervescent
A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in...
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6960602 |
Piperidine derivatives as modulators of chemokine receptors
The invention provides a compound of formula (I): wherein R 1 , R 2 , R 3 , R 3a , R 4 , R 4a , R 5 , and R 6 are as defined; or a pharmaceutically acceptable salt thereof or a solvate thereof;...
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6949257 |
Pharmaceutical compositions
Spontaneously dispersible pharmaceutical compositions comprising a piperidine, e.g. 1-acylpiperidine Substance P Antagonist and its use in the treatment of CNS disorders, e.g. depression and social...
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6943177 |
Cis-2,6-disubstituted piperidines for the treatment of psychostimulant abuse and withdrawal, eating disorders, and central nervous system diseases and pathologies
Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula:
are used to treat diseases of the central nervous system, drug abuse and withdrawal therefrom as well...
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6914061 |
4′-thio-L-xylofuranosyl nucleosides, precursors thereof, preparation and use thereof
Compounds represented by the formula 1:
A is selected from the group consisting of
wherein each R individually is H or acyl, Y is X, N 3 , NH 2 , monoalkylamino, or dialkylamino; Z...
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6900228 |
Opiate compounds, methods of making and methods of use
The present application relates to novel opioid receptor antagonists and agonists, methods of making these compounds, and methods of use thereof.
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6894059 |
Compounds and methods for treatment of asthma, allergy and inflammatory disorders
The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting...
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6878712 |
Amides as inhibitors for pyruvate dehydrogenase
A compound of formula (I):
wherein:
Ring A is a nitrogen linked mono or bicyclic heterocyclic ring as defined within; R 1 and R 2 are independently C 1-3 alkyl optionally substituted...
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6875777 |
Compounds
The present application is directed to compounds having the structure of Formula I:
where R 1 is phenyl, pyridinyl, thiophenyl, furanyl, imidazolyl or trazolyl, each optionally substituted by...
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6867221 |
Cyclic amine compounds and pharmaceutical composition containing the same
A cyclic amine compound represented by the following general formula (1):
wherein,
R 1 , R 2 and R 3 each independently represent a hydrogen atom or an alkoxy group; W 1 and W 2 ...
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6867220 |
Phenoxypropanolamines, method for producing them and pharmaceutical compositions containing them
The invention relates to compounds of formula (I)
where
R 1 represents a hydrogen or halogen atom or an —S(O) z —(C 1 -C 4 )alkyl, —S(O) z —(C 1 -C 4 )R 3 , —SO 2 —NH—(C 1 -C 4...
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6852736 |
Phenoxypropanolamines, preparation and therapeutic use thereof
The invention concerns phenoxypropanolamines of formula (I)
in which R 1 represents a hydrogen, a group —S(O) z —(C 1 -C 4 )alk-R′, (R′ being H, phenyl or (C 1 -C 4 )alkoxy), —NHSO...
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6821991 |
2-substituted thiazolidinones as β-3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein: A, X, Y, Z, R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined hereinbefore or a pharmaceutically acceptable salt...
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