|
Match
|
Document |
Document Title |
|
|
7595331 |
N-and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred...
|
|
|
7514454 |
Piperidin-2,6-dione pamoate salts and their use for the treatment of stress-related affective disorders
Novel pamoate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-dion
es and pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte changes...
|
|
|
7504419 |
Diastereomers of 4-aryloxy-3-hydroxypiperidines
The present invention relates to essentially pure diastereomers of 4-aryloxy-3-hydroxypiperidines, including purified diastereomers of ifoxetine, methods of purifying said diastereomers,...
|
|
|
7348000 |
Therapeutic compositions and methods of treating glycolipid storage related disorders
A method for treating a glycolipid storage-related disorder, comprising administering a therapeutically effective amount of an inhibitor of glycolipid synthesis in combination with an agent capable...
|
|
|
7189742 |
Piperidin-2,6-dione bisulphate salts and their use for the treatment of stress related affective disorders
Novel bisulphate salts of certain 3-phenyl-3-dimethylaminoalkyl-4,4-dimethylpiperidin-2,6-dion
es and pharmacologically acceptable solvates thereof are devoid of the weight loss and hepatocyte...
|
|
|
7078400 |
20-HETE synthase inhibitor
The present invention relates to an inhibitor for production of 20-hydroxyeicosatetraenoic acid, comprising, as an effective ingredient, specific hydroxyformamidine derivatives or...
|
|
|
7060713 |
Substituted piperidines
The present invention provides compounds having formula (II):
wherein X, n, R 1 –R 12 are defined herein, or a pharmaceutically acceptable salt thereof. The invention also provides a...
|
|
|
7034015 |
Aminobenzoephenones
The invention relates to a novel class of aminobenzophenones derivatives, to pharmaceutical preparations comprising said compounds, to dosage units of such preparations, to methods of treating...
|
|
|
RE38934 |
Method and reagents for N-alkylating ureides
A method of N-alkoxyalkylating ureides according to the invention comprises reacting a ureide of structure I
with an alkylating agent of structure III
in the presence of a basic catalyst...
|
|
|
6943179 |
Biurethane derivatives
Novel compounds of the formula I in which X, Y, Z, R, R 1 , R 2 and R 3 are as defined in Patent Claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
|
|
|
6890939 |
Aminopyrrolidine sulfonamides as serine protease inhibitors
The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine...
|
|
|
6864254 |
Inhibitor for 20-hete-yielding enzyme
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
|
|
|
6730677 |
Benzofurazan compounds which enhance AMPA receptor activity
Compounds of general structural formula ( 1 ) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors...
|
|
|
6713492 |
N-acyloxylated cycloalkyl compounds, composition containing the same and methods of use therefor
Drugs or reagents containing as the active ingredient N-acyloxylated cycloalkyl compounds represented by general formula (I): wherein A is optionally substituted C 4 or C 5 cycloalkyl which...
|
|
|
6660749 |
Inhibition of glycolipid biosynthesis
Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with...
|
|
|
6656937 |
Substituted glutarimides and their use as inhibitors of IL-12 production
Substituted glutarimides of formula I and their method of making. Also disclosed are pharmaceutical compositions comprising the glutarimidie, particularly as immunomodulators and as inhibitors...
|
|
|
6610709 |
2-n-substituted or unsubstituted-2-amino-5-methylpiperidine-3,4-diols and processes for the preparation thereof
This invention relates to (2R,3S,4R,5R)-2-amino-5-methylpiperidine-3,4-diol or a (2S,3S,4R,5R)-2-N-substituted-2-amino-5-methylpiperidine-3,4
-diol represented by the general formula (I): ...
|
|
|
6545021 |
Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
N-Substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections,...
|
|
|
6476053 |
Mycobacterial inhibitors
The invention provides the use of certain succinimide compounds in the treatment of mycobacterial diseases.
|
|
|
6465487 |
Inhibition of membrane-associated viral replication
Methods for inhibiting morphogenesis of host cell membrane-budding viruses and infections caused thereby using compounds that inhibit host cell glucosidase or glucosyltransferase enzymes. Methods...
|
|
|
6432985 |
Neuroprotective substituted piperidine compounds with activity as NMDA NR2B subtype selective antagonists
The invention relates to a compound of the formula its R,R-, S,S-enantiomers and racemic mixtures thereof and to their pharmaceutically acceptable acid addition salts. The compound of formula I...
|
|
|
6242466 |
Substituted phenylamidines
Phenylamidines of the formula (I) ##STR1## wherein: R 6 is a C 5 -12 -alkyloxycarbonyl group, and R 7 is a hydrogen atom, or a C 1 -8 -alkyl, C 4 -7 -cycloalkyl, phenyl-C 1 -4 -alkyl, or R...
|
|
|
6225325 |
Use of alkylated iminosugars to treat multidrug resistance
Methods and compositions for preventing, reducing, or reversing multidrug resistance (MDR) during cancer chemotherapy in patients undergoing treatment with therapeutically effective amounts of...
|
|
|
6191156 |
Compositions and methods for treating bladder dysfunction
A method for treating patients having bladder dysfunction is described. The method involves the step of treating a patient with a renin-angiotensin system inhibitor. Preferably the inhibitor is an...
|
|
|
6110935 |
Benzofurazan compounds for enhancing glutamatergic synaptic responses
Compounds of the general structural formula ##STR1## are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of...
|
|
|
6080742 |
Substituted benzamides
Substituted benzamides corresponding to the formula I ##STR1## wherein R 1 , R 2 and R 3 have the meanings given herein, and their use in pharmaceutical compositions. The compounds are...
|
|
|
6046214 |
Heterocyclic compounds
Novel piperidine compounds are provided, and those compounds are useful in the treatment and/or prevention of diabetes, and especially non-insulin dependent diabetes (NIDDM or type 2 diabetes)...
|
|
|
6020327 |
Control of hair growth
A method for treating hair loss is disclosed by topically adminstering an aromatase inhibitor to a mammal, including humans, on the area to be treated.
|
|
|
5981539 |
Piperidine compounds as calcium channel blockers
The present invention discloses compounds of the formula ##STR1## any of its enantiomers or any mixture thereof, or a pharmaceutically-acceptable addition salt thereof, wherein X, Ar, R, R 1 , R 2...
|
|
|
5958952 |
Substituted phenylamindines, medicaments containing these compounds and process for producing them
The present invention relates to phenyl amidines of general formula (I), ##STR1## in which R 1 to R 5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their...
|
|
|
5952376 |
Trienyl compounds
Triene-containing compounds which mimic the chemical and/or biological activity of the spongistatins are provided, as are methods and intermediates useful in their preparation.
|
|
|
5952354 |
Tris carbamic acid esters: inhibitors of cholesterol absorption
Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are...
|
|
|
5693630 |
Phenylethyl and phenylpropylamines
Compounds of the general formula ##STR1## or pharmaceutically acceptable salts thereof, wherein Z is a saturated or unsaturated 3 to 6 carbon chain, m is 2 or 3, R 1 is a hydrogen atom, or a...
|
|
|
5635537 |
8-substituted-2-aminotetralins
A compound of the formula ##STR1## Z is hydrogen or halogen, Q is COR 1 or 5-or 6-membered aryl which may contain 1 or 2 heteroatoms selected from N, 0 or S and may be substituted or fused wherein...
|
|
|
5622972 |
Method for treating a mammal infected with respiratory syncytial virus
A method is provided for treating a mammal infected with respiratory syncytial virus (RSV) comprising administering to the mammal an RSV inhibitory effective amount of a compound or its...
|
|
|
5620989 |
4-Arylmethyloxymethyl piperidines as tachykinin antagonsits
The present invention is directed to compounds of the formula (I) ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are defined herein, and pharmaceutically acceptable salts thereof,...
|
|
|
5616593 |
Compositions containing piperine
A pharmaceutical composition having increased bioavailability characterized by piperine of the formula ##STR1## and a drug for treating a disease or condition of the human cardiovascular system,...
|
|
|
5607931 |
1,2-disubstituted ethly amides as inhibitors of ACAT
Amides of the formula ##STR1## wherein: R 1 is A and R 2 is B; R 1 is B and R 2 is A; or R 1 and R 2 are independently selected from the group B; A is phenyl, substituted phenyl,...
|
|
|
5583034 |
Enhancement of adoptosis using antisense oligonucleotides
A method is disclosed for enhancement of the efficacy of therapeutic treatment for inducing cell death in a cell having an anti-apoptotic gene by the enhancement of apoptosis. An antisense...
|
|
|
5550107 |
Combination therapy for the treatment of estrogen-sensitive disease
A method of treatment of breast and endometrial cancer in susceptible warm-blooded animals may include inhibition of ovarian hormonal secretion by surgical (ovariectomy) or chemical (use of an LHRH...
|
|
|
5494929 |
Methods of inhibiting growth hormone effects
A method of inhibiting effects of growth hormone comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R 1 and R 3 are...
|
|
|
5489600 |
Piperidyl amides, sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis
The present invention relates to piperidyl amides which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in need thereof.
|
|
|
5476859 |
Antiviral compounds
A method of inhibiting lentivirus is disclosed which comprises mammalian host susceptible to said lentivirus with a virally inhibitory effective amount of an O-acylated derivative of...
|
|
|
5466691 |
Thiophene compound
Thiophene compounds of the formula ##STR1## wherein each symbol is as defined in the specification, their pharmaceutically acceptable salts, pharmaceutical compositions containing said compound and...
|
|
|
5455276 |
Method for treating depression
Pharmaceutical compositions for treating psychiatric disorders are provided. The compositions include 2-phenylethylamine ("PEA") and at least one inhibitor of monoamine oxidase B. Methods for the...
|
|
|
5451564 |
Antimicrobial composition comprising N-hydroxy heterocyclic thiones
A composition comprising (a) a metal salt or complex with an organic compound of the general formula ##STR1## and (b) an oxy-phosphorus compound where W may be --SH or an optionally substituted...
|
|
|
5424319 |
Piperidinyl-terminated non-peptidyl α-succinamidoacyl aminodiols as anti-hypertensive agents
Non-peptidyl compounds characterized generally as α-succinamidoacyl aminodiols having a piperidinyl-type group at the N-terminus are useful as renin inhibitors for the treatment of hypertension.
|
|
|
5411970 |
Method of inhibiting lentivirus
A method of inhibiting lentivirus is disclosed which comprises mammalian host susceptible to said lentivirus with a virally inhibitory effective amount of an O-acylated derivative of...
|
|
|
5321031 |
1,2-disubstituted ethyl amides as inhibitors of ACAT
Amides of the formula ##STR1## wherein: R 1 is A and R 2 is B; R 1 is B and R 2 is A; or R 1 and R 2 are independently selected from the group B; A is phenyl, substituted phenyl,...
|
|
|
5300516 |
Muscarinic receptor antagonists
Musacarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of formula (I), or a pharmaceutically acceptable salt thereof, where m is 1 or 2; R 1 and R 2 ...
|