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7625928 |
Nitroxide radioprotector formulations and methods of use
Pharmaceutical compositions useful in preventing and treating negative side effects accompanying radiotherapy are disclosed. More particularly, new formulations that can be applied to the skin and...
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7605173 |
Pharmaceutical liquid composition containing pyridone derivative
A pharmaceutical liquid composition containing the Pirfenidone in a very high concentration of more or less 25% by weight can be obtained by dissolving the Pirfenidone in diethylene glycol...
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7595331 |
N-and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred...
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7589107 |
Amelioration of vitrectomy-induced cataracts
Methods to prevent, inhibit, or slow the development of vitrectomy-induced cataracts are disclosed. The methods comprise administering to the eye of a subject a composition comprising an...
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7582655 |
Antineoplastic compounds
The present invention relates to 4-piperidone derivatives represented by the following formula (I) and the acid addition salts thereof.
The method of preparation and antineoplastic activity of...
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7569588 |
Biphenyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I:
wherein a, b, c, m, p, r, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , W and X 1 are as defined in the specification. The compounds of formula I are...
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7566729 |
Modifying pirfenidone treatment for patients with atypical liver function
Methods are provided for administering pirfenidone to a patient that has exhibited abnormal biomarkers of liver function in response to pirfenidone administration. The methods include administering...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7560459 |
Substituted sulfamate anticonvulsant derivatives
The present invention is directed to novel compounds of the formula (I)
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described in the specification, processes for the preparation of...
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7531555 |
Compositions and methods for selective inhibition of nicotine acetylcholine receptors
The present invention concerns methods for treating or preventing neurological disorders characterized by dysfunction of nicotinic acetylcholine receptors by administering...
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7517892 |
Ligands for monoamine receptors and transporters, and methods of use thereof
One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian...
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7498443 |
Process for production of carebastine
Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
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7473697 |
2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
This invention relates to new 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives of formula (1) having anticonvulsant activity which are useful as therapeutic agents for the treatment...
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7473692 |
Sulfonamide derivatives as D3-receptor ligands
The present invention relates to new D 3 dopamine receptor subtype selectice ligands of formula (I) to pharmacological compositions containing the same and to their use in therapy and/or...
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7442711 |
Amelioration of the development of cataracts and other ophthalmic diseases
Ophthalmically acceptable compositions used in arresting the development of cataracts or macular degeneration comprising a pharmaceutically acceptable carrier or diluent and a compound having the...
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7439257 |
Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics
The invention relates to a compound of formula (I):
Wherein m, n, X, Y, R 1 , R 2 , R 3 and R 4 are as defined herein. The invention also relates to the use of same in therapeutics.
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7435746 |
5-thiopiperdinyl prostaglandin E analogs
A compound comprising
or a pharmaceutically acceptable salt or a prodrug thereof is disclosed herein. Y and R are described in detail herein
A compound having an ω chain comprising
or a...
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7411093 |
Aminocycloalkanes as DPP-IV inhibitors
The present invention relates to compounds of formula (I)
wherein R 1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for...
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7407973 |
Use of pirfenidone in therapeutic regimens
The present invention provides methods for treating a disorder, and methods for inhibiting a stress-activated protein kinase (SAPK) in a cell in an individual, the methods generally involving...
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7393873 |
Arylsulfonamide derivatives
N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin...
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7378446 |
Compound having anti-HCV activity and process for producing the same
The object of the present invention is to provide a compound useful for the prevention and treatment of viral infectious diseases, and particularly liver diseases caused by HCV infection due to its...
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7368443 |
2,6-disubstituted piperidines and piperazine compounds
The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula:
which are used to treat diseases of the central nervous system,...
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7361666 |
Heterocyclic analgesic compounds and methods of use thereof
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
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7338965 |
3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are...
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7326716 |
Treatment of inflammatory bowel disease
The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of...
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7323478 |
Melanin concentrating hormone receptor ligands
Disclosed are compounds of the formula:
and the pharmaceutically acceptable salts thereof wherein Q, X, Y, Z, and R 1 R 9 , and R 12 -R 19 are defined herein.
These compounds are selective...
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7294637 |
Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a...
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7288552 |
Piperidine derivatives, process for preparation thereof, and pharmaceutical composition for alzheimer's disease containing the same
The present invention relates to novel piperidine derivatives having effect of inhibiting acetylcholinesterase and aggregation of β-amyloid, Alzheimer's disease-induced protein, and treatment for...
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7288535 |
Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates
The invention relates to compositions and methods for use in treating skeletal system disorders in a vertebrate at risk for bone loss, and in treating conditions that are characterized by the need...
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7273867 |
Phenyl derivatives
Novel compounds of the formula I in which W, X, Y, T, R 1 and R 2 are as defined in Patent claim 1 , are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or...
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7259173 |
Derivatives of 3-phenyl-n-(2-(4-benzyl)-piperidin-1-yl)-ethyl)-acrylamid with ccr-3-receptor antagonistic activity for use in the treatment of inflammations and allergic conditions
This invention relates to organic compounds of formula I,
in which Ar 1 is unsubstituted phenyl substituted by one or more halogen atoms; Ar 2 is unsubstituted phenyl or phenyl substituted by...
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7238710 |
EP4 receptor agonist, compositions and methods thereof
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
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7238709 |
Therapeutic carbamates
This invention relates to hindered carbamate derivatives that are muscarinic receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds.
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7232821 |
(2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
Compounds of formula (I) or a pharmaceutically acceptable derivative thereof:
wherein A, R 1 , R 2 , R x , R 8 , R 9 and n are as defined in the specification, a process for the preparation of...
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7214714 |
20-hydroxyeicosatetraenoic acid production inhibitors
A hydroxyformamidine compound represented by the following formula or a pharmaceutically acceptable salt thereof
[wherein R 1 represents a substituted morpholino group, a substituted...
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7179820 |
Piperidinyl prostaglandin E analogs
The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective...
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7160874 |
Phenylalanine derivatives
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7141560 |
Alanine 2,6-dialkoxyphenyl ester derivatives as hypnotics
The present invention relates to alanine 2,6-dialkoxyphenyl ester derivatives having the general formula I
The invention also relates to pharmaceutical compositions comprising said derivatives,...
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7129228 |
Heterocyclic analgesic compounds and methods of use thereof
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
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7125476 |
Microwave-attenuating composite materials, methods for preparing the same, intermediates for preparing the same, devices containing the same, methods of preparing such a device, and methods of attenuating microwaves
The present invention provides microwave attenuating, filled composite materials which contain a polymer or ceramic matrix and metallic tubules and processes for making the same and devices which...
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7109217 |
Phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
Disclosed are compounds of formula (I)
which are inhibitors of the beta-secretase enzyme and that are useful in the treatment or prevention of diseases in which the beta-secretase enzyme is...
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7108858 |
Non-anaphylactic forms of allergens and their use
The present invention is drawn to an immunogen derived from a protein allergen, which is a) a non-anaphylactic immunogenic recombinant fragment of the protein allergen which contains an IgG epitope...
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7105507 |
Cyclohexane derivatives and their use as therapeutic agents
The present invention relates compounds of formula (I), wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of formulae: (a), (b), (c), (d), and...
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7101875 |
Methods for treating arthritic disorders
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms...
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7084140 |
Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds
The invention relates to new arylglycinamide derivatives of general formula I
and the pharmaceutically acceptable salts thereof, wherein R 1 and R 2 together with the N to which they are...
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7064138 |
Methods for treating irritable bowel syndrome using optically pure (-) norcisapride
Methods for the prophylaxis, treatment, or management of irritable bowel syndrome using (−) norcisapride, or a pharmaceutically acceptable salt thereof, substantially free of its (+) stereoisomer...
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7034042 |
N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33 receptor antagonists
Compounds of formula (I) in free or salt form, where Ar 1 is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C 1 –C 8 -alkyl optionally substituted by...
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7030147 |
Combinations comprising an antidiarrheal agent and an epothilone or an epothilone derivative
Epothilone derivatives are co-administered with an antidiarrheal agent, e.g., a DPP-IV inhibitor, in the treatment of a proliferative disease.
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7015234 |
Hydroxamic acid derivatives
Compounds of the general formula (I)
are described wherein R 1 and R 2 , which may be the same or different, is each a hydrogen atom or a CF 3 , CF 2 H or CFH 2 group, provided that when one...
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