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7186733 |
4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
Compounds of general formula I
R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; where each R 1 ...
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7183270 |
Cyclic derivatives as modulators of chemokine receptor activity
The present application describes modulators of MCP-1 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis,...
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7183290 |
Fluoropyrrolidines as dipeptidyl peptidase inhibitors
The present invention relates to novel compounds, their use for inhibiting post prolin/analine-cleaving proteases, such as serine proteases, such as dipeptidyl peptidases, such as dipeptidyl...
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7179835 |
2-(3-sulfonylamino-2-oxopyrrolidin-1-yl)propanamides as factor xa inhibitors
The invention relates to compounds of formula (I) pharmaceutical compositions containing the same as well as methods of treating patients suffering from a condition susceptible to amelioration by a...
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7179819 |
VLA-4 inhibitor compounds
Compounds that selectively inhibit the binding of ligands to α4β1 integrin (VLA-4) and methods for their preparation are disclosed. In one embodiment, compounds of the invention are represented...
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7176199 |
Aryl-substituted alicyclic compound and medical composition comprising the same
An aryl-substituted alicyclic compound of the formula (I):
wherein U is 1,4,5,6-tetrahydropyrimidin-2-yl, etc., A is phenylene, etc., B is piperidine-1,4-diyl, etc., Z is —CONH—, etc., R 3 ...
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7173044 |
Imidazoline derivatives having CB1-antagonistic activity
The present invention relates to 1,2,4-tri-substituted imidazoline derivatives, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of said...
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7169782 |
Aryl substituted thiazolidinones and the use thereof
This invention relates aryl substituted thiazolidinones of Formula I:
or a pharmaceutically acceptable salt, or solvate thereof, wherein R 1 and R 2 , are defined in the specification. The...
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7166611 |
Pharmaceutical compositions having appetite suppressant activity
A pharmaceutical composition contains an extract obtainable from a plant of the genus Trichocaulon or Hoodia containing an appetite suppressant agent having the formula (1). A process for...
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7166586 |
Sulfonamide lactam inhibitors of FXa and method
Sulfonamide lactams of the following formula
wherein X, R 1 , R 2 , R 3 , R 4 , R 4a , R 5 , R 5a , R 6 , R 6a , R 7 and R 8 are as described herein, are provided which inhibitors of Factor...
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7166617 |
Cyclic amide derivatives
Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient:
wherein X represents...
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7160902 |
Amide derivatives and methods of their use
Amide derivatives of the general formulae Ia and Ib:
are disclosed. Pharmaceutical compositions containing these compounds, and methods for their use, inter alia, for treating and/or preventing...
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7153878 |
Peroxisome proliferator activated receptor modulators
The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts thereof, Formula I. (Formula I); wherein: (a) R5 is selected...
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7153868 |
N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists
The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises...
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7148219 |
Biaryl heterocyclic compounds and methods of making and using the same
The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of...
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7141584 |
2-(substituted-phenyl)amino-imidazoline derivatives
This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I:
where:
R 1 is a group represented by formula (A), (B) or (C);
...
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7141585 |
Pyrazole derivatives
This invention relates to the use of pyrazole derivatives of the formula
and pharmaceutically acceptable salts and solvates thereof, in the manufacture of a reverse transcriptase inhibitor or...
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7141583 |
Oxazolidinone derivatives with antibiotic activity
Compounds of the formula (I), or a pharmaceutically acceptable salt, or an in-vivo-hydrolysable ester thereof,
wherein HET is an N-linked 5-membered heteroaryl ring, optionally substituted on a...
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7138416 |
Compounds and therapeutic uses thereof
The invention discloses a novel series of compound represented by general formula (I),
its derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, pharmaceutically acceptable...
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7135488 |
Pyrrolyl-thiazole derivatives
The present invention relates to compounds of formula (I)
wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined in the description and claims, and pharmaceutically acceptable salts...
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7132421 |
CIS-imidazoles
The present invention provides compounds according to formula I and pharmaceutically acceptable salts and esters thereof, having the designations provided herein and which inhibit the interaction...
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7132434 |
Metalloproteinase inhibitors
Compounds of the formula (I), useful as metal-loproteinase inhibitors, especially as inhibitors of MMP12
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7125895 |
Cyclic amine derivatives and their uses
This invention relates to novel arylalkyl cyclic amine derivatives. This invention also relates to chemokine receptor antagonists that are be effective as therapeutic agents and/or preventive...
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7125887 |
Pyrrolidine modulators of CCR5 chemokine receptor activity
Pyrrolidine compounds of Formula (I), (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 and R 8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor...
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7115610 |
Substituted heterocyclic compounds
Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I:
The compounds are useful for the treatment of various disease states, in particular cardiovascular...
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7115636 |
Hetrocyclic aryl sulphonamides
The invention relates to novel sulfonamides of general formula (I)
where the substituents R 1 , R 2 , R 3 , R 4 , A and X have the given meanings, pharmaceutical compositions containing them,...
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7115635 |
Benzylpiperidine compound
The object of the present invention is to provide a compound having a treatment effect based on a chemokine inhibitory activity, which is satisfactory as a pharmaceutical product for oral...
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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7115658 |
Inhibitors of hepatitis C virus RNA-dependent RNA polymerase
Compounds of formula I are hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) inhibitors, and are useful in therapeutic and prophylactic treatment of persons infected with hepatitis C virus
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7109216 |
1H-imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
The present invention relates to a group of novel 1H-imidazole derivatives, to methods for the preparation of these compounds, and to pharmaceutical compositions containing one or more of these...
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7109186 |
HIV integrase inhibitors
The present invention describes novel compounds of Formula I which inhibit HIV integrase. The invention also describes compositions and treatments of AIDS or ARC by using these compounds
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7109208 |
Visual function disorder improving agents
The present invention provides a visual function disorder improving agent containing a compound having Rho kinase inhibitory activity, particularly...
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7105556 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
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7105546 |
Acyclic and cyclic amine derivatives
The present invention relates to acyclic and cyclic amine derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions...
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7101898 |
Amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes
Novel amides of aminoalkyl-substituted azetidines, pyrrolidines, piperidines and azepanes, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the...
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7101875 |
Methods for treating arthritic disorders
This invention provides methods for treating in mammals arthritic or rheumatic disorders using substituted indole compounds of the general formula:
and pharmaceutically acceptable salt forms...
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7101897 |
Farnesyl transferase inhibitors
This invention relates to compounds of formula (I) that inhibit farnesylation of gene products through inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to...
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7094791 |
Derivatives of 3-hydroxy-pyrrole-2,4-dicarboxylic acid and uses thereof
Chemical agents of the general formula (I) and (II), such as derivatives of 3-hydroxy-pyrrole containing hydroxamic acid, and including salts thereof, that modulate levels of gene expression in...
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7087623 |
Thiazole and other heterocyclic ligands for mammalian dopamine, muscarinic and serotonin receptors and transporters, and methods of use thereof
One aspect of the present invention relates to novel heterocyclic compounds. A second aspect of the present invention relates to the use of the novel heterocyclic compounds as ligands for various...
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7084144 |
Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction
A compound having the general formula (I):
wherein: X is N or C; R 0 is H, a lower alkyl group, a lower O-alkyl group,
lower alkyl group, a benzyl group, a phenyl group, a heterocyclic...
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7084145 |
Triazole compounds useful in therapy
The invention provides compounds of formula (I),
the pharmaceutically acceptable salts and solvates thereof, wherein A, B, R 1 , R 2 , and R 7 are as defined herein; pharmaceutical...
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7074808 |
4-(Phenyl-piperidin-4-ylidene-methyl)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestional disorders
Compounds of general formula I R 1 is selected from any one of phenyl, pyridinyl, pyrroloyl, thienyl, furanyl, imidazolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R 1 phenyl ring...
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7074785 |
Δ1-pyrrolines used as pesticides
Novel Δ 1 -pyrrolines of the formula (I)
in which
R 1 , R 2 , R 3 , A, R 4 and m have the meanings given in the description,
a number of processes for preparing these substances, and their...
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7071215 |
Anthelmintic and insecticidal compositions
Novel anthelmintic compositions containing thiophene derivatives as active ingredients are disclosed.
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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7064137 |
4-(Phenyl-(piperidin-4-yl)-amino)-benzamide derivaties and their use for the treatment of pain, anxiety or gastrointestinal disorders
Compounds of general formula (I): R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R 1 phenyl ring...
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7064135 |
Substituted piperidines
A novel class of substituted piperidines, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More...
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RE39113 |
Utilization of derivatives of tetrahydropyridines(or 4-hydroxypiperidines)-butylazols in the preparation of a medicament for the treatment of pain
Derivatives of tetrahydropyridines (or 4-hydroxypiperidines)-butylazols of formula (I), wherein R 1 , R 2 and R 3 , which are similar or different, represent each of them hydrogen, halogen, alkyl...
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7045535 |
Compounds useful for inhibiting paramyxovirus neuraminidase
Certain cyclic compounds are presented as well as their use for inhibiting paramyxovirus neuraminidase. The compounds are represented by the following formulas:
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7041682 |
NK1 antagonists
Disclosed are NK 1 antagonists having the formula:
Also disclosed are methods for treating a number of physiological disorders, symptoms or diseases, including emesis, depression, anxiety and...
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