Patents in Class 514/325

Matches 1 - 50 out of 140

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Match	Document	Document Title
1	7579364	N-deacetylthiocolchicine derivatives, their use and pharmaceutical formulations containing them Disclosed is a series of N-deacetylthiocolchicine derivatives of formula I in which: the linker is a bivalent straight or branched C 1 -C 8 alkyl residue, C 3 -C 8 cycloalkyl, a...
2	7432284	Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
3	7375117	Polypeptides The present invention relates to polypeptides, and nucleic acids DNA encoding these polypeptides, capable of eliciting an immune reaction against cancer, methods for generating T lymphocytes...
4	7326696	Amino-methyl substituted tetracycline compounds Aminomethyl substituted tetracycline compounds, pharmaceutical compositions, and methods of use thereof are discussed.
5	7314875	Tricyclic aromatic and bis-phenyl sulfinyl derivatives The present invention provides compounds of the structure: wherein the constituent members are defined herein, including pharmaceutical compositions thereof and methods of treating diseases...
6	7312222	Heterocyclic piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
7	7189757	Treatment of sleep disorders using CNS target modulators The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder....
8	RE39128	Pleuromutilin derivatives as antimicrobials The present invention relates to pleuromutilin derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medical therapy, particularly...
9	7053071	Induction of apoptosis in cancer cells The present invention provides compounds that are inducers or inhibitors of apoptosis or apoptosis preceded by cell-cycle arrest. In addition, the present invention provides pharmaceutical...
10	6908934	Therapeutic compounds for treating dyslipidemic conditions Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia and (b) Formula Ib are...
11	6894059	Compounds and methods for treatment of asthma, allergy and inflammatory disorders The present invention provides 1,4 substituted piperazines, 1,4 substituted piperidines, and 1-substituted, 4-alkylidenyl piperidines compounds. The compounds of the invention are dual acting...
12	6803378	HIV integrase inhibitors Novel diketoacid compounds of Formula I are provided which are useful as HIV integrase inhibitors and for the treatment of AIDS or ARC.
13	6800636	Farnesyl protein transferase inhibitors Disclosed are compounds of the formula: wherein R 8 represents a cyclic moiety to which is bound an imodazolylalkyl group; R 9 represents a carbamate, urea, amide or sulfonamide group; and the...
14	6767915	Substituted piperidines as melanocortin receptor agonists Certain novel 4-substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
15	6673815	Substituted acid derivatives useful as antidiabetic and antiobesity agents and method Compounds are provided which have the structure wherein Q is C or N, X 1 is CH or N and, A, E, M, G, X 2 , X 3 , X 4 , R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined...
16	6620782	Substituted 2-aminobenzamide caspase inhibitors and the use thereof The present invention is directed to novel 2-aminobenzamide thereof, represented by the general Formula I: where R 1 -R 3 , X, and A—D are defined herein. The present invention also relates to...
17	6599921	Non-steroidal estrogen receptor ligands Novel non-steroidal estrogen receptor ligands and methods of synthesis are disclosed. The novel molecules are intended for use in therapeutic preparations for the treatment of estrogen receptor...
18	6569849	N-Substituted azaheterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, A, R 1 , R 2 , r and s are as defined in the detailed part of the present...
19	6548504	Compounds The present invention therefore provides, in a first aspect, a compound of formula (I) or a salt thereof: in which the group D is selected from a group of formula (A), (B) or (C) below: in...
20	6391890	Heterocyclic compounds The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R 1 , R 2 and m are as defined in the detailed part of the present...
21	6380217	Methods for controlling GGT-positive bacteria Methods and compositions useful for controlling GGT positive bacteria have been identified.
22	6323206	Chemokine receptor antagonists and methods of use therefor Disclosed is a method of treating a subject with a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to the subject a therapeutically...
23	6316437	Spirohydantoin compounds and uses thereof Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One...
24	6303635	Thrombolytic drug A thrombolytic drug containing cyproheptadine, a compound of the following formula or a salt thereof as the active ingredient is provided. This thrombolytic drug has a function of accelerating the...
25	6281228	Heterocyclic inhibitors of microsomal triglyceride transfer protein and method Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including...
26	6268383	Substituted aromatic compounds for treatment of antibiotic-resistant infections This invention relates to compounds of the general formula: ##STR1## wherein A is a aromatic hydrocarbon ring system and R 1 is a carbon bound directly to an oxygen and is also bound to a nitrogen...
27	6239148	N-substituted azaheterocyclic carboxylic acids and esters thereof The present invention relates to novel N-substituted azaheterocyclic carboxylic acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to...
28	6214827	Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases Novel compounds of Formula ##STR1## are disclosed. Also disclosed is a method of inhibiting Ras function and therefore inhibiting the abnormal growth of cells. The method comprises administering a...
29	6150355	Phenylpiperidine derivative A phenylpiperidine derivative or pharmaceutical acceptable salt thereof represented by formula (I): ##STR1## wherein X represents CH or N; Y--Z represents CH 2 --O, CH 2 --S, CH 2 --CH 2 ,...
30	6140338	Chemokine receptor antagonists The present invention relates to a compound of the general formula: ##STR1## wherein each of R 1 and R 2 which may be the same or different, is e.g. a hydrogen atom, a halogen atom or a lower...
31	6121281	Azabicyclic carbamoyloxy mutilin derivatives for antibacterial use Compounds of formula (3), and pharmaceutically acceptable salts and derivatives thereof, in which R 1 is vinyl or ethyl; and R 2 is a group R 3 , R 4 CH 2 --, or R 5 R 6 CCH--; wherein...
32	6096740	Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions The present invention relates to pharmaceutical compositions for preventing or alleviating neurotoxicity. Said pharmaceutical compositions comprise as their active ingredient the stereospecific (+)...
33	6077852	Treatment of central nervous system disorders with selective estrogen receptor modulators The present invention provides a method of treating depression, mood swings, or Alzheimer's disease in a patient in need of such treatment by administering a selective estrogen receptor modulating...
34	6066653	Method of treating acid lipase deficiency diseases with an MTP inhibitor and cholesterol lowering drugs A method is provided for inhibiting or treating diseases associated with acid lipase deficiency by administering to a patient an MTP inhibitor, alone or optionally, in combination with another...
35	6057339	Method of inhibiting or treating phytosterolemia with an MTP inhibitor A method is provided for inhibiting onset of or treating phytosterolemia by administering to a patient an MTP inhibitor, alone or optionally, in combination with another cholesterol lowering drug,...
36	6048877	Tetralone derivatives as antiarrhythmic agents Tetralone derivatives of the formula ##STR1## where R 1 is halo, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, (aryl)alkenyl, (aryl)alkynyl, alkoxy, O-alkenyl, O-aryl, O-alkyl(heterocyclo),...
37	5883109	Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug A method is provided for lowering serum lipids, cholesterol and/or triglycerides and thereby inhibiting atherosclerosis by administering to a patient an MTP inhibitor, in combination with a...
38	5863912	Method of treatment of hormone-unresponsive metastiatic prostate cancer Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
39	5834459	Alkyl-substituted compounds having dopamine receptor affinity Described herein are D4 receptor-selective compounds of the general formula: ##STR1## wherein: A and B are independently selected, optionally substituted, unsaturated 5- or 6-membered, homo- or...
40	5827852	Coated pharmaceutical compositions Pharmaceutical composition suitable for coating comprising a composition for oral administration in unit dosage form wherein said composition has been coated with from about 0.01% to about 10% by...
41	5801149	Inhibition of signal transduction molecules A peptide capable of inhibiting the interaction of an SH2 domain containing protein with a second protein.
42	5719166	Therapeutic agents Compounds of formula I, and pharmaceutically acceptable salts thereof, useful in the treatment of neuropsychiatric disorders such as psychoses; pharmaceutical compositions comprising a compound of...
43	5712269	M.sub.2 receptor ligand for the treatment of neurological disorders Muscarinic M 2 receptor ligands are described which are suitable for the treatment of neurological disorders, and which may be administered with minimal side-effects. A method of synthesis of...
44	5705509	Tricyclic heterocyclic compounds as 5-HT.sub.4 receptor antagonists Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X 1 --(CH 2 ) x --X 2 and the aromatic carbon atoms to which they are attached form 5-7 membered ring wherein X 1 ...
45	5686469	Aminomethylene derivaties as immunosuppressants Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1##
46	5681840	Tricyclic antipsychotic compounds Compounds of formula I or I', ##STR1## wherein X and Y are independently selected from hydrogen, halo, and (1-6C)alkoxy; R 1 is selected from (A) (1-6C)alkyl; (B) phenyl and naphthyl or...
47	5656606	Camphor compounds promote release of growth hormone The present invention is directed to certain novel compounds identified as camphor derivatives of the general structural formula: ##STR1## wherein A, X, Y, R 2a , R 4 , and R 5 are as defined...
48	5629324	Thrombin inhibitors Compounds of the invention have the following structure: ##STR1## for example ##STR2## These compounds inhibit thrombin and associated thrombosis.
49	5610165	N-acylpiperidine tachykinin antagonists N-Acylpiperidines of general structure ##STR1## are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.
50	5605917	Method of treating dysmenorrhea employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog A method is provided for treating dysmenorrhea (menstrual cramps) employing an interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analog thromboxane A 2 receptor...

Matches 1 - 50 out of 140

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