Patents in Class 514/324

Matches 1 - 50 out of 356

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Match	Document	Document Title
1	7531578	Compounds and methods for treating breast cancer and other diseases Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety...
2	7524866	Prevention and treatment of androgen—deprivation induced osteoporosis This invention provides: 1) a method of treating androgen-deprivation induced osteoporosis and/or bone fractures and/or loss of Bone Mineral Density (BMD) in a male subject suffering from prostate...
3	7524841	4,4-disubstituted piperidine derivatives having CCR3 antagonism The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides...
4	7521462	4-Amino-piperidine derivatives as monoamine uptake inhibitors The present invention provides compounds of formula (I) where n, R1, R2, R3, R4, R5 and Heteroaryl are defined herein. The compounds are inhibitors of the uptake of one or more monoamines selected...
5	7517875	Piperidine derivatives having CCR3 antagonism The invention provides low molecular compounds having activity which inhibits binding of CCR3 ligands to CCR3 on target cells, i.e. CCR3 antagonists. The invention also provides compounds...
6	7511064	Derivatives of 4-(thio- or selenoxanthene-9-ylidene)-piperidine or acridine and its use as a selective 5-HT_2Breceptor antagonist The present invention relates to derivatives of 4-(Thio- or Selenoxanthene-9-ylidene)-piperidine or acridine and pharmaceutically acceptable salts thereof, use of these compounds as a medicament...
7	7479500	Antidepressant piperidine derivatives of heterocyclefused benzodioxans Compounds of the Formula: are useful for the treatment of depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder,...
8	7470710	N-aroyl cyclic amine derivatives as orexin receptor antagonists This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR 3 or a group (CH 2 ), wherein n represents 1, 2 or 3; Y represents CH 2 , CO,...
9	7468443	Alkyl ether derivatives or salts thereof An alkyl ether derivative represented by the general formula: wherein each of R 1 and R 2 represents one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl...
10	7462630	Diarylalkene derivatives and novel diarylalkane derivatives The invention relates to a compound represented by the following general formula (1) or its analogue, which selectively inhibit N-type calcium channels or its analogue, and to a method for treating...
11	7449483	Heteroaromate OSC inhibitors The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol...
12	7449453	Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption...
13	7393864	Use of ClC3 chloride channel blockers to modulate vascular tone The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking...
14	7381721	Substituted piperidine compounds 3,4-Disubstituted-4-aryl-piperidine compounds are disclosed. Pharmaceutical compositions containing the 3,4-disubstituted-4-aryl-piperidine compounds and methods of their pharmaceutical uses are...
15	7326716	Treatment of inflammatory bowel disease The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of...
16	7319104	hPPARs activators Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed....
17	7312222	Heterocyclic piperidines as modulators of chemokine receptor activity The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
18	7309691	Combined pharmaceutical preparation containing LHRH-analogous substances and anti estrogens for treating gynaecological disorders The invention relates to a pharmaceutical combined preparation of LHRH analogues and anti-oestrogens having tissue-selective oestrogen activity and also to its use for the treatment of...
19	7282497	Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the...
20	7241789	Substituted indoles and their use as integrin antagonists The present invention relates to novel substituted indole compounds that are antagonists of alpha V (αv) integrins, for example α v β 3 and α v β 5 integrins, their pharmaceutically...
21	7238713	Muscarinic agonists Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial...
22	7226934	Optically active isomers of ketotifen and therapeutically active metabolites thereof Racemic norketotifen, racemic 10-hydroxy-ketotifen, racemic 10-hydroxy-nor-ketotifen and optically active isomers of ketotifen, norketotifen, 10-hydroxy-ketotifen and 10-hydroxy-norketotifen were...
23	7189757	Treatment of sleep disorders using CNS target modulators The invention is directed to compositions used for treating Central Nervous System (CNS) disorders. In addition, the invention provides convenient methods of treatment of a CNS disorder....
24	7169768	Method of decreasing atherosclerosis and its complications A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to...
25	7153868	N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises...
26	7148240	Aminoalkoxybenzoyl-benzofuran or benzothiophene derivatives, method for preparing same and compositions containing same The invention relates to benzofuran or benzothiophene derivatives of general formula: These compounds are of use as medicinal products, in particular in the treatment of pathological syndromes...
27	7144883	Bicyclic sulfonamide compounds The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
28	7135483	Substituted heterocyclic compounds for treating multidrug resistance Substituted heterocyclinc compounds are disclosed. The compounds are useful for treating multidrug resistance. The compounds can be formulated in compositions with a carrier and, optionally, a...
29	7112594	Fused bicyclic amide compounds and medicinal use thereof Compounds represented by the following general formula (I) wherein ring A is benzene, cyclohexane, pyridine, piperidine, a derivative thereof, imidazole, a derivative thereof, etc.; the ring B...
30	7098198	Compositions of ezetimibe and methods for the treatment of cholesterol-associated benign and malignant tumors A method of prevention or treatment of a cholesterol-associated tumor is provided which comprises administering a therapeutically effective amount of an azetidinone-based cholesterol absorption...
31	7078059	Treatment of bone diseases The invention provides a method for enhancing bone formation, inhibiting osteoclastic differentiation and/or activating osteoblastic differentiation whereby to manage, treat or achieve prophylaxis...
32	6984637	Cyclic amine derivatives-CCR-3 receptor antagonists This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods...
33	6977263	Chemical compounds Provided herein are novel and useful compounds having a tryptase inhibition activity, pharmaceutical compositions comprising such compounds, and methods treating subjects suffering from a...
34	6951873	Methods for treating age-related behavioral disorders in companion animals Methods for the treatment of age-related behavioral disorders in companion animals are disclosed. These comprise administering to a companion animal in need of such treatment a therapeutically...
35	6894064	Benzothiophenes, formulations containing same, and methods This invention provides compounds of formula I and pharmaceutically acceptable salts and solvates thereof, characterized that the compound is in particulate form and having a specific size...
36	6887888	Soluble compositions of triphenylethylene antiestrogens Aqueous compositions of nonsteroidal triphenylethylene antiestrogens for pharmaceutical use comprising as a solubility enhancing agent a pharmaceutically acceptable mono- or dicarboxylic acid...
37	6784180	Piperidines derivatives and their use as serotonin receptor antagonists The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of...
38	6777429	Ophthalmic composition The present invention is related to an ophthalmic composition comprising ketotifen as a pharmaceutically active agent.
39	6767915	Substituted piperidines as melanocortin receptor agonists Certain novel 4-substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
40	6756388	Benzothiophenes and related compounds as estrogen agonists The invention is a compound of Formula (I): wherein R is —OH, R 1 is —OH, R 2 is —H, n is 2 or 3 and X is sulfur, or a pharmaceutically acceptable salt of a compound having Formula (1),...
41	6743808	4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) tetrahydropyridines or piperazines 4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH 2 and...
42	6730670	7-phenyl-benzo&lsqb b&rsqb thiophen amide derivatives A compound of the formula Compounds of formula I have a good affinity to the A2A receptor and are useful for the treatment of diseases mediated by this receptor.
43	6723739	Glucopyranoside benzothiophenes A compound of the formula or a pharmaceutically acceptable salt or solvate thereof. Also provided by the invention are methods of use of the above compounds, and processes for the preparation...
44	6720350	Therapeutic inhibitor of vascular smooth muscle cells Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic...
45	6713494	Amorphous benzothiophenes, methods of preparation and methods of use The instant invention provides an amorphous form of a compound of formula I Methods of preparing an amorphous form of a compound of formula I, pharmaceutical formulations containing same, and...
46	6683093	Aromatic sulfone hydroxamic acids and their use as protease inhibitors This invention is directed to aromatic sulfone hydroxamates (also known as aromatic sulfone hydroxamic acids) and salts thereof that, inter alia, tend to inhibit matrix metalloproteinase (also...
47	6653328	3-benzyl-benzothiophenes This invention relates to the fields of pharmaceutical and organic chemistry and provides novel 3-benzyl-benzothiophenes which are α-substituted with ether, thioether amino, cyano or halo that are...
48	6642228	α1b-adrenergic receptor antagonists There are provided compounds represented by the general formula (I): [wherein Ar is indole etc., R 1 is hydrogen etc., B is bond, or B—N—R 1 forms a ring structure and is piperidine etc.,...
49	6627645	Muscarinic agonists Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial...
50	6608090	Benzothiophenes with novel basic side chains The instant invention provides novel benzothiophene compounds for use in treating skeletal diseases.

Matches 1 - 50 out of 356

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