|
Match
|
Document |
Document Title |
|
|
6462056 |
Oxazolidines as 5-HT2A-antagonists
The invention relates to novel oxazolidine derivatives of the formula in which R 1 , R 2 and R 3 have the meanings stated in claim 1, their salts and processes for preparing the compounds...
|
|
|
6462036 |
Tricyclic pyrazole derivatives
This invention relates to certain 3-aryl or 3-heteroaryl pyrazoles with 4,5(3,4)-bicyclic ring fusion which are inhibitors of protein kinase activity, of which some are novel compounds, to...
|
|
|
6455567 |
Method of treatment
The invention provides the use of a compound of formula (I) wherein R 1 and R 2 independently represent H or C 1 -C 6 alkyl, or a pharmaceutically acceptable salt thereof, in the manufacture...
|
|
|
6451818 |
Therapeutic use of 1,6-dimethyl-8β-hydroxymethyl-10α-methoxyergoline
The invention concerns the use of 1,6-dimethyl-8β-hydroxymethyl-10α-methoxyergoline for preventing and/or treating motor neuron diseases.
|
|
|
6448243 |
1,4-substituted cyclic amine derivatives
A novel 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: (wherein A, B, C, D, T, Y and Z represent each methine or...
|
|
|
6444685 |
N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
This invention provides compounds of Formula I having the structure wherein R 1 , R 2 , R 3 , R 4 , W, X, and Y are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which...
|
|
|
6444665 |
Method for treating pain
The present invention provides a method for treating pain using an atypical antipsychotic compound.
|
|
|
6436961 |
Pharmaceutical agents for the treatment of emesis
The present invention relates to a novel process for preparing and resolving 3-amino-2-phenylpiperidine and for synthesizing from the enantiomers of such compound certain pharmaceutically active...
|
|
|
6417197 |
Acylated n-hydroxy methyl thalidomide prodrugs with immunomodulator action
Thalidomide prodrugs of the formula I: in which R is —CHR 1 —NHR 2 or —(CH 2 ) n COOH; R 1 is H or C 1-4 alkyl; R 2 is H, C 1-3 alkyl, C(O)—CH 2 —NHR 3 or an amino-protective...
|
|
|
6403581 |
Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
The invention is a method of treating, inhibiting or controlling a ras-associated disease by inhibiting farnesyl-protein transferase(FPTase) enzyme, treating ras oncogene-dependent tumors, which...
|
|
|
6403577 |
Hexamethyleneiminyl tachykinin receptor antagonists
This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention...
|
|
|
6403640 |
Method for treating chronic prostatitis or chronic pelvic pain syndrome
The use of a COX-2 selective inhibitor for the treatment of chronic prostatitis or chronic pelvic pain syndrome is disclosed.
|
|
|
6403613 |
1-oxo-and 1,3-dioxoisoindolines
1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines substituted in the 4- and/or 7-position of the isoindoline ring and optionally further substituted in the 3-position of the...
|
|
|
6399631 |
Carbazole neuropeptide Y5 antagonists
Carbazoles of the formula which are effective in treating conditions associated with neuropeptide Y-5 neurotransmission.
|
|
|
6391891 |
Bicyclic compounds as ligands for 5-HT1 receptors
The invention relates to compounds which are ligands for 5HT1, of formula (I) Wherein L, Q, R a , R b and R y are as defined in the specification, processes for their preparation and their...
|
|
|
6387932 |
Somatostatin agonists
This invention relates to non-peptide somatostatin agonist compounds which are potent with high selectivity toward the receptor subtype 2. The compounds provide an improved therapeutic index in the...
|
|
|
6380185 |
N-substituted benzoyl indoles as estrogenic agents
The present invention provides compounds of the formula: wherein R 1 , R 2 , R 3 , R 4 , X, n Y and Z, are as defined in the specification, or a pharmaceutically acceptable salt thereof, as well...
|
|
|
6380226 |
Salts of an anti-migraine indole derivatives
A crystalline, β-polymorphic form of a compound of formula (I):
|
|
|
6372764 |
Pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4c , R 4d , and R 4f are defined herein) which are useful as modulators of chemokine...
|
|
|
6369074 |
Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists
The present invention relates to novel aminomethylene substituted non-aromatic heterocycles and, specifically, to compounds of the formula wherein W, R 1 , R 2 , R 3 , A, X′, Y′ and Z′ are...
|
|
|
6369051 |
Combinations of SSRI and estrogenic agents
This invention comprises methods of depression, anxiety, generalized anxiety disorder (GAD), hot flush, post partum depression, premenstrual syndrome, obesity, obsessive compulsive disorder,...
|
|
|
6362201 |
3-cyclopropyl and 3-cyclobutyl pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4c , R 4d , and R 4f are defined herein) which are useful as modulators of chemokine...
|
|
|
6358993 |
Pharmaceutically active nitrogen ring compounds and methods of use thereof
The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof,...
|
|
|
6358943 |
N-substituted indolines as estrogenic agents
This invention provides compounds of the formula wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X, n and Y, are as defined in the specification, or a pharmaceutically acceptable salt thereof,...
|
|
|
6355642 |
Tetrahydrobenzindole compounds
A compound of formula (I) for use in the treatment or prevention of mental diseases A is N, CH, C having a double bond or CR 5 ; each of B and Z is independently N, CH or CR 1 , with the proviso...
|
|
|
6350760 |
Substituted piperidines as melanocortin-4 receptor agonists
Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are...
|
|
|
6339095 |
Therapeutic use of 1, 6-dimethyl-8β-hydroxymethyl-10-α-methoxyergoline
The invention concerns the use of 1,6-dimethyl-8β-hydroxymethyl-10α-methoxyergoline for preventing and/or treating motor neuron diseases.
|
|
|
6335326 |
Benzisoxazole derivatives having d4-antagonistic activity
The present invention relates to a group of novel benzisoxazole derivatives which are potent and selective antagonists of the dopamine D4-receptor. The compounds have general formula (I) wherein (R...
|
|
|
6335349 |
Substituted 2(2,6-dioxopiperidin-3-yl)isoindolines
Substituted 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines and 1-oxo-2-(2,6-dioxo-piperidin-3-yl)isoindolines reduce the levels of TNFα in a mammal and are useful in treating oncogenic...
|
|
|
6333339 |
3-Benzylpiperidine
The invention relates to piperidine derivatives of the formula I ##STR1## in which R 1 , R 2 , m and k have the meanings indicated in claim 1, and their salts, novel intermediates and processes for...
|
|
|
6329366 |
Pharmaceutical compounds
A pharmaceutical compound of the formula ##STR1## in which R 1 and R 2 are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, ##STR2## where R 4 and R 5...
|
|
|
6323217 |
Piperidine-4 sulphonamide compounds
A compound of formula (I): ##STR1## wherein: R 1 represents hydrogen or alkyl, R 2a and R 2b represent a group selected from hydrogen, halogen, alkyl, hydroxy, alkoxy, trihaloalkyl, cyano,...
|
|
|
6316437 |
Spirohydantoin compounds and uses thereof
Spirohydantoin compounds and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also described. One...
|
|
|
6316468 |
Phenylindole derivatives as 5-HT2A receptor antagonists
3-(Piperidin-4-yl)-1H-indole derivatives bearing an optionally substituted phenyl moiety at the 2-position of the indole ring system and an alkyl or aryl-alkyl substituent on the nitrogen atom of...
|
|
|
6313143 |
Substituted pyrroles
Disclosed are novel substituted pyrroles having the formula ##STR1## These compounds and their pharmaceutically acceptable salts are suitable for administration to patients as continuous infusion...
|
|
|
6306859 |
N-substituted imide derivatives with serotonergic activity
Compounds of the Formula (I) ##STR1## wherein R 2 , Y, X and n are as defined in the specification which compounds are useful in the treatment of disorders associated with serotonergic...
|
|
|
6306879 |
Stable aqueous solution of 3-(1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2-6-dione
An aqueous solution 3-(1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione (EM 12) is described which is suitable for parenteral administration, particularly for intravenous administration of EM...
|
|
|
6303627 |
Inhibitors of serotonin reuptake
This invention provides compounds and a method for the inhibition of serotonin reuptake in mammals.
|
|
|
6303610 |
Method of treating gout with certain indole compounds
This invention relates to a method of treating gout with certain indole compounds and other aromatic compounds.
|
|
|
6303633 |
Heteroaryl amines as novel acetylcholinesterase inhibitors
Compounds of the formula ##STR1## wherein ring A, ring B, ring D, R 2 , R 3 , R 4 , R 5 , R 6 , R 11 , R 12 , R 13 , E, G, X and P are as defined below. The compounds of formula I are...
|
|
|
6303626 |
Pharmaceutical formulations in dry form for the oral administration of a cyclic quaternary ammonium compound
The pharmaceutical formulations according to the invention contain from 0.5 to 50% by weight of a cyclic quaternary ammonium compound and pharmaceutically appropriate excipients and are formulated...
|
|
|
6297247 |
Sulfonamide inhibitors of matrix metalloproteinases
Sulfonamide compounds are described which are inhibitors of matrix metalloproteinases, particularly stromelysin-1 and gelatinase A (72 kD gelatinase). Also described are methods for the treatment...
|
|
|
6294537 |
Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools
A method for treating diseases which involve interaction of neurokinin B with NK 3 receptors in humans. The method comprises administering a therapeutically effective amount of a NK 3 antagonist...
|
|
|
6294551 |
N-linked sulfonamides of heterocyclic thioesters
This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as...
|
|
|
6288058 |
Substituted tetracyclic tetrahydrofuran derivatives
This invention concerns the compounds of formula (I), ##STR1## the N-oxide forms, the pharmaceutically acceptable addition salts and the stereoisomeric forms thereof, wherein n is zero to 6; p and...
|
|
|
6277877 |
Substituted n-(indole-2-carbonyl)glycinamides and derivates as glycogen phosphorylase inhibitors
Compounds of Formula (I) ##STR1## wherein R 6 is carboxy, (C 1 -C 8 )alkoxycarbonyl, benzyloxycarbonyl, C(O)NR 8 R 9 or C(O)R 12 as glycogen phosphorylase inhibitors, pharmaceutical...
|
|
|
6262080 |
3-(thio-substitutedamido)-lactams useful as inhibitors of matrix metalloproteinase
The present invention provides novel thio-substitutedamido lactam derivatives of the formula ##STR1## useful in as inhibitors of matrix metallo-proteinases (MMPs).
|
|
|
6262087 |
Indane or dihydroindole derivatives
The present invention relates to substituted indane or dihydroindole compounds of Formula (I) ##STR1## wherein A is an indole. These compounds have high affinity for D 4 receptors.
|
|
|
6258815 |
Specific immunophilin ligands as antiasthmatics and immunosuppressants
The novel specific immunophilin ligands of the general formula I have an antiasthmatic and immunosuppressive action and are suitable for the preparation of drugs. ##STR1##
|
|
|
6255306 |
4-indole derivatives as serotonin agonists and antagonists
The present invention relates to compounds of the formula ##STR1##
|