Matches 401 - 450 out of 524 < 1 2 3 4 5 6 7 8 9 10 11 >
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5106857 N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine and analogs as antiarrhythmic and muscle relaxing agents  
A method of treating cardiac arrhythmias and muscle tension and spasticity with N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol -2-amine and analogs and the pharmaceutical compositions...
5100903 N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds  
This invention pertains to novel N-aryl-N-[N-substituted 3-alkoxy-4-piperidinyl]amides useful as analgesics, and methods of administering analgesia, which comprises the systemic administration to...
5071848 Tricyclic quinoline antineoplastic agents  
Isothiazolo-quinoline derivatives are described which are cytotoxic for various tumor cell lines and are useful in the treatment of neoplastic diseases.
5070092 Pyrroloindole derivatives related to DC-88A compound  
DC-88A derivatives represented by the general formula: ##STR1## wherein X represents hydrogen or CO 2 R 1 (in which R 1 represents hydrogen, a straight-chain or branched alkyl having 1 to 4...
5066656 Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives  
(6,7-dihydro-5H-pyrrolo[1,2-c]imidazolyl-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridinyl-5-yl) substituted 1H-benzotriazole derivatives, compositions containing the same and methods of...
5064812 Metal complexes of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglutaminyl-(L)-mes o-diamino-pimelyl-(D-amide)-(L)-D-alanyl-D-alanine and their use in pharmaceuticals  
A complex of N-acetyl-glucosaminyl-N-acetyl-muramoyl-L-alanyl-D-isoglotam inyl- (L)-meso-diamino-pimelyl-(D-amide)-D-alanyl-D-alanine with bivalent metals chosen from the group comprising Cu 2 +,...
5064840 Anti-psychotic piperidylbenzimidazole compounds  
The present invention is directed to a new class of therapeutic agent which are useful as anti-psychotic agents and as analgesics.
5055466 N-morpholino derivatives and their use as anti-hypertensive agents  
Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
5039693 Pyrazole amides and insecticide and miticide containing them as active ingredient  
Novel pyrazole amide and an insecticidal and miticidal composition containing the pyrazole amide as an active ingredient are described. The pyrazole amide according to the present invention shows...
5034392 4-(3-(4-oxothiazolidinyl)butynylamines  
This invention relates to compounds of the formula ##STR1## where R 1 and R 2 are independently hydrogen or loweralkyl or R 1 and R 2 taken together with the carbon atom to which they are...
5030639 N-substituted-5,6-dimethoxy-1,2-benzisoxazole-3-propanamine and related compounds as analgesic and hypotensive agents  
There are disclosed compounds having the formula ##STR1## wherein R 1 is hydrogen or loweralkyl; R 2 is loweralkyl, arylloweralkyl, diarylloweralkyl or --CH 2 CHOHCH 2 OR 5 , R 5 being aryl,...
5013743 Selective antibacterial agent against campytobacter  
The compound represented by the formula; ##STR1## [wherein R 1 stands for hydrogen, methoxy or trifluoromethyl; R 2 and R 3 , being the same or different from each other, stand for hydrogen or...
5006527 Pharmacologically active N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives  
Novel N-(4-piperindyl)bicyclic condensed 2-imidazolamine derivatives and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same,...
5002957 Azaneophyl sulfides, and their use as pesticides  
Azaneophyl and silazaneophyl sulfides, processes for their preparation, agents containing them, and their use as pesticides. Compounds of the formula I, their optical isomers and mixtures thereof...
4983620 Pharmacologically active alkylthiobenzimidazole derivatives and process for the preparation thereof  
New alkylthiobenzimidazole derivatives are described which belong to the class of formula: ##STR1## wherein R 1 and R 2 each represent a 1-3 carbon atom alkyl radical or they may form with the...
4973587 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method  
Antiglaucoma compositions containing 3-aryl-carbonyl-1-aminoalkyl-1H-indoles, as the active component thereof, and a method of use thereof in the treatment of glaucoma.
4971980 Pharmacologically active benzimidazole derivatives  
Novel benzimidazole derivatives (I) are described, of formula ##STR1## wherein A represents ##STR2## n is 0 or 1; m represents 0 or an integer of from 1 to 5 inclusive, provided that when n is 0, m...
4960784 Insecticidal substituted indazoles  
Certain substituted indazoles, including all geometric and stereoisomers thereof, agricultural compositions containing the indazoles and use of the indazoles as insecticides.
4943580 Anti-histaminic benzimidazole, imidazopyridine and purine derivatives  
Novel 1-alkyl substituted benzimidazole derivatives and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same, and methods of...
4943574 (1H-azol-1-ylmethyl) substituted benzotriazole derivatives and pharmaceutical compositions containing them  
(1H-azol-1-ylmethyl)substituted benzotriazole derivatives, compositions containing the same, and methods of treating estrogen dependent disorders.
4933338 Benzimidazolesulfonamides and their application as drugs  
Benzimidazole-2-sulfonamide and imidazopyridine-2-sulfonamide derivatives corresponding to the general formula I: ##STR1## and their pharmaceutically acceptable salts, especially those of the...
4929618 Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same  
Disclosed is a compound represented by Formula (I): ##STR1## wherein Ar 1 , Ar 2 , n, A, B and Z are as defined in claims. Disclosed are also a process for preparing the compound and pharmaceutical...
4914102 N-aminocarbamates related to physostigmine, pharmacentical compositions and use  
There are disclosed various derivatives of physostigmine and related compounds of the formula below, ##STR1## where X,R 1 ,R 2 and R 3 are as defined in the specification, which compounds are...
4912107 Pyrrolocarbazole derivatives, compositions containing them, and methods for using them  
The invention concerns new pyrrolocarbazole derivatives of formula ##STR1## processes for their preparation, as well as medicaments containing these for the inhibition of protein kinases, such as...
4908372 Antihistaminic piperidinyl benzimidazoles  
The present invention is directed to a new class of piperidinyl benzimidazole antihistamines which can be described by the following formula: ##STR1## wherein Y is represented by CO or CHOH; m is...
4900738 N-heterocyclic-N-(4-piperidyl)amides and pharmaceutical compositions and their use as analgesics  
N-heterocyclic-4-piperidiyl-amides as analgesics and antagonists of opioids with respect to such undesirable side effects as respiratory depression. Exemplary compounds have the formula ##STR1## in...
4897401 N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases  
Novel N-(4-piperidinyl)bicyclic condensed 2-imidazolamine derivatives and their pharmaceutically acceptable acid addition salts having anti-histaminic properties, compositions containing the same,...
4880820 Guanine derivatives  
(S)-9-(2,3-dihydroxy-1-propoxymethyl)guanine has potent antiherpetic activity which is superior to the corresponding racemic mixture or the (R)-enantiomer and also is much more potent than...
4880804 Angiotensin II receptor blocking benzimidazoles  
Substituted benzimidazoles such as ##STR1## and pharmaceutically suitable salts thereof are useful as angiotensin II blockers. These compounds have activity in treating hypertension and congestive...
4879293 Pyrrols [3,4-8]pyrazine derivatives, their production and use as anti-anxiety agents  
The compound of the formula ##STR1## wherein X is a cyclic group which may optionally be substituted; Y is a carboxyl group which may optionally be esterified or amidated; Z is...
4874756 Benzodipyrroles, processes for the preparation thereof and pharmaceutical compositions containing them  
The present invention provides compounds of the general formula ##STR1## wherein the variables are as defined herein. The present invention also provides processes for the preparation thereof,...
4874759 5-Hydroxyindole-3-carboxylic acid amide compounds, pharmaceutical compositions and use  
Hydroxyindole-3-carboxylic acid amide compounds of the general formula: ##STR1## wherein R 1 , R 2 , R 3 and R 4 are, the same or different, respectively a hydrogen atom, an alkyl group, an aryl...
4873237 2,3-dihydro- thiazolo- and thiazino- benzimidazoles as atni-hyper secretion agents  
The invention relates to a method of treatment of ulcers or hypersecretion in a mammal which comprises administering a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof...
4871734 Substituted thienoimidazole-toluidine derivatives as inhibitors of gastric acid secretion  
Thienoimidazole-toluidines of the formula I ##STR1## in which A represents ##STR2## T denotes --S--, --SO-- or --SO 2 --, and R 1 to R 9 have the meanings stated in the description, and a...
4863945 Pyrrolobenzimidazoles and pharmaceutical compositions containing them  
Pyrrolobenzimidazoles of the formula: ##STR1## are useful for treatment of heart and circulatory diseases. R 1 is substituted phenyl; or optionally substituted naphthyl or a five- or six-membered...
4863935 Mitomycin compounds having useful anti-tumor activity  
Mitomycin derivatives having potent anti-tumor activity against solid sarcoma 180 tumors and lymphocytic leukemia P-388 tumors.
4861785 Benzoxazol-and benzothiazolamine derivatives, useful as anti-anoxic agents  
Benzoxazol-and benzothiazolamine derivatives having anti-anoxic properties which compounds are useful in the treatment of anoxia.
4857536 Antihistaminic benzimidazole derivatives  
A compound which is a benzimidazole derivative of formula (I) ##STR1## in which: R 1 is hydrogen or methyl, R 2 is hydrogen, methyl or acetyl, R 3 is hydrogen, methyl or acetyl, and R 4...
4853384 1-carbonyl derivatives of 4-aryl-4-aryloxypiperidines  
1-Carbonyl derivatives of 4-aryl-4-aryloxypiperidines and methods for alleviating pain and treating convulsions utilizing compounds or compositions thereof are disclosed.
4851425 Cyclopentapyrazole and tetrahydroindazole compounds and their use as anti-inflammatory and anti-allergic agents  
The present invention provides novel compositions of matter and their therapeutic applications. More particularly, the present invention consists of novel cyclopentapyrazole and tetrahydroindazole...
4837235 Indole and indazole keto sulphones as leukotriene antagonists  
This invention provides a series of novel keto sulfones of formula I ##STR1## in which the group A-- is selected from C(Ra)-- and N-- and the other radicals have the meanings defined in...
4835161 Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines  
Anti-allergic compositions containing one or more pharmaceutical carriers and as active ingredient at least one compound which is a N-heterocyclyl-4-piperidinamine and methods of treating allergic...
4833135 Antioestrogenic phenol derivatives  
A phenol derivative of the formula NU-A-X-R 1 wherein NU is a defined bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl; hydroxyphenyl-hydroxy-indanyl,...
4831043 Dopaminergic benzimidazol-2-ones  
Novel benzimidazol-2-ones of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms, alkenyl and...
4831032 Cardiotonic benzimidazoles  
The present invention provides benzimidazoles of the general formula: ##STR1## wherein R 1 , X, A, and R 2 are as defined in the specification. The present invention also provides processes for...
4814329 Antihyperlipoproteinemic 5-substituted sulfur-containing benzimidazole derivatives  
The invention relates to novel, sulfur-containing 5-substituted benzimidazole derivatives of formula I ##STR1## and acid-addition salts thereof antihyperlipoproteinemic action, a process for...
4794123 Thiazolo- and thiazino- benzimidazoles and their use as anti-ulcer agents  
This invention relates to a method of treating ulcers or hypersecretion in a mammal which comprises administering a compound of formula ##STR1## or a pharmaceutically acceptable salt thereof...
4772616 Treatment of ocular hypertension and glaucoma with dopamine antagonists  
Aqueous humor formation and intraocular pressure in mammals having ocular hypertension or glaucoma may be reduced by topically administering to a hypertensive eye an ophthalmologically acceptable...
4767769 Antiulcer benzimidazole derivatives  
Compounds of formula I ##STR1## in which R 1 and R 2 , which may be the same or different, are hydrogen, a C 1 to C 3 alkyl group or R 1 and R 2 together with the nitrogen to which they are...
4707487 (4-imidazolyl)piperidines, the preparation thereof and their application in therapy  
Compounds of general formula ##STR1## in which R 1 denotes H, CH 3 or C 2 H 5 , R denotes H or R 2 and R 2 denotes an alkyl, piperonyl, 3-(1-benzimidazolonyl)-propyl group; a group of formula...
Matches 401 - 450 out of 524 < 1 2 3 4 5 6 7 8 9 10 11 >