Matches 351 - 400 out of 523 < 1 2 3 4 5 6 7 8 9 10 11 >
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5436262 Pharmacologically active derivatives of 2-(benzimidazol-2-yl)-1,3-diaminopropane  
Derivatives of 2-(benzimidazol-2-yl)-1,3-diaminopropane, the process for their preparation as well as the pharmaceutical compositions containing them as active ingredients are described. The...
5434169 Piperidine derivatives, their preparation and their application in therapy  
A compound which is a piperidine derivative of formula (I) ##STR1## in which R represents hydrogen, or unbranched or branched C 1 -C 6 alkyl group; and Ar represents phenyl optionally...
5434150 Condensed 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical preparations containing these compounds  
The invention relates to cyclic imino derivatives of general formula ##STR1## wherein A to G, R 1 , Z 1 to Z 6 , X and Y are defined as in claim 1, the tautomers, stereoisomers and mixtures...
5432168 Method of treatment of hormone-unresponsive metastatic prostate cancer  
Prostate cancer particularly hormone-unresponsive metastatic prostate cancer, is treated by cyclophosphamide or other normally substantially inactive agent. Potentiation of the anti-cancer activity...
5428043 Tricyclic-cyclic amines as novel cholinesterase inhibitors  
Compounds of the formula ##STR1## wherein ring A, ring B, ring D, R 2 , R 3 , R 4 , R 5 , R 6 ,R 11 , R 12 , R 13 , E, G, X and P are as defined below. The compounds of formula I are cholinesterase...
5426105 Conformationally restricted angiotensin II antagonists  
Conformationally restricted compounds are described which are therapeutically effective as angiotensin II antagonists for the treatment of circulatory disorders. Compounds of particular interest...
5424308 Condensed pyrazole 3-oxo-propanenitrile derivatives  
Condensed pyrazole 3-oxo-propanenitrile derivatives of formula (I) ##STR1## wherein X represents a --CH(R 4 )-- group, an oxygen atom or a --S(O) n -- group where n is 0, 1 or 2; R 1 represents C...
5418241 Piperidine derivatives, their preparation and their application in therapeutics  
The invention provides a compound which is a piperidine derivative of formula (I) ##STR1## in which R 1 is hydrogen or straight or branched (C 1 -C 6 ) alkyl, R 2 is hydrogen or straight or...
5414010 Dimeric benzimidazoles as central nervous system agents  
Dimeric benzimidazoles are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents and are particularly useful as...
5391556 Benzimidazolyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them  
The invention relates to benzimidazolyl derivatives of general formula ##STR1## wherein R 1 to R 3 are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof, which...
5382588 Methyl piperidine derivatives of cinnamic acids, benzoic acids, benzoazols and benzophenones useful as skin anti-aging compounds  
Free radical deactivating 4- or 1,4-substituted, 2,2,6,6-tetramethyl piperidines are condensed with UV absorbing cinnamic acids or benzoic acids or benzoazols or benzophenones to produce skin...
5380731 Antiallergic compounds  
The present invention is directed to a new class of piperidinyl benzimidazoles that are useful in the treatment of allergic disorders.
5378714 Antipsychotic piperidine derivatives  
The present invention relates to therapeutically active piperidine derivatives, of formula 1 ##STR1## wherein, R 1 , R 2 , A, X and Y are as defined in the specification. The compounds are useful...
5371094 Azaheterocyclylmethyl-chromans for treating axiety  
Azaheterocyclylmethyl-chromans are prepared by reaction of corresponding methylchromans with corresponding azaheterocyclic compounds, optionally with subsequent variation of the substituents. The...
5364866 Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
5360807 Substituted thiazolyl and substituted pyridinyl derivatives  
Substituted thiazolyl and substituted pyridinyl derivatives of formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein --A 1...
5360809 Imidazole compounds and their use as calcium channel blockers  
The present invention discloses compounds of the formula ##STR1## wherein X is C; Y is C; R 4 to R 7 and R 11 to R 13 are as defined herein; or a pharmaceutically-acceptable addition salt...
5330997 1H-indazole-3-acetic acids as aldose reductase inhibitors  
Certain 1H-indazole-3-acetic acid derivatives, and their pharmaceutically-acceptable esters and salts, are inhibitors of the aldose reductase enzyme, and so are useful in the treatment of diabetic...
5328916 Heterocyclic compounds useful for inhibition of renin  
New heterocyclic compounds of the formula X--W--CR 1 R 2 --CO--Y--NR 3 --CHR 4 --CR 5 --CH 2 --(CR 6 R 7 ) r --Z--Het I in which R 1 to R 7 , W, X, Y, Z, r and Het...
5322850 Antiallergic piperidine derivatives of benzimidazole  
New piperidine derivatives of benzimidazole of the formula: ##STR1## wherein n is 1 or 2 and R is lower alkyl, lower alkenyl or lower cycloal, or a pharmaceutically acceptable salt thereof, are...
5302593 Aminoalkylcarbamic esters of eseroline suitable for use as chlorinesterase activity inhibitors  
Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase activity inhibitors, having general formula (I) ##STR1## where R stands for an amine selected out of the group consisting...
5302599 Therapeutically useful heterocyclic indole compounds  
A therapeutically useful compound of formula I ##STR1## or pharmaceutically acceptable salts thereof where A and B are oxygen, sulfur or CH 2 , X is an amine moiety as defined herein and R 1 and R...
5284647 Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them  
Porphyrin complex compounds, consisting of a mesotetraphenylporphyrin ligand, optionally at least one ion of an element with atomic numbers 13, 21, 32, 37-39, 42-44, 49, 50 or 57-83 as well as...
5280030 Piperidine derivatives, their preparation and their therapeutic application  
A compound which is a piperidine derivative of general formula (I) ##STR1## in which R 1 represents a hydrogen atom, a linear or branched (C 1 -6)alkyl group or a cyclo(C 3 -8)alkyl group, X...
5262418 N-(4-piperidinyl) (dihydroxybenzofuran or dihydro-2H-benzopyran)carboxamide derivatives  
Piperidine derivatives of formula ##STR1## wherein A is a radical of formula --CH 2 --CH 2 -- (a-1), --CH 2 --CH 2 --CH 2 -- (a-2),...
5258383 DC-89 derivatives  
DC-89 derivatives represented by the formula: ##STR1## wherein X represents hydrogen or CO 2 CH 3 ; and ##STR2## wherein Z represents Cl or Br; R represents hydrogen, CONR 1 R 2 (in which R 1 ...
5248683 Benzo-1,2,3-thiadiazole derivatives  
Compounds of the formula ##STR1## in which A 1 and A 2 independently of one another are CO--C 1 -C 4 alkyl, COO--C 1 -C 4 alkyl, CO--CF 3 , CO--N(R) 2 or cyano; A 1 and A 2 together are...
5240944 Cyclic guanidine derivatives, anti-ulceratives and method of manufacturing the same  
Derivatives of cyclic guanidine are disclosed, which are represented by the following formula: A--S--R wherein A is ##STR1## R 1 represent a lower alkyl or substituted phenyl or unsubstituted...
5234904 Antihypertensives containing polysaccharide peptidoglycan complexes extracted from the cell wall of lactic acid bacteria  
The present invention relates to antihypertensives and food and drinks, containing as effective component polysaccharideglycopeptide complexes derived from cell wall of Gram positive bacteria (also...
5223515 Injectable solution containing a pyridyl methylsulfinylbenzimidazole  
An injectable solution of a compound useful as an anti-ulcer agent of the formula; ##STR1## wherein R 1 represents hydrogen, methoxy or trifluoromethyl group; R 2 and R 3 , being the same as or...
5217980 Oxazolyl and piperidinyl substituted benimidazolyl compounds  
Oxazolyl derivatives of formula (I) ##STR1## wherein --A 1 A 2 --A 3 A 4 -- represents a bivalent radical having the formula --CHCH--CHCH-- (a-1), --NCH--CHCH-- (a-2), ...
5212184 1-substituted-4-pentafluorophenoxypiperidines  
1-Carbonyl derivatives of 4-pentafluorophenoxypiperidines and methods for treating convulsions, depression, and hypertension utilizing compounds or compositions thereof are disclosed.
5210091 Imidazole compounds and their use  
The application discloses benzimidazole derivatives, pharmaceutical preparations comprised the compounds, their preparation and use in the treatment of disorders of the Central Nervous System such...
5196408 N-sulfenylated pyrazolines, compositions and use  
N-sulfenylated and N-acrylated pyrazoline arthropodicides, compositions containing them and methods for controlling arthropods by applying compounds of the invention to them or to their...
RE34201 N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds  
This invention pertains to novel substituted N/aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides useful as analgesics, and methods of administering analgesia, which comprises the systemic...
5194440 Substituted cyclic sulphamide derivatives  
A class of substituted cyclic sulphamide derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and...
5192776 1-subsituted-4-pentafluorophenoxypiperidines  
Carbonyl derivatives of 4-pentafluorophenoxypiperidines and methods for treating convulsions, depression, and hypertension utilizing compounds or compositions thereof are disclosed.
5188830 Methods for thrombolytic therapy  
Certain Factor XIIIa inhibitor compounds have been discovered which have been found to be useful in the lysis of blood clots and thus adaptable for administration in thrombolytic therapy either...
5185347 Piperidine compounds and antiulcer composition containing the same  
A piperidine compound represented by formula (I): ##STR1## wherein R 1 represents a hydrogen atom, a lower alkyl group having from 1 to 4 carbon atoms, a lower alkoxy group having from 1 to 4...
5185335 N-(4-piperodinyl)(dihydrobenzofuran or dihydro-2H-benzopyran) carboxamide derivatives  
Piperidine derivatives of formula ##STR1## wherein A is a radical of formula ##STR2## wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C 1 -6 alkyl radical; ...
5169856 Piperidinoalkyl derivatives of carboxylic acid amides  
The present invention relates to unsaturated carboxylic acid amide derivatives of the formula ##STR1## wherein ring A stands for an optionally substituted aromatic ring; R 1 stands for a hydrogen...
5166152 Tricyclic 3-oxo-propanenitrile derivatives  
Compounds having the general formula (I) ##STR1## wherein X represents an oxygen atom or a --S(O) n --group, wherein n is zero, 1 or 2; R represents C 1 -C 6 alkyl, pyridyl or substituted or...
5162318 Benzimidazolinone derivatives  
Benzimidazolinone derivatives of the general formula (I): ##STR1## wherein R 1 , R 2 and R 3 , which may be the same or different, each is a hydrogen or halogen atom or a lower alkyl, halo-lower...
5143923 Benzoisothiazole- and benziosoxazole-3-carboxamides  
Novel benzisothiazole- and benzisoxazole-3-carboxamides, processes and intermediates for the preparation thereof, and methods of treating psychoses utilizing compounds and compositions thereof are...
5134150 Inhibition of the 5-lipoxygenase pathway  
A method of inhibiting the 5-lipoxygenase pathway in an animal in need thereof which comprises administering an effective, 5-lipoxygenase pathway inhibiting amount of a diaryl- substituted...
5130312 Substituted N-(3-hydroxy-4-piperidinyl)benzamides  
N-(3-hydroxy-4-piperidinyl)substituted benzamides, their N-oxide forms and pharmaceutically acceptable acid-addition salts having gastro-intestinal motility stimulating properties, compositions...
5126339 Anti-allergic bicyclic heterocyclyl-containing N-(bicyclic heterocyclyl)-4-piperidinamines  
Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of...
5124340 Use of calcium channel blocker to prevent cocaine induced craving and reinforcement  
A method of treating cocaine addiction by administering to a patient in need thereof, an anti-cocaine addicting effective amount of a calcium channel blocking agent.
5112824 Benzofuran compounds as class III antiarrhythmic agents  
Compounds of structural formula: ##STR1## wherein R' is hydrogen or an aromatic ring system, and Q is a substituted nitrogen or a nitrogen containing heterocycle, X and Y are bridging groups and p...
5106857 N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine and analogs as antiarrhythmic and muscle relaxing agents  
A method of treating cardiac arrhythmias and muscle tension and spasticity with N-(1-methyl-3-pyrrolidinyl)-1-(phenylmethyl)-1H-benzimidazol -2-amine and analogs and the pharmaceutical compositions...
Matches 351 - 400 out of 523 < 1 2 3 4 5 6 7 8 9 10 11 >