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4695575 |
4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
4-[(Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.
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4680296 |
Piperidine derivatives and pharmaceutical compositions containing them
Piperidine derivatives which are compounds of formula (I) ##STR1## wherein Ar 1 and Ar 2 independently represent a phenyl group optionally substituted by a halogen atom, a thienyl group or a...
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4670447 |
Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
Novel 3-(piperidinyl- and 3-(pyrrolidinyl)-1H-indazoles, intermediates and processes for the preparation thereof, and methods for treating psychoses, treating depression, alleviating pain, treating...
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4657905 |
Novel hypotensive imidazothiadiazolealkanecarboxamides
Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R 1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S,...
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4657908 |
Carbonyl derivatives
The invention relates to carbonyl derivatives which are histamine H-2 antagonists and which inhibit gastric acid secretion. According to the invention where is provided a guanidine derivative of...
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4647557 |
Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them
This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds. More particularly this invention provides novel heterocyclic compounds...
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4634704 |
Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
Five membered heterocyclic ring containing N-(bicyclic heterocyclyl)-4-piperidinamines having histamine and serotonine antagonistic activity which compounds are useful agents in the treatment of...
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4612312 |
Glutarimide antianxiety and antihypertensive agents
Glutarimide derivatives of the formula which are useful antihypertensive and antianxiety agents ##STR1## wherein R 1 and R 2 each independently represent hydrogen, a 1 to 4 carbon alkyl, a 1 to 4...
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4588723 |
Aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, intermediates for their preparation and their use in medicaments
The invention relates to aminoalkyl-imidazothiadiazole-alkenecarboxylic acid amides, processes for their preparation, intermediates which are used in their preparation, medicaments containing said...
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4582838 |
Derivatives of dihydro-1H-pyrrolo[1,2-c]imidazol-3,5-dione as cognition activators
Certain derivatives of dihydro-1H-pyrrolo-[1,2-c]imidazol-3,5[2H,6H]-dione are cognition-activating compounds, possessing pharmacological activity for treating senility or for reversing the effects...
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4560688 |
Tricyclic antihistamines
Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or...
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4558056 |
Analgesic 3-(4-piperidinyl)-1,2-benzisothiazoles
Novel 3-(4-piperidinyl)-1,2-benzisothiazoles, processes for the preparation thereof, and method of treating psychoses and alleviating pain employing compounds or compositions thereof are disclosed.
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4556654 |
Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones
Substituted anthra[1,9-cd]pyrazol-6(2H-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed.
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4550118 |
Heterocyclic compounds
Compounds of Formula I are described ##STR1## in which X and Y are independently --NH--, --O-- or --S--; Z may be a pyrimidine, triazine, triazole, thiazole, thiadiazole ring. The methods of...
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4530924 |
Phthalocyanine compounds and anti-microbial use
A process for combating micro-organisms in or on organic or inorganic substrates and for protecting the said substrates against attack by micro-organisms, which comprises treating the substrates...
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4522821 |
Anti-emetic esters of cyproheptadine-3-carboxylic acid and structurally related compounds
Certain esters of cyproheptadine-3-carboxylic acid and its bioisosteres are peripherally selective dopamine antagonists useful in the treatment of emesis caused by stimulation of dopamine receptors...
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4500525 |
Pharmacologically active pyrazolo/4,3-c/pyridines
The present invention is directed to new pyrazolo/4,3-c/pyridines, the process for their preparation, the pharmaceutical compositions containing them and their use as pharmocologically active...
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4492708 |
Antiviral benzimidazoles
Certain N-substituted benzimidazoles are disclosed. The compounds are potent antiviral agents. Pharmaceutical formulations containing such compounds and a method of treating viral infections are...
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4487769 |
Amidines
Mitomycin A, mitomycin C, and porfiromycin react with amide acetals and other amide derivatives to produce amidine derivatives having antitumor activity against experimental animal tumors. The...
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4470989 |
Neuroleptic n-oxacyclyl-alkylpiperidine derivatives
Neuroleptically active compounds of the formula ##STR1## wherein R 6 and R 10 are --H or CH 3 ; R 7 and R 8 are independently --H, --F, --Cl, or --CH 3 ; and R 9 is --F, --Cl, --CH 3 , or...
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4446141 |
Hypotensive piperidine derivatives
The present invention relates to a novel compound represented by the general formula: ##STR1## wherein Ar represents a naphthyl, phenyl or substituted phenyl group, Q represents ##STR2## wherein R...
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4444770 |
New imidazoazole-alkenoic acid amide compounds, intermediate products for their production, their production, and their medicinal use
The invention relates to imidazoazole-alkenoic acid amides of Formula (I) and methods for their production. Also included in the invention are compositions containing said alkenoic acid amides and...
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4443446 |
Use of psychoactive drugs as vaginal contraceptives
The use of psychoactive drugs as vaginal contraceptives is disclosed. The invention may be implemented by incorporating a psychoactive drug in a known method such as jelly, foam, or suppository...
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4420479 |
Olefinic benzimidazoles, formulations, and antiviral methods
1-Substituted-2-amino-5(or 6) olefinic benzimidazoles and intermediates therefor are disclosed. The compounds are potent antiviral agents. Pharmaceutical formulations containing such compounds and...
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4415569 |
Pyrazoloindazole derivatives and pharmaceutical composition containing the same
Pyrazoloindazole derivatives of the formula: ##STR1## [wherein R 1 is a cyano group, carboxy group, a lower alkoxycarbonyl group or a group ##STR2## (wherein R 2 and R 3 are each a hydrogen...
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4414216 |
Tetrahydrofuran compounds and analogs thereof
There are disclosed tetrahydrofuran compounds and analogs thereof of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, wherein X is oxygen or sulfur, R 1 and R 2 ...
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4411907 |
Antiinflammatory 3H-naphtho(1,2-d)imidazoles
3H-naphth[1,2-d]imidazole derivatives of formula ##STR1## wherein R stands for hydrogen, methyl or ethyl, R 1 represents hydrogen, methyl or ethyl, R 2 represents hydrogen, methyl, ethyl, phenyl...
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4410528 |
Hypotensive piperidine derivatives
A new piperidine derivative represented by the formula: ##STR1## wherein X is oxygen, sulfur, carbonyl, hydroxymethylene or methylene; R 1 is straight-chain alkylene having 1-4 carbon atoms with...
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4397853 |
Isoxazole derivatives
Isoxazole derivatives represented by the formula ##STR1## wherein Ar, R 1 , R 2 and Am are as defined in the specification, or salts thereof. These compounds are useful as drugs such as...
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4390536 |
Piperidine derivatives
New piperidine derivatives which have a useful pharmacological activity such as hypotensive activity are prepared.
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4377578 |
Piperazine derivatives
Novel 1-substituted 4-(diarylmethyl)piperazine derivatives having antianaphylactic and antihistaminic properties.
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4377577 |
Use of psychoactive drugs in uterus to prevent pregnancy
The use of psychoactive drugs by injecting or introducing such drugs directly into the uterus is disclosed as a means of preventing pregnancy after intercourse has occurred. Various means of...
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4372961 |
Derivatives of rifamycins, their preparation and pharmaceutical compositions thereof
The present invention provides compounds of the general formula: ##STR1## wherein Y is a hydrogen atom or an acetyl radical, R is a hydrogen atom, a straight-chained or branched, saturated or...
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4364942 |
2,3-Dihydro-imidazo (2,1-b)benzothiazoles compositions useful as anti-parkinsonism agents
This invention relates to a novel series of 2,3-dihydro-imidazo[2,1-b]benzothiazoles which display monoamine oxidase inhibiting activities.
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4359468 |
Antiallergic N-[4-(indolyl)-piperidino-alkyl]-benzimidazolones
Compounds of the formula ##STR1## wherein R 1 is hydrogen, halogen or methoxy; R 2 is hydrogen or lower alkyl; R 3 is hydrogen or lower alkyl; R 4 is hydrogen, lower alkyl or alkenyl...
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4359465 |
Methods for treating gastrointestinal inflammation
The present invention relates to the novel cytoprotective use for known heterocyclyalkylsulfinylbenzimidazoles, and novel, substantially non-antisecretory unit dose pharmaceutical compositions...
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4353913 |
Benzimidazolylcarbamic acid ester compounds, their production, and their medicinal use
The invention relates to 2-benzimidazolylcarbamic acid esters, substituted on the benzenoid nucleus by an aminoalkoxy, aminoalkylthio, an aminoalkylsulphinyl or an aminoalkylsulphonyl grouping. The...
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4352811 |
3-(1-Substituted-4-piperidyl)-1,2-benzisoxazoles
Novel 3-(1-substituted-4-piperidyl)-1,2-benzisoxazoles, processes for the preparation thereof, and methods of treating psychoses employing compounds and compositions thereof are disclosed.
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4344946 |
2,6-Diamino-benzo[1,2-d:5,4-d']bisthiazoles and salts thereof
Compounds of the formula ##STR1## wherein R 1 and R 1 ', which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 2 carbon atoms; R 2 and R 2 ', which may...
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4338323 |
Piperidylbenzimidazolinone derivatives
Piperidylbenzimidazolinone derivatives of the formula: ##STR1## in which: R 1 is lower alkyl, phenyl, halophenyl, lower alkylphenyl, lower alkoxyphenyl, methylenedioxyphenyl, ethylenedioxyphenyl,...
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4329353 |
1-(4-Aryl-cyclohexyl)piperidine derivatives, method of use thereof and pharmaceutical compositions thereof
Novel 1-[1-(4-aryl-cyclohexyl)-4-piperidinyl]-1,3-dihydro-2H-benzi
midazol-2-ones and 1-aryl-8-(4-aryl-cyclohexyl)-1,3,8-triazaspiro[4,5]decan-4-o
nes which are useful as antiemetic-and neuroleptic...
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4327099 |
Pyrano derivatives, a process for their preparation and their use
Compounds of the formula (I): ##STR1## wherein R 1 and R 2 are independently selected from a hydrogen atom and a C 1 -3 alkyl group; R 3 is a hydrogen atom, a C 1 -3 alkyl or C 2 -4 acyl...
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4312868 |
Isothiochromans
Isothiochromans are described. The compounds possess hypotensive and antipsychotic properties; methods and compositions using them are described.
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4288442 |
Inhibiting adrenergic β-receptors with piperidinopropyl derivatives
A piperidinopropyl derivative of the formula ##STR1## in which R 1 and R 2 each independently is hydrogen or a lower alkyl radical, or together are an alkylene radical, R 3 is hydrogen,...
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4287199 |
Benzimidazolylcarbamic acid esters substituted on the benzenoid nucleus by an oxy or thio substituent
The invention relates to 2-benzimidazolylcarbamic acid esters, substituted on the benzenoid nucleus by an aminoalkoxy, aminoalkylthio, an aminoalkylsulphinyl or an aminoalkylsulphonyl grouping. The...
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4277472 |
3,6-Disubstituted-5,7-(lower alkano)-5,6,7,8-tetrahydropyrido(4,3-C)pyridazines; their intermediates, preparation, antihypertensive use and compositions
Substituted pyridazines of formula I ##STR1## wherein A denotes a lower alkylene group, R 1 denotes an optionally-substituted or derivatized amino group, R 2 denotes an alkyl group, an...
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4264613 |
Piperidylbenzimidazolinone compounds
Piperidylbenzimidazolinone compounds of the formula: ##STR1## in which: R is hydrogen, hydroxy, hydroxymethyl, methoxycarbonyl, formamido, acetamido, mesylamino, oxalamino, ethoxalylamino,...
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4254127 |
1,3-Dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives
Novel 1,3-dihydro-1-[(1-piperidinyl)alkyl]-2H-benzimidazol-2-one derivatives which compounds are potent serotonin-antagonists and central nervous system depressants, having utility as antiemetic,...
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4235914 |
Psychotropic γ-(heterocyclic substituted) butyrophenones
Butyrophenone compounds having excellent psychotropic activity and represented by the formula: ##STR1## wherein Z is defined hereinbelow.
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4219559 |
N-Heterocyclyl-4-piperidinamines
Novel N-heterocyclyl-4-piperidinamines wherein said heterocyclic radical is an optionally substituted 1H-benzimidazol-2-yl or 3H-imidazo[4,5-b]pyridin-2-yl radical, said compounds being useful as...
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