Patents in Class 514/321

Matches 101 - 150 out of 628

Match	Document	Document Title
101	6750213	Estrogen receptor modulators The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
102	6750229	Methods for treating skin pigmentation This invention relates to methods and compositions for bringing about changes in skin pigmentation. More particularly, this invention relates to compounds which affect melanogenesis and can be used...
103	6734179	Benzothiazoles The present invention relates to compounds of the formula wherein R1 and R2 are as described within. The compounds of formula I have been found to be adenosine receptor ligands. Specifically,...
104	6730677	Benzofurazan compounds which enhance AMPA receptor activity Compounds of general structural formula ( 1 ) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors...
105	6727263	Indole and 2,3-dihydroindole derivatives, their preparation and use The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof,...
106	6720003	Serotonin reuptake inhibitor formulations A process for preparing amorphous paroxetine hydrochloride or sertraline hydrochloride is provided, which comprises preparing a solution in which paroxetine hydrochloride or sertraline...
107	6706736	Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-&lsqb 1,4&rsqb -benzodioxans Compounds of the formula useful for the treatment of depression such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction,...
108	6703408	N-formyl derivatives of paroxetine A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine...
109	6699858	Halogen substituted tetracyclic tetrahydrofuran derivatives This invention concerns the compounds of formula (I), the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein n is zero, 1, 2,...
110	6699882	Paroxetine compositions Paroxetine is adsorbed on a carrier to form a free-flowing powder useful for capsule filling or for tablet formulation; and used in therapy to treat depression.
111	6689794	Aromatic sulfone hydroxamates and their use as protease inhibitors This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known...
112	6683078	Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors This invention is directed to a process for inhibiting aggrecanase activity. The process comprises administering a therapeutically effective amount of a sulfonyl aromatic or heteroaromatic...
113	6673829	Aminoazetidine,-pyrrolidine and -piperidine derivatives Novel aminoazetidine, -pyrrolidine, and -piperidine derivatives, use of these compounds as pharmaceutical compositions, pharmaceutical compositions comprising the compounds, and a method of...
114	6667322	Antidepressant chroman and chromene derivatives of 3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole Compounds of the formula useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder,...
115	6660751	Sulfonamide derivatives as 5-HT7 receptor antagonists The invention relates to novel sulfonamide compounds having 5-HT 7 receptor antagonist activity, processes for their preparation, to compositions containing them and to their use in the treatment...
116	6656950	Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino&lsqb 2,3-b&rsqb pyridine Compounds of the formula useful for the treatment of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating...
117	6656954	Sulfonyl divalent aryl or heteroaryl hydroxamic acid compounds A sulfonyl divalent aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises...
118	6653327	Cross-regulin composition of tumeric-derived tetrahydrocurcuminoids for skin lightening and protection against UVB rays The present invention is directed to a mixture of tetrahydrocurcuminoids which can be used for regulating random, intracellular protein cross-linking an optimizing cell electric potential in a...
119	6649614	Use of a NK-1 receptor antagonist and an antidepressant and/or an anti-anxiety agent for treatment of depression or anxiety The present invention relates to the treatment of depression and/or anxiety by the administration of a combination of a specific class of NK-1 receptor antagonists and an antidepressant or...
120	6642256	Piperidine derivatives as subtype selective N-Methyl-D-Aspartate antagonists Described are piperidines of Formula I and pharmaceutically acceptable salts thereof. The compounds of Formula I are antagonists of NMDA receptor channel complexes useful for treating cerebral...
121	6642228	α1b-adrenergic receptor antagonists There are provided compounds represented by the general formula (I): [wherein Ar is indole etc., R 1 is hydrogen etc., B is bond, or B—N—R 1 forms a ring structure and is piperidine etc.,...
122	6638948	Amorphous paroxetine composition A free-flowing, amorphous paroxetine hydrochloride composition suitable as a therapeutic agent for premature ejaculation can be prepared by dissolving paroxetine free base in a hydrochloric...
123	6635643	Bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives The present invention of compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereof, R 1 and R 2 ...
124	6627645	Muscarinic agonists Compounds and methods are provided for the treatment of disease conditions in which modification of cholinergic, especially muscarinic m1, m4, or both m1 and m4, receptor activity has a beneficial...
125	6620843	Anticancer treatment using triptolide prodrugs Water soluble triptolide prodrugs are used as anticancer agents, and are found to be more effective in vivo, at lower doses, in reducing tumor size than the widely used chemotherapeutic agents...
126	6620815	Oxazolidinones and uses thereof This invention is directed to oxazolidinone compounds which are selective antagonists for human α 1A receptors. This invention is also related to uses of these compounds for lowering intraocular...
127	6617334	Antidepressant azaheterocyclylmethyl derivatives of 7,8-dihydro-1,6,9-trioxa-3-aza-cyclopenta&lsqb a&rsqb naphthalene Compounds of the formula: useful for the treatment of depression and other diseases such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder,...
128	6613776	Pyrazole compounds useful as protein kinase inhibitors This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula V: wherein Z 1 is N, CR a , or CH, and Z 2 is N or CH, provided...
129	6613780	Heat shock factor activity inhibitor A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an...
130	6602881	Anti-inflammatory uses of manzamines The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate...
131	6589956	Benzenesulphonamide compounds A compound of formula (I): wherein: R a represents a hydroxy, alkoxy, aryloxy or arylalkyloxy group, A represents a CH group or a nitrogen atom, in which case R 1 is as defined in the...
132	6579881	Indoles A 1,4-substituted cyclic amine derivative represented by the following formula or a pharmacologically acceptable salt thereof: wherein A, B, C, D, T, Y, and Z each represent a methine or a...
133	6576630	Compounds and compositions as protease inhibitors The present invention relates to novel alkanoyl-substituted heterocyclic derivatives which are cysteine protease inhibitors; the pharmaceutically acceptable salts and N-oxides thereof; their uses...
134	6559169	Antidepressant azaheterocyclymethyl derivatives of 2,3-dihydro-1,4-benzodioxan Compounds of the formula useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction,...
135	6552049	Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-&lsqb 1,4&rsqb -benzodioxans Compounds of the formula useful for the treatment of depression such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction,...
136	6552043	Benzimidazolinyl piperidines as CGRP ligands The present invention relates to benzimidazolinylpiperidine derivatives useful as ligands for CGRP (Calcitonin Gene-Related Peptide) receptors, their use in therapy, pharmaceutical compositions...
137	6548516	1-(3-heteroarylpropyl- or -prop-2-enyl)-4-benzylpiperidines used as NMDA receptor antagonists Piperidine derivatives of the formula I and their physiologically acceptable salts in which X, Y, Z, R 1 , R 2 , R 3 and R 4 are as defined in claim 1 can be as excitatory amino acid...
138	6548084	Controlled release compositions A controlled release or delayed release formulation contains a selective serotonin reuptake inhibitor (SSRI) such as paroxetine.
139	6541478	Smoking cessation treatments using naltrexone and related compounds Nicotine dependency is treated by administration of an opioid antagonist. In some embodiments, rapid or ultra rapid detoxification techniques include using a combination of an effective amount of...
140	6528514	IgE antibody production inhibitors and autoimmune diseases inhibitors The present invention relates to an IgE antibody production inhibitor and an autoimmune disease suppressant containing a heterocyclic amide compound represented by the following general formula (1)...
141	6514967	Compound for preparing medicines for treating pathologies involving extracellular glutamate, and methods for obtaining same The invention relates to compounds of the following general formula (I): in which: R 1 and R 2 represent a hydrogen atom, or form a ring, especially a benzene ring, R 3 represents a hydrogen...
142	6509368	Use of catechol derivatives as proteinase inhibitors Use of catechol derivatives of the general formula I wherein R 1 to R 5 are as defined according to claim 1 , as protease inhibitors.
143	6500846	CDK inhibitors having flavone structure The present invention relates to a novel flavone derivative, pharmaceutically acceptable salt, hydrate, solvate and isomer thereof which is useful as an inhibitor against Cyclin Dependent Kinase...
144	6500818	Naphthalenecarboxamides as tachykinin receptor antagonists Compounds having the following formula wherein L, M, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , X 1 and X 2 are as defined in the specification, pharmaceutically-acceptable salt thereof, useful for...
145	6500845	Lactam derivatives as immunomodulating agents The invention relates to the use of certain lactam derivatives corresponding to the formula I as pharmaceutical compounds with immunomodulatory activity, to new lactam derivatives, and to...
146	6498161	Pyrrolidine modulators of chemokine receptor activity The present invention is directed to pyrrolidine compounds of the formula I: (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are defined herein) which are useful as modulators of chemokine...
147	6498170	Cyclamine sulfonamides as β-3 adrenergic receptor agonists This invention provides compounds of Formula I having the structure wherein R 1 , R 2 , R 3 , W, X, and Z are as defined hereinbefore or a pharmaceutically acceptable salt thereof, which are...
148	6495568	Hydroxamic acid derivatives as matrix metalloprotease (MMP) inhibitors Compounds of formula (I): or pharmaceutically or veterinarily acceptable salts thereof, or pharmaceutically or veterinarily acceptable solvates of either entity, wherein the broken line...
149	6489340	Macrolide compounds for inducing chondrogenic differentiation Chondrogenic differentiations is induced by administering a macrocyclic lactone to mammals to prevent or treat damage to cartilage.
150	6479517	Phosphorous-containing benzothiophenes This invention relates to the fields of pharmaceutical and organic chemistry and provides novel phosphorous-containing benzothiophene compounds which are useful for the treatment of the various...

Matches 101 - 150 out of 628

< 1 2 3 4 5 6 7 8 9 10 11 12 13 >