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7122561 |
Treatment of skin conditions
The present invention provides piperine and analogues or derivatives thereof for the treatment of skin conditions treatable by stimulation of melanocyte proliferation, such as vitiligo, and also...
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7119105 |
Methods for treating neurodegenerative disorders using aspartyl protease inhibitors
The present invention relates to () non-peptide aspartyl protease inhibitors; (ii) methods for modulating the processing of an amyloid precursor protein (APP); (iii) methods for modulating the...
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7115610 |
Substituted heterocyclic compounds
Disclosed are novel substituted heterocyclic derivatives having the structure of Formula I:
The compounds are useful for the treatment of various disease states, in particular cardiovascular...
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7115632 |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
A sulfonyl aromatic or heteroaromatic ring hydroxamic acid compound that inter alia inhibits matrix metalloprotease activity is disclosed as are a treatment process that comprises administering a...
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RE39265 |
Heteroarylpiperidines, and their use as antipsychotics and analgetics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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7097848 |
Synergistic insecticidal mixtures
The invention relates to insecticidal mixtures comprising the compound of the formula (I)
and at least one further known active compound selected from the group consisting of abamectin,...
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7091219 |
Bis-sulfonamide hydroxyethyl-amino retroviral protease inhibitors
Bis-sulfonamido hydroxyethylamino compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to retroviral protease...
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7087610 |
Benzothiazole antiviral agents
The invention encompasses a series of benzothiazole compounds which inhibit HIV entry and are useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions...
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7084144 |
Sulfonyl group containing compounds and their use for the treatment of erectile dysfunction
A compound having the general formula (I):
wherein: X is N or C; R 0 is H, a lower alkyl group, a lower O-alkyl group,
lower alkyl group, a benzyl group, a phenyl group, a heterocyclic...
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7084140 |
Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds
The invention relates to new arylglycinamide derivatives of general formula I
and the pharmaceutically acceptable salts thereof, wherein R 1 and R 2 together with the N to which they are...
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7081466 |
2-aroylimidazole compounds for treating cancer
Disclosed is a compound represented by Structural Formula (I):
R 1 is a substituted or unsubstituted 2-imidazolyl group which is optionally fused to a substituted or unsubstituted aryl...
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RE39198 |
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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7071201 |
Quinoline derivatives
A novel compound of the formula:
wherein A, B, C, D, T, Y, and Z represent each methine or nitrogen; R 1, R 2 , R 3 , R 4 , and R 5 represent each a substituent; n represents 0 or an integer...
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7064136 |
Compounds
A compound having the general formula
and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
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7060725 |
Substituted sulfamate anticonvulsant derivatives
The present invention is directed to novel compounds of the formula (I)
wherein X, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as described in the specification, processes for the...
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7053086 |
4-heteroaryl-3-heteroarylidenyl-2-indolinones and their use as protein kinase inhibitors
The present invention relates to certain 4-heteroaryl-3-heteroarylidenyl-2-indolinones compounds and their physiologically acceptable salts which modulate the activity of protein kinases...
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7041673 |
Ultrashort acting hypnotic barbiturates
The subject invention concerns novel compounds that are useful as ultrashort acting hypnotic barbiturates. Specifically exemplified are derivatives of barbituric and thiobarbituric acids. They are...
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7041683 |
Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1, 4-benzodiozan
Compounds of the formula
useful for the treatment of depression and other conditions such as obsessive compulsive disorder, panic attacks, generalized anxiety disorder, sexual dysfunction,...
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7034036 |
Inhibitors of ABC drug transporters at the blood-brain barrier
The present invention relates to inhibitors of drug transporters of the ABC protein superfamily, particularly transporters present at the blood brain barrier. ABC transporter inhibitors identified...
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7019001 |
Substituted benzothiazole amide derivatives
A compound of formula I and a method of treatment of diseases, related to modulation of the adenosine A 2 receptor system comprising administering a compound of formula
to a person in need of...
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7008940 |
Dihydrobenzofuran derivatives, process for the preparing thereof and agents
A compound represented by the formula (I):
or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production,...
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7008957 |
Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments
The invention relates to compounds of the formula I
in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their...
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6987117 |
Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine
Compounds of the formula
useful for the treatment of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating...
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6984632 |
Complexes of paroxetine, with cyclodextrins or cyclodextrin derivatives
Complexes of paroxetine, as free base or salt, with a cyclodextrin or a cyclodextrin derivative having a molar ratio between paroxetine and cyclodextrin ranging from 1:0.25 to 1:20, suitable for...
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6982273 |
Compositions and methods containing bioavailable Se-methyl-L-selenocysteine for human and veterinary use
The invention discloses compositions containing Se-methyl-L-selenocysteine with enhanced bioavailability and superior antioxidant and immunomodulatory activity. These compositions can be used for...
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6958350 |
Chemical compounds
The invention provides a compound of formula (I): wherein R 1 , R 2 , R 3 , R 4 , R 5 , N, X and Y are as defined in the specification, processes, for their preparation, pharmaceutical compositions...
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6943178 |
Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
Compounds of the formula
useful for the treatment of diseases such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic...
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6927223 |
Use of serotonin agents for adjunct therapy in the treatment of cancer
The invention provides a method for the treatment of cancer comprising administering a serotonin agent. Also provided is a method for the treatment of cachexia comprising administering a serotonin...
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6916832 |
Chromeno[4,3,2-de]isoquinolines as potent dopamine receptor ligands
Novel dopamine receptor ligands of the formula:
pharmaceutical formulations of such compounds, and a method using such compounds for treating a patient suffering from dopamine-related...
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6916800 |
Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent
The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent.
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6906090 |
Compositions and methods for treating mycobacterial diseases
The invention provides the use of certain isatin and oxindole derivatives in the preparation of a medicament for use in the treatment of mycobacterial disease.
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6906098 |
Mixed steroidal 1,2,4,5-tetraoxane compounds and methods of making and using thereof
Disclosed herein are mixed steroidal tetraoxanes having the following structural formula 1
wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or...
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6903116 |
Methods of treating cancer using a heat shock factor activity inhibitor
A disease treatment is provided by controlling the expression of a protein induced by a heat shock factor. The novel compound benzo-1,3-dioxole provides an inhibitor of HSF activity or an...
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6900227 |
Benzodioxole derivatives
The present invention relates to compounds of the general formula
and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases such...
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6900222 |
Pyrrolidinyl, piperdinyl or homopiperidinyl substituted (benzodioxan, benzofuran or benzopyran) derivatives
The present invention concerns compounds of formula (I)
a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein...
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6897211 |
Thienodibenzoazulene compounds as tumor necrosis factor inhibitors
The present invention relates to the dibenzoazulene compounds represented by formula I as well as to their pharmaceutical preparations for the inhibition of tumor necrosis factor alpha (TNF-α) and...
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6890928 |
Aromatic sulfone hydroxamic acids and their use as protease inhibitors
This invention is directed to aromatic sulfone hydroxamic acids (including hydroxamates) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix...
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6887869 |
Mikanolide derivatives, their preparation and therapeutic uses
The invention concerns novel mikanolide derivatives, their preparation method and their therapeutic uses, in particular as anti-cancer and anti-viral agents. The compounds correspond to general...
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6867230 |
Hygromycin A derivatives
This invention relates to compounds of the formula
and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R 1 , R 2 , R 3 and R 10 are as defined herein. The...
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6861439 |
Treatment of cerebrovascular disease
A method of treating a cerebrovascular disease, particularly stroke, is described. A method of treating a cerebrovascular disease includes administering pyridoxal-5′-phosphate, pyridoxal,...
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6858598 |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan,...
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6852737 |
Crude and crystalline forms of lercanidipine hydrochloride
The invention describes novel lercanidipine crude Forms (A) and (B), novel lercanidipine hydrochloride crystalline Forms (I) and (II) obtained from said crude Forms, pharmaceutical,...
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6849645 |
Method of increased bioavailability of nutrients and pharmaceutical preparations with tetrahydropiperine and its analogues and derivatives
Tetrahydropiperine and analogs and derivatives thereof, including dihydropiperine, are disclosed to enhance the absorption and/or bioavailablity of nutrients, drugs and other organic compounds,...
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6844344 |
Benzofuran derivatives
The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of...
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6821977 |
Antidiabetic agents
A compound of the formula whereon R 1 is: R 5 is: and n, m, Z, R 8 , R 9 , R 10 and R 11 are as defined herein, useful in the treatment of diabetes, insulin resistance, diabetic...
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6815440 |
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids
Cyclic and heterocyclic N-substituted α-iminohydroxamic and -carboxylic acids Compounds of the formula I are suitable for preparing pharmaceuticals for the treatment of disorders in the course...
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6800628 |
N-substituted 4-((-4′-aminobenzoyl)-oxymethyl)-piperidines having gastric prokinetic properties
This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R 1 is C 1-6...
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6800642 |
Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta&lsqb a&rsqb naphthalene
Compounds of the formula: useful for treatment of disorders such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias,...
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6787559 |
Sulfonamide compounds
This invention relates to certain sulfonamide derivatives that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use and methods for...
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6787560 |
Serotonin reuptake inhibitor
A serotonin reuptake inhibitor containing a cyclic amine represented by the following formula, a prodrug thereof, or a pharmaceutically acceptable salt of said cyclic amine or prodrug as an active...
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