Matches 301 - 350 out of 529 < 1 2 3 4 5 6 7 8 9 10 11 >
Match Document Document Title
5389646 Methods for treatment and prevention of bone loss using 2,3-benzopyrans  
Methods and pharmaceutical compositions for reducing bone loss are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment...
5387596 Benzylidenethiazolidine derivatives and their use for the inhibition lipid peroxides  
Benzylidenethiazolidine compounds of formula (I): ##STR1## [in which R 1 , R 2 and R 5 are each hydrogen or alkyl; R 3 and R 4 are each hydrogen, alkyl, formyl, alkylcarbonyl, arylcarbonyl,...
5376681 Aminocoumaran derivatives, their production and use  
A novel aminocoumaran derivatives of the general formula (I): ##STR1## wherein R 1 and R 2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R 3 ...
5373009 Dibenzofuranyl esters of N-heterocyclic carboxylic acids  
A compound of the formula: ##STR1## wherein R 1 and R 2 are, independently, halo, trifluoromethyl, cyano, nitro, alkyl, alkoxy, --CO 2 H, alkylcarbonyl, alkylcarbonyloxy, alkoxycarbonyl, mono-...
5371094 Azaheterocyclylmethyl-chromans for treating axiety  
Azaheterocyclylmethyl-chromans are prepared by reaction of corresponding methylchromans with corresponding azaheterocyclic compounds, optionally with subsequent variation of the substituents. The...
5369105 7-((substituted)amino-8-((substitute d)carbonyl)-methylamino-1-oxaspiro(4,5)decanes useful in Parkinson's disease, dystonia, and other movement disorders  
Methods for using substituted phenoxy-, 1-, and 2-naphthalenyloxy-, indenyl-, indolyl-, benzo[b]furanyl-, and benzo[b]thienylcarboxamides of 7,8-(substituted-diamino)-1-oxaspiro[4.5]decanes as...
5356905 Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs  
3-Piperidino-1-chromanol derivatives and analogs having the formula ##STR1## wherein A and B are taken together and are --CH 2 CH 2 -- or A and B are taken separately and are each H; X is CH 2...
5350762 Tetrahydrocyclopent[B]indole methanamines and related compounds  
There are disclosed various compounds of the formula below, ##STR1## where the various parameters R 1 , R 2 , R 3 , R 4 , X, m and n are as defined in the specification, which show activities as a...
5344835 Piperidine and pyrrolidine derivatives  
According to the invention there is provided a compound of formula (I): R 1 --O(CH 2 ) m A(CH 2 ) n XR or a pharmaceutically acceptable salt thereof, wherein R 1 is a group of formula (a or b)...
5328914 Use of pyrimidine 3-oxide derivatives for slowing down hair loss and topical compositions used  
Pyrimidine 3-oxide derivatives and their use for the treatment of hair loss. The compositions contain in a physiologically acceptable medium at least one compound corresponding to the formula (I):...
5326771 Piperidylmethyl-substituted chroman derivatives  
Piperidylmethyl-substituted chroman derivatives can be prepared by first reducing corresponding chromancarboxylic acid derivatives, if appropriate with prior activation, with the cyclic amines and...
5322848 N-acyl-substituted azacyclic compounds, processes for their preparation, and their use as pharmaceuticals  
A compound, or solvate or salt thereof, of formula ##STR1## R 1 is hydrogen, halogen, or C 1 -6 alkyl; R 2 and R 3 are hydrogen or C 1 -6 alkyl; R 5 together with R 4 forms a --(CH) 2 ) 2 ...
5314895 Benzopyran class III antiarrhythmic agents  
The present invention relates to compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof; wherein n is 0, 1 or 2; wherein R is H or lower alkyl of 1 to 6 carbon atoms; ...
5310753 Ethanol adducts of 6-sulfonyl-substituted 3-hydroxy-chromans and their use as inhalants in diseases  
The invention relates to ethanol adducts of the compounds of the formula I ##STR1## to a process for their preparation and to their use as inhalants in diseases, in particular in asthma.
5304559 Compositions containing a 4-quinolone derivative complexed with a divalent metal ion  
The present invention concerns a fluid pharmaceutical composition intended to be brought into contact with a physiological fluid, characterized in that it contains, as active principle, at least...
5300516 Muscarinic receptor antagonists  
Musacarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of formula (I), or a pharmaceutically acceptable salt thereof, where m is 1 or 2; R 1 and R 2 ...
5292751 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-(1-propyl))pip eridinyl)-4H-1-benzopyran-4-one, its preparation and its use  
The present invention relates to 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl))piperidi nyl]-4H-1-benz opyran-4-one its preparation and its use....
5288731 2,6-methano-2H-1-benzoxocincarboxylic acids, esters and amides  
Novel compounds which are 2,6-methano-2H-1-benzoxocincarboxamides having 5-HT 3 -antagonist properties including unique CNS, antiemetic and gastric prokinetic activities and which are void of any...
5286735 Derivatives of 4-aminomethylpiperidine, their preparation and their use as therapeutics  
The application discloses pharmacologically-active derivatives of 4-aminomethyl piperidine having the general formula 1 ##STR1## wherein the symbols have the meanings set forth in the...
5284868 Pharmaceutical compounds  
A pharmaceutical compound of the formula ##STR1## in which n is 0, 1 or 2 and R 1 is attached at any of the positions 5, 6, 7, 8, 9 or 10, and each R 1 is halo, trifluoromethyl, C 1 -4 alkoxy,...
5284856 Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives  
Compounds of the formula I ##STR1## in which the substituents R 1 -R 5 and n and m are as defined are suitable for controlling tumors.
5280024 Medicinal use of 3',5'-di-tert.-butyl-4'-hydroxy flavones  
Compounds of the general formula (I): ##STR1## in which R represents: a hydrogen atom, or a radical --OR' in which R' is as defined in the description.
5278174 Sigma binding site agents  
Sigma binding site agents having the formula ##STR1## which are useful to inhibit sigma binding site-induced activity, pharmaceutical compositions including these agents, and methods of using these...
5273983 Cyclohexylbenzamide derivatives, their preparations and their use as gastrointestinal stimulants  
Novel N-cyclohexylbenzamide derivatives of formula: ##STR1## where R 1 represents an alkoxy radical capable of cyclizing with the aromatic ring; R 2 , R 3 and R 4 each independently represent...
5262418 N-(4-piperidinyl) (dihydroxybenzofuran or dihydro-2H-benzopyran)carboxamide derivatives  
Piperidine derivatives of formula ##STR1## wherein A is a radical of formula --CH 2 --CH 2 -- (a-1), --CH 2 --CH 2 --CH 2 -- (a-2),...
5254568 Benzopyrans as antiestrogenic agents  
The present invention provides compounds of formula ##STR1## wherein R 1 and R 2 , which may be the same or different, are each --H, --OH, alkoxy of 1 to 17 carbon atoms or alkoxycarbonyl of 2 to...
5252598 Labdane derivatives, a process for their preparation, and their use as medicaments  
The present invention relates to labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a...
5250542 Peripherally selective piperidine carboxylate opioid antagonists  
3,4,4-trisubstitutedpiperidinyl-N-alkylcarboxylates and intermediates for their preparation are provided. These piperidine-N-alkylcarboxylates are useful as peripheral opioid antagonists.
5248686 Substituted cyclic amines and pharmaceutical composition containing them  
The invention relates to substituted arylamines and heteroarylamines, their preparation process and the pharmaceutical composition containing them. Said substituted amine is in accordance with the...
5238954 Fluorinated flavone acetic acid  
A fluorinated flavone acetic acid suitable for use as an antitumor agent. Pharmaceutical compositions comprising the fluorinated flavone acetic acid and a pharmaceutically acceptable carrier. An...
5232921 Thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions  
The invention relates to thiazole derivatives corresponding to the general formula: ##STR1## in which: R 1 and R 2 each independently represent hydrogen; a C 1 -C 4 alkyl group; a phenyl group...
5232931 Oxazolidinones  
Novel oxazolidinones of the formula I ##STR1## in which R 1 , R 2 , R 3 , R 4 , Z and n have the meanings defined herein, and their salts have effects on the central nervous system, in particular...
5214055 Aminopiperidine 4-oxo-4H-chromen-2-yl compounds  
The invention relates to new compounds of formula I: ##STR1## in which: m represents zero, 1, 2, 3 or 4, n and p represent zero, 1 or 2, W represents an oxygen atom, an --NH-- radical, or a...
5210090 Substituted N-benzylpiperidine amides and cardiac regulatory compositions thereof  
The invention relates to compound of the formula ##STR1## useful in regulating cardiac arrhythmias. This invention also relates to pharmaceutical compositions of the above-described compounds.
5208222 4"-and 4'-alkylthio avermectin derivatives  
Avermectin derivatives are disclosed wherein the 4"-hydroxy group is replaced by a substituted alkylthio or acylthio group or an iodo group. These avermectin derivatives can be further derivatized...
5206241 Labdanes and process for their preparation  
Labdanes of the formula ##STR1## a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical...
5194440 Substituted cyclic sulphamide derivatives  
A class of substituted cyclic sulphamide derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in particular migraine and...
5185335 N-(4-piperodinyl)(dihydrobenzofuran or dihydro-2H-benzopyran) carboxamide derivatives  
Piperidine derivatives of formula ##STR1## wherein A is a radical of formula ##STR2## wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C 1 -6 alkyl radical; ...
5177072 Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives  
Heterocyclic aminoalkyl esters of mycophenolic acid, and the derivatives and pharmaceutically acceptable salts thereof, are useful as immunosuppressive agents, anti-inflammatory agents, anti-tumor...
5169856 Piperidinoalkyl derivatives of carboxylic acid amides  
The present invention relates to unsaturated carboxylic acid amide derivatives of the formula ##STR1## wherein ring A stands for an optionally substituted aromatic ring; R 1 stands for a hydrogen...
5157049 Method of treating cancers sensitive to treatment with water soluble derivatives of taxol  
The invention involves the treatment of cancer in humans by administering water soluble derivatives of taxol. The types of cancer so treatable are those sensitive to treatment with taxol.
5151437 Benzofurancarboxamides having basic substituents and therapeutic agents containing the same  
A benzofurancarboxamide of the formula: ##STR1## where: X is hydrogen or methoxy, R 1 is a radical of the formula: ##STR2## wherein R 3 to R 5 are each, independently of one another, hydrogen...
5145855 6- and 7-deoxyforskolin and derivatives thereof  
Novel forskolin derivatives, intermediates and processes for the preparation thereof, and methods for treating cardiac failure and memory deficit utilizing compounds or compositions thereof are...
5140027 Aminoalkylthiodibenzoxepins and pharmaceutical use  
Novel aminoalkylthiodibenzoxepins, physiologically tolerable acid addition salts thereof, a method of preparing same, pharmaceutical and veterinary preparations including same and methods of...
5128348 Bicyclo(3.1.0)hexane amines and bicyclo(4.1.0)-heptane amines as agricultural fungicides  
Certain hexane and heptane amines including geometric and stereoisomers, agricultural compositions containing them and their use as fungicides.
5126356 Piperidine compounds  
The compounds disclosed are 1-R'-4-RS-piperidines in which R' and R, which are different, may each represent: (1) (alkoxybenzyl)-alkyl or -alkenyl, or (2) (optionally-substituted chromanyl-,...
5116863 Dibenz[b,e]oxepin derivative and pharmaceutical compositions thereof  
Novel dibenz[b,e]oxepin derivatives are employed in the treatment and control of allergic conditions such as allergic asthma and also employed in the treatment of inflammation.
5114949 Heterocyclic derivatives, their preparation and medicinal products containing them  
Compounds are disclosed of formula: R 1 --(CH 2 ) n --Het in which R 1 represents a residue of formula ##STR1## X represents a hydrogen atom or an alkyl radical, Y represents a hydrogen atom...
5100911 Thienyloxyalkylamine derivatives, process for their preparation and medicaments containing them  
Thienyloxyalkylamine derivatives of the general formula: ##STR1## wherein --O--CH 2 --CH 2 --NR 2 R 3 is in position 4 or 5 of the thiophene ring; R 1 is hydrogen, halogen, CF 3 , alkyl or...
5098931 7-substituted HMG-CoA reductase inhibitors  
Novel HMG-CoA reductase inhibitors are useful as antihypercholesterolemic agents and are represented by structural formulae (I) and (II): ##STR1##
Matches 301 - 350 out of 529 < 1 2 3 4 5 6 7 8 9 10 11 >