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5612370 |
Phenylglycine and phenylalaninen amido benzopyran derivatives
Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein a, b and d are all carbon atoms or one of a, b and d is a nitrogen atom or --N(O)-- and the others are...
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5610157 |
N-(3-hydroxy-4-piperidinyl) (dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzo-dioxin) carboxamide derivatives
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal...
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5607950 |
Muscarinic receptor antagonists
The invetion is a method of treating irritable bowel syndrome with a compound selected from the formula ##STR1## wherein R, R 1 , m, n p are as defined in the specification, or a pharmaceutically...
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5605912 |
Certain piperdino-2,4-dienamide pesticides
A compound of the formula: ##STR1## where Q is phenyl or naphthyl optionally substituted by (a) C 1 -6 hydrocarbyl, C 1 -6 alkoxy or methylenedioxy, which in turn is optionally substituted by one...
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5604247 |
Chromone Derivatives
Compounds of formula I ##STR1## wherein rings A and B are as defined in the specification, have valuable pharmacological properties and are particularly effective as NK1 antagonists and substance P...
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5602163 |
Imidazole, triazole and tetrazole derivatives
A class of substituted imidazole, triazole and tetrazole derivatives are selective agonists of 5-HT 1 -like receptors and are therefore useful in the treatment of clinical conditions, in...
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5596004 |
Methods of inhibiting male infertility
A method of inhibiting male infertility comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R 1 and R 3 are independently...
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5594016 |
Naphthalene derivatives
Naphthalene derivatives represented by the formula (I): ##STR1## wherein the symbol ##STR2## --X-- represents --O-- or --S--, Y-- represents N-- or CR 5 --, R 1 , C 2 , R 3 , R 4 and R 5...
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5583143 |
Methods for inhibiting calmodulin activity
Methods and pharmaceutical compositions for use in inhibiting calmodulin activity in a patient are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated...
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5580883 |
Aminobenzene compounds to prevent nerve cell degradation
A compound useful for central antioxidant having inhibitory activity of degeneration and necrocytosis of cerebral cells of the formula (I): ##STR1## wherein A and B are independently (1) a group of...
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5576313 |
Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
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5554611 |
Use of coumarin derivatives
The present invention consequently relates to the use of coumarins of the general formula I ##STR1## in which R 1 and R 6 are defined as indicated in the claims, for controlling and preventing...
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5554600 |
Methods for inhibiting endometriosis
The present invention provides a method for inhibiting endometriosis comprising administering to a woman in need of treatment an effective amount of a compound of formula I ##STR1## wherein R is...
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5552413 |
Methods for inhibiting hyperproliferation of kerntinocytes
Methods and pharmaceutical compositions for the treatment of dermatitis are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated into medicaments,...
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5550129 |
Benzopyranones, processes for their preparation and their use
Described are 2H-1-benzopyran-2-ones (coumarin derivates) of general formula (I), ##STR1## wherein R 1 is a hydroxyl group, a lower-alkoxy group, a cycloalkoxy group with 4 to 6 C-atoms or the...
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5550136 |
Methanoanthrancenyl piperidyl antipsychotics
Compounds of formula I ##STR1## wherein X and Y are H or halo; R 2 is: [structures Ia, Ib or Ic;] ##STR2## R 3 is selected from unsubstituted or substituted alkyl, aryl or heteroaryl groups; R...
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5543422 |
Heterocyclic amines
Heterocyclic amines of the formula Ar-X-A-NR 1 R 2 wherein Ar is a bicyclic or tricyclic aromatic group which is unsubstituted or which bears one or more substituents selected from halo, nitro...
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5532254 |
Modulation of calcium channels using benzothiophenes
A method for modulating calcium channels, increasing the density of calcium channels in vascular and cardiac tissue with no changes in inotropic or pressor response, comprising administering to a...
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5527804 |
4-carbamoyloxy-piperidine-1-carboxylic acid esters: inhibitors or cholesterol absorption
Compounds which inhibit the enzyme cholesterol ester hydrolase (CEH) thus inhibit the formation of esterified cholesterol. Esterified cholesterol is absorbed through the intestine and inhibition of...
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5525602 |
Method of using 4-amino 6-substituted mycophenolic acid and derivatives
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other...
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5523309 |
Benzofuran pharmaceutical compounds
The present invention provides a compound of formula I ##STR1## wherein R 1 is H, OH, halo, OCO(C 1 -C 6 alkyl), OCO(aryl), OSO 2 (C 4 -C 6 alkyl), OCOO(C 1 -C 6 alkyl), OCOO(aryl), OCONH(C...
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5519023 |
New aminoalkylchromones, processes for the preparation thereof
The invention relates to compounds of the general formula (I): ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and Z are as defined in the description, their optical isomers and their addition...
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5512568 |
Method of using 4-amino derivatives of 5-substituted mycophenolic acid
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other...
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5512560 |
Conformationally restricted HIV-1 protease inhibitors
HIV protease inhibitors containing hydroxypyrrolidine or hydroxypiperidine with one or more basic amines are disclosed.
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5500425 |
Chroman derivatives and a method of treating 5-HT mediated disorders
Compounds of the formula I ##STR1## processes for their preparation, pharmaceutical preparations, use of and method of treatment of disorders in CNS by using compounds of formula I.
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5496853 |
Benzoxa condensed ring compounds, process for producing the same and pharmaceutical composition comprising the same
Pharmaceutical compositions containing a benzoxazole compound and a 2,3-dihydrobenzofuran compound represented by the following formula (I) and its pharmaceutically acceptable salt: ##STR1## In the...
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5492918 |
Use of substituted chromans, some of which are known, as medicaments, new active compounds and processes for their preparation
The present invention relates to the use of substituted chromans of the general formula (I) ##STR1## in which the substituents have the meaning indicated in the description, for the production of...
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5492922 |
Benzothiophene compounds intermediate compositions and methods for inhibiting aortal smooth muscle proliferation
The present invention provides pharmaceutically active compounds of formula I ##STR1## wherein R 1 is --H, --OH, --O(C 1 -C 4 alkyl), --OCOC 6 H 5 , --OCO(C 1 -C 6 alkyl), or --OSO 2 (C 2 ...
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5489587 |
Benzofurans used to inhibit bone loss
The present invention provides methods for inhibiting bone loss comprising administering to a mammal in need of treatment of a bone loss inhibiting amount of a compound of formula I ##STR1##...
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5486527 |
Anticholinergic agents
Selective muscarinic receptor antagonists of formula (I): ##STR1## wherein R 1 and R 2 are both optionally substituted phenyl, the broken line is an optional bond, X is >COH--, >SiOH-- or...
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5482958 |
Method for treating endometriosis
The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid...
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5478844 |
Method of using aminocoumaran derivatives for treating cerebrovascular diseases
A novel aminocoumaran derivatives of the general formula (I): ##STR1## wherein R 1 and R 2 are a hydrogen atom, an acyl group, an alkoxycarbonyl group, an aliphatic group or aromatic group; R 3 ,...
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5472977 |
Method for the treatment of uterine fibroid desease
The present invention provides novel methods of lowering serum cholesterol and inhibiting smoother muscle cell proliferation, particularly restenosis, in humans, and inhibiting uterine fibroid...
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5470872 |
Benzopyranols
Novel Compounds A compound of formula (I): ##STR1## where the substituents are defined later in the specification. The compounds are useful as muscle relaxants and as such have a number of...
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5459139 |
2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
The synthesis and the biological evaluation of a series of basic ethers of 2-benzyl-3-arylbenzofurans as antitumor agents is described. These compounds bind significantly to the...
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5459161 |
Process for the preparation of substituted benzofuran derivatives
Substituted benzofuran derivatives of the formula (I): ##STR1## wherein one of R 1 and R 2 is hydrogen or halogen and the other is, independently, an amino group or a C 2 -C 4 alkanoyl amino...
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5457103 |
3',5'-di-tert.-butyl-4'-hydroxy flavones
Compounds of the general formula (I): ##STR1## in which R represents: a hydrogen atom, or a radical --OR' in which R' is as defined in the description.
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5446071 |
Methods for lowering serum cholesterol
The present invention provides methods for lowering serum cholesterol comprising administering to a mammal in need of treatment a serum cholesterol lowering amount of a compound of formula I or...
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5441953 |
4- amino derivatives of mycophenolic acid
The disclosed derivatives of mycophenolic acid are therapeutic agents advantageous in the treatment of disease states indicated for mycophenolic acid and/or mycophenolate mofetil and other...
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5438056 |
Heterocyclic oxime carbamates
The compounds of the present invention have the following formula: ##STR1## wherein R 1 and R 2 are independently phenyl, pyridyl, thienyl, naphthyl, substituted phenyl wherein the substituent is...
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5436255 |
Method of treating diseases susceptable to treatment by blocking NMDA-receptors
3-Piperidino-1-chromanol derivatives and analogs having the formula ##STR1## wherein A and B are taken together and are --CH 2 CH 2 -- or A and B are taken separately and are each H; X is CH 2...
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5428043 |
Tricyclic-cyclic amines as novel cholinesterase inhibitors
Compounds of the formula ##STR1## wherein ring A, ring B, ring D, R 2 , R 3 , R 4 , R 5 , R 6 ,R 11 , R 12 , R 13 , E, G, X and P are as defined below. The compounds of formula I are cholinesterase...
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5428038 |
Benzopyranones, a method for producing them and uses therefor
Novel 2H-1-benzopyran-2-ones (coumarin derivatives) of the general formula (I) are provided: ##STR1## wherein R 1 , R 2 , R 3 , R 4 , X and Y are defined as in the specification, and the addition...
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5420143 |
Piperidine derivatives for treating allergy
A piperadine derivative of formula (1): ##STR1## a salt thereof and a drug containing the derivative as an effective component. This compound has excellent antihistamine activity and...
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5416097 |
Potassium channel activators/openers
This invention relates to novel potassium channel activators and their acid addition salts. The compounds of the invention as potassium channel activators/openers have therapeutic value in a number...
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5416098 |
Method for treating dermatitis and related conditions
Methods and pharmaceutical compositions for the treatment of dermatitis are disclosed. 2,3-diaryl-1-benzopyrans and their pharmaceutically acceptable salts are formulated into medicaments,...
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5407947 |
Methods for inhibiting bone loss using pyrolidine and piperidine substituted benzopyrans
A method of inhibiting bone loss comprising administering to an animal an effective amount of a compound having the formula ##STR1## wherein: R 1 and R 2 are, independently, --H, --OH, halo, --OC...
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5395842 |
Anti-estrogenic compounds and compositions
Inhibitors of sex steroid activity, for example those having the general structure ##STR1## may be used as part of a pharmaceutical composition to provide antiestrogenic effects and/or to suppress...
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5393759 |
Isochromane derivatives
The invention concerns an isochromane derivative having the general formula I ##STR1## in which R 1 is one to four substituents independently selected from hydrogen, hydroxy, alkyl (1-4 C), alkoxy...
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5391569 |
New chromene compounds having a triene side chain
A compound selected from those of formula (I): ##STR1## in which the groups R 1 to R 8 are as defined the description. Medicaments.
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