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7622449 |
Anti-hypercholesterolemic compounds
This invention provides cholesterol absorption inhibitors of Formula I:
and the pharmaceutically acceptable salts and esters thereof. The compounds are useful for lowering plasma cholesterol...
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7482439 |
Caprazene as novel compound and derivatives thereof, and caprazol as novel compound and derivatives thereof
Caprazene and caprazol could be synthesized by hydrolysis of a caprazamycin. There could be synthesized a caprazene-1′″-amide derivative of the formula (II)
and a caprazene-1′″-ester...
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7323452 |
Method for the accelerated in vivo removal of ethanol
A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as...
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7157078 |
Devices and methods for eliminating termite colonies
This invention relates to devices, kits, and methods for eliminating termite colonies. The kits, devices, and methods employ a termiticidal bait matrix containing
a) a termiticide selected...
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7153877 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7119110 |
Method and composition for preventing or reducing the symptoms of insulin resistance syndrome
A method for preventing and or reducing the symptoms of insulin resistance and a related syndrome in persons comprises identifying persons having or at risk for having such symptoms, and...
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7094431 |
Method of healing skin wounds in mammals and a composition therefor
This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or...
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7067494 |
Antimitotic eleuthesides
This invention provides analogs of eleutherobin and the eleuthesides modified at the C-11 position or comprising an epoxide functionality from C-11 to C-12. C-11 to C-12 is an ideal location for...
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6939859 |
Skin preparations for external use
An dermatological agent for external use is disclosed which contains a chromanol glycoside represented by the following general formula (1)
(wherein R 1 , R 2 , R 3 , and R 4 which may be the...
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6916849 |
Compositions for improving lipid content in the blood
The present invention relates to compositions for lowering the total amount of cholesterol in the blood and methods of using the compositions. The compositions are a mixture of pravastatin and one...
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6913772 |
Composition useful as hepatoprotectants comprising extract of plant Cryptolepis buchanani and a method thereof
The present invention relates to a composition useful for hepatoprotection, said composition comprising polar extract of plant Cryptolepis Buchanani and/or fractions of the said extract, and...
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6887854 |
Compounds as dynamic organ function monitoring agents
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function...
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6852484 |
Methods for the identification of inhibitors of asparagine synthase as antibiotics
The present inventors have discovered that Asparagine Synthase is essential for fungal pathogenicity. Specifically, the inhibition of Asparagine Synthase gene expression in fungi results in no...
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6849607 |
Galectin recognized photosensitizers for photodynamic therapy
Purpurin-carbohydrate conjugates and their method of preparation and use for treatment of cancer cells. The conjugates have the general formula:
wherein R 6 and R 7 taken together are ═NR...
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6833362 |
Method and composition for the accelerated in vivo removal of ethanol
A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or...
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6608103 |
Inhibitor for neovasculation, cell multiplication, lumen formation and FGF
This invention relates to an inhibitor having inhibitory activity against neovasculation, cell multiplication, lumen formation and fibroblast growth factor which comprises β-, γ- or δ-tocotrienol.
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6538027 |
Compositions comprising ratite oil or active fractions thereof and methods of using these composition as insect repellents
This invention provides compositions for repelling insects, particularly biting insects, such as mosquitoes, ticks, and biting flies comprising ratite oil, active fractions of ratite oil obtained...
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6518250 |
Agent for preventing and curing hindrance of ischemic reperfusion
An agent for preventing and curing the hindrance of ischemic reperfusiton is disclosed which has as an active component thereof a chromanol glycoside represented by the following general formula: ...
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6506734 |
20(S) camptothecin glycoconjugates
The present invention relates to glycoconjugates of 20(S)-camptothecin, in which a 3-O-methylated β-L-fucose unit is linked to the 20-hydroxyl group of a camptothecin derivative via a...
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6492335 |
Glycoconjugates from modified camptothecin derivatives (20-O-linkage)
The present invention relates to glycoconjugates of camptothecin derivatives in which at least one carbohydrate component is linked via suitable spacers with the 20-hydroxyl group of a camptothecin...
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6486129 |
Antithrombotic compounds
The present invention relates to compounds of formula (1), wherein R 1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso)quinolinyl, tetrahydro(iso)quinolinyl, 3,4-dihydro-1H-isoquinolinyl,...
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6239114 |
Compositions and methods for treatment of neoplastic diseases with combinations of limonoids, flavonoids and tocotrienols
Compositions and methods for the prevention and treatment of neoplastic diseases are described. Individuals at a high risk of developing or having neoplasia undergoing conventional therapies may be...
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6221357 |
Flavonoids derived from citrus peels as collagen-induced platelet aggregation inhibitor
A method for inhibiting a collagen-induced platelet aggregation in a mammal comprises administering an effective amount of a flavonoid derived from citrus peels thereto.
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6107276 |
Pharmaceutical compositions including a drug, a cross-linked polymeric substance, an oil, and a surface active agent
The pharmaceutical compositions including a slightly soluble drug incorporated in a water-swellable, but water-insoluble cross-linked polymer, a surface active agent, and an oil show much improved...
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6022866 |
Use of hyaluronic acid and forms to prevent arterial restenosis
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5977077 |
Xanthone analogs for the treatment of infectious diseases
Therapeutic compositions for the treatment of infectious diseases are disclosed. These compositions comprise xanthones and xanthone derivatives, such as 2,3,4,5,6-pentahydroxyxanthone. Also...
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5972993 |
Composition and method for treating rosacea and sensitive skin with free radical scavengers
A method for treating skin conditions, such as rosacea and sensitive skin, that manifest as a tendency towards flushing and blushing is provided. Also provided herein, are compositions for the...
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5965571 |
Cholinesterase inhibitors for treatment of Parkinson's disease
Parkinson's disease can be treated with an at least one cholinesterase inhibitor. The cholinesterase inhibitor has been found to alleviate both any symptoms of dementia as well as to reduce...
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5945406 |
Therapeutic compounds with pyrimidine base
Compounds of formula (I): ##STR1## wherein: R is halogen; Y is hydrogen, NH 2 , SH or OH; X is: ##STR2## wherein: either R 1 or R 2 is a bond, with the other being hydrogen; either R 3 ...
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5929113 |
Compositions comprising EMU oil or active fractions thereof and methods of using these compositions as insect repellents
This invention provides a method for repelling biting insects such as mosquitoes, ticks, and biting flies by topically applying to the skin of a subject emu oil, fractions of emu oil obtained by...
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5843937 |
DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
The present invention relates to novel DNA alkylating agents and the prodrugs of these agents which are useful as antitumor agents and DNA labelling agents. The compounds are hydroxy...
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5776925 |
Methods for cancer chemosensitization
Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be...
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5750563 |
Preparation for epidermis
A preparation for epidermis containing kojic acid and/or its derivative, which has improved preparation stability, is provided. The preparation stability is imparted by adding to the preparation at...
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5677285 |
Derivatives of neuraminic acid
Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including...
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5635486 |
Ophthalmic composition comprising a sleep adjusting substance
The present invention provides an ophthalmic composition comprising a sleep inducing substance or a sleep inhibiting substance, and the sleep inducing substance or the sleep inhibiting substance is...
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5583115 |
Dialkyltiacumicin compounds
Antimicrobial compounds having the formula ##STR1## as well as pharmaceutical compositions comprising such compounds and methods of treating bacterial infection and colitis by the administration...
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5525480 |
N- and O-substituted aminophenols, method and use for diagnosis
The present invention provides N- and O-substituted aminophenol derivatives of the general formula ##STR1## wherein R 1 , R 2 , R 3 , G and L are as hereinbefore defined. The present invention also...
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5512560 |
Conformationally restricted HIV-1 protease inhibitors
HIV protease inhibitors containing hydroxypyrrolidine or hydroxypiperidine with one or more basic amines are disclosed.
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5466450 |
Antiviral antibiotic BU-4224V
A novel antibiotic complex designated BU-4224V produced by fermentation of Kibdelosporangium albatum sp. nov. Strain R761-7. The complex may be separated chromatographically into bioactive...
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5367062 |
Disubstituted and deoxydisubstituted derivatives of α-d-lyxofuranosides having anti-inflammatory and anti-proliferative activity
Derivatives of disubstituted and deoxydisubstituted α-D-lyxofuranosides and intermediates for preparing these derivatives are described. These compounds exhibit significant antiinflammatory and...
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5360794 |
Disubstituted and deoxy disubstituted derivatives of α-D-mannofuranosides and β-L-gulofuranosides having anti-inflammatory and anti-proliferative activity
The compounds of the present invention are deoxy disubstituted or dideoxy disubstituted derivatives of α-D-mannofuranoside and β-L-gulofuranoside hexoses which exhibit anti-inflammatory and...
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5210077 |
Antibodies to cytokinins having a glycosylated isoprenoid side chain and immunoassay methods
Antibodies (polyclonal and monoclonal) having specificity for cytokinins having a glycosylated isoprenoid side chain are described. The antibodies simultaneously recognize a purine ring, an...
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5120718 |
Candida acid protease inhibiting compounds
Compounds which inhibit Candida acid protease are disclosed which have the formula: ##STR1## wherein R 1 is loweralkyl, loweralkenyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl,...
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5041425 |
Antitumor agent
A specified citrus limonoid such as limonin and nomilin is isolated from the citrus and is found to be useful to treat a tumor. It is useful as an additive to food.
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5023090 |
Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE
A topical composition comprising LYCD together with known topically active useful medicinal agents such as anti-wrinkling, antibiotic, anticancer, antifungal, antiinflammatory such as anti-acne,...
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5011827 |
Elaiophyline derivatives, compositions containing them and the use thereof as anthelmintic agents
The invention relates to elaiophyline derivatives of the formula I ##STR1## in which R 1 and R 1 ' are identical or different and represent a radical of the formula II/or III ##STR2## in which R 2...
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4927810 |
Efomycin G and it's use as yield promoter in animals
An animal growth promoter, efomycin G, is obtained by culturing Streptomycetes strain BS 1261. Efomycin G has the following properties: (a) The empirical formula: C 53 H 86 O 18 (b) The...
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4814347 |
Anthelmintic spiroketals and method of use
This invention pertains to a new method for killing and controlling worms (Helminths), new formulations for killing and controlling worms in animals, new chemical compounds, and a new synthesis of...
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4749694 |
Novel lysine esters used as absorption
Novel lysine esters used as absorption enhancing agents for gastrointestinally and rectally administered drugs. Also provided are processes for preparation of said lysine ester compounds as well as...
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4639436 |
Antidiabetic 3,4,5-trihydroxypiperidines
The invention includes certain 3,4,5-trihydroxypiperidine compounds, methods for their preparation, compositions containing said 3,4,5-trihydroxypiperidine compounds and methods for the use of said...
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