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7615557 |
Tetrahydro-naphthalene and urea derivatives
This invention relates to a hydroxy-tetrahydro-naphthalene or an urea derivative formula (I) and salts thereof which are useful as active ingredients of pharmaceutical preparations, wherein A...
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7612096 |
Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of an immunomodulatory compound, or a pharmaceutically...
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7598271 |
Crystalline paroxetine methane sulfonate
The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I:
wherein:
R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl...
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7592459 |
Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
The present invention provides a crystalline donepezil maleate, which is used as an intermediate in the preparation of donepezil hydrochloride. Also provided are novel processes for producing same...
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7592458 |
Dermal anesthetic compounds and pharmaceutical compositions for inducing local anesthesia and mitigating neuropathic pain
The present invention relates to new tetralin compounds, the methods of preparing said tetralin compounds, the method of using said tetralin compounds as local anesthetics and dermal anesthetics,...
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7582653 |
Mercaptophenyl naphthyl methane compounds and synthesis thereof
Novel mercaptophenyl naphthyl methane compounds, their pharmaceutically acceptable salts and compositions comprised thereof are useful for the prevention or treatment of various medical indications...
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7576103 |
Tetralin and indane derivatives and uses thereof
Compounds of the formula I:
or pharmaceutically acceptable salts thereof,
wherein m, p, q, Ar, R 1 and R 2 are as defined herein. Also provided are methods for preparing, compositions...
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7572787 |
Substituted naphthalene sulfonamides
The present invention relates to substituted sulfonamide compounds of the general formula (I), wherein P is sulfonamide or amide-substituted sulfonic acid, which compounds are potentially useful...
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7569586 |
Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 ,R 5 , R 6 , R 7 , R 8a , R 8b , W, a, b, c and m are as defined in the specification, or a pharmaceutically...
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7563810 |
Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
Methods of treating, preventing and/or managing a myeloproliferative disease are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically...
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7563808 |
Methods for treating cognitive impairments or dementia
The invention describes novel methods for treating and preventing dementia caused by vascular diseases; dementia associated with Parkinson's disease; Lewy Body dementia; AIDS dementia; mild...
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7560560 |
Crystalline forms of donepezil hydrochloride
The present invention provides novel crystalline forms of donepezil hydrochloride, processes for their preparation and pharmaceutical compositions containing them.
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7550485 |
Substituted N-heterocycle derivatives and methods of their use
The present invention is directed to substituted N-heterocycle derivatives, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions...
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7547788 |
Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these...
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7531535 |
Lactam-containing compounds and derivatives thereof as factor Xa inhibitors
The present application describes lactam-containing compounds and derivatives thereof of Formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7...
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7528153 |
Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group...
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7507753 |
Biaryl compound and use thereof
The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I):
wherein...
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7501441 |
Naphthyl compounds, intermediates, processes, compositions, and methods
The present invention is a method for treating uterine fibroid disease using a compound of formula I
wherein
R 1 is —H, —OH, —O(C 1 -C 4 alkyl), —OCOC 6 H 5 , —OCO(C 1 -C 6 ...
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7495111 |
Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
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7439365 |
Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil)
The present invention relates to the oxalate salt of 1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl]methyl piperidine, commonly known as Donepezil, and its method of preparation.
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7432284 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7429602 |
Treating conjunctivitis by topically administering an epinastine solution to the conjunctiva
Treating allergic conjunctivitis by administered aqueous solutions containing epinastine, optionally in the form of its racemate or its enantiomers and optionally, in the form of the...
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7405222 |
Methods and compositions for treatment of erectile dysfunction
Disclosed are methods and compositions for treatment of male sexual dysfunction. A method of treating male sexual dysfunction includes administering a pharmaceutical composition effective to cause...
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7378447 |
Muscarinic agonists
The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor
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7368462 |
Melanin concentrating hormone antagonists
The present invention relates to compounds capable of serving as moderators of human and mammalian appetite and as such provide a means for reducing body mass and controlling obesity.
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7326716 |
Treatment of inflammatory bowel disease
The present invention provides a method of treating inflammatory bowel disease which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of...
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7312222 |
Heterocyclic piperidines as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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7307078 |
Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel polycyclic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7276491 |
Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
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7255984 |
Combination therapy for osteoporosis
Pharmaceutical combination compositions including certain estrogen agonists/antagonists and prostaglandins or prostaglandin agonists/antagonists. The compositions are useful for the treatment of...
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7238683 |
Fused phenylalanine derivatives as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
The present invention is directed to fused phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-RV inhibitors”) and which are useful in the treatment or...
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7217706 |
Propanolamine derivatives
This invention relates to new propanolamine derivatives or salts thereof represented by the following formula [I]:
Wherein each symbol is as defined in the specification or salts thereof which...
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7211589 |
Atisane compounds and use thereof
The present invention provides a novel compound exhibiting an excellent suppressing effect to cell injury caused by radicals and neurotoxicity induced by excitatory nuerotransmitters such as...
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7208488 |
N-substituted benzene sulfonamides
Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease.
In Formula (I), R 1 , R 2 , R 3 , R 4 , R 3′ , R 10 and R...
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7205294 |
Selected CGRP-antagonists process for preparing them and their use as pharmaceutical compositions
The present invention relates to substituted piperidines of general formula
wherein A, B, D, E, X, R 1 and R 2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers,...
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7189740 |
Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes
Methods of treating, preventing and/or managing myclodysplastic syndromes are disclosed. Specific methods encompass the administration of an immunomodulatory compound, or a pharmaceutically...
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7153868 |
N-(3-(4-substituted-1-piperidinyl)-1-phenylpropyl) substituted sulfonamides as NK-3 receptor antagonists
The present invention provides a method of treatment of a subject suffering from a disease, such as schizophrenia, for which the administration of an NK-3 antagonist is indicated which comprises...
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7144898 |
Indole derivatives for the treatment of depression and anxiety
The present invention provides compounds of formula (I): which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of...
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7125887 |
Pyrrolidine modulators of CCR5 chemokine receptor activity
Pyrrolidine compounds of Formula (I), (wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6a , R 6b , R 7 and R 8 are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor...
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7125880 |
Corticotropin releasing factor antagonists
Corticotropin-releasing factor (CRF) antagonists having the formulae
wherein the dashed lines, A, B, Y, Z, G, R 3 , R 4 , R 5 , R 6 , R 16 and R 17 are as defined in the application, and...
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7125869 |
Polycyclic compounds which modulate PPARγ type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel polycyclic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7115633 |
Benzosuberonylpiperdine compounds as analgesics
Compounds of formula (I) or a derivative thereof, wherein; R is C 1-6 alkyl, C 3-7 cycloalkyl, C 1-6 alkoxy, hydroxy, halo, C 1-6 alkenyl, C 1-6 alkynyl, amino, C 1-6 alkylamino, di(C 1-6...
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7109214 |
Substituted cyclopentene compounds
The present invention relates to substituted cyclopentene compounds of the general formula I, to a process for the production thereof, to pharmaceutical preparations containing these compounds and...
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7105541 |
Naphthyl compounds, intermediates, compositions, and methods of use
The instant invention provides novel substituted naphthyl compounds, intermediates, compositions, pharmaceutical formulations, and methods of use.
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7105540 |
Cholinesterase inhibitors to treat disorders of attention
The present invention provides novel methods of treating disorders of attention or improving attention in humans by administering an effective amount of a cholinesterase inhibitor.
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7091218 |
4-substituted piperidine compound
The present invention provides a novel compound having an excellent acetylcholinesterase inhibitory effect. That is, it provides a compound represented by formula:
(wherein R 1 and R 2 ...
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7090853 |
Noscapine derivatives as adjuvant compositions and methods of use thereof
An adjuvant composition comprising noscapine and its derivatives, for use in the treatment of tumors, cancer, as an adjuvant for vaccines.
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7087622 |
Pyridone compounds as inhibitors of bacterial type III protein secreation systems
In accordance with the present invention, compounds that inhibit Type III protein section have been identified, and methods for their use provided. In one aspect of the invention, compounds useful...
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7087599 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7084140 |
Arylglycinamide derivatives, method of producing said derivatives and pharmaceutical compositions containing these compounds
The invention relates to new arylglycinamide derivatives of general formula I
and the pharmaceutically acceptable salts thereof, wherein R 1 and R 2 together with the N to which they are...
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