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7081465 |
Alpha-substituted naphthyloxy omega-substituted alky/aryl amino-substituted alkane derivatives as agent for treatment or prophylaxis of diabetes and related metabolic disorders
This invention relates to novel {overscore (ω)}-substituted-naphthyloxy-amino alkanes, their preparation and use as antihyperglycemic agents and for the treatment and prevention of cardiovascular...
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7064124 |
NF-κB inhibitor containing substituted benzoic acid derivative as active ingredient
A NF-κB inhibitor represented by the following formula (I) is provided:
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7064136 |
Compounds
A compound having the general formula
and methods of using such compounds for the treatment of diseases and pharmaceutical composition comprising such compounds.
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6995183 |
Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
Compounds are provided having the formula (I)
wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be...
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6974821 |
Methods for treating neuropsychiatric disorders
The invention provides methods for treating neuropsychiatric disorders such as schizophrenia, Alzheimer's Disease, autism, depression, benign forgetfulness, childhood learning disorders, closed...
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6969724 |
Compounds
Compounds of formula I, or a salt thereof or a hydrate thereof, as follows:
wherein
X and Y are selected independently from hydrogen and aryl, which aryl is unsubstituted or substituted one...
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6960608 |
Fused indazoles and indoles and their use for the treatment of glaucoma
Novel fused indazoles and indoles are disclosed. Also disclosed are methods for the lowering and controlling of normal or elevated intraocular pressure as well as a method for the treatment of...
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6951872 |
Monocyclic or bicyclic carbocycles and heterocycles as factor Xa inhibitors
The present application describes monocyclic or bicyclic carbocycles and heterocycles and derivatives thereof of Formula I:
or pharmaceutically acceptable salt forms thereof, which are useful...
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6949257 |
Pharmaceutical compositions
Spontaneously dispersible pharmaceutical compositions comprising a piperidine, e.g. 1-acylpiperidine Substance P Antagonist and its use in the treatment of CNS disorders, e.g. depression and social...
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6939880 |
Compounds with growth hormone releasing properties
Compounds of peptide mimetic nature having the general formula I
wherein a and b are independently 1 or 2, R 1 and R 2 are independently H or C 1-6 alkyl, G and J are independently, inter...
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6916800 |
Combination therapy including a matrix metalloproteinase inhibitor and an antineoplastic agent
The present invention provides methods to treat or prevent neoplasia disorders in a mammal using a combination of a matrix metalloproteinase inhibitor and an antineoplastic agent.
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6911475 |
Use of nicotine or its derivatives in a drug for treating neurological disease, in particular Parkinson's disease
The present invention concerns the use of nicotine or a derivative thereof for producing a drug for continuous or progressive administration of 0.2 mg to 5 mg per day per kilogram of body weight in...
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6906064 |
Method for treating a patient with neoplasia using Iressa
This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an inhibitor of human epidermal growth factor receptor tyrosine kinase and...
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6906098 |
Mixed steroidal 1,2,4,5-tetraoxane compounds and methods of making and using thereof
Disclosed herein are mixed steroidal tetraoxanes having the following structural formula 1
wherein n is 0, 1, 2, or 3; R is H; ethanoyl, propanoyl, or benzoyl; R1 is H, methyl, ethyl, or...
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6906083 |
4-substituted piperidine compound
The present invention provides a novel compound having a superior acetylcholinesterase inhibitory action. It provides a compound represented by the formula:
(In the formula, R 1 represents a...
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6878707 |
Carboxamides useful as inhibitors of microsomal triglyceride transfer protein and of apolipoprotein b secretion
Compounds of formula (I) wherein R 2 —C, R 3 —C, R 4 —C or R 5 —C may be replaced by N; and wherein n is 1, 2 or 3; R 1 is aryl, heteroaryl or (aryl or heteroaryl)-lower alkoxy; R 2 , R 3...
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6864266 |
4-piperidinyl alkyl amine derivatives as muscarinic receptor antagonists
This invention relates to the (R)-isomers of compounds which are generally muscarinic receptor antagonists and which are represented by Formula I:
wherein p, R 1 , R 2 , R 3 and A are as...
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6861418 |
4-aryl substituted indolinones
The present invention relates to 4-arylindolinones, as well as pharmaceutical compositions thereof, capable of modulating protein kinase signal transduction in order to regulate, modulate and/or...
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6858598 |
Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
A method of using an MMP inhibitor and optionally radiation therapy, and one or more antineoplastic agents of the topoisomerase class selected from the group consisting of irinotecan and topotecan,...
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6844344 |
Benzofuran derivatives
The present invention provides compounds of formula (I) which are useful for treating depression, anxiety, and alleviating the symptoms caused by withdrawal or partial withdrawal from the use of...
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6821985 |
Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
This invention relates to methods of treating traumatic brain injury (TBI) or hypoxic or ischemic stroke, comprising administering to a patient in need of such treatment an NR2B subtype selective...
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6815454 |
Percutaneously applicable preparation and suppository containing an antidementia medicament
The present invention provides a percutaneously applicable preparation containing an antidementia medicament, wherein the antidementia medicament is incorporated a higher alcohol, a lactate of a...
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6806278 |
Amino-tetralin derivatives as muscarinic receptor antagonists
This invention relates to compounds which are generally muscarinic M2/M3 receptor antagonists and which are represented by Formula I: wherein R 1 , R 2 , R 3 and R 4 are as defined in the...
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6803368 |
Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-6,9-dioxa-1,3-diaza-cyclopenta&lsqb a&rsqb naphthalene
Compounds of the formula useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced...
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6777418 |
Retinoid compounds (I)
The current invention provide novel retinoid compounds and methods for their synthesis, methods of treating or preventing emphysema, cancer and dermatological disorders and pharmaceutical...
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6774136 |
Substituted 1 and 2 naphthol mannich bases
The invention relates to substituted 1 and 2 naphthol Mannich bases, a method for the production thereof, medicaments containing said compounds and the use of said compounds in the production of...
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6743808 |
4-aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) tetrahydropyridines or piperazines
4-Aryl-1-(indanmethyl, dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl)piperidine, -tetrahydropyridine or -piperazine compounds of general formula (I), wherein one of X and Y is CH 2 and...
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6730677 |
Benzofurazan compounds which enhance AMPA receptor activity
Compounds of general structural formula ( 1 ) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors...
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6730671 |
Compounds useful as reversible inhibitors of cathespin S
Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are...
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6720350 |
Therapeutic inhibitor of vascular smooth muscle cells
Methods are provided for inhibiting stenosis or restenosis following vascular trauma in a mammalian host, comprising administering to the host a therapeutically effective dosage of a cytostatic...
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6689795 |
Methods for treating dementia due to HIV disease
The invention describes novel methods for treating and preventing dementia caused by vascular diseases; dementia associated with Parkinson's disease; Lewy Body dementia; AIDS dementia; mild...
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6673814 |
Delivery systems and methods for noscapine and noscapine derivatives, useful as anticancer agents
The present invention relates to methods useful for the treatment of neoplastic diseases, tumor cells, and the treatment of cancer delivering compounds of the formula The invention provides...
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6653321 |
Naphthylsulfonic acids and related compounds as glucose uptake agonists
Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or...
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6642228 |
α1b-adrenergic receptor antagonists
There are provided compounds represented by the general formula (I): [wherein Ar is indole etc., R 1 is hydrogen etc., B is bond, or B—N—R 1 forms a ring structure and is piperidine etc.,...
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6635650 |
Substituted dimeric compounds
The invention relates to compounds of formula (I): A-G 1 -Cy-G 2 -Cy-G 3 -B (I) wherein: A represents NR 1 C(Q)R 2 , C(Q)NR 2 R 3 or NR 1 C(Q)NR 2 R 3 , B represents NR 1 C(Q)R 2 , C(Q)NR 2 R 3...
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6617325 |
Biphenyl derivatives, production thereof and uses as medicines
The present invention relates to biphenyl derivatives of general formula wherein R a to R g and n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically...
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6617361 |
Behavior chemotherapy
A protocol for prevention of Alzheimer's disease onset is described. The protocol involves stimulating the implicit memory, followed by continuing such stimulation in conjunction with psychological...
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6613798 |
Small organic molecule regulators of cell proliferation
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the...
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6610705 |
Process for the preparation of diaryl naphthyl methanes
The invention relates to novel diaryl naphthyl methane compounds having general formula I as shown herein below, and said compounds useful in the treatment of esterogen related disease or syndrome,...
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6608088 |
Use of donerezil for the treatment of functional and/or organic pain syndromes
Methods of use of donepezil having central action for the treatment of function (migraine and primary fibromyalgia) and/or organic (amputation, “phantom limb”, tumoral or traumatic denervation...
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6599920 |
Naphthalene compounds, intermediates, formulations, and methods
This invention relates to the field of pharmaceutical and organic chemistry and provides naphthalene compounds, intermediates, formulations, and methods.
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6596271 |
Insect control method with genetically engineered biopesticides
Insect pests can be controlled by treating the pests or their loci with a combination of recombinant virus and organic insecticide. The recombinant virus preferably is a baculovirus. Combinations...
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6576646 |
Methods for treating cognitive impairments caused by traumatic brain injuries
The invention describes novel methods for treating and preventing cognitive impairments caused by traumatic brain injuries by administering a therapeutically effective amount of at least one of the...
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6552046 |
Materials and methods for the treatment of gastroesophageal reflux disease
The subject invention provides novel compounds and compositions for the safe and effective treatment of gastroesophageal reflux and related conditions. In a preferred embodiment, the compositions...
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6545021 |
Use of substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds for treating hepatitis virus infections
N-Substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds of Formula I are effective in treatment of hepatitis infections, including hepatitis B and hepatitis C. In treating hepatitis infections,...
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6544987 |
Compounds, compositions, and methods for stimulating neuronal growth and elongation
The present invention concerns methods, pharmaceutical compounds, and compositions for stimulating neuroite outgrowth in nerve cells leading to nerve regeneration. These methods, compounds and...
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6531464 |
Methods for the treatment of neurodegenerative disorders using substituted phenanthridinone derivatives
This invention provides a novel class of substituted 6(5H)phenanthridinone compounds. The invention also includes pharmaceutical compositions, and methods of making and using the compounds, or a...
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6531472 |
Tetralone derivatives
The present invention provides compounds of formula I and pharmaceutically acceptable salts, wherein R1, R2, R3, R4, R5, X and Y have the meanings defined in the specification. The compounds...
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6514996 |
Derivatives of benzofuran or benzodioxole
An oxygen-containing heterocyclic compound represented by following Formula (I): wherein R 1 and R 2 independently represent hydrogen, lower alkyl, cyano, —(CH 2 ) n —E 1 —CO—G 1 ...
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6511994 |
Modulators of CCR5 chemokine receptor activity
Compounds of Formula I: (wherein R 1 , R 2 , R 3 , R 4 , Q, and X are defined herein) are described. The compounds are modulators of CCR5 chemokine receptor activity. The compounds are useful,...
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