|
Match
|
Document |
Document Title |
|
|
7622589 |
Substituted sulfonylaminoarylmethyl cyclopropanecarboxamide as VR1 receptor antagonists
This invention provides a compound of the formula (I):
wherein, variables A, B, D, E, and R 1 to R 11 are as defined in the specification.
|
|
|
7622486 |
Pyridine compounds, process for their preparation and compositions containing them
The present invention provides new heterocyclic compounds, particularly substituted pyridines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a...
|
|
|
7618970 |
3-aminocyclopentanecarboxamides as modulators of chemokine receptors
The present invention is directed to compounds of Formula I:
which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment...
|
|
|
7612094 |
Tri-substituted heteroaryls and methods of making and using the same
Compounds of formula (I) possess unexpectedly high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic...
|
|
|
7608629 |
(Piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-HT1F agonists
The present invention relates to compounds of formula 1: and pharmaceutically acceptable acid addition sails thereof. The compounds of the present invention are useful for activating 5-HT 1F ...
|
|
|
7601843 |
4-(2-furoyl)aminopiperidine compound useful as therapeutic agent for itching
There are provided compounds represented by the following general formula (I):
[where R 1 is 5-methylpyridin-2-yl, p-tolyl or mesityl, R 2 is one of the following general formulas (II)-(IX):
...
|
|
|
7598392 |
2-amido-4-phenylthiazole derivatives, the preparation and the therapeutic use thereof
The disclosure relates to 2-amido-4-phenylthiazole derivatives of general formula (I) below:
in which R 1 , R 2 , R 3 , Y, m, n, and p are as defined in the disclosure; as well as to their...
|
|
|
7598270 |
Diagnostic agent, method for detecting a carcinoma, and means for the treatment thereof
A diagnostic agent and a method for detecting a carcinoma are described, where at least one HERG potassium channel is detected in a tissue biopsy of the human colon or rectum. In addition, the use...
|
|
|
7595331 |
N-and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred...
|
|
|
7592373 |
Amide compounds with MCH antagonistic activity and medicaments comprising these compounds
Compounds of formula (I)
wherein A, B, b, W, X, Y, Z, R 1 , R 2 , and R 3 have the meanings given in claim 1 , pharmaceutical compositions these compounds, and methods of preventing or...
|
|
|
7592358 |
Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
Alkyne compounds having MCH-receptor antagonistic activity, which are useful for preparing pharmaceutical compositions for the treatment of metabolic disorders and/or eating disorders, particularly...
|
|
|
7589087 |
Benzoimidazol-2-yl pyridines as modulators of the histamine H4receptor
Benzoimidazol-2-yl pyridines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H 4 receptor activity, including allergy, asthma,...
|
|
|
7585866 |
Protein tyrosine kinase inhibitors
The present invention relates to compounds of the Formula I, the pharmaceutically acceptable salts and stereoisomers thereof, which inhibit, regulate and/or modulate tyrosine kinase signal...
|
|
|
7579347 |
Vanilloid receptor ligands and their use in treatments
Compounds having the general structure
and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
|
|
|
7572815 |
Amide derivative
Amide derivatives represented by the formula (I):
wherein:
A is a cycloalkyl group, an aryl group or a heteroaryl group; X is a nitrogen atom or CR17; Y is —NRa—, —(CRbRb′)m-,...
|
|
|
7572812 |
Therapeutic agents useful for treating pain
Piperidine Compounds; compositions comprising a Piperidine Compound; and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism,...
|
|
|
7572461 |
Borer-resistant wood, wood products, and wooden structures and methods
The invention provides methods for suppressing the degradation of wood, wood products, and wooden structures due to infestation by wood-boring organisms, by use of a polyurea composition. The...
|
|
|
7569586 |
Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 ,R 5 , R 6 , R 7 , R 8a , R 8b , W, a, b, c and m are as defined in the specification, or a pharmaceutically...
|
|
|
7560546 |
Tyrosine kinase inhibitors
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The...
|
|
|
7557127 |
HDAC inhibitor
Compounds having the formula (I):
wherein
R 1 is hydrogen, lower alkyl, lower alkenyl, lower or higher alkynyl, cyclo(lower)alkyl, cyclo(higher)alkyl, cyclo(lower)alkyl(lower)alkyl,...
|
|
|
7557126 |
Diphenylmethyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I:
wherein a, b, c, e, m, n, Ar 1 , R 1 , R 2 , R 3 , R 4a , R 4b , R 5 and R 6 are as defined in the specification. The compounds of formula...
|
|
|
7550484 |
Chemokine receptor binding heterocyclic compounds with enhanced efficacy
Compounds that interact with the CXCR4 receptor are described. These compounds are useful in treating, for Example, HIV infection and inflammatory conditions such as rheumatoid arthritis, as well...
|
|
|
7547693 |
Piperidine derivative
Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty...
|
|
|
7544701 |
Sulfonyldihydrobenzimidazolone compounds as 5-hydroxytryptamine-6 ligands
The present invention provides a compound of formula I and the use thereof in the therapeutic treatment of a central nervous system disorder related to or affected by the 5-HT6 receptor.
|
|
|
7541369 |
Amino-derivatives as novel inhibitors of histone deacetylase
This invention comprises the novel compounds of formula (I)
wherein n, m, t, R 1 , R 2 , L, Q, X, Y, Z and
have defined meanings, having histone deacetylase inhibiting enzymatic activity;...
|
|
|
7538122 |
Heterocyclic antiviral compounds
This invention relates to piperidine derivatives of formulae Ia and Ib with substituents as defined herein useful in the treatment of a variety of disorders, including those in which the modulation...
|
|
|
7524863 |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I:
or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
|
|
|
7507753 |
Biaryl compound and use thereof
The present invention provides a compound having melanocortin receptor agonist activity or antagonist activity, which is a novel biaryl compound represented by the formula (I):
wherein...
|
|
|
7507752 |
Biosynthetic gene cluster for the production of a complex polyketide
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided...
|
|
|
7504417 |
Substituted benzene derivatives or salts thereof
There are provided compounds having an anticoagulant action on the basis of inhibition of activated blood coagulation factor X and being useful as anticoagulants or preventive/therapeutic agents...
|
|
|
7501518 |
Methods of making 2,6-diaryl piperidine derivatives
Methods for preparing 2,6-diaryl piperidine derivatives are described. More particularly, 2,6-diaryl piperidines having formula 1-4 are prepared by cyclocondensation of an aryl or heteroaryl...
|
|
|
7501440 |
Substituted benzoylureidopyridylpiperidine-and-pyrrolidinecarboxylic acid derivatives, processes for preparing them and their use
The invention relates to compounds of the formula I
where the radicals are as defined, and their physiologically tolerated salts. The compounds are suitable, for example, as medicaments for...
|
|
|
7501418 |
Fused heterocyclic isoxazoline derivatives and their use as anti-depressants
The invention concerns fused heterocyclic isoxazoline derivatives of Formula (I), the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof...
|
|
|
7498346 |
Chemokine receptor binding compounds
The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine...
|
|
|
7494989 |
Pyridine compounds useful as N-type calcium channel antagonists
Achiral pyrimidine derivatives and pyridine derivatives of the following formulae or analogs thereof have selective N-type calcium channel antagonistic activity and showed analgesic action when...
|
|
|
7491724 |
Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
The present invention provides compounds of the formula I:
its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof,...
|
|
|
7488738 |
Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof
There is provided an aminophenoxyacetic acid derivative of the following formula (I):
wherein, R 1 , R 2 , R 3 and R 4 are, independent from each other, alkoxy group, alkyl group or aryl...
|
|
|
7482371 |
N-phenylbenzamide derivatives as drugs for the treatment of COPD
The invention relates to the use of a pharmaceutically active derivative of N-phenylbenzamide of Formula (I) or of a pharmaceutically acceptable salt thereof, for preparing a medicament for the...
|
|
|
7482364 |
Phenylalkynes
Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
|
|
|
7482341 |
Pyridines
Compounds of formula
as well as pharmaceutically acceptable salts and esters thereof, wherein R 1 to R 6 have the significance given in claim 1 can be used in the form of pharmaceutical...
|
|
|
7462612 |
Pyridine inhibitors of ERK2 and uses thereof
The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
|
|
|
7456197 |
Pyridinium cationic lipids as gene transfer agents
Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of...
|
|
|
7456164 |
3- or 4-monosubtituted phenol and thiophenol derivatives useful as H3 ligands
The invention relates to 3- or 4-monosubstituted phenol and thiophenol derivatives of formula (I) and to processes for the preparation of, intermediates used in the preparation of, compositions...
|
|
|
7452907 |
Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method
Compounds are provided which have the structure
wherein Q is C or N, X 1 is C or N, and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, A, m, n, X 2 , X 3 and X 4 are as defined herein, which...
|
|
|
7452906 |
Pyridine derivatives as Raf kinase inhibitors
Compounds and their use as pharmaceuticals particularly as Raf kinase inhibitors for the treatment of neurotraumatic diseases, cancer, chronic neurodegeneration, pain, migraine and cardiac...
|
|
|
7452891 |
MCH antagonists and their use in the treatment of obesity
The present invention discloses compounds which, are novel antagonists for melanin-concentrating hormone (MCH), as well as methods for preparing such compounds. In another embodiment, the invention...
|
|
|
7449467 |
3-aminocyclopentanecarboxamides as modulators of chemokine receptors
The present invention is directed to compounds of Formula I:
which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment...
|
|
|
7449462 |
Triazole derivatives which inhibit vasopressin antagonistic activity
Compounds of formula (I),
or pharmaceutically acceptable derivatives thereof, wherein:
Het represents 2-pyridinyl or 2-pyrimidinyl; R 1 represents H, C 1-3 alkyl or a...
|
|
|
7449460 |
3-Quinolinecarbonitrile protein kinase inhibitors
This invention provides a compound of Formula 1
where Ar, X, R 1 , R 2 , R 3 , and R 4 are defined herein, or a pharmaceutically acceptable salt thereof useful in the prevention or inhibition...
|
|
|
7435743 |
Pyridine derivatives
Pyrimidine compounds of general formula:
wherein —R 1 represents
in which R 11 is hydrogen, C 1-6 alkyl, halogen, hydroxy, C 1-12 alkoxy, nitro, amino, C 1-6 alkylsulfonylamino, C...
|