Match Document Document Title
9029378 Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands  
Substituted bicyclic aromatic carboxamide and urea compounds as vanilloid receptor ligands, pharmaceutical compositions containing these compounds, and a method of using these compounds in the...
9029357 Benzazole derivatives as histamine H4 receptor ligands  
The present patent application concerns new ligands of the H4-receptor, their process of preparation and their therapeutic use.
9018224 Substituted cyclopropyl compounds useful as GPR119 agonists  
Substituted cyclopropyl compounds of the formula (I): and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The...
9018230 Identification, assessment, and therapy of cancers with innate or acquired resistance to ALK inhibitors  
Described herein are compositions, kits, and methods for determining whether subjects having cancer(s) positive for ALK mutations are likely to respond to treatment with an ALK inhibitor and/or...
9018200 Substituted piperidinyl compounds useful as GPR119 agonists  
Substituted piperidinyl compounds of the formula (I): are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as...
9006266 Heteroarylpiperidine and -piperazine derivatives as fungicides  
Heteroarylpiperidine and -piperazine derivatives of the formula (I) in which the symbols A, X, Y, L1, L2, G, Q, p, R1, R2 and R10 are each as defined in the description, and salts, metal complexes...
9006242 Substituted benzene compounds  
The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by...
8999971 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha  
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral...
8999966 Compounds that are ERK inhibitors  
Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring; and B is a monocyclic heterocycloalkyl...
8993575 [1,3,4] oxadiazole derivative and application thereof  
The present invention belongs to the medicinal chemistry field, and specifically discloses a [1,3,4]oxadiazole derivative with the structure of general formula (I) and pharmaceutically acceptable...
8987248 Substituted piperidines as Par-1 antagonists  
The invention relates to novel substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments...
8987303 AMPK-activating heterocyclic compounds and methods for using the same  
Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted...
8987276 Substituted triazolyl piperazine and triazolyl piperidine derivatives as gamma secretase modulators  
The present invention is concerned with novel substituted triazolyl piperazine and triazolyl piperidine derivatives of Formula (I) wherein R1, R2, R3, R4a, R4b, R5, X, Y1, Y2, L1, and L2 have the...
8980921 AMPK-activating heterocyclic compounds and methods for using the same  
Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted...
8980890 Compositions and methods of treating cell proliferation disorders  
The invention relates to compounds and methods for treating cell proliferation disorders.
8969383 Picolinamide derivatives as TTX-S blockers  
The present invention relates to picolinamide derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention...
8957063 Amine and ether compounds which modulate the CB2 receptor  
Compounds which modulate the CB2 receptor are disclosed. The compounds are useful for treating CB2 receptor-mediated diseases such as pain.
8946236 Anthranilic acid diamide derivative with hetero-aromatic and hetero-cyclic substituents  
The present invention relates to new insecticides of the formula (I) in which R1, R2, R3, R4, R5, R6, A, Q and n can have the definitions stated in the description, to a number of processes for...
8940768 Antifungal triazole derivatives  
Disclosed are novel triazole derivatives. Exhibiting excellent antifungal activity and in vivo safety, they are useful for the treatment or prevention of fungal infections caused by a wide...
8940774 Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors  
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a...
8933098 Dimethyl-benzoic acid compounds  
The present invention provides a compound of the Formula II: wherein A is: R1 is CH3, CF3, or F;R2 is H, CH3, or F;R3 is CH3, OCH3, OH, F;R4 is OH or CH2OH; andX is CH or N;or a pharmaceutically...
8933099 Monocyclic pyridine derivative  
The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically,...
8921373 Compounds having TRPV1 antagonistic activity and uses thereof  
The invention relates to compounds of Formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of Formula I or a pharmaceutically...
8912218 Alkylthiazol carbamate derivatives, preparation thereof and therapeutic use thereof  
The invention relates to the novel products of formula (I): in which: Ra represents H, Hal, aryl or heteroaryl, which is optionally substituted; Rb represents H, Rc, —COORc-CO—Rc or —CO—NRcRd;...
8912184 Therapeutic and diagnostic methods  
The invention relates to methods of treating diseases, particularly cancers, that respond favorably to the inhibition of Nicotinamide phosphoribosyltransferase (Nampt); it also relates to...
8906938 C5aR antagonists  
Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and...
8901115 Cyclic P1 linkers as factor XIa inhibitors  
The present invention provides compounds of Formula (Ia): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These...
8895584 Inhibitors of c-fms kinase  
The invention is directed to compounds of Formula I: wherein Z, X, J, R2 and W are set forth in the specification, as well as solvates, hydrates, tautomers and pharmaceutically acceptable salts...
8895551 Acrylamide compounds and the use thereof  
The invention relates to acrylamide compounds of Formula I mentioned below. The invention is also directed to the use compounds of Formula I to treat or prevent a disorder responsive to the...
8895583 Soluble guanylate cyclase activators  
This inventions relates to compounds having the structure Formula I and pharmaceutically acceptable salts thereof which are soluble guanylate cyclase activators. The compounds are useful for...
8889690 TRPV1 antagonists including dihydroxy substituent and uses thereof  
The invention relates to compounds of formula IA and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula IA or a pharmaceutically...
8889673 Triazolopyridine JAK inhibitor compounds and methods  
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4 and R5 are defined herein, are useful as JAK kinase inhibitors....
8889714 3,4-substituted piperidine derivatives as renin inhibitors  
The present invention relates to 3,4-substituted piperidinyl-based renin inhibitor compounds bearing at 4-position oxopyridine and having the formula (I). The invention further relates to...
8889674 Piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonism  
The present invention discloses novel piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by...
8889670 Heterocyclic compounds which modulate the CB2 receptor  
Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those...
8889715 Substituted pyridoxine-lactam carboxylate salts  
The present invention provides salt adducts comprising at least one positively charged moiety being a pyridoxine or a derivative thereof and at least one carboxylated 5- to 7-membered lactam ring,...
8883825 Aqueous liquid preparations and light-stabilized aqueous liquid preparations  
An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidino] butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized...
8883774 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha  
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral...
8877168 Aqueous liquid preparations and light-stabilized aqueous liquid preparations  
An aqueous liquid preparation containing (+)-(S)-4-[4-[(4-chlorophenyl) (2-pyridyl)methoxy]piperidino]butyric acid or a pharmacologically acceptable acid addition salt thereof, which is stabilized...
8877778 Benzofurane compounds  
The present invention is concerned with novel dual modulators of the 5-HT2A and D3 receptors of formula (I) wherein n, x, Y, R1, R2, R3, and R4 are as described herein, as well as pharmaceutically...
8877780 5-substituted isoindoline compounds  
This invention relates to 5-substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions...
8871770 Carboxamide compounds and methods for using the same  
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x...
8865741 Aminoindane compounds and use thereof in treating pain  
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by...
8859588 Substituted N-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof  
The present disclosure relates to a series of substituted N-heteroaryl bipyrrolidine carboxamides of formula (I). wherein R1, R2, R3, R4, Q1, Q2, Q3, Q4, X, m and p are as described herein. More...
8859557 Substituted oxindole derivatives and their use as vasopressin receptor ligands  
The present invention relates to novel oxindole derivatives of the general formula (I) to medicaments comprising them and to their use for the prophylaxis and/or treatment of diseases vasopressin...
8853205 Heteropyrrole analogs acting on cannabinoid receptors  
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects...
8853243 Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases  
The present invention provides compounds of the formula I: its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof,...
8846675 N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders  
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
8841313 CCR2 antagonists and uses thereof  
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) and their use for providing medicaments for treating conditions and diseases, especially pulmonary diseases...
8841321 Quinoline derivatives as antibacterial agents  
Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being...