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6015819 |
Use of alpha-1C specific compounds to treat benign prostatic hyperplasia
A method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of a compound which binds to a human α 1C adrenergic...
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6013656 |
2-(arylalkenyl) azacycloalkane derivatives as ligands for sigma receptors
New 2-(arylalkenyl)azacycloalkane derivatives which are ligands for sigma receptors, of the formula (I) ##STR1## in which: Ar is aryl or heteroaryl, optionally mono- to trisubstituted, m has the...
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6008223 |
Therapeutic compounds
Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , and Q 4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
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6004950 |
2-aminopyridines as inhibitors of cyclooxygenase-2
The invention encompasses the novel compound of Formula I as well as a method of treating cyclooxygenase-2 mediated diseases comprising administration to a patient in need of such treatment of a...
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6004577 |
Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions
Improved electrotransport of therapeutic agents which include agent cations and polybasic anionic counterions. Improved electrotransport is obtained by treating the therapeutic agent with a...
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6001836 |
Dihydropyridine NPY antagonists: cyanoguanidine derivatives
A series of non-peptidergic antagonists of NPY have been synthesized and are comprised of cyanoguanidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula (I). ##STR1## As antagonists of...
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6001856 |
β-adrenergic agonists to reduce a wasting condition
The present invention relates to the use of certain β-adrenergic agonists to reduce a wasting condition in a mammal (e.g., human).
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6001860 |
N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT)
A compound of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R 17 , R 18 and R 1 are as defined below. The compounds of formula I are inhibitors of acyl coenzyme...
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5998438 |
5-cyclo indole compounds
Described herein are compounds selective for a 5-HT 1D -like receptor, which have the general formula: ##STR1## wherein A is selected from a six-membered, non-aromatic, optionally substituted...
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5998454 |
Leukotriene antagonists useful for treating iritis
This invention provides methods for the treatment or inhibiting of iritis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
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5998416 |
Piperazine, piperidine and tetrahydropyridine derivatives as 5-HT receptor agonists
A class of N-substituted piperazine, piperidine, and tetrahydropyridine derivatives, further subltitutedat the 4-position by an optionally substituted alkenyl, alkynyl, aryl-alkyl or...
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5998444 |
Piperidinyl compounds as NK1 or NK2 antagonists
Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , Q 4 , and Q 5 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are...
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5990107 |
Fibrinogen receptor antagonist prodrugs
Fibrinogen receptor antagonist alcohol prodrugs having the structure, for example, of ##STR1## more particularly, ##STR2##
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5990128 |
α.sub.1C specific compounds to treat benign prostatic hyperplasia
This invention provides a method of treating benign prostatic hyperplasia in a subject which comprises administering to the subject a therapeutically effective amount of an α 1C antagonist which...
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5990105 |
Benzosulfone derivatives
The present invention relates to novel compounds of the general formula ##STR1## wherein R 1 is hydrogen; R 2 is hydrogen, trifluoromethyl or lower alkyl; R 3 is hydrogen or amino; or R...
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5977139 |
Carboxysubstituted cyclic carboxamide derivatives
The present invention relates to novel carboxy substituted cyclic carboxamide derivatives of formula (1), ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as...
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5977144 |
Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines
This invention relates to compositions for benzylidene- and cinnamylidene-anabaseines and methods for using these compositions for treating conditions associated with defects or malfunctioning of...
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5977110 |
Substituted cyclohexylamines as central nervous systems agents
Substituted cyclohexylamines and derivatives thereof are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful as central nervous system agents...
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5977154 |
Selective β3 adrenergic agonist
The present invention is in the field of medicine, particularly in the treatment of Type II diabetes and obesity. More specifically, the present invention relates to selective β3 adrenergic...
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5972962 |
Treatment of pruritus
The use of certain known 1,3,4 trisubstituted 4-aryl-piperidines for the treatment of pruritus in humans and animals is disclosed.
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5972947 |
Oxazolidinone derivatives, processes for the production thereof and pharmaceutical agents containing these compounds
The present invention concerns new oxazolidinone derivatives, processes for their production as well as pharmaceutical agents containing these substances. The present invention concerns compounds...
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5968956 |
Substituted piperidine derivative and medicine comprising the same
Disclosed herein is a substituted piperidine derivative represented by the following general formula (1): ##STR1## wherein R 1 means an aryl or heteroaryl group which may have at least one...
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5968954 |
2-aminoindan compounds as 5HT.sub.1B antagonists
New 2-aminoindan compounds of formula: ##STR1## wherein: n, Ar, R, E, X 1 , X 2 , X 3 , and X 4 are as defined in the description, in the form of a racemic mixture and in the form of optical...
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5962474 |
5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)-and 3-(piperidin-4-yl)-1h-indoles: 5-HT.sub.1F agonists
This invention provides novel 5-HT 1F agonists of Formula I ##STR1## where A--B, R,R 1 and X are as defined in the specification, which are useful for the treatment of migraine and associated...
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5958923 |
Use of thiazole and thiadiazole compounds
The present invention relates to the use of thiazole and thiadiazole compounds of the following formula: ##STR1## where R 1 , A, B and Ar have the meanings stated in the description. The compounds...
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5958952 |
Substituted phenylamindines, medicaments containing these compounds and process for producing them
The present invention relates to phenyl amidines of general formula (I), ##STR1## in which R 1 to R 5 are as defined in claim 1, their tautomers, their stereoisomers and their mixtures and their...
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5958949 |
N-linked ureas and carbamates of piperidyl thioesters
This invention relates to neurotrophic low molecular weight, small molecule N-linked ureas and carbamates of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as...
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5952354 |
Tris carbamic acid esters: inhibitors of cholesterol absorption
Inhibition of the enzymes cholesterol ester hydrolase (CEH) and/or acyl coenzyme A: cholesterol acyltransferase (ACAT) results in the inhibition of the esterification of cholesterol and are...
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5948792 |
Fluorine-containing 1,4-disubstituted piperidine derivatives
Novel fluorine-containing 1,4-disubstituted piperidine derivatives, represented by general formula I! ##STR1## such as, for example, (2R)-N- 1-(6-aminopyridin-2-ylmethyl)piperidin-4-yl!-2-...
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5948778 |
Difluoro statone antiviral analogs
This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.
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5948785 |
Heterocyclic amide compounds and pharmaceutical use of the same
Heterocyclic amide compounds of the formula (I) ##STR1## wherein each symbol is as defined in the specification, pharmacologically acceptable salts thereof, pharmaceutical compositions thereof and...
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5948793 |
3-pyridyloxymethyl heterocyclic ether compounds useful in controlling neurotransmitter release
Novel heterocyclic ether compounds of the formula: ##STR1## wherein n, *, R 1 , R 2 , R 3 and y are specifically defined, or pharmaceutically acceptable salts or prodrugs thereof, which are useful...
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5942523 |
Compounds which are selective antagonists of the human NK.sub.3 receptor and their use as medicinal products and diagnostic tools
A compound of formula: in which: Ar represents a pyrid-2-yl or a phenyl which is unsubstituted or substituted by a halogen, a methyl or a (C 1 -C 4 )alkoxy; R 1 represents a methyl group; ...
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5939436 |
Five-membered heteroaromatic compounds as dopamine receptor subtype ligands
A class of heteroaromatic compounds incorporating a substituted five-membered heteroaromatic nucleus which contains at least two nitrogen atoms are ligands for dopamine receptor subtypes within the...
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5935973 |
Heterocyclcarboxamide derivatives and their use as therapeutic agents
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R 1 is an optional substituent; U is an alkylene...
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5932594 |
Muscarinic receptor antagonists
A compound of the formula: or a pharmaceutically acceptable salt thereof, wherein Y is a direct link, --(CH 2 --, --(CH 2 ) 2 --, --CH 2 O-- or CH 2 S--; R is --CN or --CONH 2 ; and R 1 is a...
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5925634 |
Use of ibogaine for treating neuropathic pain
This invention discloses that ibogaine, a plant derivative, can be used safely to treat neuropathic pain (i.e, pain which does not respond conventionally to opiate drugs such as morphine). Ibogaine...
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5922722 |
Alpha 1a adrenergic receptor antagonists
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as selective alpha 1a adrenergic receptor antagonists. One application of these compounds...
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5922720 |
Piperazinothiopyridines for the control of Helicobacter bacteria
Compounds of formula I are piperazinothiopyridines which are useful for controlling Helicobacter bacteria. They are useful as active compounds for treating diseases based on such bacteria, and are...
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5922738 |
Heteroarylpyridine herbicides
The novel heteroaryloxypyridines of formula I: ##STR1## (A, B, R 1 and R 2 are defined in the specification) show excellent selective herbicidal activity. The new compounds can be prepared...
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5919782 |
Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
Novel antidiabetic compounds, their tautomeric forms, their derivatives, their steroisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates...
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5919796 |
Hydroximic acid derivatives, pharmaceutical compositions containing them, and processes for preparing the same
Hydroximic acid derivatives possess anti-ischemic effects, and therefore, they are useful for treating ischemic states and diseases, such as myocardial ischemia (which may be induced by occlusion...
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5919801 |
N-substituted piperidines as PDE4 inhibitors
New N-substituted cyclic amines of formula: ##STR1## wherein: X, R 1 , R 2 and R are as defined in the description, their optical and geometric isomers and physiologically tolerable salts thereof....
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5919802 |
Methods of preventing and/or treating temporal lobe epilepsy
A method of preventing and/or treating epileptic seizures in a mammal in need of such treatment, which comprises administration to said mammal of a therapeutic amount of a 5HT1A antagonist.
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5914328 |
Heterocyclic ether compounds useful in controlling neurotransmitter release
Novel heterocyclic ether compounds of the formula: ##STR1## wherein *, A,B, n, R 1 , R 2 and X are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are useful...
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5914340 |
Leukotriene antagonists useful for treating dermatoses
This invention provides methods for the treatment or inhibiting of dermatitis which comprises administering to a mammal in need thereof an effective amount of a compound having activity as a...
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5910505 |
Leukotriene antagonists for use in the treatment or inhibition of oral squamous cell carcinoma
This invention provides methods for the treatment or inhibitor of oral squamous cell carcinoma which comprises administering to a mammal in need thereof an effective amount of a compound having...
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5902815 |
Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
This invention relates to a new method for treating or preventing brain damage caused by NMDA receptor hypofunction (NR/hypo), using drugs such as lisuride which stimulate (agonize) activity at the...
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5900418 |
Method for treatment of obesity
A method is provided for the control of obesity comprising administering to a mammal including humans suffering from obesity an acetylcholine esterase reactivator or prodrug derivative thereof...
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5889035 |
1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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