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6391871 |
Preventing neuronal degeneration in Alzheimer's disease
A method of treating Alzheimer's disease is disclosed, not just with palliatives, but in a manner that prevents the progressive degeneration caused by Alzheimer's disease. Certain types of...
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6391891 |
Bicyclic compounds as ligands for 5-HT1 receptors
The invention relates to compounds which are ligands for 5HT1, of formula (I) Wherein L, Q, R a , R b and R y are as defined in the specification, processes for their preparation and their...
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6391881 |
Thiourea derivatives of dihydropyridine NPY antagonists
A series of antagonists of NPY have been synthesized and are comprised of thiourea linked piperazine and piperidine derivatives of 4-phenyl-1,4-dihydropyridines of Formula 1. where Z is NR 7 R 8...
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6387898 |
Treatment for CNS injuries
This invention relates to a novel use of imidazole compounds in the treatment of CNS injuries.
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6384052 |
Anticoccidial compounds
Trisubstituted pyrroles are useful in the control of coccidiosis in poultry.
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6384028 |
N-acylpiperidinylcarbonylaminocarboxylic acids and their use as glycoprotein IIb/IIIa antagonists and fibrinogen-blood platelets binding inhibitors
β-alanine compounds or a pharmaceutically acceptable salt thereof, which is useful as a glycoprotein IIB/IIIa antagonist, inhibitor of blood platelet aggregation and inhibitor of the binding of...
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6380201 |
Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F agonists
This invention provides methods for the treatment or amelioration of the symptoms of the common cold or allergic rhinitis which comprises administering to a mammal in need thereof a serotonin 5-HT...
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6380190 |
Nonnucleoside inhibitors of reverse transcriptase, composite binding pocket and methods for use thererof
Novel compounds that are potent inhibitors of HIV reverse transcriptase (RT) are described in the invention. The novel compounds also inhibit replication of a retrovirus, such as human...
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6380220 |
Derivatives from piperidine-keto acid, their preparation and use
Piperidineketocarboxylic acid derivatives of the general formula I and their tautomeric and isomeric forms, and physiologically tolerable salts thereof, where the variables have the meanings...
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6362195 |
Branched alkoxy-substituted 2-aminopyridines as NOS inhibitors
The present invention relates to 6-phenyl-pyridin-2-ylamine derivatives of the formula wherein R 1 , R 2 , R 3 and R 4 are defined as in the specification, that exhibit activity as nitric...
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6353004 |
Peripherally acting anti-pruritic opiates
Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: wherein: R, R 2 , R 3 , R 4 , R 7 , Ar 1 and Ar 2 are as defined in the...
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6350744 |
Compounds having cytokine inhibitory activity
There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which exhibit utility for the treatment of cytokine mediated diseases such as arthritis.
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6344464 |
Use of tetrahydropyridine derivatives to prepare medicines for treating diseases causing demyelination
The invention relates to the use of tetrahydropyridine derivatives of the formula in which: R 1 is a halogen or a CF 3 , (C 1 -C 4 )alkyl or (C 1 -C 4 )alkoxy group; Y is a nitrogen atom or a...
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6342504 |
Aromatic heterocyclic derivatives as enzyme inhibitors
The present invention discloses peptide aldehydes which are potent and specific inhibitors of thrombin, their pharmaceutically acceptable salts, pharmaceutically acceptable compositions thereof,...
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6342509 |
Piperidine quaternary salts- CCR- 3 receptor antagonists
This invention relates to certain piperidine quatemrwy salts of Formula (I): that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods...
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6337394 |
Compounds
There is provided compounds of formula I, wherein R 1 , R 2 , R 3 , R x , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases,...
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6335348 |
Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal, using...
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6333359 |
Regulation of cellular apoptosis using modulators of β-AR receptors
The invention concerns the use of β2-adrenergic modulators for regulating cellular apoptosis.
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6333340 |
Small molecule sulfonamides for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal using...
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RE37478 |
1-(arylthioalkyl, arylaminoalkyl, or arylmethylenealkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents, the compounds are especially useful for treating psychoses by administering to a mammal a...
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6329366 |
Pharmaceutical compounds
A pharmaceutical compound of the formula ##STR1## in which R 1 and R 2 are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, ##STR2## where R 4 and R 5...
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6326381 |
Arylpiperidine and aryl-1,2,5,6-tetrahydropyidine amide derivates
Compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , X and n are defined in the specification, are useful for the treatment of anxiety, depression and related CNS disorders, and other...
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6323222 |
1-aza-2-alkyl-6-aryl-cycloalkane compounds
Compound of formula (I): ##STR1## wherein: {character pullout} n represents 0 or 1, {character pullout} R 1 represents hydrogen, arylalkyl, alkyl, acyl, alkoxycarbonyl, arylalkoxycarbonyl or...
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6319932 |
Oxazolidinones useful as alpha 1A adrenoceptor antagonists
Novel oxazolidinone compounds and pharmaceutically acceptable salts thereof are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also...
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6319920 |
2-arylethyl-(piperidin-4-ylmethyl)amine derivatives
This invention relates to muscarinic receptor antagonist compounds selected from the group of compounds represented by Formula I: ##STR1## wherein the substituents are as defined in the...
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6316431 |
Use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ratio and detrusor urethral sphincter dyssynergia in men and method to study the dyssynergia in male rodents
This invention relates to the use of an aromatase inhibitor in the treatment of decreased androgen to estrogen ration (DATER) as well as to a method for the treatment of detrusor urethral sphincter...
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6316445 |
Carboxy substituted acylic carboxamide derivatives
The present invention relates to novel carboxy substituted acyclic carboxamide derivatives of formula (1)): ##STR1## and stereoisomers and pharmaceutically acceptable salts thereof and their use as...
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6316467 |
Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6313148 |
Aromatic amine compounds that antagnoize the pain enhancing effects of prostaglandins
Compounds antagonistic of the pain enhancing effects of prostaglandins are disclosed. The compounds comprise an optionally-substituted A ring with a --CH(R 3 )N(R 2 )B--R 1 and --OD groups...
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6306878 |
Pharmaceutical compositions containing hydroximic acid derivatives
The invention refers to pharmaceutical compositions suitable for the protection of the mitochondrial genom and/or mitochondrium from damages or for the treatment of diseases connected with such...
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6303593 |
3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity
The present invention is directed to pyrrolidine compounds of the formula I: ##STR1## (wherein R 1 , R 2 , R 3 , R 4c , R 4d , and R 4f are defined herein) which are useful as modulators of...
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6303637 |
Heterocyclic potassium channel inhibitors
The present invention relates to a class of heterocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like....
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6303638 |
Substituted pyridines as modulators of the mammalian neuronal nicotinic acetylcholine receptor
Novel compounds are provided that modulate the neuronal nicotinic acetylcholine receptor (nAChR), particularly the mammalian nAChR (m-nAChR). The compounds are substituted pyridine derivatives such...
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6300333 |
Substituted piperidines, processes for their preparation and their use as pesticides and fungicides
Substituted piperidines, processes for their preparation and their use as pesticides and fungicides. The invention relates to substituted piperidines of the formula ##STR1## in which R 1 is H,...
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6297259 |
Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl) benzamides useful for the treatment of allergic diseases
The present invention relates to novel substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamide derivatives of the formula ##STR1## stereoisomers thereof, and pharmaceutically acceptable...
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6294537 |
Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools
A method for treating diseases which involve interaction of neurokinin B with NK 3 receptors in humans. The method comprises administering a therapeutically effective amount of a NK 3 antagonist...
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6294551 |
N-linked sulfonamides of heterocyclic thioesters
This invention relates to neurotrophic low molecular weight, small molecule N-linked sulfonamides of heterocyclic thioesters having an affinity for FKBP-type immunophilins, and their use as...
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6291480 |
Diaryl piperidyl pyrrole derivatives as antiprotozoal agents
Trisubstituted pyrroles are antiprotozoal agents useful in the treatment and prevention of protozoal diseases in human and animals, including the control of coccidiosis in poultry.
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6284775 |
3-[4-(1-substituted-4-piperazinyl)butyl]-4-thiazolidinone and related compounds
There are disclosed compounds of the formula, ##STR1## where n is 0, 1 or 2; A is ##STR2## where X in each occurrence is independently hydrogen, halogen, loweralkyl, hydroxy, nitro, loweralkoxy,...
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6281228 |
Heterocyclic inhibitors of microsomal triglyceride transfer protein and method
Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including...
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6281233 |
Method of treating gastrointestinal motility disorders
The present invention relates to a novel method for treating a mammal suffering from gastrointestinal motility disorders.
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6277865 |
Piperididinyl and N-amidinopiperidinyl derivatives
This invention is directed to a compound of formula I which is useful for inhibiting the activity of Factor Xa, by combining said compound with a composition containing Factor Xa. The present...
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6277845 |
Hydrazono-benzazulene derivatives, pharmaceutical compositions and intermediates
Compounds of the formula ##STR1## wherein the substituents are as defined in the application and their pharmaceutically acceptable acid and base salts thereof which are useful for preventing loss...
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6268384 |
Compounds possessing neuronal activity
The present invention relates to compounds, methods and pharmaceutical compositions for stimulating the growth of neurites in nerve cells. The compounds and the compositions and methods that...
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6268380 |
Urea derivatives useful as platelet aggregation inhibitors
Novel urea derivatives of the formula are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using such derivatives.
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6258825 |
2-oxoimidazole derivatives
The present invention relates to a compound represented by Formula [I] ##STR1## wherein ##STR2## represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a...
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6251919 |
Heterocyclic substituted aniline calcium channel blockers
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6251921 |
Antithrombotic diamines
This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of...
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6245783 |
Method of using neurotrophic sulfonamide compounds
This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme...
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6242450 |
5-HT1F antagonists
This invention provides 5-HT 1f antagonists of Formula I: ##STR1## where AR 1 , AR 2 , R, and R' are as defined in the specification.
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