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5900418 |
Method for treatment of obesity
A method is provided for the control of obesity comprising administering to a mammal including humans suffering from obesity an acetylcholine esterase reactivator or prodrug derivative thereof...
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5889035 |
1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
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5889023 |
Fibrinogen receptor antagonist
A fibrinogen receptor antagonist which is 3(R)- 2-(Piperidin-4-yl)ethyl!-2-piperidon-1-ylacetyl-3(S)-(3-pyri
dyl)-.be ta.-alanine.
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5883107 |
Arginine mimic derivatives as enzyme inhibitors
The present invention provides peptide aldehydes having an azetidinyl, prolyl or pipecolyl group as part of the peptide backbone and an arginine mimic group such as an amidinopiperidine or...
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5883094 |
Benzimidazolone derivatives with central dopaminergic activity
This invention relates to novel, pharmaceutically active benzimidazolone derivatives of the formula ##STR1## wherein the dashed line, R 0 through R 6 and X 1 through X 3 are defined as in the...
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5872115 |
2-ureido-benzamide derivatives
This invention is concerned with 2-ureido-benzamide compounds of the formula (1) ##STR1## in which R 1 is H, halogen atom, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy or (C 1 -C 4 )dialkylamino and R 2...
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5866589 |
Alkyl substituted piperadinyl and piperazinyl anti-AIDS compounds
Anti-AIDS compounds of formula (I) ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 are as defined in the specification and R 8 is alkyl of substituted alkyl.
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5863913 |
Aromatic compound and pharmaceutical composition
An aromatic compound of the formula (I): ##STR1## specifically, for example, 3- (4-carboxyphenyl)methyl!valeramido!-4-dimethylaminobenzoic acid 4'-methylpiperazide, or a salt thereof, and a...
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5861395 |
Compounds useful for inhibition of farnesyl proteins transferase
Novel compounds of the formula: ##STR1## are disclosed. Compounds of Formula 1.0 are represented by the compounds of formulas: ##STR2## wherein R 1 , R 3 and R 4 are each independently selected...
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5852045 |
Fibrinogen receptor antagonists
Fibrinogen receptor antagonists having the structure, for example, of ##STR1## for example ##STR2##
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5834465 |
Treatment with combined NMDA and non-NMDA antagonists to reduce excitotoxic CNS damage
This invention involves a pharmaceutical mixture for preventing or reducing excitotoxic brain damage caused by hypoxia/ischemia (such as stroke) and various other factors. This mixture comprises an...
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5817677 |
5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation
5-Membered heterocyclic compounds, of which the following compounds are exemplary: (a) 4- trans-4-(2-carboxyethyl)cyclohexyl!aminocarbonyl!-1-(4-piper
idyl)imida zole, (b) 5- ...
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5817684 |
Leukotriene antagonists for use in the treatment or inhibition of cerebral focal stroke
This invention provides methods for the treatment or prevention of cerebral focal ischemia which comprises administering to a mammal in need thereof an effective amount of a compound having...
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5807865 |
3,3-disubstituted piperidine derivatives and their use as therapeutic agents
The present invention relates to compounds of the formula (I) ##STR1## wherein X, Z, R, R 1 , R 2 , Ar, n and m are as defined herein which are of use in the treatment or prevention of neuropathy,...
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5807870 |
Substituted pipecolinic acid derivatives as HIV protease inhibitors
Disclosed herein are compounds of formula 1 ##STR1## wherein X is a terminal group, for example, an aryloxycarbonyl, an alkanoyl or an optionally mono- or disubstituted carbamoyl; B is absent or an...
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5795901 |
Insecticidal N-(substituted arylmethyl)-4- bis(substituted aryl)hydroxymethyl!piperidinium salts
Compounds of the following structure are disclosed as effective insecticides: ##STR1## in which Q is hydroxy; U is --(CH 2 ) n --, where n is 1; R is ##STR2## in which V, W, Y, and Z are each...
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5795893 |
Fibrinogen receptor antagonists
This invention relates to novel compounds which inhibit platelet aggregation, pharmaceutical compositions containing the compounds, and methods of using the compounds.
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5792778 |
2-substituted aryl pyrroles, compositions containing such compounds and methods of use
The present invention addresses 2-substituted aryl pyrroles, as well as compositions containing such compounds and methods of treatment. Cytokine mediated diseases refers to diseases or conditions...
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5789422 |
Substituted arylalkylamines as neurokinin antagonists
Compounds represented by the structural formula ##STR1## or a pharmaceutically acceptable salt thereof are disclosed, wherein: A 1 is --CH 2 R 6 , --OR 6 , --N(R 6 )(R 7 ), --S(O) e R 13 ,...
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5786371 |
Pyridine and pyridazine derivatives, processes for the production thereof and pharmaceutical agents containing these compounds
Compounds of Formula I ##STR1## in which the variables are defined herein, processes for the production thereof as well as pharmaceutical agents containing these compounds for the treatment of...
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5783576 |
Benzoyl guanidine derivatives, the preparation thereof and their use in pharmaceutical compositions
New compounds of general formula (I) are provided: ##STR1## which are explained in the specification can be prepared by a variety of methods. The compounds may be used in pharmaceutical compositions.
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5780480 |
Fibrinogen receptor antagonists
Fibrinogen receptor antagonists of the general formula: X-A-Y-Z-B I and which includes, for example, the compounds of formula ##STR1## are useful...
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5780484 |
Methods for stimulating neurite growth with piperidine compounds
The present invention relates to methods for stimulating the growth of neurites in nerve cells. The methods comprise treating nerve cells with piperidine compounds alone or in combination with a...
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5776954 |
Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
The present invention addresses substituted pyridyl pyrroles, as well as compositions containing such compounds and methods of treatment. The compounds in the present invention are glucagon...
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5767116 |
Bicyclic aromatic compounds as therapeutic agents
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or --O--; B is methylene or --O--; and g is 0, 1, 2, 3 or 4; R 1 , R 2 , R 3 , R 4 , U, Q...
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5767130 |
Use of kainic acid antagonists to prevent toxic side effects of NMDA antagonists
This invention discloses that kainic acid receptor antagonists (KA antagonists) can act as "safener" agents to reduce or prevent adverse side effects caused by NMDA antagonists. NMDA antagonists...
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5763476 |
Sublingual or buccal pharmaceutical composition
The invention relates to a sublingual or buccal pharmaceutical composition comprising trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz 2,3:6,7!oxepino- 4 ,5-c!pyrrole or a pharmaceutically...
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5763458 |
1-phenylalkanone 5-HT.sub.4 receptor ligands
The present invention relates to novel 5-HT 4 receptor ligands which are 1-(5-halo-4-aminophenyl) (C 2 -6)alkan-1-one derivatives in which the 5-halo-4-aminophenyl group is substituted at its...
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5760018 |
Gem-disubstituted azacyclic tachykinin antagonists
The present invention is directed to certain compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 ,...
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5756508 |
Muscarine antagonists
This invention is concerned with novel 1,3-dihydro-1- 1-(1-heteroarylpiperidin-4-yl)piperidin-4-yl!-2H-benzimidaz olones, derivatives thereof, their preparation, method of use and pharmaceutical...
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5753679 |
Benzyl-piperidine derivatives
Benzly-piperidine derivatives of formula I and their pharmaceutically acceptable salts are used in the control of psychotic disorders which are caused by damage to the dopamine system, especially...
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5750540 |
1,4-di-substituted piperidine derivatives
This invention provides novel 1,4-di-substituted piperidine derivatives of the general formula I! ##STR1## and the pharmaceutically acceptable salts thereof, wherein: Ar represents a phenyl group...
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5750541 |
Method of treating schizophrenia
The present invention relates to a novel method for treating a mammal suffering from or susceptible to schizophrenia and schizophreniform diseases by administering thiadiazole or oxadiazole compounds.
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5747057 |
Sustained release pyriproxifen compositions for parasite control
The invention comprises a composition of matter containing a matrix, a plasticizer and pyriproxifen for controlling fleas.
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5744485 |
Carbamates and ureas as modifiers of multi-drug resistance
The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical...
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5741799 |
Heterocyclic thrombin inhibitors
Heterocyclic thrombin inhibitors are provided which have the structure ##STR1## wherein n, R, R 1 , R 2 , R 3 , G, G x , R 6 ', Ra, Xa, R 6 , Rb, R 3 , p, Q, A and R 4 are as defined herein.
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5741802 |
Anabaseine derivatives useful in the treatment of degenerative diseases of the nervous system
The invention concerns novel anabaseine-related compounds that are useful in treating certain degenerative neural diseases such as Alzheimer's and Parkinson's which apparently involve decreased...
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5739134 |
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2h-benzopyran, dihydrobenzodioxin, benzodioxole, dihydrobenzodioxepin, or tetrahydrobenzoxepin)carboxamide derivatives
N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives, their N-oxide forms and pharmaceutically acceptable salts having gastrointestinal...
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5731309 |
Substituted heteroalkyleneamine neurokinin antagonists
Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , and Q 4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide...
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5726184 |
Tetralin compounds with improved MDR activity
The present invention relates to compounds that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylactic agents. This invention also relates to pharmaceutical...
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5721252 |
5HT.sub.1F agonists for the treatment of migraine
This invention provides novel 5-HT 1F agonists which are useful for the treatment of migraine and associated disorders.
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5721251 |
Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone
The present invention is directed to certain novel compounds identified as substituted piperidines, pyrrolidines and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein R 1 ,...
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5721250 |
Di-and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines promote release of growth hormone
The present invention is directed to certain novel compounds identified as di- and tri-substituted piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1##...
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5718912 |
Muscarine agonists
This invention is concerned with novel 1- cycloalkylpioeridin-4-yl!-2H benzimidazolones, their compositions and method of use. The novel compounds are selective muscarinic agonists of the m2...
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5716958 |
Amino acid derivative having anti-CCK activity
A compound represented by the formula (1): ##STR1## wherein, m is an integer of 1 to 3; n is an integer 0 or 1; A represents CH or N atom, and forms together with the N atom bonded to the...
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5712297 |
Piperdine compounds and their preparation and use
The present invention relates to therapeutically active piperidine compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are...
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5710169 |
Therapeutic heterocycles
Compounds of formula I ##STR1## wherein Q 1 , Q 2 , Q 3 , Q 4 , and Q 5 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are...
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5710166 |
N-acyl beta amino acid derivatives useful as platelet aggregation inhibitors
Novel N-Acyl Beta Amino Acid derivatives of the formula ##STR1## are provided which inhibit platelet aggregation. This invention also pertains to pharmaceutical compositions and methods of using...
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5710156 |
Ester and carbamate derivatives of azolones
The invention is concerned with the compounds having the formula ##STR1## the pharmaceutically acceptable acid addition salts and the stereochemically isomeric form thereof, wherein X and Y are CH...
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5703065 |
Heteroarylamino and heteroarylsulfonamido substituted 3-benyzlaminomethyl piperidines and related compounds
The invention relates to compounds of the formula ##STR1## and to pharmaceutically acceptable salts thereof, wherein A, W, P, R 3 , Q and R 1 are as defined herein. The compounds of formula I, and...
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