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7425554 |
1,2-di(cyclic)substituted benzene compounds
In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action...
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7419990 |
Piperidine derivatives as melanocortin-4 receptor agonists
Certain novel piperidine derivatives are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore...
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7417057 |
Pesticidal heterocycles
It has now been found that certain novel heterocyclic derivatives have provided unexpected insecticidal activity. These compounds are represented by formula (I): R Preferred are those compounds of...
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7414039 |
Interstitial therapy for immediate symptom relief and chronic therapy in interstitial cystitis
The present invention relates to a disorder of the lower urinary tract, and in particular, reducing the symptoms (including treatment) of interstitial cystitis in vivo. In a preferred embodiment,...
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7410971 |
1,2-di(cyclic)substituted benzene compounds
A compound represented by the following general formula (1) or (100), a salt thereof or a hydrate of the foregoing has excellent cell adhesion inhibitory action or cell infiltration inhibitory...
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7393873 |
Arylsulfonamide derivatives
N-aryl arylsulfonamide derivatives are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin...
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7393864 |
Use of ClC3 chloride channel blockers to modulate vascular tone
The present invention provides methods for the modulation of vascular tone in a patient having compromised vascular tissue, which methods comprise the administration of a chloride channel blocking...
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7393862 |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide....
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7393849 |
Substituted sulfonamides and ureas useful for inhibiting kinase activity
Sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said...
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7390823 |
Use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal products that are useful in the treatment or prevention of all mood disorders, adaptation disorders or mixed anxiety-depression disorders
The present invention relates to the use of saredutant and of its pharmaceutically acceptable salts for the preparation of medicinal products that are useful in the treatment or prevention of all...
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7381734 |
Serine protease inhibitors
Compounds of formula (I)
where R 5 , R 6a , each X, L, Cy and Lp are as defined in the specification, are tryptase inhibitors useful as antiinflammatory agents.
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7378412 |
Pharmaceutical compounds
Compounds or their salts having general formula:
A-B—C—NO 2
wherein: A...
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7371746 |
1,2,4-Thiadiazole compounds and pests controlling composition containing the same
The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R 1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene...
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7368443 |
2,6-disubstituted piperidines and piperazine compounds
The present invention is directed to 2,6-disubstituted piperidine and piperazine analogs having the following general formula:
which are used to treat diseases of the central nervous system,...
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7365082 |
N-(substituted arylmethyl)-4-(disubstituted methyl)piperidines and piperazines
It has now been found that certain novel N-(substituted aryl)-4-(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are...
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7326719 |
Cathepsin S inhibitors
This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin...
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7323478 |
Melanin concentrating hormone receptor ligands
Disclosed are compounds of the formula:
and the pharmaceutically acceptable salts thereof wherein Q, X, Y, Z, and R 1 R 9 , and R 12 -R 19 are defined herein.
These compounds are selective...
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7320990 |
Crystalline form of a biphenyl compound
The invention provides a crystalline naphthalene-1,5-disulfonic acid salt of biphenyl-2-ylcarbamic acid 1-{9-[(R)-2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydro-quinolin-
5...
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7319100 |
Substituted pyrazinones, pyridines and pyrimidines as corticotropin releasing factor ligands
Compounds provided herein are novel substituted pyrazinones, pyridines and pyrimidines of Formula (I) and (II):
Such compounds are particularly useful as CRF receptor ligands, and hence, in the...
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7317066 |
Liquid crystal polymers
Liquid crystal polyester derived from phenylene-naphthalene monomers and one or more comonomers display an improved balance of properties, including low melt viscosity, fast cycle time in molding,...
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7317007 |
Benzothiazole derivatives with activity as adenosine receptor ligands
The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.
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7312222 |
Heterocyclic piperidines as modulators of chemokine receptor activity
The present application describes modulators of CCR3 of formula (I):
or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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7309709 |
Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula:
wherein R 1 to R 6 , X, Z and A are as defined. These compounds have activity inhibiting production of Aβ-peptide. The invention...
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7307091 |
Deuterated 3-piperidinopropiophenone and medicaments containing said compounds
The invention discloses deuterated 3-piperidinopropiophenones as well as their physiologically tolerated salts. Furthermore, the invention concerns the use of deuterated 3-piperidinopropiophenones...
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7300946 |
N-(substituted arylmethyl)-4-(disubstituted methyl) piperidines and pyridines
It has now been found that certain novel N-(substituted aryl)-4(disubstituted methyl)piperidine and pyridine derivatives have provided unexpected insecticidal activity. These compounds are...
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7294637 |
Method of treating addiction or dependence using a ligand for a monamine receptor or transporter
One aspect of the present invention relates to a method of treating of drug addiction or drug dependence in a mammal, comprising the step of administering to a mammal in need thereof a...
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7291617 |
Arylamidine derivative or salt thereof
An arylamidine derivative represented by a general formula described below or a salt thereof has an excellent antifungal action and high safety, and it is useful as an antifungal agent with good...
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7291599 |
Use of inhibitors of enzymes having activities of amino peptidase N and/or dipeptidyl peptidase IV and of pharmaceutical preparations thereof for a therapy and prevention of chronical neurodegenerative diseases
The invention relates to a process for the treatment of neurodegenerative diseases wherein mis-folded proteins accumulate in characteristic lesions and contribute substantially to a pathogenesis...
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7285574 |
Methods for treating neural cell swelling
A composition comprising a novel Ca 2+ -activated, [ATP] i -sensitive nonspecific cation (NC Ca-ATP ) channel is described. The channel is found in mammalian neural cells and exhibits a different...
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7285568 |
Biaromatic compounds which activate PPARgamma type receptors and cosmetic/pharmaceutical compositions comprised thereof
Novel biaromatic compounds having the structural formula (I) below:
are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology,...
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7285565 |
Benzamides and related inhibitors of factor Xa
Novel benzamide compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or...
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7265133 |
Biphenyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I:
wherein a, b, c, m, p, s, t, W, Ar 1 , X 1 , R 1 , R 2 , R 3 , R 4 , R 6 , and R 7 are as defined specification. The compounds of formula I are...
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7265132 |
Compounds useful as reversible inhibitors of cysteine proteases
Disclosed are cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases....
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7253204 |
Inhibitors of histone deacetylase
The invention relates to the inhibition of histone deacetylase. The invention provides compounds and methods for inhibiting histone deacetylase enzymatic activity. The invention also provides...
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7244769 |
Methods for treating an impairment in memory consolidation
Impairments in memory consolidation are treated with an amphetamine compound. In one embodiment, the method includes administering an l-amphetamine compound. In another embodiment, the method...
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7241765 |
Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-aryl-piperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are...
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7241757 |
Amidino derivatives and their use as thrombin inhibitors
There is provided compounds of formula I
wherein R 1 , R x , Y, R y , n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases, such...
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7238710 |
EP4 receptor agonist, compositions and methods thereof
This invention relates to potent selective agonists of the EP 4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which...
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7238709 |
Therapeutic carbamates
This invention relates to hindered carbamate derivatives that are muscarinic receptor antagonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds.
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7229969 |
Combinations of enzyme inhibitors and the use thereof
Combination of inhibitors of dipeptidyl peptidase IV (DP IV) and enzymes having the same substrate specificity (DP IV-analogous enzymatic activity) and inhibitors of alanyl aminopeptidase...
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7229557 |
Method to separate stereoisomers
A method to resolve the stereoisomers of an optically active compound comprising an amine moiety. The method provides a mixture comprising two stereoisomers of a compound comprising a amine moiety....
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7223763 |
Substituted sulfonamides and ureas useful for inhibiting kinase activity
Sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said...
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7220752 |
Compounds active at the glucocorticoid receptor II
This invention relates to novel compounds that are liver selective glucocorticoid receptor antagonists, to methods of preparing such compounds, and to methods for using such compounds in therapy...
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7208488 |
N-substituted benzene sulfonamides
Disclosed are N-substituted benzenesulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease.
In Formula (I), R 1 , R 2 , R 3 , R 4 , R 3′ , R 10 and R...
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7205317 |
4[piperidin-4-yliden-(3-carbamoylpheny)methyl]benzamide derivatives and their use for the treatment of pain spinal injuries or gastrointestinal disorders
Compounds of general formula (I) wherein R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl and triazolyl; where each R 1 phenyl ring and R 1 ...
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RE39558 |
5-Substituted-6-cyclic-5,6,7,8-tetrahydronaphthalen 2-ol compounds which are useful for treating osteoporosis
Compounds of this formula
are useful for treating or preventing, obesity, breast cancer, osteoporosis, endometriosis, cardiovascular disease and prostatic disease.
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7202259 |
Therapeutic agents useful for treating pain
4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an...
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7186733 |
4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
Compounds of general formula I
R 1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; where each R 1 ...
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7183279 |
Histogranin-like peptides and non-peptides, processes for their preparation and uses thereof
The invention relates to new basic amino acid derivatives of general formulae I, II and III, and the preparation and use thereof in treatment of pain. The compounds have histogranin-like...
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7183253 |
Substantially pure glycopeptide antibiotics AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5
The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
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