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7619092 |
Piperidine compounds
The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene...
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7619005 |
Methods for treating cognitive impairment in humans with Multiple Sclerosis
Cognitive impairments in humans with multiple sclerosis are treated and cognition is improved with an amphetamine compound. In one embodiment, the method includes administering an l-amphetamine...
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7618967 |
Indane compounds
The invention provides novel indane compounds which are useful in the treatment of affective disorders, pain disorders, attention deficit hyperactivity disorder (ADHD), cognitive disorders,...
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7612096 |
Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of an immunomodulatory compound, or a pharmaceutically...
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7601844 |
Piperidinyl derivatives as modulators of chemokine receptor activity
The present application describes substituted piperidinyl modulators of MIP-1α or CCR-1 or stereoisomers or pharmaceutically acceptable salts thereof. In addition, methods of treating and...
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7601740 |
Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases
Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This...
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7598271 |
Crystalline paroxetine methane sulfonate
The invention relates to a compound, and pharmaceutically acceptable salts, having the formula I:
wherein:
R represents an alkyl or alkynyl group having 1-4 carbon atoms, or a phenyl...
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7595331 |
N-and O-substituted 4-[2-(diphenylmethoxy)-ethyl]-1-[(phenyl)methyl]piperidine analogs and methods of treating CNS disorders therewith
N- and O-substituted 4[2-diaromaticmethoxy and methylamino)alkyl]piperidines exhibit high CNS activity with respect to the dopamine transporter (DAT) and serotonin transporter (SERT). Preferred...
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7595329 |
Benzimidazolone carboxylic acid derivatives
This invention relates to compounds of the formula (I):
wherein R 1 , R 2 , R 3 , A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions...
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7592360 |
3-fluoro-piperidines as NMDA/NR2B antagonists
Compounds represented by Formula (I) or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for treating conditions such as, for example, Parkinson's disease,...
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7592359 |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
This invention generally relates to derivatives of substituted azabicyclo hexanes. The compounds of this invention can function as muscarinic receptor antagonists, and can be used for the treatment...
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7589107 |
Amelioration of vitrectomy-induced cataracts
Methods to prevent, inhibit, or slow the development of vitrectomy-induced cataracts are disclosed. The methods comprise administering to the eye of a subject a composition comprising an...
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7582766 |
Inhibitors of papilloma virus
The use of a compound of formula (II):
or its enantiomers or diastereoisomers thereof, or salts or pharmaceutically-acceptable esters thereof, in the treatment or prevention of a papilloma...
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7579465 |
Antiviral agents
This invention relates to compounds of formula I
their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the...
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7576102 |
Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation
The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general...
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7572790 |
Biphenyl carboxylic amide p38 kinase inhibitors
Compound of formula (I):
or pharmaceutically acceptable derivatives thereof, and their use as pharmaceuticals, particularly as p38 kinase inhibitors.
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7569586 |
Compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
This invention provides compounds of formula I:
wherein R 1 , R 2 , R 3 , R 4 ,R 5 , R 6 , R 7 , R 8a , R 8b , W, a, b, c and m are as defined in the specification, or a pharmaceutically...
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7560562 |
Piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
This invention relates to novel piperidine derivatives useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method...
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7560561 |
Process for production of piperidine derivatives
The present invention discloses processes for preparing piperidine derivative compounds of the formula:
wherein
n is 0 or 1; R 1 is hydrogen or hydroxy; R 2 is hydrogen; or, when n is...
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7560483 |
Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
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7557126 |
Diphenylmethyl compounds useful as muscarinic receptor antagonists
This invention provides compounds of formula I:
wherein a, b, c, e, m, n, Ar 1 , R 1 , R 2 , R 3 , R 4a , R 4b , R 5 and R 6 are as defined in the specification. The compounds of formula...
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7553872 |
Compounds and compositions for delivering active agents
Carrier compounds and compositions therewith which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.
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7547788 |
Alkyl substituted piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
This invention relates to novel alkyl substituted piperidine derivatives useful as monoamine neurotransmitter re-up-take inhibitors. In other aspects the invention relates to the use of these...
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7547693 |
Piperidine derivative
Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty...
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7538138 |
Amines as histamine-3 receptor ligands and their therapeutic applications
Compounds of formula (I)
or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the...
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7528154 |
Polyarylcarboxamides useful as lipid lowering agents
Polyarylcarboxamide compounds of formula (I)
are useful as lipid lowering agents.
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7528153 |
Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
The invention provides a new class of deoxynojirimycin analogues, or pharmaceutically acceptable salts thereof which can suitably be used for the treatment of a disease selected from the group...
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7524965 |
Dialkylphenyl compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity
This invention relates to compounds of formula I:
wherein R 1 and R 2 are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The...
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7524862 |
Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
Alkyne compounds of formula I
wherein A, B, W, X, Y, Z, R 1 , and R 2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical...
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7517991 |
N-sulfonylpiperidine cannabinoid receptor 1 antagonists
The present application describes compounds according to Formula I, wherein R 1 , R 2 , R 3 , R 4 , X and Y are described herein. Additionally, the present application describes pharmaceutical...
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7517892 |
Ligands for monoamine receptors and transporters, and methods of use thereof
One aspect of the present invention relates to heterocyclic compounds. A second aspect of the present invention relates to the use of the heterocyclic compounds as ligands for various mammalian...
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7507752 |
Biosynthetic gene cluster for the production of a complex polyketide
A polyketide synthase complex composed of polyketide synthase with 15 total modules, a non-ribosomal peptide synthetase with 1 module, and a cytochrome P450 hydroxylase is described. Also provided...
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7498345 |
Process for production of piperidine derivatives
Processes are disclosed for preparing piperidine derivative compounds of the formulae I, II or III:
The processes involve reacting a compound of formula Ia, IIa or IIIa
with isobutyrate or...
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7498344 |
Arylpiperidinol and arylpiperidine derivatives and pharmaceuticals containing the same
A pharmaceutical composition, especially a pharmaceutical composition for the alleviation or treatment of symptoms due to ischemic diseases and symptoms derived from seizures, epilepsy, and...
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7491724 |
Substituted cyclic hydroxamates as inhibitors of matrix metalloproteinases
The present invention provides compounds of the formula I:
its enantiomers, diastereomers, racemic mixtures thereof, prodrugs, crystalline forms, non-crystalline forms, amorphous forms thereof,...
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7485651 |
Compounds with activity on muscarinic receptors
Compounds and methods are provided for the alleviation or treatment of diseases or conditions in which modification of muscarinic m1 receptor activity has a beneficial effect. In the method, a...
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7485626 |
Combinations of enzyme inhibitor-containing preparations and the use thereof
The invention comprises a process wherein the DNA synthesis and, thus, the proliferation of mononuclear cells (MNZ) and of T cells as well is inhibited by the simultaneous and combined inhibition...
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7482365 |
Piperidylcarboxamide derivatives and their use in the treatment of tachykinin-mediated diseases
The present invention relates to piperidine derivatives of formula (I):
wherein R, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X, Y, m and n are as defined herein; and pharmaceutically acceptable salts...
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7473779 |
Derivatives of amidines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
Novel derivatives of amidines of formula
wherein the substituents are defined as in the specification which are useful for inhibiting activity on NO-synthase enzymes producing nitrogen mono...
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7459467 |
Manufacturing process for methyl phenidate and intermediates thereof
The present invention discloses selective and complete reduction of pyridine ring in a biaryl system comprising ∝-substituted or non-substituted benzene ring and relates more specifically, not...
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7456222 |
Anti tubercular drug: compositions and methods
Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the...
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7456197 |
Pyridinium cationic lipids as gene transfer agents
Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of...
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7449481 |
Thio-substituted biaryl-methanesulfinyl derivatives
The present invention is related to chemical compositions, processes for the preparation thereof and uses of the composition. Particularly, the present invention relates to compositions that...
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7449466 |
Cyclic aminophenyl sulfamate derivative
This invention provides cyclicamino-phenyl sulfamate derivatives represented by a formula
wherein each of R 1 and R 2 stands for hydrogen or lower alkyl; each of R 3 and R 4 stands for...
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7446115 |
Peptidomimetic ligands for cellular receptors and ion channels
One aspect of the present invention relates to novel peptidomometic compounds. A second aspect of the present invention relates to the use of the novel peptidomimetic compounds as...
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7442711 |
Amelioration of the development of cataracts and other ophthalmic diseases
Ophthalmically acceptable compositions used in arresting the development of cataracts or macular degeneration comprising a pharmaceutically acceptable carrier or diluent and a compound having the...
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7435851 |
Puleganic amides
The present invention provides substituted puleganic amides and compositions thereof, which are both useful as a topical treatment for skin, such as a repellant for insects and arthropods.
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7435824 |
Prodrugs of potassium channel inhibitors
Compounds useful as prodrugs of potassium channel inhibitor compounds, in particular as prodrugs of Kv1.5 channel inhibitors.
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7432284 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7425554 |
1,2-di(cyclic)substituted benzene compounds
In one aspect, the present invention provides compounds having formula (1) or (100), a salt thereof or a hydrate of the foregoing, which compounds exhibit excellent cell adhesion inhibitory action...
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