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6417184 |
Triple drug therapy for the treatment and prevention of acute or chronic pain
A triple drug therapy, pharmaceutical kit, composition, and method of treatment regimen utilized as a combination of effective amounts of an anxiolytic agent, centrally acting alpha antiadrenergic...
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6410548 |
Spiropiperidine derivatives as melanocortin receptor agonists
Certain novel spiropiperidine compounds are agonists of melanocortin receptor(s) and are useful for the treatment, control or prevention of diseases and disorders responsive to the activation of...
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6410538 |
Benzamidine derivatives
Benzamidine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof are provided. These compounds have an effect of inhibiting activated...
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6403612 |
Thrombin receptor antagonists
A thrombin receptor antagonist having the formula or a pharmaceutically acceptable salt thereof, useful for inhibiting the aggregation of blood platelets. The compounds can be used in a method...
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6399632 |
Method of providing an antihistaminic effect in a hepatically impaired patient
The present invention relates to a method of providing an antihistaminic effect in a hepatically impaired patient in need thereof comprising administering to said patient an effective...
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6395752 |
Method of treating depression using 1-threo-methylphenidate
A method of treating dysphoria or depression is disclosed in a patient which comprises the step of administering orally or non-orally to said patient, a therapeutically effective amount of...
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6391871 |
Preventing neuronal degeneration in Alzheimer's disease
A method of treating Alzheimer's disease is disclosed, not just with palliatives, but in a manner that prevents the progressive degeneration caused by Alzheimer's disease. Certain types of...
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6376548 |
Enhanced propertied pesticides
This invention relates to enhanced propertied pesticides which can be used as fungicides, herbicides, insecticides, rodenticides or biocides, compositions comprising enhanced propertied pesticides,...
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6369078 |
Solenopsin derivatives and analogues as fire ant suppressants
The present invention relates to solenopsin alkaloid derivatives which are trans-2,6-disubstituted piperidines according to the structure: wherein R 1 and R 2 are selected from a C 1 to C 20 ...
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6369090 |
Fungicidal mixture
Fungicidal mixtures comprise a.1) a carbamate of the formula I.a, in which X is CH or N, n is 0, 1 or 2 and R is halogen, alkyl or haloalkyl, or a.2) the oxime ether carboxamide of the formula...
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6365592 |
Phosphonic and carboxylic acid derivatives as inhibitors of protein tyrosine phosphatase-1B (PTP-1B)
The invention encompasses compounds represented by formula I: as well as compositions and methods of treatment. The compounds are inhibitors of the PTP-1B enzyme.
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6362203 |
4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same
Described is a 4-hydroxy-4-phenylpiperidine derivative represented by the following formula (1): [wherein, R 1 and R 2 are the same or different and each independently represents a hydrogen...
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6362212 |
Oxime derivative and bactericide containing the same as active ingredient
A compound represented by general formula (I) or a salt thereof, a process for producing the same, an intermediate for the production thereof, and a bactericide (fungicide) containing the same as...
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6358977 |
Use of 4-piperidinemethanol derivatives in treatment of neurodevelopmental disorders
Disclosed is the use of a compound with Formula (I) wherein n is 2, 3, or 4, and R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, C 1-6 alkyl, halogen, trifluoromethyl, hydroxy, C 1-6 ...
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6355695 |
Substituted heterocycles
Compounds of formula I wherein Q 1 , Q 2 , Q 3 , Q 4 and Q 5 have any of the meanings given in the specification, their N-oxides, and their pharmacuetically acceptable salts are nonpeptide...
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6353004 |
Peripherally acting anti-pruritic opiates
Anti-pruritic compositions and methods of using the compositions for the prevention or treatment of pruritus comprising: wherein: R, R 2 , R 3 , R 4 , R 7 , Ar 1 and Ar 2 are as defined in the...
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6342509 |
Piperidine quaternary salts- CCR- 3 receptor antagonists
This invention relates to certain piperidine quatemrwy salts of Formula (I): that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods...
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6335348 |
Nitrogen-containing linear and azepinyl/ compositions and uses for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal, using...
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6333340 |
Small molecule sulfonamides for vision and memory disorders
This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance in an animal using...
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6329390 |
5-Bicycloindole compounds
Disclosed herein are compounds selective for a 5-HT 1D receptor, the compounds having the general formula (I): ##STR1## Also disclosed is the use of these compounds as pharmaceuticals to treat...
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6326372 |
Lactam and cyclic urea derivatives useful as alpha 1a adrenoceptor antagonists
Lactam and cyclic urea derivatives and their pharmaceutically acceptable salts are disclosed. The synthesis of these compounds and their use as alpha 1a adrenergic receptor antagonists is also...
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6323038 |
Diagnostic reagent for complications associated with diabetes or renal failure
In view of the situation of the prior art, the present invention specifies the structure of a late-stage product of Mailard reaction in vivo having a close relation with various tissue disorders,...
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6323219 |
Methods for treating immunomediated inflammatory disorders
This invention relates to methods ands compositions for bringing about changes in skin pigmentation and for treating inflammatory disorders. More particularly, this invention relates to compounds...
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6316467 |
Elevation of HDL cholesterol by 4-[(Aminothioxomethyl)-hydrazono]-N-(substituted)-4-arylbutanamides
Compounds of this invention increase plasma levels of high density lipoprotein or HDL, the "good" cholesterol and as such may be useful for treating diseases such as atherosclerosis. These...
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6303637 |
Heterocyclic potassium channel inhibitors
The present invention relates to a class of heterocyclic compounds of Formula I that are useful as potassium channel inhibitors to treat autoimmune disorders, cardiac arrhythmias, and the like....
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6300332 |
Methods for reducing respiratory depression and attendant side effects of mu opioid compounds
A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed...
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6291479 |
Use of NR2B-selective NMDA-receptor antagonists for the treatment of ophthalmic diseases
The invention is directed to the use of improved NR2B antagonists for the prevention and treatment of retinal or optic nerve head damage in mammals. Compositions and methods are disclosed.
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6291530 |
Aryl-substituted acrylamides with Leukotriene B4 (LTB-4) receptor antagonist activity
##STR1## Disclosed are compounds of formula (I) wherein W is CH or N; R is (mono- or di cabocyclic or heterocyclic aryl)-lower alkyl; R 1 is hydrogen or lower alkyl; R 2 and R 3 are hydrogen,...
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6288071 |
1-ethylene-2-alkylene-1,4-cyclohexadiene pesticides
Pesticidally active cyclohexadienyl derivative compounds of the formula I that are esters, oximes or amides are claimed. These compounds may be used as fungicides, acaricides and insecticides in...
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6284805 |
Plastics container containing stabilized drug formulation
A plastics container containing a sterile aqueous solution of an acid addition salt of a 1-alkyl-N-(2,6-dimethylphenyl)-2-piperidinecaboxamide, wherein the solution is buffered.
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6284773 |
Therapeutic combinations comprising a selective estrogen receptor modulator and prostaglandin E2
This invention is directed to pharmaceutical combination compositions and methods comprising (-)-cis-6-phenyl-5-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-5,6
,7,8-tetrahydr onaphthalene-2-ol or a...
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6277836 |
Methods and compositions for treating inflammatory bowel disease
The present invention provides a method and composition of medications use to treat inflammatory bowel disease. The invention further provides combinations of anti-atypical mycobacterial agents...
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6277864 |
Use of R- +)-α-(2,3-dimethoxyphenyl-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol for the treatment of sleep disorders
A method of treating a patient for a Sleep Disorder comprising administering an effective amount of R-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4
-piperidi nemethanol or a...
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6274596 |
Benzoquinoline derivatives useful as antibacterial agents
Disclosed are pharmaceutical compositions and formulations comprising benzoquinoline derivatives having the formula (I) to (V), wherein formula (I) is: ##STR1## X is selected from the group...
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6274599 |
Cisapride extended release
The present invention concerns extended release formulations comprising cisapride-(L)-tartrate, in particular an oral formulation, the use thereof as a medicine, especially in treating...
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6265421 |
Phospholamban inhibitors and a method for increasing coronary flow
A method for obtaining direct dilatation of the coronary arteries by administering a therapeutically effective amount of a phospholamban inhibitor is described. Compounds which are effective in...
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6265404 |
Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants
This invention is directed to benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives which are useful as anti-coagulants. This invention is also directed to...
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6262072 |
Orally administered antimicrobial pharmaceutical formulations of ciprofloxacin
The invention provides three orally administered ciprofloxacin formulations: The first formulation comprises 60-75 wt % of ciprofloxacin or at least one of pharmacologically acceptable salt; 0.3-10...
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6262078 |
Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain
Compounds selected from the group of compounds represented by Formula I: ##STR1## as an individual isomer or as a racemic or non-racemic mixture of isomers, and their pharmaceutically acceptable...
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6262081 |
Composition for and method of treating neurological disorders
The invention relates to a method of treating neurological disorders associated with neurotransmitter deficit in a mammal comprising administering to the mammal a therapeutically effective amount...
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6251918 |
Aniline derivatives as calcium channel blockers
The present invention provides compounds that block calcium channels having formula (I). The present invention also provides methods of using the compounds of formula (I) to treat stroke, cerebral...
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6245783 |
Method of using neurotrophic sulfonamide compounds
This invention relates to a method of using neurotrophic low molecular weight, small molecule sulfonamide compounds having an affinity for FKBP-type immunophilins, as inhibitors of the enzyme...
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6242468 |
Carbamate and urea compositions and neurotrophic uses
This invention relates to pharmaceutical compositions and methods for effecting a neuronal activity using low molecular weight, small molecule carbamates and ureas having an affinity for FKBP-type...
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6235791 |
Use of amines to produce drugs for preventing tumor cell proliferation
The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of...
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6221898 |
Amidino derivatives and their use as thrombin inhibitors
There is provided compounds of formula I, ##STR1## wherein R 1 , R 2 , R 3 , Y, n and B have meanings given in the description which are useful as competitive inhibitors of trypsin-like proteases,...
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6221883 |
Method of dopamine inhibition using l-threo-methylphenidate
This invention provides methods of effecting dopamine inhibition in a mammal by administering to the mammal l-threo-MPH which is substantially free from d-threo-MPH. Also provided by the invention...
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6211172 |
Methods and compositions for controlling biofouling using sulfonamides
The present invention relates to a method to inhibit bacteria from adhering to a submergible surface. The method contacts the submergible surface with an effective amount of at least one...
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6207682 |
Modified release formulations containing (R)-1-(10,11-dihydro-5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1propyl)-3-pipe ridinecarboxylic acid
Modified release formulations with zero-order drug release containing (R)-1-(3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene
)-1-propyl)-3- piperidinecarboxylic acid, or a pharmaceutically...
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6207681 |
Methods and compositions for treating urinary incontinence using enantiomerically enriched (R)-trihexyphenidyl
A method for treating urinary incontinence, such as incontinence resulting from bladder detrusor muscle instability, using enantiomerically enriched (R)-trihexyphenidyl. The method comprises...
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6194435 |
Lactams as selective factor Xa inhibitors
Novel lactams, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of Formula I below: ##STR1## are useful in vitro or in vivo for...
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