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4244963 |
1-[2-(Alkyl and arylsulfonyl)-2-propenyl and propyl] substituted piperidines useful as antimicrobial and antiinflammatory agents
1-[2-(Alkyl and arylsulfonyl)-2-propenyl and propyl] substituted piperidines of the formula: ##STR1## where A is ##STR2## and R 1 -R 5 are various substituents, are useful as antimicrobial and...
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4241071 |
Antidepressant (α-phenyl-2-tolyl)azacycloalkanes
Novel azacycloalkanes, azacycloalkenes and derivatives thereof and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants, tranquilizers and...
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4241058 |
Heterocyclics useful as fungicides and fungicidal compositions thereof
Heterocyclic compounds characterized by the formula ##STR1## wherein R 1 , R 3 , R 4 , R 5 , R 6 , X and z are as hereinafter set forth, prepared, inter alia, by reacting a compound characterized...
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4239759 |
Morpholino containing compounds, compositions and use thereof
Compounds of the formula R--A--Z wherein R is a 4-biphenylyl or 4-phenoxyphenyl or a corresponding group monosubstituted or polysubstituted by one or more of F, Cl, and Br; A is --CH(CH 3 )--CH 2...
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4237141 |
Derivatives of α-methyl-β-aminopropiophenone and use thereof
Novel α-methyl-β-aminopropiophenone derivatives having bronchodilator activity represented by the following general formula: ##STR1## where R represents alkyl having 1-6 carbon atom benzyl or...
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4235896 |
Benzyl-phenoxy acid esters and hyperlipaemia compositions containing the same
Compounds of the formula ##STR1## in which A is lower alkyl, or a substituted or unsubstituted phenyl, thienyl, furyl, indolyl or thiaindolyl radical, R, X 4 and X 5 are hydrogen or lower alkyl,...
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4235914 |
Psychotropic γ-(heterocyclic substituted) butyrophenones
Butyrophenone compounds having excellent psychotropic activity and represented by the formula: ##STR1## wherein Z is defined hereinbelow.
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4233298 |
Esters of p-carbonylphenoxy-isobutyric acids
This invention is concerned with esters of p-carbonylphenoxy-isobutyric acids of the general formulae: ##STR1## wherein R is a phenyl group substituted by one or two halogen atoms; R' is H, CH 3...
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4228187 |
Alkyl and cycloalkylthiophenylalkylaminoalkanols, their salts and the preparation thereof
Amino-alcohols of the formula ##STR1## wherein R 1 represents either a linear or branched chain alkyl radical having 1 to 4 carbon atoms, or a cycloalkyl radical having 5 or 6 carbon atoms; R 2 ...
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4225608 |
Phenoxy heterocyclic amines and use thereof
Phenoxyalkylamines of the formula Ar--O--R wherein Ar is phenyl or phenyl which is monosubstituted or disubstituted by F, Cl, Br, alkyl or alkoxy each of 1-4 carbon atoms, cycloalkoxy of 3-6...
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4198419 |
Phenylthiophenylpiperidines
Novel phenylthiophenylpiperidines and methods of preparing same are described. These compounds are useful as analgetics, antidepressants, anticonvulsants and intermediates for preparing other...
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4198417 |
Phenoxyphenylpiperidines
Novel phenoxyphenylpiperidines and methods of preparing same are described. These compounds are useful as analgetics, antidepressants, anticonvulsants and intermediates for preparing other...
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4191771 |
Analgesic method using 1,3,4-trisubstituted-4-arylpiperidines
1,3,4-Trisubstituted-4-arylpiperidines are used to impart analgesia and to treat narcotic addiction.
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4191765 |
1-Aryloxy-2-hydroxy-3-aminopropanes
Compounds of formula I ##STR1## wherein R 1 and R 1 ' are identical or different and represent hydrogen, an alkyl radical or alkoxy radical having 1-4 carbon atoms, the allyl group, a halogen atom...
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4190668 |
Stabilized aqueous amide antimicrobial composition
Aqueous antimicrobial compositions which comprise a halogenated amide antimicrobial, such as 2,2-dibromonitrilopropionamide, a water miscible organic solvent such as a straight chain polyalkylene...
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4188396 |
New phenylazacycloalkanes
New 4-(phenyl)-piperidine compounds of the general formula I ##STR1## in which R 1 represents hydrogen or lower alkyl, Ph represents a p-phenylene group optionally substituted by lower alkyl,...
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4186185 |
Compositions comprising arylene substituted poly(orthoesters) containing useful agents
This invention concerns polymeric orthoesters having a repeating mer comprising a hydrocarbon radical and an orthoester functionality of the general formula: ##STR1## wherein R 1 is a monovalent...
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4182776 |
Method of treating lipidemia with aryloxyalkylaminobenzoic acids and esters
Aryloxyalkylaminobenzoic acids and esters as hypolipemic compounds.
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4180583 |
Olefinic 4-substituted piperidino derivatives as therapeutics
Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##STR1## wherein R and R 1 each represent hydrogen; or R and R 1 ...
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4163790 |
Method for increasing coronary blood flow in mammals
Compounds of the following general formula are useful for increasing coronary blood flow in mammals: ##STR1## wherein R is hydrogen, acetyl, p-fluorobenzoylpropyl, carbamoyl, N-methylcarbamoyl,...
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4148923 |
1-(3'-Trifluoromethylthiophenyl)-2-ethylaminopropane pharmaceutical composition and method for treating obesity
Trifluoromethylthiophenylethylamine derivatives, made from the corresponding acid chlorides by successive reduction, condensation with nitroethane, reduction, and condensation with an amine,...
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4140770 |
Benzoylethers and processes for their production
Processes for preparing benzoylethers, their acid additive salts and their quaternary ammonium salts are disclosed. These compounds have useful pharmacodynamic properties.
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4138485 |
Phenylalanine derivatives
This invention relates to certain derivatives of phenylalanine having interesting pharmaceutical properties, in particular, a lipid-lowering activity.
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4115570 |
Morpholine compounds and methods of use
Compounds of the formula ##STR1## wherein A is alkylene, R 1 , R 2 , and R 3 are hydrogen or lower alkoxy, and R 4 is ##STR2## in which R 5 and R 6 are hydrogen or lower alkyl, with the proviso...
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4110447 |
Anti-inflammatory (halo-4-biphenylyl)-alkanolamines
Compounds of the formula R--A--Z wherein R is 4-biphenylyl or 4-phenoxyphenyl or a corresponding group monosubstituted or polysubstituted by one or more of F, Cl and Br; A is --CH(CH 3 )--CH 2 ...
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4105795 |
Antispasmodic substituted sulphoximides
This invention provides compounds of the general formula I ##STR1## wherein R 1 and R 2 independently represent groups selected from the group consisting of straight chain alkyl groups; branched...
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4104383 |
Derivatives of phenylpropenylamine
Compounds having psychostimulant, antispasmodic, hypotensive and analgesic properties are disclosed. The compounds have the formula: ##STR1## in which R 2 is selected from the group consisting of...
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4104380 |
Dibenzyl glycolic acid derivatives
The present invention is concerned with new dibenzylglycolic acid derivatives and with the preparation thereof. These derivatives show an extraordinary anti-hypertensive and antisecretory profile.
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4101662 |
Method for inhibiting emesis and compositions therefor
1,4-(3-)Disubstituted piperidines are disclosed which have useful antiemetic properties. The compounds have the general formula: ##STR1## wherein R is halogen, R 1 is hydrogen and halogen, n is a...
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4098889 |
Antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides
Novel antithrombotic 2-(aminoalkylthio)-N,N'-p-phenylenebissulfonamides, a method for inhibiting blood platelet aggregation, and pharmaceutical compositions.
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4094976 |
Anticoccidial cyclicamino ethanols and esters thereof
Novel anticoccidial poultry compositions comprising an anticoccidially effective amount of a compound of the formula: ##STR1## wherein n is 3, 4 or 5 and R is hydrogen or an acyl radical derived...
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4078066 |
Cyclohexane tetrols and derivatives thereof
The compounds of the invention have the formula ##STR1## wherein Y is a radical of the formula ##STR2## or of the formula ##STR3## WHEREIN (CH 2 ) is a straight or branched chain alkyl radical, n...
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4070461 |
Biphenylyl ethers
Biphenylyl ethers of the formula ##STR1## and their physiologically acceptable acid addition salts exhibit pharmaceutically useful serum cholesterol and triglyceride lowering, fibrinolytic,...
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4066747 |
Polymeric orthoesters housing beneficial drug for controlled release therefrom
This invention concerns polymeric orthoesters having a repeating mer comprising a hydrocarbon radical and an orthoester functionality of the general formula: ##STR1## wherein R 1 is a monovalent...
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4065584 |
Sulphur containing arylamine derivatives
The invention provides new compounds of the formula: Ar--SO Y --Alk--NR 1 R 2 in which Ar represents a phenyl group, a phenyl group substituted by one or more C 1 -C 4 alkyl, CF 3 and COOH...
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4060609 |
Biphenylyl ethers and method of use
Biphenylyl ethers of the formula R--O--CH 2 --CR 1 (OH)--CH 2 Z wherein R 1 is H or CH 3 ; Z is dialkylamino of 2-8 carbon atoms, morpholino, pyrrolidino, piperidino, homopiperidino,...
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4056632 |
2-Hydroxymethyl-2'-aminomethyl-diphenylsulfides and method of use
Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a...
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4056630 |
Diphenylpropylamines for treating depression
1,1-DIPHENYL-2-HYDROXY-3-AMINOPROPANE DERIVATIVES ARE USEFUL FOR THEIR PSYCHOTROPIC ACTIVITY AND, IN PARTICULAR, ARE USEFUL AS ANTIDEPRESSANTS.
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4049827 |
Method of treating arrhythmia with diarylbutanolamines
4,4-Diphenyl-2-hydroxybutylamines are prepared by condensing amines with 1,2-epoxy-4,4-diphenylbutanes. The new compounds exist in the free base form, as acid addition salts and quaternary ammonium...
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4021565 |
Process for the alleviation of depression by administration of non-addicting meperidine analogues
A process is provided for the alleviation of depression by administration of meperidine analogues corresponding to the formula: ##STR1## in which R 1 and R 2 are each lower alkyl or allyl.
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4016280 |
4,4-Diarylpiperidine compositions and use
4,4-Diarylpiperidine compounds, preferably 4,4-diphenylpiperidine which are substituted or unsubstituted in the 1-position of the piperidine nucleus, such as 1-(lower...
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4011332 |
Hemorrhagic-lesion producing and anticoagulant-containing compositions and their use
A combination of a physiologically-active component which produces hemorrhagic gut and/or stomach lesions and a physiologically-active component which inhibits blood clotting, ingested by a rodent...
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3995047 |
Propiophenone derivatives in the treatment of pathological muscular conditions
New propiophenone derivatives prepared by the reaction of propiophenone, formaldehyde and piperidine, as well as pharmacologically acceptable acid-addition salts thereof are provided, which possess...
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3985887 |
3-Substituted-4-hydroxyphenyl-2-piperidylcarbinols as β-adrenergic stimulants
3-Substituted-3-hydroxyphenyl-2-piperidylcarbinols are prepared. These compounds are β-adrenergic stimulants and are useful in particular as bronchodilators.
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3968218 |
Cosmetic composition containing a hydroxylated amino thioether for application to the hair and skin
A method and composition for combatting the greasy and unaesthetic appearance of the hair and to improve the appearance of the skin comprises in a carrier at least one active component of the...
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3966949 |
Pharmaceutical compositions and preparing same
Water-insoluble therapeutic agents having a tertiary nitrogen capable of being protonated are stabilized and solubilized via the formation of water-soluble lipophilic liquid fatty acid salts.
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3965257 |
Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions
Novel compounds useful as antihistamine agents, antiallergy agents, and bronchodilators are represented by the following formula ##SPC1## Wherein R represents hydrogen or hydroxy; R 1 represents...
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3934015 |
Oral male antifertility method and compositions
A class of substituted 2-cycloalkylaminoalkylphenols, preferably D,L-6-(N-α-pipecolinomethyl)-5-hydroxyindane, enantiomers thereof and acid addition salts thereof have been found to exhibit oral...
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3843794 |
PHARMACEUTICAL COMPOSITIONS COMPRISING HYDROXYPHENYL-2-PIPERIDINYLCARBINOLS
Hydroxyphenyl-2-piperidinyl carbinols prepared by the condensation of an appropriately substituted ether derivative of a hydroxybenzaldehyde with 2-pyridyl lithium followed by removal of the ether...
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3683086 |
DERIVATIVES OF ACETIC ACID FOR THE ALLEVIATION OF HYPERLIPEMIA
The compounds are of the class of bis-(4-trifluoromethylphenoxy) acetic acid compounds, e.g., bis-(4-trifluoromethylphenoxy)acetic acid 1-methyl-4-piperidyl ester. The compounds are useful as...
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