Matches 651 - 700 out of 791 < 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >
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4530925 Aminocyclopentane esters and pharmaceutical formulations  
Compounds are described of the formulae (1a) and (1b) ##STR1## in which: --COR 1 is an ester group, n is 1 or 2, W is C 1 -7 alkylene, X is cis or trans --CHCH or --CH 2 CH 2 --, ...
4524146 Certain -2-heterocycle substituted pyrazoloquinolines  
Pyrazolo[4,3-c]quinolin-3-ones of the formula ##STR1## e.g. wherein R 1 is an aromatic heterocyclic radical selected from quinolyl, isoquinolyl, pyrimidyl and thiazolyl, or such said heterocyclic...
4508724 Aryloxymethylpyrrolidinols and piperidinols having antidepressant, antiarrhythmic or hypotensive activity  
Novel aryloxymethylpyrrolidinols and piperidinols are provided of the formula: ##STR1## wherein R 1 is hydrogen, loweralkyl and phenylloweralkyl; R 2 is hydrogen, loweralkyl and acyl; R 3 is...
4485109 4-Aryl-4-piperidinecarbinols  
4-Aryl-4-piperidinecarbinols, for example, ##STR1## useful as antidepressants and, in some cases, as anorectic agents.
4485105 Method of treating hyperlipidemia with 4-(monoalkylamino)benzoic acid amides  
This disclosure describes a method of treating hyperlipidemia and atherosclerotic lesions with 4-(monoalkylamino)benzoic acid amides and compositions therefor.
4474751 Ophthalmic drug delivery system utilizing thermosetting gels  
This invention describes the application of selected polymers as novel drug delivery systems which use the body temperature and pH to induce a liquid to gel transition of the polymer which contains...
4472412 Control of fungi using phenylpropylammonium salts  
A fungicidal agent contains a phenylpropylammonium salt of the formula ##STR1## where R 1 , R 2 and R 3 are each hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted aryl or...
4454158 Allyl amine MAO inhibitors  
Compounds of the formula ##STR1## wherein: R is phenyl, phenyl monosubstituted, disubstituted, or trisubstituted by (C 1 -C 8 ) alkyl, (C 1 -C 8 )alkoxy, hydroxy, chlorine, bromine, iodine,...
4444780 Method for treating atopic dermatitis  
A method for treating atopic dermatitis with cyproheptadine or its acid addition salt is described.
4443460 2-[4-(Diphenylmethylene)-1-piperidinyl]-acetic acids and their amides  
New 2-[4-(diphenylmethylene)-1-piperidinyl]-acetic acids and their amides, processes for the preparation thereof and therapeutic compositions. These compounds have the formula ##STR1## wherein...
4442113 Long-term weight reduction of obese patients using femoxetine  
A method for assisting with appetite and weight control and reduction in obese human patients, which comprises the step of orally or rectally administering an appetite-suppressant compound selected...
4435398 Guanidine compounds  
Compounds of the formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. The compounds are useful as anthelmintics.
4430334 Phenethanolamine derivatives for use against cerebrovascular disease  
Phenethanolamine derivatives in the (+)-erythro form of the formula: ##STR1## wherein X represents a halogen atom, are new compounds useful in therapy.
4426386 Substituted phenyl piperidines  
Compounds of the formula ##STR1## wherein n is 1 or 2, Y is OH, R 1 COO--, R 2 R 3 NCOO-- or R 4 O whereby R 1 is an alkyl group, or a possibly substituted phenyl group, R 2 is an alkyl,...
4425352 Substituted phenoxyacetates of cyclic amines  
The invention relates to substituted phenoxyacetates of cyclic amines. These compounds are of the formula: ##STR1## wherein X is chlorine, fluorine or the trifluoromethyl radical n is 0 or 1, ...
4419363 Alkanolamine derivatives  
Novel 1-aryloxy-3-amidoamidoalkylamino-2-propanol derivatives, processes for their manufacture, pharmaceutical compositions containing them and methods of using them in the treatment of heart...
4418079 Conjugated ketone compounds in preventing platelet thrombosis  
Conjugated ketone compounds of the formula: ##STR1## wherein Ar is naphthyl, furyl, thienyl, or phenyl optionally bearing one or more substituents selected from the group consisting of chlorine,...
4414219 Antidepressant (α-phenyl-2-tolyl)azacycloalkanols and derivatives thereof  
Novel azacycloalkanes, azacycloalkenes and derivatives thereof and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants, tranquilizers and...
4414220 Organic diamine therapeutic compositions  
A series of organic diamine base compounds derived from either an aromatic, alicyclic or heterocyclic ring and possessing, for the most part, an intervening methylene group between the ring and the...
4409206 Transdermal release system for pharmaceutical preparation  
This invention is directed to a pharmaceutical preparation for transdermal application, which comprises a film comprising a skin-compatible polyacrylate, which swells in water and a...
4395410 Quaternary ammonium antiarrhythmic drugs  
Quaternary ammonium salts of certain phenylpropylamines and phenylbutylamines are useful antiarrhythmic drugs. A method for treating arrhythmia and prolonging the action potential of cardiac tissue...
4391827 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor  
Cycloalkanones, cycloalkanols and unsaturated analogs thereof, each of which has at the 3-position a 2-hydroxy-4-substituted phenyl group wherein the 4-position substituent is alkyl which can have...
4390537 1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, compositions and use  
1-(Substituted-aminoalkoxyphenyl)-2-methylene-1-alkanones, a class of compounds possessing anti-allergic properties for use in the treatment of allergic conditions, such as asthma prepared by...
4383999 Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters  
N-Substituted azaheterocyclic carboxylic acids and their esters, useful as inhibitors of GABA uptake, are prepared by reacting an appropriate N-alkylating derivative with an ester of an...
4371530 Aminocyclopentanone amides and pharmaceutical formulation  
Compounds are described of the formula ##STR1## in which R 1 is unsubstituted or substituted phenylalkyl, thienylalkyl or naphthylalkyl, or cinnamyl; R 2 is a hydrogen atom, methyl or alkyl...
4362738 Esters and amides containing the 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetyl moiety  
Compounds of the formula ##STR1## wherein each X, which may be identical or different from the other X, is oxygen or imino; R 1 is hydrogen, fluorine, chlorine or bromine; R 2 and R 3 ,...
4361573 α,α-Diaryl-β-(tert-amino)-propanols and diuretic pharmaceutical compositions containing them  
α,α-Diaryl-β-(tert-amino)-propanols having the general formula: ##STR1## wherein R', R" and R 1 to R 10 represent certain specific substituent groups, exhibit a diuretic and saluretic...
4358450 O-Alkylated oximes and pharmaceutical composition thereof  
Compounds of general formula ##STR1## wherein R 1 represents a member selected from the group consisting of (a) an unsubstituted at most binuclear aryl group having from 6 to 10 carbon atoms, such...
4347252 Rodenticidal 1-(3,5-bistrifluoromethylphenyl)-3-(4-t-butylpiperidino)prop-1-yne  
The hitherto unknown phenylpropargylamine derivative 1-(3,5-bistrifluoromethylphenyl)-3-(4-tert-butylpiperidino)p rop-1-yne, and acid addition salts thereof, have been found to be useful for...
4344952 Method of treating diarrhoea with gamma-piperidino-butyrophenones  
A method of treating diarrhoea and promoting weight gain in mammals by administration of an effective amount of a compound selected from the group consisting of...
4342756 Aminocyclopentane alkenoic acids and esters and pharmaceutical compositions  
Compounds are described of the formula ##STR1## (and their salts and solvates) in which: X is cis or trans --CHCH--; R 1 is C 1 -7 alkyl terminated by --COOR 3 where R 3 is H, C 1 -6 alkyl...
4342762 Basic ethers and pharmaceutical compositions containing the same  
The invention relates to novel basic ethers of the general formula /I/ and pharmaceutically acceptable acid addition salts and quaternary salts thereof, ##STR1## wherein R 1 and R 2 may be the...
4335124 1-Alkyl, 1-phenyl-butenes  
The compounds are 4-phenyl-4-lower alkyl-substituted-3-buten-2-ones, and -2-halo-1,3-butadienes, e.g., 2-(p-biphenylyl)-2-penten-4-one, and are useful as pharmaceuticals.
4333941 Inhibition of enveloped viruses with phenyl ketones  
Enveloped viruses such as rhabdoviruses, herpes viruses, influenza viruses, α viruses and paramyxo viruses are inactivated by contacting the viruses or virus infected cells with a...
4323568 Pharmaceutically active (omega-aminoalkoxy)bibenzyls  
(Omega-aminoalkoxy)bibenzyls are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.
4311703 Antidepressant and tranquilizing (α-phenyl-2-tolyl)-azacycloalkenes  
Novel azacycloalkanes, azacycloalkenes and derivatives thereof and methods of preparing same are described. These compounds are useful as antidepressants, anticonvulsants, tranquilizers and...
4294841 Derivatives of 1-phenyl 3-(4-piperidyl) 1-propanone usable as drugs  
A drug useful as antiarhythmic, antidepressant and anxiolytic containing as an active agent a compound of the formula ##STR1## wherein X and Y are the same or different and represent hydrogen or...
4291041 Alicyclic piperidine derivatives as insect repellents  
A number of alicyclic carboxamides of the formula ##STR1## wherein n, R 1 , R 2 , and R 3 are defined hereinbelow have been found to be useful insect repellents.
4291059 Cycloaliphatic compounds, analgesic compositions thereof and method of use thereof as analgesics  
Compounds are disclosed of general formula (I) ##STR1## in which R 1 represents a hydrogen atom, a halogen atom or a group OR 2 , in which R 2 represents a hydrogen atom, an alkyl group or an...
4285957 1-Piperidine-alkanol derivatives, pharmaceutical compositions thereof, and method of use thereof  
Novel compounds of the following formula: ##STR1## wherein R 1 is hydrogen or hydroxy; R 2 is hydrogen; or R 1 and R 2 taken together form a second bond between the carbon atoms bearing R 1 ...
4285958 1-Piperidine-alkylene ketones, pharmaceutical compositions thereof and method of use thereof  
Pharmaceutically useful compounds of the following formula: ##STR1## wherein R 1 represents hydrogen or hydroxy; R 2 represents hydrogen; or R 1 and R 2 taken together form a second bond...
4284632 3-Pyrrolin-2-one derivatives and compositions  
New 3-cyclicaminoalkoxy-4-phenyl-3-pyrrolin-2-ones are disclosed. These compounds exhibit anti-hypertensive and vasodilatory action.
4284638 Pharmaceutical compositions with central depressant and antipsychotic activity having a butyrophenone derivative which is substituted in the 4-position and a C-(2-benzofuranyl)-piperidine or C-(2-benzofuranyl)-tetrahydro-pyridine  
The invention relates to pharmaceutical compositions which contain, as active ingredients, a butyrophenone derivative I which is basically substituted in the 4-position and has central depressant...
4284635 Analgesic 1,2,4,5-tetra-alkyl-4-arylpiperidines  
4-Phenylpiperidines bearing substituents at the 1,2,4 and 5-positions are potent analgesics. Pharmaceutical formulations containing such compounds and a method for effecting analgesia are provided.
4283404 Aroylethenylpiperidinobutyrophenone antipsychotic agents  
4-Aroylethnyl-1-piperidinobutyrophenone derivatives and pharmaceutically acceptable salts thereof of the following general structure: ##STR1## wherein R is hydrogen, alkyl, alkoxy, halogen or...
4273787 1-Alkyl,1-phenyl-butenes  
The compounds are 4-phenyl-4-lower alkyl-substituted-3-buten-2-ones, and -2-halo-1,3-butadienes, e.g., 2-(p-biphenylyl)-2-penten-4-one, and are useful as pharmaceuticals.
4259337 Method for using m-trifluoromethylphenyl-piperidines  
Novel m-trifluoromethylphenyl-piperidines of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, branched or straight chain alkyl of 1 to 5 carbon atoms, alkenyl of 3...
4256745 New prostane derivatives and process for their preparation  
Prostan-1-ol esters and intermediates for their preparation are described; the former compounds exhibit improved organ specificity and a longer duration of activity at lower dosages than the...
4254130 Piperidine derivatives  
Pharmaceutically useful compounds of the following formula: ##STR1## wherein R 1 represents hydrogen or hydroxy; R 2 represents hydrogen; or R 1 and R 2 taken together form a second bond...
4252804 Therapeutically useful 3,4,5-trimethoxybenzene derivatives  
Compounds of the formula I ##STR1## wherein m and n are 0, 1 or 2, X represents oxygen, imino, benzylimino, or morpholinoethylimino, Y represents CO, CONH, COO or SO 2 , and NR 1 R 2 represents a...
Matches 651 - 700 out of 791 < 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 >