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4837236 |
Fungicidal morpholine compounds, and their production and use
A heterocyclic compound of the formula: ##STR1## wherein A is an oxygen atom or a sulfur atom; B is either one of the groups: --CH 2 --CHR 1 -- or --CHCR 1 -- (in which R 1 is a hydrogen...
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4835164 |
Aryloxymethyl derivatives of nitrogenous heterocyclic methanols and ethers thereof
Novel heterocyclicmethanols are disclosed having the formula: ##STR1## wherein Z is pyrrolidinyl, piperidinyl, homopiperidinyl or pyridinyl; R 1 is hydrogen, loweralkyl or carbethoxymethyl; R 2...
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4822802 |
Method of fentanly administration for postoperative pain relief
A method of postoperative pain relief using transdermal delivery of fentanyl or its analgetically effective derivatives preceded by a dose of said material to increase the serum drug levels to...
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4822778 |
Membrane stabilizing phenoxy-piperidine compounds and pharmaceutical compositions employing such compounds
Compounds of the formula (I) ##STR1## optically active isomers thereof, and/or pharmaceutically acceptable acid addition salts thereof are disclosed, wherein R 1 is selected from the group...
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4820717 |
Antimicrobial aromatic derivatives substituted by an (omega amino) alkanol group and compositions containing them
The present invention relates to new aromatic derivatives of formula: ##STR1## wherein: Alk is an alkylene group with 1 to 10 carbon atoms, R 1 is hydrogen or an alkyl with 1 to 6 carbon atoms,...
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4810713 |
Arylalkyl-heterocyclic amines, n-substituted by aryloxyalkyl groups used in a method for allergy treatment
A method of treating allergy with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain novel...
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4808630 |
Method of treating psychotic illnesses
This invention is directed towards methods for treating patients having a psychotic illness such as schizophrenia and/or inhibiting the occurrence of movement disorders in patients receiving or...
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4792555 |
Phospholipase A.sub.2 inhibitors
There are disclosed compounds of the formula ##STR1## wherein R 1 is lower alkyl, lower alkoxycarbonyl lower alkyl, aralkoxycarbonyl, aralkoxycarbonyl lower alkyl or indol-2-yllower alkyl; R 2 ...
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4788130 |
1-amino-2,3-dihydro-1H-indene compounds
Novel 2,3-dihydro-1H-indene derivatives and salts thereof represented by the general formula (1), ##STR1## [wherein R 1 and R 2 are each a hydrogen atom, a lower alkyl group, a phenyl group which...
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4783471 |
N-aralkyl piperidine methanol derivatives and the uses thereof
This invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives...
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4767775 |
Substituted pyrazolin-5-ones, composition containing them, and method of combating fungi or bacteria
Microbicidal substituted pyrazolin-5-ones of the formula ##STR1## in which R 1 and R 2 independently of one another each represent hydrogen, alkyl, alkenyl, alkinyl, cyanoalkyl, hydroxyalkyl,...
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4760061 |
Ether and ester derivatives of phenols
Mono- or bis-complex esters or ethers of a phenol derivative of the formula NU--A--X--R 1 wherein NU is a defined mono- or bis-phenolic nucleus including a hydroxyphenyl-hydroxynaphthyl;...
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4758564 |
Ether and thioether amines and their use as fungicides
Amines of the general formula ##STR1## where A is alkyl, alkenyl, cycloalkyl, cycloalkenyl, phenylalkyl or phenylalkenyl, X is oxygen or sulfur, B is an alkylene chain and R 1 and R 2 are each...
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4755522 |
Derivatives of N-[3-(2,4,6-trimethoxybenzoyl)propyl]piperidine, and their use in therapeutics
This invention is drawn to compounds of the formula: ##STR1## in which R is --CH 2 OH, --COOH and --COOR 1 , R 1 being a C 1 to C 4 alkyl group, and their pharmaceutically acceptable salts. The...
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4753954 |
Fungicidal compositions and methods of combatting fungi employing a synergistic combination of propiconazol and fenpropidin
Combinations of the fungicides propiconazol and fenpropidin, which are both inhibitors of ergosterol biosynthesis, exhibit a synergistically enhanced activity against fungi. The active components...
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4738960 |
1,3,4-Thiadiazole derivatives and pharmaceutical preparations useful as inhibitors for histamine-H.sub.2 receptors
1,3,4-Thiadiazole derivatives corresponding to the general formula I ##STR1## which constitute highly effective inhibitors for histamine-H 2 receptors are described. These compounds in addition...
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4729999 |
Antiestrogen therapy for symptoms of estrogen deficiency
The invention involves a method for treating symptoms secondary to estrogen deficiency without using estrogen. Weakly estrogenic antiestrogens are administered to estrogen deficient women in the...
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4725593 |
Method of treating smooth muscle spasm
A new method of treating a patient suffering smooth muscle spasm comprises administering to the patient an effective amount of anti-spasmodic compound having the general formula: ##STR1## where R...
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4719219 |
Phenyl-azacycloalkanes and use thereof in treatment of central nervous system disorders
Compound of the formula ##STR1## wherein n is 1 or 2, Y is OH, R 1 COO--, R 2 R 3 NCOO-- or R 4 O whereby R 1 is an alkyl group, or a possibly substituted phenyl group, R 2 is an alkyl,...
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4707480 |
Method for stabilizing a detrusor muscle while increasing detrusor muscle strength
A method for inhibiting unplanned or premature detrusor muscle contractions while at the same time increasing the force of contraction of the detrusor muscle is provided. The method comprises...
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4705795 |
(2,4,6-trimethoxyphenyl)-(3-piperidinopropyl)-ketone derivatives
The present invention relates to new derivatives of (2,4,6-trimethoxyphenyl)-(3-piperidinopropyl)-ketone which are selected from the group consisting of: (i)...
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4701461 |
Substituted cyclic amines
Compounds of the formulae: ##STR1## wherein, Z and Y are each alkylene or oxy-alkylene containing one to about five carbon atoms in the principal chain or said alkylene subtituted with OH,...
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4690931 |
Therapeutically useful 1-phenyl-2-piperidinoalkanol derivatives
Compounds of the formula: ##STR1## wherein R 1 is hydrogen, halogen, trifluoromethyl, alkyl, hydroxyl, alkyoxy, benzyloxy, alkanoyloxy, or benzoyloxy, or when R 2 is hydroxyl or methoxy in the...
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4678780 |
Anti-spasmodic agents having a ring in the main chain
A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where R, X, m, n and p are defined hereinbelow.
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4673683 |
Fungicidal piperidine derivatives
and its plant-tolerated acid addition salts, excluding the compounds where, simultaneously, R 4 is hydrogen, acetyl or propionyl, n is 0 or 1 and R 1 , R 2 and R 3 are hydrogen, and fungicides...
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4671953 |
Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics
The present invention is directed to methods and compositions for noninvasively administering drugs having a sedative, analgesic, or anesthetic effect. A drug capable of absorption through mucosal...
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4659714 |
Anesthetic methods for mammals
Improved methods of anesthesia for mammals, especially humans, are provided wherein the prolonging effect upon local anesthesia which is exhibited by co-administration of vasoconstrictors,...
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4659721 |
Alkanol derivatives, and pharmaceutical preparation containing these compounds
Alkanol derivatives corresponding to the general formula I R 1 R 2 N--(CH 2 ) m --Q--CH 2 X--CH 2 --Y--(CH 2 ) n --NHR 3 (I) which have a highly selective action on...
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4656180 |
Diamine derivatives and pharmaceutical preparations containing these compounds
Diamine derivatives corresponding to the general formula I R 1 R 2 N--(CH 2 ) m --Q--A--NH--R--NH--B--Q'--(CH 2 ) n NR 3 R 4 (I) which have a highly selective action on histamine-H 2 ...
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4647562 |
Anti-spasmodic agents having three branch chains
A new class of anti-spasmodic compounds having three branch chains is provided. These compounds have the general formula: ##STR1## where R 1 , R 2 and R 3 are saturated straight chain or branched...
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4647557 |
Novel heterocyclic derivatives bearing an amino radical, processes for their production and the pharmaceutical compositions containing them
This invention relates to novel heterocyclic derivatives bearing an amino group and to processes for making said compounds. More particularly this invention provides novel heterocyclic compounds...
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4645774 |
Aminoethoxybenzylalcohol derivatives, process for their preparation and pharmaceutical compositions containing them
The invention relates to new aminoethoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R 1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy...
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4632929 |
Method of hypertensive treatment using phenyl-alkylene-2-pyridyl derivatives
Compounds of the formulae: ##STR1## wherein, Z and Y are each alkylene or oxy-alkylene containing one to about five carbon atoms in the principal chain or said alkylene substituted with OH,...
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4616017 |
Aminohydroxypropoxy substituted aryl compounds
Novel tertiary aminohydroxypropoxy substituted aryl compounds exhibit α 1 -adrenoceptor and serotonin antagonism and are also useful as antihypertensive agents.
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4613597 |
Aminocyclopentanes and their preparation and pharmaceutical formulation
Compounds are described of the formulae (1a) and 1b) ##STR1## in which: R 1 is -H, C 1 -6 alkyl or C 7 -10 aralkyl, W is C 1 -7 alkylene X is cis or trans --CHCH--, Y is a saturated...
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4612320 |
Aminopropanol derivatives of 1-(2-hydroxyphenyl)-3-phenylpropanols and therapeutic agents containing these compounds
Compounds of the general formula ##STR1## where R 1 , R 2 , R 3 , R 4 and n have the meanings given in the description, are useful for treating cardiac disorders.
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4610995 |
Certain 1,1-diaryl-propenyl-3-(1-pyrrolidino-2-carboxylic acids, derivatives thereof and their anti-histaminic properties
The invention provides a compound of the formula (I): ##STR1## or a salt, ester or amide thereof; wherein R 1 is hydrogen or C 1 -4 alkyl and R 2 is C 1 -4 alkyl substituted by a group R 3 CO 2 ...
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4605673 |
7H-dibenzo(a,c,)cyclohepten-5-one-(7) derivatives
The invention is concerned with 7H-dibenzo(a,c)-cyclohepten-5-one-(7) derivatives of general formula I ##STR1## wherein R 1 and R 2 can be the same or different, a hydrogen atom, an alkyl radical...
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4599346 |
Propan-2-ol derivatives, a process for their production and medicaments containing these compounds
The invention relates to new propan-2-ol derivatives corresponding to the following general formula ##STR1## in which R represents ##STR2## and to salts thereof with pharmacologically acceptable...
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4599419 |
Pharmaceutically active (3-cyclic aminopropoxy)bibenzyls as inhibitors of platelet aggregation
(3-Aminopropoxy)bibenzyl derivatives are prepared and found useful as pharmaceutical agents, particularly as inhibitors of platelet aggregation.
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4593036 |
(-)-Trans-4-(4-fluorophenyl)-3-[(4-methoxyphenoxy)meth yl]-1-methylpiperidine useful as 5-HT potentiator
The compound (-)-trans-4-(4-florophenyl)-3-[(4-methoxyphenoxy)methyl]-1-m
ethylpiperidin e and pharmaceutically-acceptable acid addition salts thereof, pharmaceutical compositions thereof, and...
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4593037 |
1,3-disubstituted piperidine compounds as neuroleptic agents
Certain novel 1-(substituted-alkyl)-3-(3-hydroxyphenyl)piperidine compounds, and the pharmaceutically-acceptable acid-addition salts thereof, possess pharmaceutical activity as neuroleptic agents,...
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4585777 |
(-)-Trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiperidine for potentiating 5-HT
The compound (-)-trans-4-(4-fluorophenyl)-3-(4-methoxyphenoxy)methylpiper
idine and pharmaceutically-acceptable acid addition salts thereof, pharmaceutical compositions thereof, and their use in...
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4569941 |
Method of using phenyl-alkylene-2-pyridyl derivatives to increase cardiac contractility in a mammal
Compounds of the formulae: ##STR1## wherein, Z and Y are each alkylene or oxy-alkylene containing one to about five carbon atoms in the principal chain or said alkylene substituted with OH,...
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4567176 |
4H-Imidazol-4-ones and their pharmaceutical use
This invention relates to Mannich-furyl(thienyl, pyridyl or phenyl) alkylaminoimidazolinones which have histamine H 2 -antagonist activity. A specific compound of this invention is...
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4565821 |
Method and ophthalmic composition for treating ocular hypertension and glaucoma with butyrophenones
Aqueous humor formation and intraocular pressure in mammals having ocular hypertension or glaucoma may be reduced by topically administering to a hypertensive eye an ophthalmologically acceptable...
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4560553 |
Use of eucalyptol for enhancing skin permeation of bio-affecting agents
Eucalyptol is used to enhance skin permeation of bio-affecting agents.
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4551465 |
Piperidine derivatives and pharmaceutical compositions containing them
The invention relates to new piperidine derivatives of the formula (I) ##STR1## wherein R 1 is halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon...
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4543353 |
Ester and amide derivatives of 13,14-didehydro prostaglandins
Esters of 13,14-didehydro prostaglandins have been prepared.
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4534978 |
Perfluorocycloamines
Perfluorocycloamines represented by the general formula: ##STR1## wherein either or both of ring A and ring B may be substituted with lower perfluoroalkyl group(s), m and n are independently 4, 5,...
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