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5059620 |
Aryl substituted aminomethyl benzene derivatives
The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R 1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole,...
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5057524 |
4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders
Novel compounds useful in the treatment of allergic disorders and having the formula: ##STR1## where Ar and Ar 1 are pyridinyl, phenyl, or substituted phenyl and where Y is --OH,--O .crclbar . M...
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5055474 |
2,3-dihydro-1H-indene derivatives and their use as pharmaceutical agents
Novel 2,3-dihydro-1H-indene derivatives and salts thereof represented by the general formula (1), ##STR1## [wherein R 1 and R 2 are each a hydrogen atom, a lower alkyl group, a phenyl group which...
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5053430 |
Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments, new 2,7-diamino-1,2,3,4-tetrahydronaphthalenes and processes for their preparation
Novel compounds having the general formula ##STR1## wherein R 1 , R 2 , R 3 and R 4 are as defined herein. These compounds are useful in the treatment of schizophrenia.
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5049568 |
Liquid pharmaceutical composition for piperidinoalkanol derivatives
The present invention relates to a liquid pharmaceutical composition comprising (a) a piperidinoalkanol in an amount of from about 2 to about 25 mM; (b) a suitable buffer, selected from the group...
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5049214 |
Aerosol-forming pyrotechonic composition
A mixture containing 3,3-bis(aziodomethyloxetane) and EA3834A for use, when gnited, as a physiologically activating agent against enemy personnel on the battlefield by friendly forces.
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5047229 |
Treatment of cardiovascular and cerebral toxicity using calcium modulators
Calcium modulators can be effectively used to treat cardiovascular and cerebral toxicity induced by materials that alter the normal interaction of neurotransmitters with the calcium transport...
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5047432 |
Arylcyclobutylmethylamine therapeutic agents
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof; in which R 1 and R 2 , which are the same or different, are H or an optionally substituted hydrocarbon group or R 1 ...
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5045547 |
Leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas and use thereas
Lipoxygenase-inhibiting and leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas of the formula ##STR1## and physiologically acceptable salts thereof.
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5039528 |
EAA antagonists as anti-emetic drugs
This invention relates to a method and a class of pharmaceutical agents for suppressing vomiting, nausea, and other emetic symptoms. The method involves administering to a susceptible mammal a...
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5036077 |
1-(benzylpiperidino)propan-2-ol derivatives, their preparation, their use as antimicrobial agents and the products in which they are present
The invention relates to compounds of the formula: ##STR1## in which: Ar represents a phenyl group substituted by R 2 , R 3 and R 4 , or a naphth-1-yl or naphth-2-yl group, unsubstituted or...
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5023266 |
Method of treatment of psychotic disorders
Ifenprodil and its analogues are useful for the treatment of psychoses such as schizophrenia.
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5023073 |
Method of combating flupropadine poisoning using phenothiazines
Antidotes to the rat poison flupropadine and substances acting in the same way include compounds which modulate (e.g. inhibit) aminergic systems in the gut or adrenal tissues. Such compounds...
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5021428 |
Novel chemical compounds for the prophylactic treatment of migraine
The invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives...
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5019582 |
Piperidine compounds and their preparation and use
Novel piperidine compounds having the formula ##STR1## wherein R 3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C 1 -6 -alkyl, C 1 -6 -alkoxy,...
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5017585 |
Method of treating calcium overload
Novel piperidine compounds having the formula ##STR1## wherein R 3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more halogen, C 1 -6 -alkoxy,...
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5015648 |
Use of a thromboxane receptor antagonist in pregnancy-induced hypertension and related conditions
The use is described of [1R-[1α(Z),2β,3β,5α]]-(+)-7-[5-[[(1,1'-biphenyl)-4-y l]methoxy]-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-hepteno
ic acid or a physiologically acceptable salt, solvate...
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5006523 |
Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
Novel compounds of the formula ##STR1## and tautomers thereof are disclosed. These compounds possess potassium channel blocking activity and, as such, are useful as antiarrhythmic agents.
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5002974 |
Anesthetic/skin moisturizing composition and method of preparing same
A long lasting, esthetically pleasing medicated skin care moisturizing composition comprising (1) an oil phase comprising oil from about 30% to about 80% and a non-ionic surface active agent...
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5002958 |
Hypotensive agent
4'-ethyl-2-methyl-3-piperidinopropiophenone or a pharmacologically acceptable salt thereof is useful as a hypotensive agent.
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4987146 |
N-hetaryl imidazole derivatives
N-hetaryl imidazole derivatives of general Formula I ##STR1## are disclosed in which Het represents an optionally substituted monocyclic or bicyclic heteroaromate, R 3 represents hydrogen, a...
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4987132 |
Saturated heterocyclic carboxamide derivatives
A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity. ##STR1##
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4983614 |
Benzhydryloxyethylpiperidine derivatives, process for their preparation and pharmaceutical compositions, in which they are present
The invention relates to benzhydryloxyethylpiperidine derivatives corresponding to one of the formulae below: ##STR1## in which: R 1 , R 2 , R 3 and R 4 , which are identical or different,...
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4977163 |
Aminocyclopentanol acids and esters and their preparation and pharmaceutical formulation
Compounds are described of the formula ##STR1## in which R 1 is H, C 1 -6 alkyl or C 7 -10 aralkyl; W is C 1 -7 alkylene; X is cis or trans --CHCH-- or --CH 2 CH 2 --; n is 1 or 2; ...
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4968676 |
Fungicidal cyclohexylamines
Cyclohexylamines of the formula ##STR1## where X is a single bond or an alkylene chain, Y is hydrogen or an aryl, cyclohexyl, 4-cyclohexylcyclohexyl, perhydro-1- or 2-naphthyl or piperidyl radical,...
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4960798 |
Methods for the treatment of angina
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
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4957927 |
(Diarylmethoxy alkyl)-1-pyrrolidines and piperidines having cardiovascular activity
1-[(diarylmethoxy)alkyl]pyrrolidines and piperidines represented by the following formula: ##STR1## wherein X is hydrogen or a fluorine atom, Alk is a linear-chain or branched alkyl group having...
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4957941 |
Anti-spasmdoic agents having an acetylenic bond
A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula: ##STR1## where Y is H or OH; j is an integer from 0 to 4; k is an integer...
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4950674 |
Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment
A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which...
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4933346 |
Diarylalkyl piperazine derivatives, a process for their preparation, their use, and medicaments containing them
Compounds I are described ##STR1## with R 1 equal to (cyclo)alk(en)yl or ##STR2## R 2 /R 3 equal to phenyl or phenylalkyl, A equal to ##STR3## m equal to 2-4, and n equal to 1-4. Compounds I and...
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4933367 |
Carboxylic acid derivatives, processes for the preparation thereof, the use thereof, and pharmaceutical compositions which contain these compounds
This invention relates to carboxylic acid derivatives and their use thereof. The compounds are useful in treatment of various diseases such as diabetes, prediabetic conditions, adipositas ailments...
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4929605 |
Pharmaceutical composition for piperidinoalkanol derivatives
A pharamaceutical composition in solid unit dosage form comprising (a) a therapeutically effective amount of a piperidinoalkanol compound, or a pharmaceutically acceptable salt thereof, (b)...
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4927634 |
Pharmaceutical compositions containing dyclonine HC1 and phenol
Novel pharmaceutical compositions of matter are disclosed for use in eliciting a topical anesthetic and antimicrobial response, preferably for oral health care purposes, said compositions...
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4918082 |
Anti-spasmodic agents containing quaternary nitrogen
A new class of anti-spasmodic compounds having two branch chains is provided. The compounds have the general formula ##STR1## where R 2 is a radical selected from the group consisting of ##STR2##...
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4917894 |
Rapid-onset long-duration oral anesthetic composition
An oral anesthetic composition comprising an anesthetically effective amount of a compound of formula (I) ##STR1## wherein R is alkyl of 2 to 8 carbon atoms or a pharmaceutically acceptable salt...
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4912117 |
Novel chemical compounds
This invention relates to a new class of compounds having important biochemical and pharmacological properties. More particularly, this invention relates to N-aralkyl piperidinemethanol derivatives...
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4912116 |
Propiophenone derivatives for treatment of pollakiuria (frequency urination)
A method for the treatment of pollakiurea in a subject in need thereof, comprising the step of administering to said subject an effective antipollakiurea amount of a propiophenone of the formula...
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4898889 |
Methods for the treatment of hypertension
Acetylene compounds of the formula (I): ##STR1## wherein Y, R 1 , R 2 , R 3 , and R 4 are as described herein, m is 0-3, n is 0-2 and Ar is phenyl or an aromatic heterocycle are disclosed. The...
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4897397 |
Aryl-alkynoic, alkenoic or alkanoic compounds and compositions useful as antiallergy and anti-inflammatory agents
Certain aryl-alkynoic, alkenoic and alkanoic acids and derivatives and their use in treating inflammation, allergy and hyperproliferative skin disease are disclosed.
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4894373 |
Antiestrogens and their use in treatment of menopause and osteoporosis
Disclosed is a method for treating menopausal symptoms and treating and preventing osteoporosis, wherein a true antiestrogen is administered and estrogen is not. This treatment is effective for...
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4882342 |
5-alkylbenzimidazoles, method of use and pharmaceutical compositions
The present invention concerns new 5-alkylbenzimidazoles of the formula: ##STR1## wherein R 1 is a phenyl ring of the formula: ##STR2## or R 1 is naphthyl, heterocycle or a bicyclic heterocycle...
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4880800 |
Aminocyclopentyl ethers and pharmaceutical formulation
Compounds are described of the formula ##STR1## where: R 1 is --H or --CH 3 , n is 1, m is 2-4 and X is --CHCH-- or --CH 2 CH 2 --; Y is a saturated heterocyclic amino group, R 2 is...
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4879300 |
Novel piperidine derivatives
A compound, or a solvate or salt thereof, of formula I: ##STR1## in which: R.CO-- is an acyl group containing a substituted or unsubstituted carbocyclic aromatic or heterocyclic aromatic group; ...
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4877799 |
Method of treating calcium overload in brain cells of mammals
Novel piperidine compounds having the formula ##STR1## wherein R 3 is 3,4-methylenedioxyphenyl, aryl or heteroaryl which are optionally substituted with one or more C 1 -6 -alkyl, C 1 -6 -alkoxy,...
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4877798 |
Treatment of fibromyalgia
The present invention relates to a method for relieving or alleviating the symptomatology associated with fibromyalgia comprising administering to a patient a compound as described by Formula I.
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4871748 |
Phenylpropargylamine derivatives
Compounds of the formula: ##STR1## wherein R represents hydroxymethyl, alkoxymethyl of 2 to 6 carbon atoms, optionally substituted phenoxymethyl, alkanoyloxymethyl of 3 to 10 carbon atoms,...
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4870083 |
1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants
The present invention relates to 1,4-disubstituted-piperidinyl compounds and their use as analgesic agents and as muscle relaxants.
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4863966 |
Pesticidal amines
Compounds of formula (I) are pesticides having activity against arthropods: ##STR1## wherein R 1 , R 2 and R 3 are H, alkyl, alkoxy, halo, cyano or trifluoromethyl, or two of R 1 , R 2 and R 3 ...
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4857525 |
Quaternary ammonium retinoates, their use in cosmetics and in dermopharmacy
Quaternary ammonium retinoate, characterized in that it corresponds to the formula: ##STR1## in which: X-- denotes either an all-trans-retinoate of formula (I): ##STR2## or a 13-cis= retinoate of...
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4839155 |
Iodotamoxifen derivatives and use for estrogen receptor-positive breast cancer detection and therapy
Iodotamoxifen derivatives which are compounds of formula (3) ##STR1## wherein X represents 3- or 4- iodo and R 1 and R 2 , which may be the same or different, represent C 1 -3 alkyl, especially...
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