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9023854 5-halogen-substituted oxindole derivatives and use thereof for treating vasopressin-dependent diseases  
The present invention relates to novel 5-halogen-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
9018200 Substituted piperidinyl compounds useful as GPR119 agonists  
Substituted piperidinyl compounds of the formula (I): are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts are included as...
8999971 Methods for increasing the stabilization of hypoxia inducible factor-1 alpha  
Disclosed herein are methods for controlling the activity of hypoxia-inducible transcription factor 1-alpha (HIF-1α) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral...
8987303 AMPK-activating heterocyclic compounds and methods for using the same  
Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted...
8962656 CCR2 antagonists  
The present invention relates to novel antagonists for CCR2 (CC chemokine receptor 2) of formula (Ia) and their use for providing medicaments for treating conditions and diseases, especially...
8952004 CXCR3 receptor antagonists  
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R3, A, B, X, and n are as defined herein. The invention also relates to...
8940774 Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors  
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylcholine receptors. Also provided are methods of using the compounds for modulating the function of a...
8937086 Compounds for the treatment of pathologies associated with aging and degenerative disorders  
The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject,...
8921394 Prolylcarboxypeptidase inhibitors  
Compounds of structural formula (I) are inhibitors of prolylcarboxypeptidase (PrCP). The compounds of the present invention are useful for the prevention and treatment of conditions related to the...
8921395 Crystalline forms of a biphenyl compound  
The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamin o}ethyl)piperidin-4-yl ester, and pharmaceutically acceptable...
8916555 3,5-diaminopyrazole kinase inhibitors  
Provided herein are 3,5-diaminopyrazoles, for example, compounds of Formula IA, that are useful for modulating regulated-in-COPD kinase activity, and pharmaceutical compositions thereof. Also...
8889716 Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof  
Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt...
8889670 Heterocyclic compounds which modulate the CB2 receptor  
Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those...
8871770 Carboxamide compounds and methods for using the same  
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x...
8865641 Methods of treatment of fatty liver disease by pharmacological activation of cholinergic pathways  
A method of treating a fatty liver disease in a subject. The method comprises administering to the subject an effective amount of a cholinergic pathway stimulating agent, wherein the fatty liver...
8865702 B1-antagonists  
Disclosed are compounds of the formula I wherein A, Y, R1, R2, R3, R4 and R5 are defined, suitable for treating diseases and symptoms of diseases caused at least to some extent by stimulation of...
8846675 N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders  
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control.
8841323 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors  
The present invention relates to novel compounds, in particular novel pyridinone derivatives according to Formula (I) wherein all radicals are defined in the application and claims. The compounds...
8835419 Substituted anilines as CCR(4) antagonists  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
8815857 Soluble guanylate cyclase activators  
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical...
8815869 Lactam acetamides as calcium channel blockers  
The present application relates to calcium channel inhibitors containing compounds of formula (I) wherein Ar1, n, R1, X and Y are as defined in the specification. The present application also...
8815905 Propionic acids, propionic acid esters, and related compounds  
The invention relates to propionic acids, propionic acid esters, and related compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds for the...
8809362 Anticancer agent sensitivity-determining marker  
To provide a marker for determining sensitivity of a patient to an anti-cancer agent, and novel cancer therapeutic means employing the marker. The marker for determining sensitivity to an...
8795699 Wasp repellents  
A method of repelling wasps, which method comprises using a preparation comprising (a) one or more of ethyl 3-(N-n-butyl-N-acetylamino)propionate, dihydronepetalactone, and extract of catmint, and...
8796254 Methods for using carboxamide, sulfonamide and amine compounds  
Disclosed are uses of carboxamide, sulfonamide and amine compounds for the treatment and amelioration of disorders and conditions related to oxidative stress, mitochondrial dysfunction, free...
8791136 Substituted pyridine, pyridazine, pyrazine and pyrimidine compounds and methods for using the same  
Disclosed are substituted pyridine compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure wherein E, J, T, the ring system denoted...
8785449 Carboxamide compounds and methods for using the same  
Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R1, R2, R3, R4, D, J, Z, T, p, q, w and x...
8778929 Substituted heteroaryl inhibitors of B-RAF  
The present invention relates to new compounds of general formula (I), wherein the groups R1 to R3, X1, X2, X3 and L1 are defined as in claim 1, which are suitable for the treatment of diseases...
8765764 2-acylaminothiazole derivative or salt thereof  
A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on...
8741894 Arylsulfonamide CCR3 antagonists  
Provided herein are arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing,...
8735426 Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them and use thereof for treating pain and other conditions  
Compounds corresponding to formula I: which act as vanilloid receptor ligands, pharmaceutical compositions containing such compounds, a process for the producing such compounds, and the use...
8729081 Compositions and methods for treating alcohol use disorders, pain and other diseases  
The present invention provides compounds which antagonize epsilon protein kinase C (PKCε). These compounds have a structural formula (Ia), (Ic) or (II). The present invention also provides...
8722742 Chemical compounds having antiviral activity against Dengue virus and other Flaviviruses  
Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the...
8716312 Inhibitors of diacylglycerol acyltransferase  
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use...
8716313 Crystalline forms of a biphenyl compound  
The invention provides crystalline forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamin o}ethyl)piperidin-4-yl ester, and pharmaceutically acceptable...
8703774 Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases  
The present invention relates to novel carbamate-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
8703803 Tris-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors  
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a...
8703775 Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses  
The present invention relates to novel amidomethyl-substituted oxindole derivatives, pharmaceutical compositions comprising them, and their use for the treatment of vasopressin-dependent disorders.
8697727 N-substituted-heterocycloalkyloxybenzamide compounds and methods of use  
The present invention provides N-substituted-heterocycloalkyloxybenzamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment of the invention is a compound having...
8691845 Tetra-O-substituted butane-bridge modified NDGA derivatives, their synthesis and pharmaceutical use  
The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified...
8691846 Piperidine sulphonamide derivatives  
The present invention relates to piperidine sulphonamide derivatives of formula wherein Ar1, Ar2, R1, R2, m and n are as defined in the description and claims, or pharmaceutically suitable acid...
8685959 Substituted benzimidazoles and benzopyrazoles as CCR(4) antagonists  
Benzimidazole, benzopyrazole and benzotriazole compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft...
8658636 TRPV4 antagonists  
The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
8653107 Fentanyl composition for nasal administration  
The treatment of acute pain with a sufficient dosage by intranasal administration of fentanyl results in a time to onset of action comparable to intravenous administration and a significantly...
8648094 IAP BIR domain binding compounds  
Disclosed herein is an isomer, enantiomer, diastereoisomer or tautomer of a compound represented by Formula I: or a prodrug, or a pharmaceutically acceptable salt, or labeled with a detectable...
8648067 Substituted phenoxypropylcycloamine derivatives as histamine-3 (H3) receptor ligands  
The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.
RE44733 6-mercapto-cyclodextrin derivatives:reversal agents for drug-induced neuromuscular block  
Disclosed is a 6-mercapto-cyclodextrin derivative having general formula (I) wherein m is 0-7 and n is 1-8 and m+n=7 or 8; R is (C1-6)alkylene, optionally substituated with 1-3 OH groups, or...
8623857 N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1  
The present invention provide Imidazole Carboxamide Compounds of Formula (I): wherein D, T, R1, R2, R3, and R6 are as defined herein, and pharmaceutically acceptable salts of such Imidazole...
8598206 Trypsin-like serine protease inhibitors, and their preparation and use  
The invention provides compounds that are effective as inhibitors of human plasmin and plasma kallikrein, and that are useful for the prevention of blood loss and as components of fibrin...
8575168 Compounds and compositions as modulators of GPR119 activity  
The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity...