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7615566 |
Substituted pyrrolidine and related compounds
This invention is directed to compounds of formula I:
wherein R 1 -R 5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof. The...
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7612096 |
Methods for treatment, modification and management of radiculopathy using 1-oxo-2-(2,6-dioxopiperidin-3yl)-4-aminoisoindoline
Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of an immunomodulatory compound, or a pharmaceutically...
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7612093 |
Compositions of treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-D-glucitol compounds in combination therapy
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
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7598269 |
Methods and compositions for treating amyloid-related diseases
Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-+related disease.
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7598249 |
Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states,...
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7595329 |
Benzimidazolone carboxylic acid derivatives
This invention relates to compounds of the formula (I):
wherein R 1 , R 2 , R 3 , A and m are each as described herein or a pharmaceutically acceptable salt or solvate thereof, and compositions...
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7589107 |
Amelioration of vitrectomy-induced cataracts
Methods to prevent, inhibit, or slow the development of vitrectomy-induced cataracts are disclosed. The methods comprise administering to the eye of a subject a composition comprising an...
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7576101 |
Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents
The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions...
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7572792 |
Azetidine glycine transporter inhibitors
The present invention is directed to azetidine compounds that inhibit the glycine transporter GlyT1 and which are useful in the treatment of neurological and psychiatric disorders associated with...
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7563789 |
1-Adamantyl chalcones for the treatment of proliferative disorders
The present invention relates to the compounds of the general formula (I), a composition for and a method of treating breast cancer or other proliferative disorders in a subject using a compound of...
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RE40851 |
3,3-diphenylpropylamines, their use and preparation
The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R 1 signifies hydrogen or methyl, R 2 and R 3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl,...
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7553837 |
Phenylazole compounds production process and antioxidants
The present invention is directed to compounds represented by the formula (1): B-D-Z (1), wherein B represent the following formula (B-1), (B-2) or (B-3);
A represents an optionally substituted...
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7547693 |
Piperidine derivative
Provided are a histamine-H3 receptor antagonist; and a preventive and/or a remedy for metabolic system diseases such as obesity, diabetes, hormone secretion disorder, hyperlipemia, gout, fatty...
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7541476 |
Radiolabeled astemizole and method of making
The present invention provides a radiolabeled astemizole of formula (III)
and a process for preparing the radiolabeled astemizole of formula III.
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7541045 |
Concentrated, non-foaming solution of quaternary ammonium compounds and methods of use
A concentrated quaternary ammonium compound (QAC) solution comprising a QAC with a concentration from greater than about 10% by weight and at least one solubility enhancing agent, such as an...
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7534814 |
Mutilin derivatives and their use as antibacterials
A compound of formula
wherein R 2 is arylene or heterocyclene; or R and R 2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues...
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7528152 |
Hemiasterlin derivatives and uses thereof in the treatment of cancer
The present invention provides compounds having formula (I):
and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of cancer, wherein...
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7524867 |
Tetrasubstituted imidazole derivatives as cannabinoid CB1 receptor modulators with a high CB1/CB2 receptor subtype selectivity
The present invention relates to 1,2,4,5-tetrasubstituted imidazole derivatives as selective cannabinoid CB 1 receptor modulators, in particular CB 1 receptor antagonists or inverse agonists...
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7514453 |
Method for enhancing mutant protein activity
Provided is a method for enhancing the activity of a protein, which protein when mutated, folds in an incorrect conformation in the endoplasmic reticulum, by contacting the protein with an...
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7507767 |
Cannabinoid receptor ligands
There are disclosed compounds of the formula
a prodrug thereof, or a pharmaceutically acceptable salt, solvate or stereoisomer of the compound or of said prodrug; which exhibit...
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7501439 |
Tartrate salt of isofagomine and methods of use
A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine...
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7495111 |
Compounds useful as serotonin inhibitors and 5-HT1A agonists and antagonists
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Such compounds are useful for modulating activity of a 5-HT 1A receptor (agonizing or...
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7495012 |
Arylsulfonamides and uses related thereto
Arylsulfonamide compounds of formula I are described and have therapeutic utility, particularly in the treatment of diabetes, obesity and related conditions and disorders:
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7479563 |
Method of producing polymorphic crystals of donepezil hydrochloride
The present invention provides a simple method of producing polymorphic crystal (III), which has high safety to environment and the bodies of operators; is gentle to environment; and can produce at...
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7473697 |
2-Oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives for the treatment of epilepsy and other neurological disorders
This invention relates to new 2-oxo-piperidinyl- and 2-oxo-azepanyl alkanoic acid derivatives of formula (1) having anticonvulsant activity which are useful as therapeutic agents for the treatment...
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7470722 |
Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease
Disclosed herein are carbonyl compounds of Formula I as described herein.
Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune...
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7465811 |
Indoline compounds
Sulfonylindoline compounds of formula I,
wherein R1 through R4, Y and Z have defined meanings, a process for preparation of such compounds, and the use as pharmaceutically active substances,...
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7456292 |
Hydroxamic acid-containing amino acid derivatives
Novel hydroxamic acid containing amino acid derivatives are provided that are useful for treatment of inflammation, inflammatory and immunological diseases; lowering blood glucose, serum insulin,...
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7446204 |
Amino substituted aryloxybenzylpiperidine derivatives
This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a...
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7446098 |
Combination therapy for treating protein deficiencies
This application provides methods of improving gene therapy by combining gene therapy with active site-specific chaperones (ASSCs). The ASSC increases the stability and efficiency of the protein...
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7442711 |
Amelioration of the development of cataracts and other ophthalmic diseases
Ophthalmically acceptable compositions used in arresting the development of cataracts or macular degeneration comprising a pharmaceutically acceptable carrier or diluent and a compound having the...
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7432284 |
Estrogen receptor modulators
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen...
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7432283 |
Heterocyclic GABAA subtype selective receptor modulators
This invention relates to a method for modulating α 2 subtype GABA A receptors with heterocyclic compounds of formula I, and salts, solvates and prodrugs thereof. The invention further relates...
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7423170 |
Anticancer agents based on regulation of protein prenylation
Oncoproteins such as Ras and RhoB are known to induce cell division in an unrestrained manner when such proteins are localized at the inner surface of a cancer cell membrane. The localization is...
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7393862 |
Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
Methods of treating, preventing or managing leukemias are disclosed. The methods encompass the administration of an immunomodulatory compound of the invention known as Revlimid® or lenalidomide....
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7390821 |
Methods of reducing angiogenesis
The present invention provides methods of reducing angiogenesis in an individual. The methods generally involve administering to the individual an effective amount of a nicotinic acetyl choline...
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7387271 |
Immunostimulatory combinations
The present invention provides immunostimulatory combinations. Generally, the immunostimulatory combinations include a TLR agonist and a TNF/R agonist. Certain immunostimulatory combinations also...
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7384959 |
Treatment of convulsive states
Single enantiomer-threo-methylphenidate is useful in the therapy of a convulsant state, e.g. epilepsy, a bipolar disorder or narcolepsy. It may be administered topically.
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7381727 |
Pyrrole derivatives, their preparation and their therapeutic use
The invention concerns compounds of formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are as defined herein. The invention also concerns the method for preparing said...
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7371746 |
1,2,4-Thiadiazole compounds and pests controlling composition containing the same
The present invention relates to a 1,2,4-thiadiazole compound of the formula (I) represented by the formula (1): wherein R 1? represents C3-C7 alkynyl and X represents C4-C7 straight alkylene...
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7361669 |
Compositions and method for inhibiting TGF-β
This invention provides compounds that are inhibitors of the TGF-β signaling pathway. The compounds are represented by formula I:
where A′ is N or CH; Ring B is preferably an triazolyl,...
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7351718 |
Substituted pyrrolidine and related compounds
This invention is directed to compounds of formula I:
wherein R 1 -R 5 and a-e are as defined in the specification; or pharmaceutically-acceptable salt or solvate or stereoisomer thereof....
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7345059 |
Diphenylpyridine derivatives, preparation and therapeutic application thereof
The invention relates to 5,6-diphenylpyridine-3-carboxamide derivatives of general formula (I):
where:
R 1 represents hydrogen or a (C 1 -C 4 )alkyl; R 2 represents:
a monoazo...
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7342043 |
Medicinal compositions improving brain function and method for improving brain function
An alkyl ether derivative represented by the formula:
wherein R 1 , R 2 , R 3 , R 4 , m and n are as defined in the specification, or salts thereof exhibits synergistically improved...
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7335681 |
Amino ceramide-like compounds and therapeutic methods of use
Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of...
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7320978 |
Oxazole derivatives, preparation and therapeutic use thereof
This invention relates to compounds of formula (I):
Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as described herein. The invention further relates to a method for prevention...
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7317025 |
Non-peptidic NPY Y2 receptor inhibitors
The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to...
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7312219 |
Heteroaromatic inhibitors of fructose 1,6-bisphosphatase
Novel FBPase inhibitors of the formula I and X
are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.
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7312218 |
Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If:
or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
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7309709 |
Thiazole sulfonamide compounds for the treatment of neurodegenerative disorders
The present invention relates to compounds of the Formula:
wherein R 1 to R 6 , X, Z and A are as defined. These compounds have activity inhibiting production of Aβ-peptide. The invention...
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