Matches 401 - 450 out of 670 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >
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5434166 Methods of inhibiting demyelinating and desmyelinating diseases  
A method of inhibiting demyelinating or dysmyelinating diseases or their symptoms comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1##...
5430024 Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation  
Acetic acid derivatives of formula H 2 N(NH)C--X--Y--CO--Z--CH(Q 1 )COOQ 2 I and hydrates, solvates and physiologically acceptable salts thereof are useful to inhibit the binding of...
5424309 N-substituted acylamino acid compounds, process for their production and their use  
The present invention provides an N-substituted acylamino acid compound of the formula: ##STR1## a process for their production and pharmaceutical uses, and intermediates useful for their production.
5420164 Cycloalkylurea compounds  
A cycloalkylurea compound of the formula (I): ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, which compound inhibits ACAT and is...
5418252 Method for inhibiting cartilage degradation  
A method of inhibiting cartilage degradation comprising administering to a human or other mammal in need of treatment an effective amount of a compound having the formula ##STR1## wherein R 1 and...
5411933 Bromopropargyl quarternary ammonium compounds having antimicrobial activity  
Antimicrobial compounds of the formula ##STR1## wherein R, R 1 and R 2 are selected according to the following: A. R is (C 11 -C 16 ) alkyl (straight or branched), and R 1 and R 2 are...
5411970 Method of inhibiting lentivirus  
A method of inhibiting lentivirus is disclosed which comprises mammalian host susceptible to said lentivirus with a virally inhibitory effective amount of an O-acylated derivative of...
5399589 Oxalyl hydrazide-hydroxamic acid derivatives, their preparation and their use as fungicides  
Oxalyl hydrazide-hydroxamic acid derivatives of the formula I ##STR1## where the substituents have the following meanings: R, R 1 , R 2 and R 3 independently of one another are hydrogen,...
5399567 Method of treating cholera  
This invention discloses a method of treating cholera infection in a human by administering an effective amount of 1,5-dideoxy-1,5-imino-D-glucitol or a derivative thereof.
5393754 Organophosphorus compounds, and insecticides, acaricides and nematocides containing same  
Insecticidal, acaricidal or nematocidal compositions which comprise a series of organophosphorus compounds represented by the following representative structural formulae: ##STR1## show excellent...
5393762 Pharmaceutical agents for treatment of emesis  
The present invention relates to a method of treating or preventing emesis in mammals, including humans, using certain quinuclidine derivatives, piperidine derivatives, azanorbornane derivatives...
5385918 Aminomethylene-peptides as immunosuppressants  
Compounds which suppress human T-lymphocyte proliferation are disclosed. The active compounds essentially contain at least the following structure: ##STR1## wherein A, R 1 , R 2 , R 3 , n, X 1 and...
5385902 Iodopropargylated oxalic derivatives as antimicrobial agents  
Antimicrobial compounds of the formula ##STR1## wherein A is selected from the group consisting of alkyl; phenyl; alkoxy; phenoxy; benzyloxy; monoalkylamino; dialkylamino; cyclic amino, anilino;...
5382588 Methyl piperidine derivatives of cinnamic acids, benzoic acids, benzoazols and benzophenones useful as skin anti-aging compounds  
Free radical deactivating 4- or 1,4-substituted, 2,2,6,6-tetramethyl piperidines are condensed with UV absorbing cinnamic acids or benzoic acids or benzoazols or benzophenones to produce skin...
5366997 Oxygen substituted derivatives of nucleophile-nitric oxide adducts as nitric oxide donor prodrugs  
There are disclosed cardiovascularly active compounds possessing antihypertensive properties, and pharmaceutical compositions containing these agents and a method of treating cardiovascular...
5362731 Use of piribedil derivatives and analogs for the treatment of hyperactive or unstable bladders  
Piribedil is administered to patients to treat unstable or hyperactive bladders.
5350758 Piperidyl sulfonamides and sulfoxamides as inhibitors of cholesterol biosynthesis  
The present invention relates to piperidyl sulfonamides and sulfoxamides which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in patients in...
5348964 Piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis  
The present invention relates to certain novel piperidyl ethers and thioethers which are useful as inhibitors of cholesterol biosynthesis and as agents which lower total serum cholesterol in...
5342838 Phenolic thioetheramides  
The present invention relates to phenolic thioetheramides of the formula ##STR1## wherein R 1 and R 2 are tert-alkyl or phenyl, Alk 1 and Alk 2 are alkylene; X is sulfur or oxygen, m is 0, 1,...
5340801 Compounds having cholecystokinin and gastrin antagonistic properties  
This invention relates to N-arylcarbamoyl proline analogues which are useful as cholecystokinin and gastrin antagonists, to pharmaceutical compositions including such proline analogues, and to...
5326688 Coating compositions for antistatic layers for photographic elements  
A solvent mixture of 8 to 30 weight percent of n-propyl acetate 1-methoxy-2-propanol or cyclohexane, 50 to 55 weight percent of acetone and the balance methanol is employed in a coating composition...
5322852 Aminooxy piperidines as ornithine decarboxylase inhibitors  
The invention relates to compounds of formula I ##STR1## wherein either R 1 is a radical of formula Ia, --(CH 2 ) n --O--NH 2 (Ia) in which n is 0 or 1, is hydrogen...
5314681 Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging  
The invention relates to a modification of electron spin resonance enhanced magnetic resonance imaging (ESREMRI) in which two magnetically responsive materials (contrast agents) are introduced into...
5306718 Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment  
Pharmaceutically useful nitrogen containing cyclic oxime and amine substituted compounds of the following general Formulas I, II and III are disclosed: ##STR1## Specifically the compounds are...
5294430 Use of dithiocarbamates to treat myelosuppression  
A process for preventing or ameliorating the myelosuppression which can occur in a mammal such as a human cancer patient being treated with a platinum-free antineoplastic drug is provided,...
5292750 Therapeutic agents  
Compounds are described which are useful for lowering the activity of α 2 -PI, for the treatment of myocardial infarctions and cerebral infarctions, as urokinase secretion accelerators, as...
5290789 Penta and tetrasubstituted piperidines and compositions and method of treating psychosis  
The invention is related to compounds, being useful in treating psychosis, of the formula: ##STR1## wherein: R 1 is hydrogen, lower-alkyl or phenyl-lower-alkyl; R 2 and R 4 are the same or...
5286733 Substituted 3-piperidinealkanoates and alkanones and compositions and method of use thereof  
The invention is related to compounds, being useful in treating psychosis, of the formula: ##STR1## wherein: R 1 is hydrogen, lower-alkyl, phenyl-lower-alkyl, C 3 -C 7 -monocyclic...
5272155 (+)-2-methylpiperidine as modulator of cholinergic systems  
Pharmaceutical compositions comprising a therapeutically effective amount of (+) 2-methylpiperidine and a pharmaceutically-acceptable carrier or diluent, as well as to a method of treating...
5270310 N-aminoalkyl amide inhibitors of protein kinase C  
The present invention provides methods for inhibiting protein kinase C which comprise contacting protein kinase C with an inhibitory amount of a compound having the formula ##STR1## wherein R 1 is...
5266567 Halopropargylated cyclic quaternary ammonium compounds as antimicrobial agents  
Antimicrobial compounds of the formula ##STR1## wherein R is selected from (A) (C 1 to C 20 ) straight or branched alkyl, optionally substituted with hydroxy, halogen, alkoxy, phenoxy, or...
5262427 3-substituted and optionally 1-substituted azacyclic or azabicyclic compounds, pharmaceutical compositions, thereof and their use as stimulants of cognitive functions  
Azacyclic compounds selected from the group consisting of ##STR1## wherein R 1 is H or C 1 -6 -alkyl R 3 is ##STR2## wherein R' is C 3 -8 -alkyl, cyclopropyl, C 4 -8 -cycloalkyl, benzyl which...
5256657 Succinamide derivative matrix-metalloprotease inhibitors  
Compounds having the structural formula ##STR1## wherein X is HONH or HO and especially wherein the carbon atom bearing CH 2 R 1 has the R-configuration, the carbon atom bearing CH 2 R 2 has...
5250542 Peripherally selective piperidine carboxylate opioid antagonists  
3,4,4-trisubstitutedpiperidinyl-N-alkylcarboxylates and intermediates for their preparation are provided. These piperidine-N-alkylcarboxylates are useful as peripheral opioid antagonists.
5250292 Use of cyclic organic amines in dermatological compositions  
The use of cyclic organic amines, as free radicals deactivators, in the preparation of cosmetic and dermatological compositions.
5250558 Substituted triazolinones, triazolinethiones, and triazolinimines as neurotensin antagonists used to treat psychosis  
Substituted triazolinone, triazolinethione, and triazolinimine compounds of formula (I) are as neurotensin II antagonists. These compounds have the general formula: ##STR1##
5250194 N-dodecyl heterocyclic compounds useful as industrial microbicides and preservatives  
A method for inhibiting the growth of microorganisms in which an N-dodecyl heterocyclic compound in an amount effective to inhibit the growth of microorganisms is contacted with an aqueous system...
5236922 Method for treating depression using 1-(aminophenyl)-2-aminopropanone derivatives  
The present invention relates to the preparation of new 1-(aminophenyl)-2-aminopropanone derivatives of the general formula: ##STR1## in which X is NH 2 , Y is H or a halogen atom, Z is H or a...
5219866 Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphate and a process for its preparation  
Octadecyl-[2-(N-methylpiperidino)-ethyl]-phosphate and a process for its preparation. This compound is useful for the treatment of cancer.
5217979 Substituted alkyl piperidines  
The present invention relates to a group of compounds which are novel substituted alkyl piperidines and which act to inhibit the synthesis of cholesterol in mammals and in fungi.
5215998 Alkylphosphonothioate insecticides  
Compounds and compositions containing alkylphosphonothioates, for insecticidal control, particularly for use as soil and/or foliar insecticides, having the formula. ##STR1## in which R is C 1 -C 3...
5214052 Method for dissolving arginineamides and pharmaceutical compositions containing them  
A method for dissolving an arginineamide of the invention comprising dissolving N 2 -arylsulfonyl-L-arginineamide having the general formula (I) ##STR1## wherein R 1 represents a (2R,...
5210089 D-rhamnono-1,5-lactone  
The novel D-rhamnono-? ,5-lactone and a novel method of synthesis of said compound from the monoacetonide of L-gulono-γ-lactone is disclosed. D-Rhamnono-1,5-lactone is a potent inhibitor of α-and...
5196439 Piperidine compounds useful to treat cerebrovascular diseases  
A cyclic amine is defined by the formula: ##STR1## in which A is naphthyl, phenyl, quinolyl or alkyl, X is a group containing carbonyl, n is 2 or 3 and B is alkyl, halogen, phenyl or --YZ, Y being...
5192774 Substituted acetamide derivatives, process for their preparation and antiulcer drug containing same  
A substituted acetamide derivative of general formula (I): ##STR1## [in which Y represents as piperidino group, 1-pyrrolidinyl group or 3-hydroxy-1-pyrrolidinyl group, and Z represents a group...
5187102 Inhibitors for the anticoagulant pretreatment of blood samples  
Meizothrombin- and thrombin-inhibiting inhibitors which do not bind bivalent cations and which are used for the anticoagulant pretreatment of blood samples to be used in the determination of the...
5185335 N-(4-piperodinyl)(dihydrobenzofuran or dihydro-2H-benzopyran) carboxamide derivatives  
Piperidine derivatives of formula ##STR1## wherein A is a radical of formula ##STR2## wherein one or two hydrogen atoms in said radicals (a-1) to (a-3) may be replaced by a C 1 -6 alkyl radical; ...
5173487 Mevinic acid derivatives  
Antihypercholesterolemic activity, due to competitive inhibition of HMG CoA reductase, is exhibited by a compound of the formula ##STR1## m is 0 to 3; R is selected from: (1) alkyl; (2)...
5164388 Heterocyclic peptide renin inhibitors  
A renin inhibiting compound of the formula ##STR1## wherein X is N, O or CH; R 1 is absent or a functional group; A and L are independently selected from absent, CO, SO 2 and CH 2 ; D is...
5153205 Method to reduce introacular pressure without causing miosis  
Topical administration of a cholinomimetic agent, such as pilocarpine, in combination with a cholinergic M 3 receptor antagonist, such as 4-diphenyl-acetoxy-N-methylpiperidine, to the eye of a...
Matches 401 - 450 out of 670 < 1 2 3 4 5 6 7 8 9 10 11 12 13 14 >