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6984627 |
Peptide derivatives
Pharmaceutical preparation containing an effective amount of acetylsalicylic acid and a compound of Formula I.
A 1 —A 2 —NH—(CH 2 )...
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6977252 |
Use of 1,4-benzothiazepine derivatives as drugs for overcoming resistance to anticancer drugs
The present invention relates to use of compounds represented by the following general formula [1] or salts or prodrugs thereof:
[where R 1 represents hydrogen atom or lower alkoxy group; R 2 ...
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6974814 |
Neuropharmacological treatment of sleep-related breathing disorders
The present invention relates to pharmacological methods for the prevention or amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess...
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6974590 |
Sublingual buccal effervescent
A pharmaceutical dosage form adapted to supply a medicament to the oral cavity for buccal, sublingual or gingival absorption of the medicament which contains an orally administerable medicament in...
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6969521 |
Aerosol insect repellent composition having low VOC content and method of applying same to the skin
Disclosed is an aerosol insect repellent composition. The composition has (a) an amount of an insect repellent effective to repel insects when applied to the skin and (b) a cosmetically-acceptable...
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6967196 |
Sulfonamide compounds and uses thereof
In accordance with the present invention, there is provided a novel class of sulfonamide compounds. Compounds of the invention contain a core sulfonamide group. Variable moieties connected to the...
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6956044 |
Compositions and methods for treatment of epilepsy
A method of treating a mammal with an epileptic condition, comprising: administering to said mammal a pharmaceutical composition containing an effective amount of an N-phenyl substituted 2-pyridone...
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6949257 |
Pharmaceutical compositions
Spontaneously dispersible pharmaceutical compositions comprising a piperidine, e.g. 1-acylpiperidine Substance P Antagonist and its use in the treatment of CNS disorders, e.g. depression and social...
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6916821 |
Methods of treating disorders with Group I mGluR antagonists
mGluR5 antagonists are used for the treatment and prevention of disorders, including Fragile X, autism, mental retardation, schizophrenia and Down's Syndrome. The methods of the invention can be...
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6916829 |
Method for enhancing mutant enzyme activity in gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance...
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6911456 |
Use of estrogen antagonists and estrogen agonists in inhibiting pathological conditions
The present invention provides novel methods of inhibiting pathological conditions related to organ systems which respond to estrogen agonists comprising administering to a mammal in need of such...
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6903085 |
Substituted piperidine compounds useful as modulators of chemokine receptor activity
The invention provides compounds of formula (I) wherein R 1 , R 2 , R 3 , R 6 , Z, Q, m, n, X 1 , X 2 , X 3 , X 4 and T are as defined in the specification, processes for their preparation,...
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6902727 |
Biocidal mixture of 2-propenal-releasing polymer and isothiazolones
A synergistic biocidal composition comprising a mixture of 2-propenal polymer (APC) and 5-chloro-2-methyl-4-isothiazoline-3-one (CIT) and 2-methyl-4-isothiazoline-3-one (MIT).
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6894063 |
Substituted urea neuropeptide Y Y5 Receptor antagonists
A novel class of compounds such as antagonists of the neuropeptide Y Y5 receptor, methods of making such compounds, pharmaceutical compositions containing one or more such compounds, methods of...
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6887887 |
Asymmetric synthesis of (S,S,R)-(-)-actinonin and its analogs and uses therefor
The present invention provides methods for the asymmetric synthesis of (S,S,R)-(−)-actinonin and its analogs and the compounds thereby synthesized having a structural formula:
where R 1 is...
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6887886 |
Therapeutic compositions comprising excess enantiomer
The present invention is concerned with pharmaceutical compositions comprising a mixture of amlodipine enantiomers, which compositions have both anti-hypertensive and additional cardiovascular...
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6884424 |
Method for treating the pathological lesions of the skin that develop by ultraviolet radiation of the sunlight
The invention relates to methods for prevention and/or treatment of skin lesions caused by exposure to ultraviolet radiation. Exemplary condition that can be prevented or treated are actinic...
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6881424 |
Highly acidic metalated organic acid
A highly acidic metalated organic acid composition and its preparation. The acidic composition can be prepared by mixing a monovalent or polyvalent cation and an organic acid in the presence of a...
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6872716 |
Antipsychotic sulfonamide-heterocycles, and methods of use thereof
One aspect of the present invention relates to heterocyclic compounds comprising a sulfonamide moiety. A second aspect of the present invention relates to the use of the heterocyclic compounds...
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6852735 |
Siastatin B derivatives having a glycosidase inhibitory activity and processes for producing the same
A compound of the formula (I):
and a compound of the formula (V):
as well as a compound of the formula (X):
which are each a novel siastatin B derivative having a potent inhibitory...
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6846492 |
Use of phenylethylamine derivatives for the antimicrobial treatment of surfaces
The use of compounds of formula (1) is described, in which compounds R 1 , R 2 and R 3 are each independently of the others hydrogen; C 1 -C 20 alkyl; C 3 -C 7 cycloalkyl; C 2 -C 20 alkenyl; C 4...
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6835371 |
Diagnostic and therapeutic piperazine and piperidine compounds and process
Piperazine or piperidine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The...
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6835726 |
Pyrimidine derivatives
Compounds and compositions are provided which are useful for the treatment of viral infections, particularly human Cytomegalovirus infection. The compounds include novel pyrimidine-based derivatives.
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6825216 |
Alkaloid that inhibits biosynthesis of microtoxins and method for screening for mycotoxin inhibitors
The present invention provides an alkaloid compound that is an inhibitor of mycotoxin biosynthesis. The alkaloid is an alkenyl piperidine amide wherein the alkenyl is a C18 alkenyl with one or more...
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6818638 |
Melvinolin derivatives
Mevinolin derivatives wherein the lactone ring is modified have interesting pharmaceutical properties, particularly in preventing or treating disorders or diseases mediated by LFA-1/ICAM-1...
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6809083 |
Use of N-substituted-1, 5-dideoxy-1, 5-imino-D-glucitol compounds for treating hepatitis virus infections
Provided are methods and compositions for treating hepatitis virus infections in mammals, especially humans. The methods comprise (1) administering N-substituted-1,5-dideoxy-1,5-imino-D-glucitol...
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6790847 |
Topical application of cetirizine and loratadine
The present invention relates to a drug composition containing the non-sedating H 1 antihistamines cetirizine, loratadine, mixtures or pharmaceutically acceptable salts thereof for topical...
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6780876 |
Composition for keeping away vermin
The invention describes essentially a non-therapeutical process for deterring vermin, which is based on the usage of the largely known compounds of formula (I), as defined herein before....
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6774135 |
Method of enhancing lysosomal α-galactosidase A
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related...
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6770658 |
Substituted &ggr -phenyl-&Dgr -lactams and uses related thereto
γ-Phenyl-substituted Δ-lactams are disclosed. They may be formulated into pharmaceutical compositions, and/or used in the treatment or prevention of inflammation or other conditions or disease...
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6759430 |
Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress
The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O 2 − ) scavenger, their preparation and their use in the treatment of conditions...
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6747044 |
Neurokinin antagonists
The invention relates to new compounds of formula I or the pharmaceutically acceptable salts thereof, wherein R 1 denotes 3-hydroxypropyl, 1,3-dihydroxyprop-2-yl or C 3 -C 6 -cycloalkylmethyl,...
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6734177 |
Certain salts of discodermolide acid, pharmaceutical compositions containing them and their use in treating tumors
The present invention relates to certain salts of discodermolide acid, pharmaceutical compositions containing said salts, the use of said salts in treating tumors and to a process for making said...
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6734195 |
Pharmaceutical compositions containing donepezil hydrochloride
The invention provides a pharmaceutical composition for the treatment of dementia or Alzheimer's disease in which the active therapeutical agent is donepezil hydrochloride in an amorphous state.
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6730677 |
Benzofurazan compounds which enhance AMPA receptor activity
Compounds of general structural formula ( 1 ) are shown to have AMPA receptor enhancing properties. The compounds are useful for such therapeutic purposes as facilitating the learning of behaviors...
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6720340 |
Nicotine receptor agonists in stem cell and progenitor cell recruitment
The present invention features methods for recruitment of bone marrow-derived stem cells (e.g., endothelial cell precursors, hematopoietic stem cells) by administration of nicotine or other...
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6713467 |
Acid derivatives useful as serine protease inhibitors
Compounds of formula I and II, or pharmaceutically-acceptable salts thereof, are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B...
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6710040 |
Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
The invention relates to new therapeutically active and selective inhibitors of the enzyme dipeptidyl peptidase-IV, pharmaceutical compositions comprising the compounds and the use of such...
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6703425 |
Sulfonamide derivatives
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful for the treatment of conditions associated with glutamate hypofunction, such...
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6696440 |
Treatment of asthma with MEK inhibitors
This invention provides a method of preventing or treating asthma by administering to a patient in need of treatment an effective amount of a selective MEK inhibitor, especially a phenyl amine of...
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6673365 |
Formulation for treatment of thromboembolism
A new pharmaceutical formulation comprising the thrombin inhibitor HOOC—CH 2 —(R)-Cgl-Aze-Pab in combination with medium chain glycerides, a process for the preparation of such a pharmaceutical...
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6667342 |
Benzenesulfonamide-derivatives and their use as medicaments
Compounds of formula (I), pharmaceutically acceptable salts or in vivo hydrolysable esters thereof, wherein: Ring X is phenyl or a six membered heteroaryl ring containing one or two ring nitrogens...
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6660749 |
Inhibition of glycolipid biosynthesis
Methods for treating lipid storage diseases using compounds that inhibit glucosyltransferase enzymes are disclosed herein. The invention relates to the treatment of lipid storage disease with...
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6656964 |
Method of inhibiting phosphodiesterases with substituted alkanohydroxamic acids
Imido and amido substituted alkanohydroxamic acids reduce the levels of TNFα and inhibit phosphodiesterase in a mammal. A typical embodiment is...
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6653324 |
Stabilization of wood substrates
The invention relates to a method of protecting wood against light-induced degradation by treatment with an impregnation which penetrates the surface of the wood comprising a) water without an...
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6653321 |
Naphthylsulfonic acids and related compounds as glucose uptake agonists
Methods for treating conditions associated with hyperglycemia, especially Type II diabetes, with novel naphthylsulfonic acids and related compounds. These compounds, as single stereoisomers or...
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6645990 |
Thiazolyl urea compounds and methods of uses
Selected novel urea compounds are effective for prophylaxis and treatment of diseases, such as cell proliferation or apoptosis mediated diseases. The invention encompasses novel compounds, analogs,...
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6630490 |
Methods for treatment of disease-induced peripheral neuropathy and related conditions
A method of treating disease-induced peripheral neuropathy comprises administering to a patient with disease-induced peripheral neuropathy an effective quantity of a purine derivative or analogue,...
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6620806 |
Methods and kits for improving vascular health
The present invention provides methods and kits for improving or maintaining vascular health, including preventing myocardial infarction or stroke; maintaining or improving vascular reactivity;...
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6617337 |
Use of nitroxides for the treatment of essential hypertension
The present invention encompasses methods of treating patients for essential hypertension. The invention also includes related pharmaceutical compositions of nitroxides. Specific drugs, such as...
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