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8691842 Pharmaceutical composition for preventing or treating rheumatoid arthritis, containing rebamipide  
The present invention provides a pharmaceutical composition for preventing or treating rheumatoid arthritis comprising rebamipide as an active ingredient and a pharmaceutically acceptable carrier....
8691844 Method for treating thrombosis and inhibiting platelet aggregation with 21-(S)-argatroban  
A method for inhibiting coagulation including administering to a patient in need thereof a pharmaceutical composition containing 21-(S)-Argatroban and/or a pharmaceutically acceptable salt thereof....
8691815 Substituted oxindole derivatives, drugs containing said derivatives and the use thereof  
The invention relates to novel oxindol derivative of general formula (I), wherein substituents R1, R2, A, B and Y are such as defined in a claim 1. Drugs containing said derivatives and the use...
8685974 Thienylpyri(mi)dinylazole  
Thienylpyri(mi)dinylazole of the formula (I) in which R1 to R8 and X1 have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for...
8685984 Methods for treating HCV  
The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks....
8685975 PDE10 inhibitors and related compositions and methods  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
8680106 Methods for treating HCV  
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies...
8680115 Tetrahydroquinoline analogues as muscarinic agonists  
The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with...
8669272 2,5-disubstituted piperidine orexin receptor antagonists  
The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and...
8669274 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8664245 Fumarate salts of a histamine H3 receptor antagonist  
The disclosure relates to fumarate salts of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethy l}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, to pharmaceutical compositions thereof,...
8658183 Antimicrobial parenteral formulation  
This invention relates to a parenteral formulation containing an effective amount of the compound of the following formula I: water, and an isotonic agent. Also disclosed is a method of treating an...
8658170 Combination therapy with MDM2 and EFGR inhibitors  
Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various...
8658636 TRPV4 antagonists  
The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
8653105 Quinoline derivatives as kinase inhibitors  
A series of quinoline derivatives, substituted by an optionally substituted bicyclic heteroaryl moiety consisting of two fused six-membered aromatic rings attached via an alkylene chain optionally...
8653070 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8642598 Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors  
The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said...
8637543 Quinoline derivatives as kinase inhibitors  
A series of quinoline and quinoxaline derivatives, substituted by a fused bicyclic pyridine or pyrimidine moiety attached via an alkylene chain optionally linked to a heteroatom, being selective...
8633187 Quinoline derivatives as PI3 kinase inhibitors  
Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune...
8629147 Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders  
The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.
8609648 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8609649 Compositions and methods for the diagnosis, treatment, and prevention of amyotrophic lateral sclerosis and related neurological diseases  
One aspect of the invention relates to a method of treating or preventing a neurodegenerative disease, comprising the step of administering to a patient in need thereof a therapeutically effective...
8604016 Heterocyclic inhibitors of glutaminase  
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the novel heterocyclic compounds of the...
8604054 Triglyceride-lowering agent and hyperinsulinism-ameliorating agent  
The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating agent. The triglyceride-lowering agent and...
8604055 Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors  
The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using...
8604040 Pyridinylcarboxylic acid derivatives as fungicides  
Pyridinylcarboxylic acid derivatives of the formula (I) in which the symbols A, X, Y1, Y2, Y3, L1, L2, RG, and R1 are each as defined in the description, and also salts, metal complexes and...
8586565 Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases  
The present invention is concerned with novel compounds useful in the treatment of hyperproliferative diseases and mammalian cancers, especially human cancers. The invention also pertains to...
8586608 Quinazoline derivatives and pharmaceutical compositions containing them  
A compound of general formula I wherein: Ra is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group;Rb is a dimethylamino, N-methyl-N-ethylamino, diethylamino, N-methyl-N-isopropylamino,...
8580773 Small-molecule inhibitors of the androgen receptor  
The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. The present invention provides a method of using tetrahydropyrvinium...
8580784 Method for treating a disease related to the glucocorticoid receptor  
A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-dihydroquinoline compound.
8575193 N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds  
Compounds of a certain formula (I) wherein R1, R2, R3, X, Y, r, s, t, u and v have the meanings as defined in the specification, and the salts, solvates and hydrates thereof are novel effective...
8563580 Flavivirus inhibitors and methods for their use  
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a...
8563551 Method for preventing or treating a disease related to the glucocorticoid receptor  
A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-dihydroquinoline compound or a...
8557823 Family of PFKFB3 inhibitors with anti-neoplastic activities  
A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer,...
8546374 Amino-tetrazoles analogues and methods of use  
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and compositions...
8536165 Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors  
The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their use...
8524699 Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors  
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the...
8524712 Triazinone and diazinone derivatives useful as HSP90 inhibitors  
The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the...
8518970 Compounds and methods of use  
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In...
8507509 Saturated and insaturated bi- or tricyclic aryloxyacetamine derivatives and their use as fungicides  
Compounds of the general formula (I), wherein the substituents are as defined in claim 1, are useful as fungicides.
8501774 Oxazolidinone-quinolone hybrid antibiotics  
The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
8501746 Organic compounds  
The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase...
8501747 Functionally selective alpha2C adrenoreceptor agonists  
In its many embodiments, the present invention provides a novel class of biaryl compounds as inhibitors of ΓΏ2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical ...
8501773 4-fluoro-piperidine T-type calcium channel antagonists  
The present invention is directed to 4-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and...
8497283 Autotaxin inhibitors  
The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or...
8492386 Methods for treating HCV  
The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks....
8486969 Therapeutic compounds  
Disclosed herein is compound having a structure Therapeutic methods, compositions, and medicaments are also disclosed herein.
8481534 5- and 6-membered heterocyclic compounds  
5- and 6-membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use...
8476249 Method of treating thrombocytopenia  
Invented is a method of treating thrombocytopenia in a human, in need thereof which comprises the in vivo administration of a therapeutically effective amount of a peptide or a non-peptide TPO...
8470529 Methine-substituted cyanine dye compounds  
Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6...