Patents in Class 514/314

Matches 1 - 50 out of 1155

Match	Document	Document Title
1	8440706	Inhibitors of serine proteases The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C...
2	8440660	Method for treating a disease related to the glucocorticoid receptor A method for treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-hydroquinoline compound.
3	8426440	Indolymaleimide derivatives A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these...
4	8426406	Glucocorticoid receptor agonist comprising 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivatives having substituted oxy group The present invention is related to glucocorticoid receptor agonists comprised of a compound represented by formula (1) which is 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative or a salt...
5	8415376	Inhibitors of PI3 kinase The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and...
6	8415374	Combinations of hepatitis C virus inhibitors The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising...
7	8415377	Triazole compounds that modulate HSP90 activity The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of...
8	8404715	Methods and compositions using racemic, (R)-, and (S)-fexofenadine in combination with leukotriene inhibitors Methods and pharmaceutical compositions employing a terfenadine metabolite and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma, or...
9	8404726	Activating agent for peroxisome proliferator activated receptor δ A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like;Aa is thiazole, oxazole, or thiophene, which can ...
10	8399484	Combination therapy for treating HCV infection The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin....
11	8394794	Therapeutic compounds The invention provides compounds of Formula (I) and (IV): as described herein, as well as salts thereof. The compounds have anti-cancer properties and/or chemosensitization properties.
12	8389519	Adamantyl diamide derivatives and uses of same The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions...
13	8389546	Compounds for modulating TRPV3 function The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
14	8383647	Quinoline derivative The present invention provides a compound having a melanin-concentrating hormone receptor antagonistic action and low toxicity, which is useful as an agent for the prophylaxis or treatment of...
15	8383646	Therapeutic ((bicylicheteroaryl)imidazolyl) methylheteroaryl compounds Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
16	8377963	Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the...
17	8377962	Macrocyclic serine protease inhibitors Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof....
18	8367679	Biaryl carboxamides This invention provides compounds of Formula (I) which are PAFR antagonists: Formula (I) and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated...
19	8362032	Bicyclic derivatives as modulators of ion channels Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
20	8362008	Amido-thiophene compounds and their use as 11-beta-HSD1 inhibitors The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
21	8357700	2,3-disubstituted piperidine orexin receptor antagonists The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and...
22	8357702	Bicyclic derivatives as modulators of voltage gated ion channels Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
23	8357701	Galactokinase inhibitors Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
24	8357717	Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity Substituted spiroamide compounds corresponding to formula (I): wherein A, B, Q1, Q2, Q3, Q4, R1, R8, R9a, R9b, R12, R13, R200 and R210 have defined meanings, processes for their preparation,...
25	8354429	Inhibitors of human immunodeficiency virus replication Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
26	8349869	Macrocylic inhibitors of hepatitis C virus Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is...
27	8349830	Aryl aminopyridine PDE10 inhibitors The present invention is directed to aryl aminopyridine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10...
28	8343970	PDE10 inhibitors and related compositions and methods Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
29	8343998	Triazolothiadiazole inhibitor of c-Met protein kinase The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1...
30	8324217	Cold menthol receptor antagonists Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein...
31	RE43802	α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
32	8299094	Hepatitis C virus inhibitors Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for u...
33	8299063	Amido-thiophene compounds and their use The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
34	8293732	Antibacterial quinoline derivatives The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a N-oxide...
35	8282909	Pharmaceutical composition for topical application of poorly soluble compounds The present invention provides a formulation which contains a poorly water soluble pharmaceutically active compound at a concentration of 50 mg per 100 g formulation or above. The solubility is...
36	8273768	Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and...
37	8268803	5, 6-ring annulated indole derivatives and use thereof The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the...
38	8263622	Fused-ring derivative and medical application of same The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to...
39	8263588	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:...
40	8247431	Heterocyclic hydrazide compound and pesticidal use of the same A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.
41	8247432	Tripeptidyl peptidase inhibitors The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as...
42	8242135	Biphenyl derivatives This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or...
43	8236801	2-aza-bicyclo[2.2.1]heptane derivatives The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of...
44	8231888	Isoxazolines for controlling invertebrate pests Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting...
45	8227504	Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof The present invention discloses and claims a series of substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides of formula (I). Wherein R, R1, R2, R3 and R4 are as described herein. More...
46	8221737	Hepatitis C virus inhibitors The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
47	8222248	Organic compounds The present invention provides compounds of the following structure; A-L1-B—C-D that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, p...
48	8217056	Triazolothiadiazole inhibitor of c-Met protein kinase The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1...
49	8211910	Tri-, tetra-substituted-3-aminopyrrolidine derivative A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria,...
50	8207194	Compounds having a 4-pyridylalkylthio group as a substituent A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane...

Matches 1 - 50 out of 1155

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >