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8440706 |
Inhibitors of serine proteases
The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C...
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8440660 |
Method for treating a disease related to the glucocorticoid receptor
A method for treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-hydroquinoline compound.
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8426440 |
Indolymaleimide derivatives
A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these...
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8426406 |
Glucocorticoid receptor agonist comprising 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivatives having substituted oxy group
The present invention is related to glucocorticoid receptor agonists comprised of a compound represented by formula (1) which is 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative or a salt...
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8415376 |
Inhibitors of PI3 kinase
The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and...
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8415374 |
Combinations of hepatitis C virus inhibitors
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising...
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8415377 |
Triazole compounds that modulate HSP90 activity
The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of...
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8404715 |
Methods and compositions using racemic, (R)-, and (S)-fexofenadine in combination with leukotriene inhibitors
Methods and pharmaceutical compositions employing a terfenadine metabolite and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma, or...
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8404726 |
Activating agent for peroxisome proliferator activated receptor δ
A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like;Aa is thiazole, oxazole, or thiophene, which can ...
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8399484 |
Combination therapy for treating HCV infection
The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin....
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8394794 |
Therapeutic compounds
The invention provides compounds of Formula (I) and (IV): as described herein, as well as salts thereof. The compounds have anti-cancer properties and/or chemosensitization properties.
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8389519 |
Adamantyl diamide derivatives and uses of same
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions...
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8389546 |
Compounds for modulating TRPV3 function
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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8383647 |
Quinoline derivative
The present invention provides a compound having a melanin-concentrating hormone receptor antagonistic action and low toxicity, which is useful as an agent for the prophylaxis or treatment of...
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8383646 |
Therapeutic ((bicylicheteroaryl)imidazolyl) methylheteroaryl compounds
Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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8377963 |
Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof
The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the...
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8377962 |
Macrocyclic serine protease inhibitors
Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof....
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8367679 |
Biaryl carboxamides
This invention provides compounds of Formula (I) which are PAFR antagonists: Formula (I) and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated...
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8362032 |
Bicyclic derivatives as modulators of ion channels
Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
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8362008 |
Amido-thiophene compounds and their use as 11-beta-HSD1 inhibitors
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
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8357700 |
2,3-disubstituted piperidine orexin receptor antagonists
The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and...
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8357702 |
Bicyclic derivatives as modulators of voltage gated ion channels
Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
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8357701 |
Galactokinase inhibitors
Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
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8357717 |
Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity
Substituted spiroamide compounds corresponding to formula (I): wherein A, B, Q1, Q2, Q3, Q4, R1, R8, R9a, R9b, R12, R13, R200 and R210 have defined meanings, processes for their preparation,...
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8354429 |
Inhibitors of human immunodeficiency virus replication
Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
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8349869 |
Macrocylic inhibitors of hepatitis C virus
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is...
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8349830 |
Aryl aminopyridine PDE10 inhibitors
The present invention is directed to aryl aminopyridine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10...
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8343970 |
PDE10 inhibitors and related compositions and methods
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
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8343998 |
Triazolothiadiazole inhibitor of c-Met protein kinase
The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1...
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8324217 |
Cold menthol receptor antagonists
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein...
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RE43802 |
α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
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8299094 |
Hepatitis C virus inhibitors
Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for u...
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8299063 |
Amido-thiophene compounds and their use
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
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8293732 |
Antibacterial quinoline derivatives
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a N-oxide...
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8282909 |
Pharmaceutical composition for topical application of poorly soluble compounds
The present invention provides a formulation which contains a poorly water soluble pharmaceutically active compound at a concentration of 50 mg per 100 g formulation or above. The solubility is...
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8273768 |
Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization
The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and...
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8268803 |
5, 6-ring annulated indole derivatives and use thereof
The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the...
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8263622 |
Fused-ring derivative and medical application of same
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to...
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8263588 |
Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:...
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8247431 |
Heterocyclic hydrazide compound and pesticidal use of the same
A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.
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8247432 |
Tripeptidyl peptidase inhibitors
The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as...
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8242135 |
Biphenyl derivatives
This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or...
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8236801 |
2-aza-bicyclo[2.2.1]heptane derivatives
The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of...
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8231888 |
Isoxazolines for controlling invertebrate pests
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting...
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8227504 |
Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof
The present invention discloses and claims a series of substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides of formula (I). Wherein R, R1, R2, R3 and R4 are as described herein. More...
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8221737 |
Hepatitis C virus inhibitors
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
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8222248 |
Organic compounds
The present invention provides compounds of the following structure; A-L1-B—C-D that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals, p...
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8217056 |
Triazolothiadiazole inhibitor of c-Met protein kinase
The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1...
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8211910 |
Tri-, tetra-substituted-3-aminopyrrolidine derivative
A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria,...
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8207194 |
Compounds having a 4-pyridylalkylthio group as a substituent
A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane...
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