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8809327 Sulfonamides as TRPM8 modulators  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein...
8809545 Aryl pyridine as aldosterone synthase inhibitors  
The present invention provides a compound of formula I; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of...
8809360 Use of a pyridine compound for the preparation of a medicament for the treatment of skin lesions  
The present invention relates to use of a pyridine compound of the following formula [I]: wherein R is a substituted pyridyl group having the following formula: R0 is a C1-6 alkoxy-C1-6 alkyl...
8802702 Compounds for reducing drug resistance and uses thereof  
This invention provides compounds capable of reducing drug resistance in a subject undergoing cancer treatment, methods using the compounds, compositions, and methods for identifying such compounds.
8796259 N3-heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles useful as axl inhibitors  
N3-Heteroaryl substituted triazoles and N5-heteroaryl substituted triazoles and pharmaceutical compositions containing the compounds are disclosed as being useful in inhibiting the activity of the...
8791114 Dihydropyrazoles  
Novel dihydropyrazole derivatives of formula (I) wherein L, R, R3, R4, R5, R6, R7, X1, X2, X3, X4, Y, m and n have the meaning according to the claims, are positive allosteric modulators of the FSH...
8785433 Quinoline derivatives as PI3 kinase inhibitors  
Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune...
8785474 Vanilloid receptor ligands, pharmaceutical compositions containing them, process for making them, and use thereof to treat pain and other conditions  
Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds...
8778976 Compositions and methods for the treatment of metabolic disorders  
The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog thereof. In other aspects, the compound for...
8778965 Lotion preparation containing pyridonecarboxylic acid derivative  
It is intended to provide a lotion preparation which exerts an excellent antibacterial effect, is excellent in the stability of active ingredient and does not contain an additive having a safety...
8772316 Substituted 6,7-dialkoxy-3-isoquinolinol derivatives as inhibitors of phosphodiesterase 10 (PDE10A)  
The invention relates to compounds of the formula wherein R′, R1, through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are u...
8771665 Inhibitors of hepatitis C virus polymerase  
The present invention provides, among other things, compounds represented by the general Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, R1A, R1B, R2, and R3 are as defined...
8759341 Bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives and uses thereof  
This invention relates to novel bi- and tricyclic indazole-substituted 1,4-dihydropyridine derivatives having protein tyrosine kinase inhibitory activity, to a process for the manufacture thereof...
8754105 Macrocyclic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) the N-oxides, salts, and stereochemically isomeric forms thereof, wherein each dashed line (represented by ) represents an optional double bond; X is N,...
8754106 Macrocyclic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is...
8748420 Pyridinylcarboxylic acid derivatives as fungicides  
Pyridinylcarboxylic acid derivatives of the formula (I) in which the symbols A, X, Y1, Y2, Y3, L1, L2, RG and R1 are each as defined in the description, and also salts, metal complexes and N-oxides...
8741926 Macrocyclic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, whereineach dashed line represents an optional double bond;X is N, CH and where X bears a double bond it is...
8741924 Compounds and methods for treatment of systemic lupus erythematosus  
Small molecule compounds are provided for treating lupus as are methods of treating lupus using these compounds.
8735362 Insecticidal compounds based on isoxazoline derivatives  
The present invention relates to compounds of formula (I): Wherein A1, A2, A3, A4, G1, L, Y1, Y2, Y3, Y4, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the...
8735424 Bicyclic kinase inhibitors  
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In...
8734777 Heterocyclic antiviral compounds  
Compounds having the formula (I) wherein R1, R2, R3 and X are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV...
8729098 Tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof  
New tertiary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof are disclosed. These compounds are useful as antifungal agents....
8729063 3-aminopyrrolidine derivatives as modulators of chemokine receptors  
The present invention relates to 3-aminopyrrolidine derivatives of the formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y and X are as defined herein) which are useful as modulators of...
8729093 Soil treating agent or seed treating agent comprising quinoline compounds or salts thereof as active ingredient, or method for preventing plant diseases by using the same  
A soil treating agent or a seed treating agent having excellent prevention effects against various plant pathogens (particularly against rice blast) is provided. A soil treating agent or seed...
8729076 Secondary 8-hydroxyquinoline-7-carboxamide derivatives  
The present invention provides new secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as...
8716284 Adamantyl diamide derivatives and uses of same  
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions...
8716265 4-quinolinemethanols as anti-malarial agents  
The present invention relates to substituted 4-qinolinemethanols and pharmaceutical compositions thereof and methods of using the same for treating of malaria, tuberculosis, and other infectious...
8716289 Carbamate derivatives of alkyl-heterocycles, preparation thereof and therapeutic use thereof  
Compound corresponding to general formula (I): in which R2 is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C1-6-alkyl, C1-6-alkoxy or NR8R9 group; n is an integer equal to 1,...
8710043 TRPM8 antagonists and their use in treatments  
Compounds of Formula I are useful as antagonists of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and...
8703803 Tris-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors  
Provided are tris-quaternary ammonium compounds which are modulators of nicotinic acetylocholine receptors. Also provided are methods of using the compounds for modulating the function of a...
8691842 Pharmaceutical composition for preventing or treating rheumatoid arthritis, containing rebamipide  
The present invention provides a pharmaceutical composition for preventing or treating rheumatoid arthritis comprising rebamipide as an active ingredient and a pharmaceutically acceptable carrier....
8691844 Method for treating thrombosis and inhibiting platelet aggregation with 21-(S)-argatroban  
A method for inhibiting coagulation including administering to a patient in need thereof a pharmaceutical composition containing 21-(S)-Argatroban and/or a pharmaceutically acceptable salt thereof....
8691815 Substituted oxindole derivatives, drugs containing said derivatives and the use thereof  
The invention relates to novel oxindol derivative of general formula (I), wherein substituents R1, R2, A, B and Y are such as defined in a claim 1. Drugs containing said derivatives and the use...
8685974 Thienylpyri(mi)dinylazole  
Thienylpyri(mi)dinylazole of the formula (I) in which R1 to R8 and X1 have the meanings given in the description, and agrochemically active salts, to their use and to methods and compositions for...
8685984 Methods for treating HCV  
The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks....
8685975 PDE10 inhibitors and related compositions and methods  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
8680106 Methods for treating HCV  
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies...
8680115 Tetrahydroquinoline analogues as muscarinic agonists  
The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with...
8669272 2,5-disubstituted piperidine orexin receptor antagonists  
The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and...
8669274 Metalloenzyme inhibitor compounds  
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
8664245 Fumarate salts of a histamine H3 receptor antagonist  
The disclosure relates to fumarate salts of 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethy l}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide, to pharmaceutical compositions thereof,...
8658183 Antimicrobial parenteral formulation  
This invention relates to a parenteral formulation containing an effective amount of the compound of the following formula I: water, and an isotonic agent. Also disclosed is a method of treating an...
8658170 Combination therapy with MDM2 and EFGR inhibitors  
Provided is a method of treating a proliferative disease, condition, or disorder in a subject by administering a combination of an inhibitor of p53 and MDM2 binding and an EGFR inhibitor. Various...
8658636 TRPV4 antagonists  
The present invention relates to quinoline analogs, pharmaceutical compositions containing them and their use as TRPV4 antagonists.
8653105 Quinoline derivatives as kinase inhibitors  
A series of quinoline derivatives, substituted by an optionally substituted bicyclic heteroaryl moiety consisting of two fused six-membered aromatic rings attached via an alkylene chain optionally...
8653070 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8642598 Heterocyclic compounds and their use as glycogen synthase kinase 3 inhibitors  
The present invention relates to a heterocyclic compound of the general formula (I) and their use and preparation, methods of making the compounds, compositions containing at least one of said...
8637543 Quinoline derivatives as kinase inhibitors  
A series of quinoline and quinoxaline derivatives, substituted by a fused bicyclic pyridine or pyrimidine moiety attached via an alkylene chain optionally linked to a heteroatom, being selective...
8633187 Quinoline derivatives as PI3 kinase inhibitors  
Invented is a method of inhibiting the activity/function of PI3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune...
8629147 Heterocyclic compounds useful in the treatment of neoplastic diseases, inflammatory disorders and immunomodulatory disorders  
The present invention provides compounds capable of modulating tyrosine kinases, compositions comprising the compounds and methods of their use.