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7342026 Substituted quinolines for the treatment of protozoa and retrovirus co-infections  
The invention relates to the use of quinolines having general formula (I), wherein R1 denotes H; alkyl C1-C15; alkenyl or alkynyl C2-C15; —CHO; heteroaryl; alkyl C1-C15 or alkenyl or alkynyl C2-C7...
7332504 Heterocyclic substituted aminoazacycles useful as central nervous system agents  
Heterocyclic substituted aminoazacyclic compounds of formula I Z-R3I, wherein Z is a defined aminoazacycle and R3 is a defined heterocycle moiety, pharmaceutical compositions of these compounds,...
7323477 7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline  
A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
7320992 Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use  
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and...
7312218 Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors  
The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula Ia-If: or pharmaceutically acceptable salt forms thereof, wherein ring G is a mono- or bicyclic...
7312222 Heterocyclic piperidines as modulators of chemokine receptor activity  
The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
7304062 Peroxisome proliferator activated receptor alpha agonists  
The present invention is directed to compounds represented by the following structural formula, and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or...
7304066 Pyridyl cyanoguanidine compounds  
Compounds according to formula (I) wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C1-6 hydrocarbon radical, optionally substituted with...
7291631 CXCR4 chemokine receptor binding compounds  
The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to...
7288559 Carboxamide spirohydantoin CGRP receptor antagonists  
The present invention is directed to compounds that are antagonists of CGRP receptors and that are useful in the treatment or prevention of diseases in which the CGRP is involved, such as...
7276491 Anticoagulant and fibrinolytic therapy using p38 MAP kinase inhibitors  
Disclosed are methods for a treating a disease or condition relating to blood coagulation and fibrinolysis using p38 MAP kinase inhibitors.
7276522 4-(substituted cycloalkylmethyl) imidazole-2-thiones, 4-(substituted cycloalkenylmethyl) imidazole-2-thiones, 4-(substituted cycloalkylmethyl) imidazol-2-ones, 4-(substituted cycloalkenylmethyl) imidazol-2-ones and related compounds  
The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha2B adrenergic receptors in preference over alpha2A and alpha2C adrenergic receptors, and as such has...
7268148 Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes  
Acne-affected skin has been found to be accompanied by the presence of matrix-degrading enzymes such as MMPs and neutrophil elastase, induction of neutrophils, and a reduction in procollagen...
7265115 Diazabicyclic CNS active agents  
Compounds of formula I: or pharmaceutically acceptable salts thereof, are useful for controlling synaptic transmission in mammals.
7259157 N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists  
Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
7253168 Substituted 1-benzyl-4-substituted piperazine analogues  
Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly...
7253170 Pyrazole-amine compounds useful as kinase inhibitors  
The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where W, X, R1, R2, R3, R4, R5, R6 and m are as defined herein. The...
7241745 Pyridyl alkene and pyridyl alkine acid amides as cytostatics and immunosupressives  
The invention relates to a new pyridyl alkene and pyridyl alkine acid amides according to the general formula (I) as well as methods for their production, medicaments containing these compounds as...
7235566 Pyridinone derivatives for treatment of atherosclerosis  
Compounds of formula (I): are inhibitors of the enzyme Lp-PLA2 and are of use in therapy, in particular for treating atherosclerosis.
7232817 α- and β-amino acid hydroxyethlamino sulfonyl urea derivatives useful as retroviral protease inhibitors  
α- and β-amino acid hydroxyethylamino sulfonyl urea derivative compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
7226942 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors  
Novel compounds are provided which are glycogen phosphorylase inhibitors which are useful in treating, preventing or slowing the progression of diseases requiring glycogen phosphorylase inhibitor...
7226940 Substituted heterocycles for the treatment of diabetes and other diseases  
The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2...
7223759 Antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds  
The invention relates to antibacterial 3,5-diaminopiperidine-substituted aromatic and heteroaromatic compounds and pharmaceutical compositions thereof. This invention also relates to a method of...
7220760 Quinoline derivatives as CRTH2 antagonists  
The invetion relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the description, their use as medicament, pharmaceutical compositions containing them...
7220756 N-sulfonylheterocyclopyrrolyl-alkylamine compounds as 5-hydroxytryptamine-6 ligands  
The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of a CNS disorder relating to or affected by the 5-HT6 receptor
7214674 Heterocyclymethylpiperidines and -piperazines possessing affinity at 5ht-1 type receptors  
Compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed: wherein: A is optionally substituted phenyl, naphthyl, indolyl, quinolinyl, quinazolinyl, indazolyl,...
7214690 Tricyclic quinolinone and tricyclic quinoline androgen receptor modulator compounds and methods  
Novel non-steroidal tricyclic quinolinone and tricyclic quinoline compounds and compositions that are agonists, partial agonists and/or antagonists for androgen receptors (AR), their preparation...
7211588 N-substituted indolyl-3-glyoxylamides, their use as medicaments and process for their preparation  
The invention relates to novel N-substituted indolyl-3-glyoxylamides of the general formula I, their preparation and use as medicaments, in particular for the treatment of tumors
7205299 Indole derivatives having an apoptosis-inducing effect  
The invention relates to indole derivatives which are used as drugs for treating tumor diseases, in particular when there is drug resistance against other active compounds and where there is a...
7205316 Tri- and bi-cyclic heteroaryl histamine-3 receptor ligands  
Compounds of formula (I) wherein R1 or R2 is a tricyclic or bicyclic ring, each of which contains at least two heteroatoms, and R1, R2, R3, R3a, R3b, R4, R5, L, X, X′, Y, Y′, Z, and Z′ are as...
7199134 Hydroxamic acid compounds and methods of use thereof  
The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl containing groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety,...
7192971 4-Heteroaryl-tetrahydroquinolines and their use as inhibitors of the cholesterin-ester transfer protein  
Hetero-tetrahydroquinolines can be prepared either by condensing correspondingly substituted hetero-tetrahydroquinoline aldehydes with the desired substituent or by reducing the corresponding...
7189758 Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof  
A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and...
7186720 Tetrahydropyridyl-alkyl-heterocycles, method for preparing the same and pharmaceutical compositions containing the same  
The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; R2 and R3 independently represent a hydrogen atom...
7183291 Method for the treatment of malaria by the use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4- (6-methoxy-8-quinolinyl)-1,4-pentanediamine as gametocytocidal agent  
The present invention a novel use of primaquine derivative N1-(3-ethylidinotetrahydrofuran-2-one)-N4-(6-methoxy-8-quino linyl)-1,4-pentanediamine in the treatment and controlling the spread of...
7166612 Methods for reducing platelet activation platelet aggregaton or thrombosis  
The invention provides methods and compositions for reducing platelet activation, platelet aggregation and thrombosis. The invention further provides compositions and methods for treating or...
7160900 Tetrahydropyridino or piperidino heterocyclic derivatives  
A tetrahydropyridino or piperidino heterocyclic derivative represented by the formula [I]: A-Het [I] has a high affinity for CRF receptors and is effective against diseases in which CRF is...
7144896 Hetero-bridge substituted 8-arylquinoline pde4 inhibitors  
8-arylquinolines wherein the aryl group at the 8-position contains a meta one or two atom bridge to a phenyl, 5 or 6 member heteroaryl or fused bicyclic heteroaryl group, and wherein at least one...
7141581 Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use  
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating...
7138376 Methods and compositions for treating hepatitis C virus using 4'-modified nucleosides  
A compound, method and composition for treating a host infected with a hepatitis C viral comprising administering an effective hepatitis C treatment amount of a described 4′-disubstituted...
7132432 Hydantoin derivatives as inhibitors of tumor necrosis factor-alpha converting enzyme (TACE)  
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables L, Z0, R1, R4, R5, and R11 are defined are as...
7122560 Lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme  
The present invention provides compounds of Formula (I): or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, R1, R2, U, X, Y, Z, Ua, Xa, Ya, and Za are...
7105537 2-substituted cyclic amines as calcium sensing receptor modulators  
The present invention relates to modulators of the calcium sensing receptor having the formula I wherein Ar1, X, n, R1, R2, R3 and Q are as defined herein.
7105538 2-pyrrolidin-2-yl-[1,3,4]-oxadiazole compounds and their use as anti-depressants  
Substituted 2-pyrrolidin-2-yl compounds corresponding to formula I a method for their production, pharmaceutical compositions containing them, and methods of using them, especially for treating...
7101893 (2-Carboxamido)(3-amino)thiophene compounds  
A method of treatment of hyperproliferative disorders comprises administering an effective amount of a compound represented by Formula II: or a pharmaceutically acceptable salt thereof.
7101894 Bicyclic compounds as inhibitors of chemokine binding to US28  
Methods for treating CMV or a CMV-related disease are provided that use compounds having the formula: wherein Ar is a substituted or unsubstituted 5–14 membered heteroaryl group having from 1 to 5...
RE39265 Heteroarylpiperidines, and their use as antipsychotics and analgetics  
Heteroarylpiperidines, pyrrolidines, and piperazines are useful as antipsychotic and analgesic agents. The compounds are especially useful for treating psychoses by administering to a mammal a...
7098222 Bicyclic-substituted amines having cyclic-substituted monocyclic substituents  
Compounds of formula (I) wherein R1 or R2 is an aromatic or non-aromatic ring directly joined or joined by a linker, as represented by L2 and L3, to a heteroaromatic core, and X, X′, Y, Y′, Z, Z′,...
7098219 Inhibitors of cellular efflux pumps of microbes  
Compounds are described which are efflux pump inhibitors of cellular efflux pumps of microbes. Also described are methods of preparing such compounds, methods of using such efflux pump inhibitor...
7087626 Pyrrole derivatives as pharmaceutical agents  
Novel pyrrazole derivative compounds and their use as pharmaceutical agents, in particular their use as TGF-beta signal transduction inhibitors. The disclosed invention relates to compounds of the...