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7585878 Benzamide derivative or salt thereof  
There is provided a compound having a capsaicin receptor VR1 inhibitory activity and useful as a therapeutic agent for various pains including inflammatory pain and neurogenic pain, migraine,...
7576098 Heterocyclic compounds as inhibitors of factor VIIa  
The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
7576100 Muscarinic agonists  
The present invention relates to tetrahydroquinoline compounds as muscarinic receptor agonists; compositions comprising the same; methods of inhibiting an activity of a muscarinic receptor with...
7572810 Alkene piperidine derivatives as antiviral agents  
This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine...
7572794 Anthranilamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors  
The invention relates to novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors, their production and use as pharmaceutical agents for preventing or treating diseases that are...
7569604 Heterocyclic derivatives for modulation of calcium channels  
Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
7569584 4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihydro-imidazole-2-thione as specific alpha2b agonist and methods of using the same  
The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha2B adrenergic receptors in preference over alpha2A and alpha2C adrenergic receptors, and as such has...
7566710 Dual molecules containing a peroxide derivative, synthesis and therapeutic applications thereof  
The invention relates to dual molecules formed from coupling products complying with the formula whereinA represents a residue of molecule with anti-malarial activity,Y1 and Y2, represent a linear...
7563807 Removal of aldehyde impurity by reactive polystyrene resini  
A purification method in the preparation of a substituted 8-arylquinoline, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, utilizes a polystyrene-based...
7563804 FMF treatment  
The method of improving FMF control, in humans, which includes administering, on an average daily basis, between 5 and 15 milligrams of LTRA to a patient suffering from FMF.
7550481 Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease  
The present invention is directed to phenylamide and pyridylamide derivative compounds of which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in...
7538121 Vanilloid receptor modulators  
Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, R3, P, X, Y, q, r ans s are as defined in the specification, a process for preparing...
7534802 Compounds having 4-pyridylalkylthio group as substituent  
A subject of the present invention is to provide a novel aromatic five- or six-memberd heterocyclic derivative having 4-pyridylalkylthio as a substituent or a salt thereof which is useful as a...
7531554 4-oxoquinoline compound and use thereof as HIV integrase inhibitor  
Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity. A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically...
7524883 Eponemycin and epoxomicin analogs and uses thereof  
The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, E, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally...
7524862 Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds  
Alkyne compounds of formula I wherein A, B, W, X, Y, Z, R1, and R2 have the meanings given herein, which have MCH-receptor antagonistic activity and are useful for preparing pharmaceutical...
7514452 2-furancarboxylic acid hydrazides and pharmaceutical compositions containing the same  
The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof:...
7511062 Substituted 2-quinolyl-oxazoles useful as PDE4 inhibitors  
The invention claims compounds of the formula wherein is a 5-membered heteroaryl;X is S or O;R1 is H, alkyl, cycloalkyl, cylcoalkylalkyl-, —CH2F, —CHF2, —CF3, —C(O)alkyl or —C(O)NR18R19;R3 and R4...
7511063 High affinity quinoline-based kinase ligands  
Quinoline-based inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and...
7511065 Mixed lineage kinase modulators  
The present invention provides a compound of the formula: (Formula I); or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising an effective amount of a compound of...
7507749 Antitumor agents  
The invention provides compounds of formula I: wherein Y is F, Cl, Br, methyl or methoxy; and pharmaceutically acceptable salts thereof. The compounds are effective antitumor agent. The invention...
7498343 Mycobacterial inhibitors  
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib) the pharmaceutically acceptable acid or base addition...
7491714 Quinolines and nitrogenated derivatives thereof and their use as antibacterial agents  
Quinoline and naphthridine derivatives useful in the treatment of bacterial infections in mammals, particularly humans.
7488740 Substituted quinolin-4-ylamine analogues  
Substituted quinolin-4-ylamine analogues are provided. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the...
7488738 Aminophenoxyacetic acid derivatives and pharmaceutical composition containing thereof  
There is provided an aminophenoxyacetic acid derivative of the following formula (I): wherein, R1, R2, R3 and R4 are, independent from each other, alkoxy group, alkyl group or aryl group, etc.; E1...
7482342 Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors  
Compound corresponding to general formula (I): in which, R1 represents a hydrogen or halogen atom, an NH2, NHR2, NHCOR2, NO2, CN, CH2NH2 and CH2NHR2; or alternatively R1 represents an optionally...
7470709 Benzimidazole quinolinones and uses thereof  
Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt...
7456196 Bicyclic-substituted amines as histamine-3 receptor ligands  
Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the...
7449479 Hepatitis C virus inhibitors  
Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for...
7439257 Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics  
The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.
7439256 (Arylamidoaryl) cyanoguanidine compounds  
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R5 and J are defined herein, are useful in the treatment of cancer.
7435750 Method of using substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof  
The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present...
7432282 Pyridinalkyl-aminoalkyl-IH-indole derivatives having an inhibitory action on 5-HT and serotonin reuptake as antidepressants and anxiolytics  
Novel indole derivatives of the formula (I), in which X, Y, R1, R1′, m and n have the meanings indicated in Patent Claim 1, have a strong affinity to the 5-HT1A and in some cases to the 5-HT1D...
RE40525 Hepatitis C inhibitor tri-peptides  
A racemate diastereoisomer and optical isomer of a compound of formula (I): wherein B is H, a C6 or C10 aryl, C7-16 aralkyl; Het or (lower alkyl)-Het, all of which may be optionally substituted...
7425564 Quinoline derivative and quinazoline derivative inhibiting self-phosphorylation of hepatocytus prolifertor receptor and medicinal composition containing the same  
An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically...
7419967 Sulfonamide inhibitors of aspartyl protease  
The present invention relates to a novel class of sulfonamides which are aspartyl protease inhibitors. In one embodiment, this invention relates to a novel class of HIV aspartyl protease...
7417062 Substituted arylamides  
Substituted benzamide compounds are provided along with methods for the use of those compounds for treating cancer.
7407974 Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade  
The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are...
7402606 Derivatives of 1-(oxoaminoacetyl) pentylcarbamate as cathepsin K inhibitors for the treatment of bone loss  
Heterocycle substituted ketoamide derivatives of Formula (I), wherein the substitutes A, D, A and R are defined as in claim in, which are useful as cathepsin K inhibitors are described herein. The...
7396838 Use of 1H-indol-3-yl-2-oxoacetamide compounds  
A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein R1, R2, R3, R4, and n are as defined herein.
RE40418 Treatment of neoplasms with CCI-779/EKB-569 combination  
This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.
7388012 (Hydrazido)(amino)thiophene compounds  
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A and J are defined herein, are useful in the treatment of tumors and cancers such as...
7381738 Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity  
The present application describes modulators of MCP-1 of formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, wherein X, Z, a, b, c, d, n, R1, R2, R3, R4, R5, R10, R10a, and...
7365081 Indole derivatives and their use as medicaments  
The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors
7358261 Heteroaryl alkylamide derivatives useful as bradykinin receptor modulators  
This invention is directed towards novel alkylamide derivatives as bradykinin receptor antagonists useful for the treatment of bradykinin modulated disorders such as pain, inflammation, asthma and...
RE40245 Gyrase inhibitors and uses thereof  
The present invention relates to compounds of the formula I: or a pharmaceutically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity....
7354933 Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors  
The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it...
7351729 JNK inhibitors for use in combination therapy for treating or managing proliferative disorders and cancers  
The present invention relates to methods and compositions designed for the treatment, management or prevention of cancer. The methods of the invention comprise the administration of an effective...
7345058 Pyrazoles  
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and...
7342027 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof  
Provided are 1-phenylpiperidin-3-one derivatives and pharmaceutically acceptable salts thereof, having cysteine protease inhibitory activity, pharmaceutical compositions containing the same as an...