AcclaimIP-ad

Match Document Document Title
7825132 Inhibition of FGFR3 and treatment of multiple myeloma  
Methods of inhibiting fibroblast growth factor receptor 3 and treating various conditions mediated by fibroblast growth factor receptor 3 are provided that include administering to a subject a...
7825131 Quinoline potassium channel inhibitors  
The present invention relates to compounds having the structure (I) useful as potassium channel inhibitors to treat cardiac arrhythmias, and the like.
7825115 Cyclic urea compounds, preparation thereof and pharmaceutical use thereof as kinase inhibitors  
The disclosure relates to a cyclic urea compound of formula I: as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an...
7816372 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds  
The present invention is directed to compounds, pharmaceutical compositions, and methods for modulating processes mediated by AR. Also provided are methods of making such compounds and...
7816352 Apoptosis inhibitors  
The present invention provides compounds that act as selective agents to protect against unintentional cell death or tissue damage and can relieve side effects of cancer treatment such as, for...
7807694 Chemokine receptor binding heterocyclic compounds  
Compounds which modulate chemokine receptor activities are disclosed. These compounds are preferably tertiary amines comprising tetrahydroquinoline and benzimidazole.
7807692 Antidiabetic oxazolidinediones and thiazolidinediones  
Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that...
7807693 Substituted prolinamides, manufacturing, and the use thereof as medicaments  
The present invention relates to new substituted prolinamides of general formula (I) wherein D, L, E, G, J, M, R3, R4, R5 and R13 are defined as in the specification, the tautomers, the...
7807682 Pyridyl cyanoguanidine compounds  
Compounds according to formula I wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C1-6 hydrocarbon radical, optionally substituted with...
7786137 Bicyclic derivatives as modulators of ion channels  
Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
7781438 Indolylmaleimide derivatives  
A compound of formula (I) wherein R, R1, and R2, ring A and ring B are as defined in the specification, processes for their production, their uses, in particular in transplantation, and...
7776922 Substituted [(phenylethanoyl)amino]benzamides  
The invention relates to substituted [(phenylethanoyl)amino]benzamides and methods for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of...
7776883 Quinolin-4-ones as inhibitors of retroviral integrase for the treatment of HIV, AIDS and AIDS related complex (ARC)  
Novel quinoline inhibitors of retroviral integrase, particularly HIV-1 integrase. The quinoline inhibitors are oxoquinolines that can be used for preventing or treating AIDS or HIV infection in a...
7776529 Methine-substituted cyanine dye compounds  
Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6...
7772250 Compounds  
This invention relates to cinnamate salts of 5-[(R)-2-(2-{4-[4-(2-amino-2-methyl-propoxy)-phenylamino]-ph enyl}-ethylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-o ne.
7767670 Substituted 3-carboxamido isoxazoles as kinase modulators  
The invention provides methods and compositions for treating conditions mediated by various kinases wherein substituted 3-carboxamido isoxazoles compounds are employed. The invention also provides...
7754717 Bis-aryl amide compounds and methods of use  
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one...
7754735 Substituted indoles  
The present invention relates to substituted indoles of formula (I), useful as pharmaceutical compounds for treating respiratory disorders.
7745456 Synthesis and antimicrobial activity of novel dicationic “reversed amidines”  
The present invention relates to novel 2,5-bis{[alkyl (or aryl) imino] aminophenyl}furans and thiophenes of the general formula in which R1, R2, R3 and R4 are each independently selected from the...
7745463 Alkene piperidine derivatives as antiviral agents  
This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with alkene piperidine...
7728007 Therapeutic amides  
The invention provides compounds of the formula: wherein X, Y, and Z are as defined in the specification. The compounds are effective anti-tumor agents. The invention also provides pharmaceutical...
7709022 Sustained-release preparations of quinolone antibiotics and method for preparation thereof  
The present invention relates to an orally administrable preparation comprising a quinolone antibiotic which releases the active compound with a delay.
7705018 Substituted quinolines and their uses in treatment of inflammatory and related conditions  
Substituted bicyclic heteroaryls having the general formula and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory...
7705023 Indoles useful in the treatment of inflammation  
There is provided a compound of formula: (I), wherein X, R1, R2, R3, R4, R5 and R6 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful...
7704997 Amino-tetrazole analogues and methods of use  
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and...
7700621 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations  
This invention describes the new 6-alkenyl- and 6-alkinyl-epothilone derivatives of general formula (I) in which R1a, R1b, R2a, R3a, R3b, R4, R5, R6, R7, A, Y, D, E, G, Y and Z have the meanings...
RE41253 Antineoplastic combinations  
This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.
7700552 Macrocyclic inhibitors of hepatitis C virus  
Compounds of the formula (I): and N-oxides, salts and stereoisomers thereof wherein A is OR1, NHS(═O)pR2, NHR3, NRaRb, C(═O)NHR3 or C(═O)NRaRb wherein; R1 is hydrogen, C1-C6alkyl,...
7696226 HIV protease inhibiting compounds  
A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
7696227 Small-molecule inhibitors of the androgen receptor  
The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2, R3 and R8 are each independently...
7696225 (2-carboxamido)(3-Amino) thiophene compounds  
Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.
7687516 Alcohol free formulation of argatroban  
An aqueous formulation of argatroban and of related compounds is disclosed along with a reconstitutable formulation, each of which is substantially, if not totally alcohol free. The formulations...
7683076 Tetrahydro-quinolinylurea derivatives  
This invention relates to tetrahydro-quinolinylurea derivatives and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-quinolinylurea derivative of...
7678812 Aminotetralin-derived urea modulators of vanilloid VR1 receptor  
This invention is directed to vanilloid receptor VR1 ligands. More particularly, this invention relates to β-aminotetralin-derived ureas that are potent antagonists or agonists of VR1 which are...
7678814 Aroyl-piperidine derivatives  
The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloy-lam ino)-piperidines of the formula . . . wherein Y and R each are as defined above and the ring A is...
7671070 Method of treating ophthalmic infections with moxifloxacin compositions  
Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The...
7662815 Diaryl ether β2 adrenergic receptor agonists  
The invention provides novel β2 adrenergic receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat...
7662834 Methods of 1H-indol-3-yl-2-oxoacetamide compounds  
This invention relates to treating cancer or an angiogenesis-related disease using a compound of formula 1: wherein R1, R2, R3, R4, and n are defined herein.
7659298 Pyrazole derivatives and use thereof as orexin receptor antagonists  
The present invention relates to the orexin receptor antagonists compounds of the general formula (I) as well as to their isomers, salts and solvates, to the pharmaceutical compositions containing...
7659286 N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl)benzamide  
N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-yl methyl)piperidin-4-ylidene)methyl)benzamide, pharmaceutically acceptable salts thereof, and/or mixtures thereof, as well as,...
7655688 Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function  
Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions...
7629340 N-(6-membered aromatic ring)-amido anti-viral compounds  
Disclosed are compounds having Formula (I) and the compositions and methods relating to these compounds, for treating or preventing a viral infection mediated at least in part by a virus in the...
7618965 (Arylamidoanilino)nitroethylene compounds  
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R1, R2, and R5 are defined herein, are useful in the treatment of tumors and...
7615563 Compositions useful as inhibitors of voltage-gated sodium channels  
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
7612069 Acyl guanidines as beta-secretase inhibitors  
There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4 and R5 as defined herein, their...
7608614 Process for preparing macrocyclic compounds  
Intermediates of the formula QUIN: and methods for their preparation are described. The intermediate compounds are useful for preparing active agents for the treatment of hepatitis C virus (HCV)...
7598236 Diazabicyclic central nervous system active agents  
Compounds of formula I pharmaceutical compositions of these compounds, and use of said compositions to control synaptic transmission in mammals.
7592357 Compounds  
Novel Inhibitors of Rho-kinases are disclosed.
7592337 Di-aryl substituted tetrazole modulators of metabotropic glutamate receptor-5  
Tetrazole compounds substituted directly, or by a bridge, with i) a heteroaryl moiety containing N adjacent to the point of connection of the heteroaryl and ii) another heteroaryl or aryl ring,...
7589068 Inhibitors of Akt activity  
The instant invention provides for compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for...