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8071601 Aminoquinoline derivatives and their use as adenosine A3 ligands  
The present invention relates to an adenosine A3 receptor ligand of the general formula (I).
8067401 Compounds and compositions for treating infection  
Compounds from 14 Kenyan plants, including from the root of Dovyalis abyssinica and Clutia robusta have been characterized and isolated, and their uses are disclosed.
8048898 Inhibitor of binding of S1P1  
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof: (wherein Y1 represents a nitrogen atom or a group represented by CRA, Y2 represents a nitrogen atom or a group...
RE42889 α- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors  
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
8044068 Aminopyrrolidine compound  
Disclosed is an aminopyrrolidine compound represented by the formula [I] or a pharmaceutically acceptable salt thereof. The compound or the salt is useful as a prophylactic/therapeutic agent for...
8039490 Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors  
The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in...
8026258 Aryloxyalkylcarbamate-type derivatives, preparation method thereof and use of same in therapeutics  
The invention relates to a compound of formula (I): Wherein m, n, X, Y, R1, R2, R3 and R4 are as defined herein. The invention also relates to the use of same in therapeutics.
8026253 Quinoline inhibitors of HCV polymerase  
Compounds having the formula I wherein wherein R1, R2, R3, R4, X1, X2, X3 and X4 and as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods...
8017601 Bis-aryl kinase inhibitors and method  
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
8008324 Indole derivatives and their use as medicament  
The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
8008306 Quinoline compounds  
To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia;...
7998980 Compounds for modulating TRPV3 function  
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
7998971 Combinations containing a 4-acylaminopyridine derivative  
The instant disclosure describes compositions and methods for treating diseases and conditions of the central and peripheral nervous system. The disclosure includes compositions and methods based...
7994189 Dihydropyridine derivatives  
The present invention relates to dihydropyridine derivatives having general formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl,...
7994174 Pyridyl sulfonamides as modulators of ion channels  
The present invention relates to pyridyl sulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds...
7989453 Indole derivatives and their use as medicament  
The invention relates to novel indole derivatives of the general formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.
7985762 Inhibitors of serine proteases  
The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C...
7977355 N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-ylmethyl)piperidin-4-ylidene)methyl  
N-(2-hydroxyethyl)-N-methyl-4-(quinolin-8-yl(1-(thiazol-4-yl methyl)piperidin-4-ylidene)methyl)benzamide, pharmaceutically acceptable salts thereof, and/or mixtures thereof, as well as,...
7977354 Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents  
The invention is related to compound which comprises at least one radical C═Y, Y being O or S, and an oxidable and non protonable nitrogen atom N wherein the distance (d) between the at least one...
7973030 Benzothiazepine and benzothiepine compounds  
A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated...
7968577 Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof  
Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including inflammatory and...
7968567 Compounds for the modulation of PPARγ activity  
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
7964616 Compounds 679  
The invention provides compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them, a process for preparing the pharmaceutical compositions, and their...
7964204 Isoxazolines for controlling invertebrate pests  
Disclosed are compounds of Formula (1), including all geometric and stereoisomers, N-oxides, and salts thereof, Formula (1): wherein A1, A2, A3, A4, A5 and A6 are independently, selected from the...
7960409 Pharmaceutical phenylquinoline and chromen-2-one triazole compounds  
The instant invention provides compounds of Formula I which are leukotriene biosynthesis inhibitors. Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic,...
7956071 Imidazole compounds  
Imidazole compounds, compositions, and methods of using them in leukocyte recruitment inhibition, in modulating H4 receptor expression, and in treating conditions such as inflammation, H4...
7947683 3-(1,2,4-triazol-3-ylalkyl) azabicyclo (3.1.0) hexane derivatives as modulators of dopamine D3 receptors  
The present invention relates to novel compounds of formula (I) or pharmaceutically acceptable salt thereof: processes for their preparation, intermediates used in these processes, pharmaceutical...
7947713 Tripeptidyl peptidase inhibitors  
The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as...
7947711 Bicyclic-substituted amines as histamine-3 receptor ligands  
Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising the...
7943605 Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses  
The present invention relates to compounds of formula (I) comprising a lactam or a lactam derivative moiety, processes for preparing them, pharmaceutical compositions comprising said compounds and...
7943640 Compositions and methods for inhibiting TGF-β  
The present invention provides compounds of the formula: and pharmaceutically acceptable isomers, salts, hydrates, solvates, and prodrug derivatives thereof, wherein R1, R6, R7, R8, Pg, and n are...
7943641 7-((1H-imidazol-4-yl)methyl)-5,6,7,8-tetrahydroquinoline  
A compound having a structure or a pharmaceutically acceptable salt, or a prodrug thereof is disclosed herein. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
7928133 Compounds and compositions as hedgehog signaling pathway modulators  
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from...
7915291 Hepatitis C virus inhibitors  
Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for...
7915292 Antibacterial quinoline derivatives  
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof,...
7910561 Inhibitors of Akt activity  
The present invention is directed to compounds which contain substituted naphthyridines which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to...
7902181 Compounds 010  
The present invention provides compounds of formula (I) in which n, y, X1, X2, A, B, R1, R2, R3, R4 and R5 are as defined in the specification, a process for their preparation, pharmaceutical...
7884114 Compounds  
The present invention relates to a compound which is N-(4-{4-[(6-butyl-8-quinolinyl)oxy]-1-piperidinyl}butyl)etha nesulfonamide and salts thereof, processes for its preparation, to compositions...
7879879 Biphenyl derivatives  
This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate...
7872020 TGF-β inhibitors  
The present invention provides crystalline 2-(6-methyl-pyridin-2-yl)-3-[6-amido-quinolin-4-yl)-5,6-dihy dro -4H-pyrrolo[1,2-b]pyrazole monohydrate.
7872004 6-(heterocyclyl-substituted benzyl)-4-oxoquinoline compound and use thereof as HIV integrase inhibitor  
The present invention relates to a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a...
7872010 Substituted diazabicycloalkane derivatives having affinity for nicotinic acetylcholine receptors  
Provided herein are compositions of a class of substituted diazabicycloalkane derivative compounds, which are useful as modulators of nicotinic acetylcholine receptors. The compounds are useful in...
7863293 CXCR4 chemokine receptor binding compounds  
The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to...
7858629 Substituted imidazole 4-carboxamides as cholecystokinin-1 receptor modulators  
Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R)....
7858641 Substituted dihydroisoquinolinone compounds  
A variety of low molecular weight, guanidino-containing dihydroisoquinolinoines capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases. The...
7858642 Substituted hydroxyethylamine aspartyl protease inhibitors  
The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a...
7855203 Indazolyl-substituted pyrroline compounds as kinase inhibitors  
The present invention is directed to novel indazolyl-substituted pyrroline compounds of Formula (I): useful as kinase or dual-kinase inhibitors, methods for producing such compounds and methods...
7846925 Azolidinone-vinyl fused-benzene derivatives  
The present invention is related to azolidinedione-vinyl fused-benzene derivatives of formula (I) for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases,...
7834030 Phenyl-[1,2,4]-oxadiazol-5-one derivatives, pharmaceutical compositions and therapeutic use thereof  
The present invention comprises phenyl-[1,2,4]-oxadiazol-5-one derivatives of the general formula I: wherein the R1-R10 and B, U, V, W, X, Y and Z substituents are defined herein. The claimed...
7834016 Inhibitors of the interaction between MDM2 and p53  
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds of formula (I) wherein...