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8357700 2,3-disubstituted piperidine orexin receptor antagonists  
The present invention is directed to 2,3-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and...
8357702 Bicyclic derivatives as modulators of voltage gated ion channels  
Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
8357701 Galactokinase inhibitors  
Therapeutic agents for treatment of Galactosemia and disorders thereof, and other enzyme related disorders thereof are identified. The compounds inhibit galactokinase (GALK) and other kinase...
8354429 Inhibitors of human immunodeficiency virus replication  
Compounds of formula I: wherein R4, R6 and R7 are defined herein, are useful as inhibitors of HIV replication.
8349869 Macrocylic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond;X is N, CH and where X bears a double bond it...
8349830 Aryl aminopyridine PDE10 inhibitors  
The present invention is directed to aryl aminopyridine compounds which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10...
8343970 PDE10 inhibitors and related compositions and methods  
Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological...
8343998 Triazolothiadiazole inhibitor of c-Met protein kinase  
The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1...
8324217 Cold menthol receptor antagonists  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
RE43802 α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors  
α- and β-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.
8299094 Hepatitis C virus inhibitors  
Hepatitis C virus inhibitors are disclosed having the general formula: wherein R1, R2, R3, R′, B, Y and X are described in the description. Compositions comprising the compounds and methods for...
8299063 Amido-thiophene compounds and their use  
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
8293732 Antibacterial quinoline derivatives  
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): including any stereochemically isomeric form thereof, a N-oxide...
8282909 Pharmaceutical composition for topical application of poorly soluble compounds  
The present invention provides a formulation which contains a poorly water soluble pharmaceutically active compound at a concentration of 50 mg per 100 g formulation or above. The solubility is...
8273768 Iso CA-4 and analogues thereof as potent cytotoxic agents inhibiting tubuline polymerization  
The invention relates to a compound of the formula (I) in which: R1, R2 and R3 are independently a methoxy group optionally substituted by one or more fluorine atoms; R4 is a hydrogen atom; R5 and...
8268803 5, 6-ring annulated indole derivatives and use thereof  
The present invention relates to 5,6-ring annulated indole derivatives of the formula (I), compositions comprising at least one 5,6-ring annulated indole derivatives, and methods of using the...
8263622 Fused-ring derivative and medical application of same  
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates...
8263588 Gonadotropin-releasing hormone receptor antagonists and methods relating thereto  
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the...
8247431 Heterocyclic hydrazide compound and pesticidal use of the same  
A hydrazide compound represented by the formula (I), an N-oxide thereof or suitable salt thereof: has excellent pesticidal activity.
8247432 Tripeptidyl peptidase inhibitors  
The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as...
8242135 Biphenyl derivatives  
This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate...
8236801 2-aza-bicyclo[2.2.1]heptane derivatives  
The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of...
8231888 Isoxazolines for controlling invertebrate pests  
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein A1, A2, A3, A4, A5 and A6 are independently selected from the group consisting...
8227504 Substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof  
The present invention discloses and claims a series of substituted N-phenyl-pyrrolidinylmethylpyrrolidine amides of formula (I). Wherein R, R1, R2, R3 and R4 are as described herein. More...
8221737 Hepatitis C virus inhibitors  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
8222248 Organic compounds  
The present invention provides compounds of the following structure; A-L1-B—C-D that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in animals,...
8217056 Triazolothiadiazole inhibitor of c-Met protein kinase  
The present invention relates to compound 1, which is useful in the inhibition of c-Met protein kinase. The invention also provides pharmaceutically acceptable compositions comprising Compound 1...
8211910 Tri-, tetra-substituted-3-aminopyrrolidine derivative  
A quinolone synthetic antibacterial agent and a therapeutic agent for an infection which exhibit broad spectrum and strong antibacterial activity for both Gram positive and Gram negative bacteria,...
8207194 Compounds having a 4-pyridylalkylthio group as a substituent  
A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a...
8207196 Compositions and methods for the treatment of metabolic disorders  
The present invention relates to treatment and/or prevention of one or more metabolic disorders utilizing fatostatin A and/or a derivative and/or analog thereof. In other aspects, the compound for...
8202886 Small molecule E2F inhibitor  
A small molecular inhibitor of E2F (HLM006474) was identified using a computer-based virtual screen and the known crystal structure of the DNA bound E2F4/DP2 heterodimer. Treatment of multiple...
8198301 Quinazoline and quinoline derivatives as irreversibe protein tyrosine kinase inhibitors  
A compound of formula (I), a pharmaceutically acceptable salt, or hydrate thereof, and a method of preparing the same. A method of treating or preventing a physiological disorder caused by...
8198275 Adamantyl diamide derivatives and uses of same  
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions...
8193218 Aroyl-piperidine derivatives and method of treating disorders induced by substance P  
The invention relates to a method of administering N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylami no)-piperidines of the formula wherein Y is ═N— or ═N(O)—, R is OH when Y is ═N— and...
RE43431 Quinazoline derivatives and pharmaceutical compositions containing them  
A compound of general formula I wherein: Ra is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group;Rb is a dimethylamino, N-methyl-N-ethylamino, diethylamino, N-methyl-N-isopropylamino,...
8183258 Heterocyclic compounds and their uses  
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders,...
8183259 Heterocyclic compounds and their uses  
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders,...
8178558 Substituted pyridylmethyl bicycliccarboxyamide compounds  
This invention relates to novel substituted pyridylmethyl bicyclocarboxamide compounds and to their use in therapy. These compounds are particularly useful as modulators of the VR1 (Type I...
8163729 Modulators of α7 nicotinic acetylcholine receptors and therapeutic uses thereof  
The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to...
8153659 4′-O-substituted isoindoline derivatives and compositions comprising and methods of using the same  
Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical...
8148399 Macrocyclic inhibitors of hepatitis C virus  
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it...
8143259 Cold menthol receptor antagonists  
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows:...
8143278 Organic compounds  
The present invention provides a compound of formula I: said compound is inhibitor of aldosterone synthase, and/or 11beta-hydroxylase (CYP11B1), and thus can be employed for the treatment of a...
8129415 Fungicide hydroximoyl-tetrazole derivatives  
The present invention relates to hydroximoyl-tetrazole derivatives of formula (I) wherein T represent a tetrazolyl substituent, A represents a carbo- or heterocycle, L1 and L2 represent various...
8124622 Triglyceride-lowering agent and hyperinsulinism-ameliorating agent  
The present invention is directed to a triglyceride-lowering agent, exhibiting excellent triglyceride-lowering effect and a hyperinsulinemia-ameliorating agent. The triglyceride-lowering agent and...
8119660 Small-molecule inhibitors of the androgen receptor  
The present invention provides a method of inhibiting an androgen receptor by administering a compound of Formula I: or a compound of Formula II: wherein R1, R2, R3 and R8 are each independently...
8114893 Compounds and methods of use  
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In...
8097637 Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors  
The present invention relates to compounds of formula (I) wherein R1 and A are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their...
8097623 Indoles useful in the treatment of inflammation  
There is provided compounds of formula (I), wherein X1, Q, T, Y, R1, R2, R3, R4 and R5 have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are...
8071616 Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors  
This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i)...