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8586608 Quinazoline derivatives and pharmaceutical compositions containing them  
A compound of general formula I wherein: Ra is a benzyl, 1-phenylethyl, or 3-chloro-4-fluorophenyl group;Rb is a dimethylamino, N-methyl-N-ethylamino, diethylamino, N-methyl-N-isopropylamino,...
8586565 Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases  
The present invention is concerned with novel compounds useful in the treatment of hyperproliferative diseases and mammalian cancers, especially human cancers. The invention also pertains to...
8580784 Method for treating a disease related to the glucocorticoid receptor  
A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-dihydroquinoline compound.
8580773 Small-molecule inhibitors of the androgen receptor  
The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. The present invention provides a method of using tetrahydropyrvinium...
8575193 N-substituted tetrahydroisoquinoline/isoindoline hydroxamic acid compounds  
Compounds of a certain formula (I) wherein R1, R2, R3, X, Y, r, s, t, u and v have the meanings as defined in the specification, and the salts, solvates and hydrates thereof are novel effective...
8563580 Flavivirus inhibitors and methods for their use  
Methods of treating, preventing, and/or ameliorating a Flavivirus infection in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a...
8563551 Method for preventing or treating a disease related to the glucocorticoid receptor  
A method for preventing or treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-dihydroquinoline compound or a...
8557823 Family of PFKFB3 inhibitors with anti-neoplastic activities  
A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer,...
8546374 Amino-tetrazoles analogues and methods of use  
A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R5, are as defined in the description. Methods and...
8536165 Azabiphenylaminobenzoic acid derivatives as DHODH inhibitors  
The present disclosure relates to new azabiphenylaminobenzoic acid derivatives of formula (I); as well as processes for their preparation, pharmaceutical compositions comprising them, and their...
8524699 Substituted dihydropyrazolones and use thereof as HIF-prolyl-4-hydroxylase inhibitors  
The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the...
8524712 Triazinone and diazinone derivatives useful as HSP90 inhibitors  
The present invention relates to compounds according to formulae (IA) to (ID) and compositions that inhibit the activity of Hsp90. The invention further relates to methods of inhibiting the...
8518970 Compounds and methods of use  
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In...
8507509 Saturated and insaturated bi- or tricyclic aryloxyacetamine derivatives and their use as fungicides  
Compounds of the general formula (I), wherein the substituents are as defined in claim 1, are useful as fungicides.
8501774 Oxazolidinone-quinolone hybrid antibiotics  
The present invention relates to compounds of the Formula (I) that are useful antimicrobial agents and effective against a variety of multi-drug resistant bacteria:
8501773 4-fluoro-piperidine T-type calcium channel antagonists  
The present invention is directed to 4-fluoro-piperidine compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of neurological and...
8501747 Functionally selective alpha2C adrenoreceptor agonists  
In its many embodiments, the present invention provides a novel class of biaryl compounds as inhibitors of ÿ2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical...
8501746 Organic compounds  
The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase...
8497283 Autotaxin inhibitors  
The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or...
8492386 Methods for treating HCV  
The present invention features interferon- and ribavirin-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks....
8486969 Therapeutic compounds  
Disclosed herein is compound having a structure Therapeutic methods, compositions, and medicaments are also disclosed herein.
8481534 5- and 6-membered heterocyclic compounds  
5- and 6-membered heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described as are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical...
8476249 Method of treating thrombocytopenia  
Invented is a method of treating thrombocytopenia in a human, in need thereof which comprises the in vivo administration of a therapeutically effective amount of a peptide or a non-peptide TPO...
8470529 Methine-substituted cyanine dye compounds  
Cyanine dye compounds having a substituted methine moiety that are nucleic acid stains, particularly for fluorescent staining of RNA, including compounds having the formula where R1 is a C1-C6...
8466159 Methods for treating HCV  
The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration, such as no more than 12 weeks. In one aspect, the therapies...
8466148 1,2-disubstituted heterocyclic compounds  
1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and...
8461156 Modulators of ATP-binding cassette transporters  
Compounds of the present invention, and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including...
8455516 HIV-1 fusion inhibitors and methods  
A new series of HIV-1 fusion inhibitors and methods of use are disclosed. The compounds are based on a substituted indole, benzimidazole, indoline or isoindoline fragment. The compounds find use...
8445491 Wnt protein signalling inhibitors  
The present invention generally relates to protein signalling. In particular, compounds that inhibit the Wnt protein signalling pathway are disclosed. Such compounds may be used in the treatment...
8440706 Inhibitors of serine proteases  
The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C...
8440660 Method for treating a disease related to the glucocorticoid receptor  
A method for treating a disease related to the glucocorticoid receptor involving administering a pharmacologically effective amount of a 1,2-hydroquinoline compound.
8426406 Glucocorticoid receptor agonist comprising 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivatives having substituted oxy group  
The present invention is related to glucocorticoid receptor agonists comprised of a compound represented by formula (1) which is 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative or a salt...
8426440 Indolymaleimide derivatives  
A compound of formula (I), wherein R, R1, R2, ring A, which ring contains one or two nitrogen atoms, and ring B are as defined in the Specification, pharmaceutical compositions containing these...
8415376 Inhibitors of PI3 kinase  
The present invention relates to compounds of Formula (I), or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and...
8415374 Combinations of hepatitis C virus inhibitors  
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit Hepatitis C virus (HCV), compositions comprising...
8415377 Triazole compounds that modulate HSP90 activity  
The present invention relates to substituted triazole compounds and compositions comprising substituted triazole compounds. The invention further relates to methods of inhibiting the activity of...
8404715 Methods and compositions using racemic, (R)-, and (S)-fexofenadine in combination with leukotriene inhibitors  
Methods and pharmaceutical compositions employing a terfenadine metabolite and a leukotriene inhibitor for the treatment or prevention of inflammation or allergic disorders, such as asthma, or...
8404726 Activating agent for peroxisome proliferator activated receptor δ  
A compound represented by the following general formula (II) or a salt thereof is used as an activator of PPARδ. wherein Ga is O, CH2 or the like;Aa is thiazole, oxazole, or thiophene, which can...
8399484 Combination therapy for treating HCV infection  
The present invention relates to therapeutic combinations comprising (a) Compound (1), or a pharmaceutically acceptable salt thereof, as herein described, (b) an interferon alfa and (c) ribavirin....
8394794 Therapeutic compounds  
The invention provides compounds of Formula (I) and (IV): as described herein, as well as salts thereof. The compounds have anti-cancer properties and/or chemosensitization properties.
8389546 Compounds for modulating TRPV3 function  
The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
8389519 Adamantyl diamide derivatives and uses of same  
The present invention provides adamantyl-diamide derivatives of formula (I): wherein R1 and R2 are as defined herein, or a pharmaceutically acceptable salt thereof; and pharmaceutical compositions...
8383646 Therapeutic ((bicylicheteroaryl)imidazolyl) methylheteroaryl compounds  
Disclosed herein is a compound of the formula (I) therapeutic methods, compositions, and medicaments related thereto are also disclosed.
8383647 Quinoline derivative  
The present invention provides a compound having a melanin-concentrating hormone receptor antagonistic action and low toxicity, which is useful as an agent for the prophylaxis or treatment of...
8377963 Insulin-regulated aminopeptidase (IRAP) inhibitors and uses thereof  
The present invention relates to inhibitors of insulin-regulated aminopeptidase (IRAP) and methods for inhibiting same, as well as compositions comprising said inhibitors. In particular, the...
8377962 Macrocyclic serine protease inhibitors  
Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof....
8367679 Biaryl carboxamides  
This invention provides compounds of Formula (I) which are PAFR antagonists: Formula (I) and the pharmaceutically acceptable salts thereof. The compounds are useful for treating PAF-mediated...
8362008 Amido-thiophene compounds and their use as 11-beta-HSD1 inhibitors  
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit...
8362032 Bicyclic derivatives as modulators of ion channels  
Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
8357717 Spiro group-containing amide compounds having bradykinin 1 receptor (B1R) activity  
Substituted spiroamide compounds corresponding to formula (I): wherein A, B, Q1, Q2, Q3, Q4, R1, R8, R9a, R9b, R12, R13, R200 and R210 have defined meanings, processes for their preparation,...