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6051583 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indoles, processes for preparing them and their use as pharmaceutical compositions  
The present invention relates to new substituted 2,3,3a,4,9,9a-hexahydro-8-hydroxy-1H-benz[f]indole derivatives, processes for preparing them and their use as pharmaceutical compositions. The...
6048875 Benzothiophene, benzofuran and indole compounds  
A compound of formula (I): ##STR1## wherein: X represents oxygen, sulphur, or NR3 wherein R3 is as defined in the description, Y represents oxygen, sulphur, NR3, or may a single bond when X...
6046212 Chalcone derivatives and drugs containing the same  
This invention relates to chalcone derivatives represented by the following formula (1): wherein A represents a phenyl group, a quinolyl group or the like, W represents a vinylene group or the...
6043263 (2,3-dihydrobenzofuranyl)-thiazoles as phosphodiesterase inhibitors  
The invention relates to compounds of the formula (I), wherein R1, R2, R3, R4, R5 and n have the meanings cited in the description said compounds being new effective bronchial therapeutic agents.
6034100 Method for inhibiting cytokine secretion  
A method for the prophylaxis and treatment of diseases induced by acceleration of secretion of cytokines (e.g. TNF-α, IL-1, IL-6, IL-8, and IFN-γ) which comprises administering a benzoheterocyclic...
6028072 3,4-substituted pyrazoles for the treatment of inflammation  
A class of pyrazolyl compounds is described for use in treating inflammation and inflammation related disorders. Compounds of particular interest are defined by Formula I: ##STR1## wherein R1 is...
6017916 Nonpeptide endothelin antagonists I  
Novel nonpeptide antagonists of endothelin I are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of...
6011033 Phenylene derivatives  
This invention relates to a phenylene derivative represented by the following formula (1) or a salt thereof and also to a medicine containing it as an effective ingredient. ##STR1## wherein R1...
6011037 Thiazole derivatives with phosphodiesterase-inhibiting action  
PCT No. PCT/EP97/04435 Sec. 371 Date Feb. 26, 1999 Sec. 102(e) Date Feb. 26, 1999 PCT Filed Aug. 13, 1997 PCT Pub. No. WO98/08841 PCT Pub. Date Mar. 5, 1998Compounds having the formula (I):...
6008230 Quinoline compounds as H+ -ATPases  
This invention relates to a quinoline compound of the formula: ##STR1## wherein R1 is a pyridyl group or aryl, each of which may be substituted with suitable substituent(s), A is --COHN-- or...
6008231 N-substituted indole-3 glyoxylamides having anti-asthmatic antiallergic and immunosuppressant/immuno-modulating action  
The invention relates to novel N-substituted indole-3-glyoxylamides, to processes for their preparation and to their pharmaceutical use. The compounds have antiasthmatic, antiallergic and...
6004988 Carboxylic acid derivatives, their preparation and their use  
Carboxylic acid derivatives of the formula I ##STR1## here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the...
6001807 Use of CRF-antagonists for treating emesis  
CRF-antagonists are useful in the treatment of emesis.
5998437 Benzimidazole derivatives  
The present invention provides novel benzimidazole derivatives or salts thereof represented by the general formula, ##STR1## wherein R1 is a hydrogen atom or a halogen atom; R2 is a phenyl-lower...
5994368 Pyridopyrimidones, quinolines and fused N-heterocycles as bradykinin antagonists  
This invention relates to a compound of the formula: ##STR1## wherein Z is a group of the formula: ##STR2## in which X1 is N or C--R1, X2 is N or C--R9, X3 is N or C--R2, R1 is lower alkyl, R2 is...
5977136 Tetrahydroquinolines as NMDA antagonists  
Compounds of formula (I) or a salt, or metabolically labile ester thereof, processes for the preparation thereof and their use as antagonists of excitatory amino acids. ##STR1##
5977169 Substituted tetronic acids useful for treating HIV and other retroviruses  
This invention comprises novel substituted tetronic acid type compounds, 2, 4(3H, 5H)-furandiones, that are useful for the inhibition of the HIV protease enzyme. The compounds may be useful for...
5972975 Substituted 2-aminopyridines as inhibitors of nitric oxide synthase  
Substituted 2-aminopyridine compounds of Formula (I) and pharmaceutically acceptable salts which have been found useful in the treatment of nitric oxide synthase mediated diseases and disorders....
5972959 Oxime derivatives, their preparation and their therapeutic use  
Compounds of formula (I): ##STR1## wherein: R1 is hydrogen or alkyl; R2 is alkylene; R3 is hydrogen, alkyl, alkoxy, alkylthio, halogen, nitro group, amino group, monoalkylamino, dialkylamino,...
5968548 Use of liposome encapsulated cirprofloxacin as an immunotherapeutic drug  
Liposome-encapsulated quinolones and specifically liposome-encapsulated ciprofloxacin dramatically enhances macrophage functions, induces NO production and augments the production of cytokines,...
5968952 Farnesyl transferase inhibiting 2-quinolone derivatives  
The present invention is concerned with compounds of formula (I), ##STR1## the stereoisomeric forms thereof and the pharmaceutically acceptable acid or base addition salts thereof, wherein the...
5965562 Aroyl-piperidine derivatives  
The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(azanaphthoyl -amino)-piperi dines of the formula ##STR1## wherein X and Y are each independently of the other N...
5965582 N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect  
The N-benzylindole- and benzopyrazole derivatives of the general formula 1 ##STR1## possess anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effect and are suitable for the...
5965565 Piperidines promote release of growth hormone  
The present invention is directed to certain piperidines, pyrrolidines, and hexahydro-1H-azepines of the general structural formula: ##STR1## wherein B is selected from: ##STR2## and R1, R1a, R2a,...
5962468 7-(4-aminomethyl-3-methyloxyiminopyrrolidin-1-yl)-1- cyclopropyl-6-fluoro-4-oxo-1, 4-dihydro-1, 8-naphthyridine-3-carboxylic acid and the process for the preparation thereof  
The present invention relates to a novel quinolone compound having an excellent antibacterial activity. More specifically, the present invention relates to...
5962513 2-aminomethyl-chromans effective in the treatment of psychoses and depression  
Diseases characterized by disturbances of the serotoninergic system, psychoses and depression are treated by administration of an aminomethyl-chroman of the formula ##STR1##
5958948 Substituted pyrazoles as CRF antagonists  
The compounds of the formula wherein A, R1, R3, X1, Y and Z are as defined herein, have corticotropin-releasing factor (CRF) antagonist activity. They are useful in the treatment of illnesses...
5955474 Use of neurotensin antagonists for the treatment of edematous conditions  
This invention relates to the treatment of edematous conditions in an animal by administering a neurotensin antagonist having diuretic activity.
5952349 Muscarinic antagonists for treating memory loss  
1,4 Di-substituted piperidine muscarinic antagonists of formula I ##STR1## or a pharmaceutically acceptable salt, ester, or solvate thereof, wherein X is a bond, --O--, --SO0-2 --, --CO--,...
5952346 Use of non-peptide bradykinin antagonists for the treatment or prevention of Alzheimer's disease  
The invention relates to the use of non-peptide bradykinin antagonists for the production of pharmaceuticals for the prevention and treatment of Alzheimer's disease. Suitable Compounds are...
5948778 Difluoro statone antiviral analogs  
This invention relates to novel statone antiviral analogs, to the processes and intermediates useful for their preparation and to their use as antiviral agents.
5948791 Quinoline derivatives for treating malaria  
The invention relates to novel quinoline derivatives and their therapeutic use against malaria.
5948782 Pharmaceutical composition containing quinoline and quinazoline derivatives and novel compounds therefor  
There is disclosed an anti-inflammatory agent comprising a compound of the formula (I): ##STR1## The quinoline compounds included in the compound (I) are novel and there is also disclosed...
5942535 a!-Annelated pyrrole derivatives and pharmaceutical use thereof  
The present invention relates to heterocyclic compounds of the formula ##STR1## in which R1 -R7, B, a and X have the meanings recited in the specification. These compounds are usable in the...
5935973 Heterocyclcarboxamide derivatives and their use as therapeutic agents  
Compounds of formula I ##STR1## and pharmaceutically acceptable salts thereof in which A is methylene or O; B is methylene or O; g is 0,1,2,3 or 4; R1 is an optional substituent; U is an alkylene...
5932591 C3 substituted trioxanes useful as antiparasitic drugs  
Novel biologically-active 3-substituted trioxanes of the formula ##STR1## wherein R represents a substituted alkyl or aryl group of 1-20, preferably 1-12, carbon atoms, and methods for the use of...
5932592 Quinoline or quinazoline derivatives, their production and use  
A compound represented by the general formula: ##STR1## wherein Y represents a nitrogen atom or C-G (G represents a carboxyl group which may be esterified); ring R is a nitrogen-containing...
5929087 Decahydroquinoline-based anti-cholinergic agents  
Compounds of formula I or formula II: ##STR1## wherein R, J, and Q have any of the values defined in the specification, and their pharmaceutically acceptable salts and related...
5925651 Inhibitors of farnesyl-protein transferase  
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to...
5925653 Substituted pyridines and pyrimidines processes for their preparation and their use as pesticides and fungicides  
Substituted pyridines and pyrimidines, processes for their preparation and their use as pesticides and fungicides.The invention relates to compounds of the formula ##STR1## in which A is N or CH,...
5922733 Pyridil carboxamides as 5HT2B/2C receptor antagonists  
Novel heterocyclic compounds having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the treatment of CNS disorders are disclosed.
5922725 Benzimidazole compounds and their use as modulators of the GABAA receptor complex  
The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R3 is ##STR2## wherein A, B and D each is...
5908824 Nasally administrable compositions containing physiologically active peptides  
A nasally administrable composition having a physiologically active peptide dispersed homogeneously in and adsorbed homogeneously onto a unique carrier. The composition contains an effective...
5889038 Methods and products for treating diarrhea and scours: use of clotrimazole and related aromatic compounds  
A method and product for treating and preventing diarrhea and scours is provided. The method involves treating a subject who has diarrhea, or scours, or is at risk of getting diarrhea or scours...
5889022 Indole, indoline and quinoline derivatives with 5HT1D (anti-depressive) activity  
Novel indole, indoline and quinoline derivatives of formula (I) processes for their preparation, pharmaceutical compositions containing them, and their use in medicine is disclosed. A structurally...
5889003 Flavone compounds  
A compound of general formula (I): ##STR1## in which: R1 represents alkyl, X represents oxygen, --CHR'-- or --CR', R' is chosen from hydrogen and alkyl, R2 represents optionally substituted alkyl...
5889045 Benzopyran compounds  
A compound of formula (I): ##STR1## in which: R1 represents alkyl, R2, R4 and R5, which may be identical or different, represent hydrogen or alkyl, R3 represents any one of the groups as defined...
5874451 Propanolamine derivatives, processes for their preparation, pharmaceuticals comprising these compounds, and their use  
The invention relates to substituted propanolamine derivatives and their acid addition salts.Propanolamine derivatives of formula I, ##STR1## in which R1 to R8 have the meanings indicated in the...
5861424 Composition and method for treating cancer  
A pharmaceutical composition for treatment of cancer in a mammal comprising: (A) a therapeutically effective amount of at least one compound selected from the group consisting of compounds...
5856337 2-arylquinolines and process for producing the same  
2-Arylquinolines represented by formula (1): ##STR1## wherein R1, R3 to R9 each represents hydrogen, halogen, lower alkyl, cyclic lower alkyl, aryl, aralkyl, alkoxy or --Cm F2m+1 ; R2 represents...