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9181191 Heterobicyclic sphingosine 1-phosphate analogs  
Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
9040553 Phenoxyisobutyric acid compounds and method of synthesis  
The present invention provides a process for the synthesis of substituted phenoxymethylpropionic acid and related compounds. The compounds are useful for inhibiting the formation of AGEs (Advanced...
9040558 Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors  
The invention is directed to novel substituted benzylamino quinolines, compounds comprising substituted benzylamino quinolines, methods of making substituted benzylamino quinolines, the use of...
9040021 Heterocyclic compounds as imaging probes of tau pathology  
Heterocyclic compounds of formula (I) useful as imaging probes of Tau pathology in Alzheimer's disease are described. Compositions and methods of making such compounds are also described.
9034901 Pitavastatin calcium and process for its preparation  
The invention provides the process for the preparation of pitavastatin and its pharmaceutically acceptable salts thereof. In particular, the invention provides a process for the preparation of...
9029392 Quinoline derivatives as kinase inhibitors  
Disclosed are a series of quinoline and quinoxaline derivatives comprising a fluorinated ethyl side-chain, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine,...
9023848 Small-molecules as therapeutics  
The present invention provides compounds of formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful in...
9012496 Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof  
A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxo-5-yl)-N-(1-(2,3-dihydr oxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-ind ol-5-yl)cyclopropanecar...
9012474 Fluoroquinolone compositions  
The invention relates to pharmaceutical compositions comprising (i) a fluoroquinolone, (ii) a salt formed between a carboxylate anion and a divalent metal cation, (iii) a liquid comprising an...
8999972 Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration  
The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting...
9000009 Small molecule activators of mitochondrial function  
Methods for improving mitochondrial function, decreasing iron accumulation, and/or decreasing oxidative stress by exposing cells or treating a subject to compounds or compositions of the general...
8993595 Macrocyclic serine protease inhibitors  
Provided herein are macrocyclic serine protease inhibitor compounds, for example, of Formula Ia or Ib, pharmaceutical compositions comprising the compounds, and processes of preparation thereof....
8987301 Heteroarylaminoquinolines as TGF-beta receptor kinase inhibitors  
Novel hetarylaminoquinoline derivatives of formula (I) wherein X, Z, Het, R1, R2, R3 and R4 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed,...
8980917 Methods for treating or preventing brain infections  
The invention is directed to methods of treating organ specific infections in a host organism by administering compounds that target host receptors and/or host cellular signaling molecules to...
8980919 Combination of a carbostyril and carnitine  
The present invention relates to a medicament for treating occlusive and/or ischemic vascular disorder comprising a carbostyril derivative and carnitine.
8975278 8-hydroxy quinoline derivatives  
The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a...
8969378 Inhibitor of the differentiation of T cells into Th1 cells  
The present invention is to provide an inhibitor that inhibits differentiation of T cells into Th1 cells. The inhibitor that inhibits differentiation of T cells into Th1 cells contains, as an...
8969407 Administration of coumarin, butylated hydroxyanisole and ethoxyquine for the treatment of canities  
At least one compound selected from among coumarin and/or derivative thereof, butylated hydroxyanisole, ethoxyquine and mixtures thereof, and admixtures thereof with other active agents selected...
8969397 Systems and methods to treat pain locally  
Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting...
8969380 Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents  
The present invention provides secondary 8-hydroxyquinoline-7-carboxamide derivatives of general formula (I) and pharmaceutically acceptable salts thereof. These compounds are useful as antifungal...
8946153 Fast dissolving pharmaceutical composition  
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.
RE45314 N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors  
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of...
8916601 Aza-aryl 1H-pyrazol-1-YL benzene sulfonamides  
Compounds are provided that act as potent antagonists of the CCR(9) receptor. Animal testing demonstrates that these compounds are useful for treating inflammation, a hallmark disease for CCR(9)....
8916586 Anti-angiogenic compound  
A styrylquinoline derivative of structure I or IV or a benzodioxol isoquinoline of structure II or III for use in the treatment of an angiogenesis-related disease or disorder. The invention also...
8912186 Allosteric protein kinase modulators  
The invention provides specific small molecule compounds that allosterically regulate the activity or modulate protein-protein interactions of AGC protein kinases and the Aurora family of protein...
8911765 Biodegradable, polymer coverings for breast implants  
A biodegradable, flexible covering for a breast implant is provided which comprises one or more biodegradable polymer layers dimensioned and shaped to cover at least a portion of the breast...
8901119 Peptide deformylase inhibitors  
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods...
8877775 Substituted 2-aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin C  
This invention relates to 2-Aza-bicyclo[2.2.2]octane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1 and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing...
8871789 Method of preventing or treating viral infection  
Disclosed are compounds and pharmaceutical compositions containing compounds that inhibit JMJD2 proteins, including those of the formula (I): wherein R1, R2, R3, R4, and R5 are as defined herein...
8865739 Substituted heterocyclic compounds as ion channel modulators  
The present invention relates to sodium channel inhibitors of Formula (I): in which R1, R2, R3, R4, R5, X, Y, and Z are as defined herein, and to their use in the treatment of various disease...
8865736 Antibacterial agents  
Compounds of formula (I) have antibacterial activity: wherein R represents hydrogen or 1, 2 or 3 optional substituents; W is ═C(R1)—; R1 is hydrogen and R2 is hydrogen, methyl, or fluorine; or R1...
8859587 (2E)-3-phenyl-N-[2,2,2-Trifluoro-1-[[8-quinolineamino)thiomethyl]amino]ethyl]-2-acrylamide and pharmaceutical uses thereof  
The present invention relates to an acrylamide compound of Formula I, or an isomer, pharmaceutically acceptable salt and solvate thereof, to a composition comprising the compound or an isomer,...
8859599 Androgen receptor modulating compounds, preparation and uses thereof  
The present invention concerns compounds of general formula (I): Method of preparation and uses thereof.
8853242 Nitrogenous-ring acylguanidine derivative  
[Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT5A receptor modulating action, is provided. [Means for Solution] It was...
8853258 C-linked hydroxamic acid derivatives useful as antibacterial agents  
The present invention is directed to a new class of hydroxamic acid derivatives of Formula I, wherein the variables G, T, D, L, A, X, R1 and R2 are as described hereinabove, and their use as LpxC...
8841328 Selective insecticides based on anthranilic acid diamides and safeners  
The present invention relates to the use of selective insecticidal compositions, characterized by an effective amount of an active compound combination comprising (a) (1) at least one...
8835458 Quinoline or quinazoline derivatives with apoptosis inducing activity on cells  
Provided is a pharmaceutical composition comprising, as an active ingredient, a quinoline or quinazoline derivative of formula (I), a pharmaceutically acceptable salt, an isomer, a hydrate, and a...
8835123 Methods for detecting progenitor cells and uses thereof  
Diagnostic and therapeutic methods pertaining to diseases and disorders of the breast, uterus and ovary are encompassed herein. More particularly, diagnostic methods for early detection of...
8828966 Method for treatment of macular degeneration by modulating P2Y12 or P2X7 receptors  
Provided is a method of treating or preventing age-related macular degeneration (AMD) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal...
8822452 Inhibitor compounds of 11-beta-hydroxysteroid dehydrogenase type 1  
The compounds of formula (I) are derived from perhydroquinoline and perhydroisoquinoline and are useful as active pharmaceutical ingredients for the prophylaxis or treatment of diseases caused by...
8822467 Biaryl oxyacetic acid compounds  
The present invention provides biaryl oxyacetic acid compounds which may be useful for treating inflammatory disorders, including disorders affecting the respiratory system and skin. The compounds...
8815900 Compounds and compositions for reducing lipid levels  
Compositions comprising extracts or isolated or purified compounds from plants of the genus Corydalis provide prevention and treatment of hyperlipidemia, hypercholesterolemia,...
8815241 Use of combination of anti-angiogenic substance and c-kit kinase inhibitor  
The object of the present invention is to find a pharmaceutical composition and a method for treating cancer that show an excellent antitumor effect. Combinational use of...
8815901 Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors  
The invention relates to compounds of formula (I) wherein the substituents are as defined in the specification, in free form or in the form of a pharmaceutically acceptable salt, solvate, ester,...
8809369 Tetrahydroquinoline derivatives  
The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions...
8809368 Compounds affecting gap junction activity  
This invention relates to novel quinoline compounds which affect gap junction activity. Also provided are methods of using such compounds and compositions containing the compounds to treat gap...
8802666 Inhibitors of cyclophilins and uses thereof  
The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2;A is in particular CH or N;X is in particular CO, SO2, CS, and R1 is in particular H,R2 is a group of formula...
8802701 Compounds derived from artesunate, preparation process, pharmaceutical composition and use of the respective medicine  
The present invention refers to new compounds represented by the general formula (I) where X is represented by the general formula (II) and Y is represented by the general formula (III). The...
8802675 Neuroprotective multifunctional compounds and pharmaceutical compositions comprising them  
Multifunctional compounds are provided, comprising two or more functional moieties selected from: (i) a moiety that imparts an iron chelator function; (ii) a moiety that imparts a neuroprotective...
8791090 Prophylactic and/or therapeutic agent for anemia comprising tetrahydroquinoline compound as active ingredient  
Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed...