Patents in Class 514/311

Matches 1 - 50 out of 908

Match	Document	Document Title
1	7618965	(Arylamidoanilino)nitroethylene compounds Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein A, Q, Y, R 1 , R 2 , and R 5 are defined herein, are useful in the treatment of tumors...
2	7612115	Aqueous pharmaceutical compositions The present invention has an object to provide an antibacterial aqueous pharmaceutical composition and an aqueous pharmaceutical composition which have a sufficiently low gelation temperature even...
3	7612107	Treatment and inhibition of disease conditions using flexible heteroarotinoids The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions...
4	7601841	Quinolinyl and benzothiazolyl modulators Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate...
5	7601741	Process for making montelukast and intermediates therefor The reaction of methylmagnesium halide is improved by the presence of a cerium (III) salt such as cerium trichloride. The reactions are typically associated with the production of montelukast, a...
6	7598242	Compounds for the treatment of inflammatory disorders This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions...
7	7595328	Methods of use of quinolone compounds against pneumococcal and Haemophilus bacteria This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against certain pathogenic bacteria, particularly quinolone...
8	7592356	Triazoles as farnesyl transferase inhibitors a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L 1 and L 2 are R 1 —Y— wherein each (R 1 —Y)— substituent is defined independently...
9	7579347	Vanilloid receptor ligands and their use in treatments Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster...
10	7576110	Benzothiazole cyclobutyl amine derivatives Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
11	7576099	Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a...
12	7576098	Heterocyclic compounds as inhibitors of factor VIIa The present invention relates generally to compounds that inhibit serine proteases. In particular it is directed to novel heterocyclic compounds, or a stereoisomer or pharmaceutically acceptable...
13	7572794	Anthranilamide pyridinureas as vascular endothelial growth factor (VEGF) receptor kinase inhibitors The invention relates to novel anthranilamide pyridinureas as VEGF receptor kinase inhibitors, their production and use as pharmaceutical agents for preventing or treating diseases that are...
14	7569584	4-(2-methyl-5,6,7,8-tetrahydro-quinolin-7-ylmethyl)-1,3-dihydro-imidazole-2-thione as specific alpha_2bagonist and methods of using the same The compound of the formula wherein the * indicates an asymmetric carbon, is specific to alpha 2B adrenergic receptors in preference over alpha 2A and alpha 2C adrenergic receptors, and...
15	7563807	Removal of aldehyde impurity by reactive polystyrene resini A purification method in the preparation of a substituted 8-arylquinoline, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, utilizes a polystyrene-based...
16	7563804	FMF treatment The method of improving FMF control, in humans, which includes administering, on an average daily basis, between 5 and 15 milligrams of LTRA to a patient suffering from FMF.
17	7560559	Polymorphic form of montelukast sodium The invention provides novel polymorphic form of montelukast sodium, as well as methods of using and pharmaceutical compositions containing saud novel form. Also provided are montelukast sodium:...
18	7560483	Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require...
19	7553853	Solid-state montelukast A solid form of a compound of formula 1: is provided. The compound of formula 1 can be obtained in solid state by precipitation from a solution containing the same. The compound is useful as...
20	7547710	Fused heterocyclic compounds as peptidase inhibitors A compound represented by the formula wherein ring A is an optionally substituted 5- to 10-membered aromatic ring; R 1 and R 2 are the same or different and each is an optionally substituted...
21	7544805	Stable amorphous forms of montelukast sodium An amorphous form of montelukast sodium and a montelukast sodium lactose co-precipitate, processes for producing same, pharmaceutical compositions containing same and methods of treatment utilizing...
22	7544717	2-amino- and 2-thio- substituted 1,3-diaminopropanes Disclosed are compounds of the formula: where variables Q, Z, X, R 15 , R 2 , R 3 , and R c are defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are...
23	7524859	(2-carboxamido)(3-amino)thiophene compounds A method of treatment of hyperproliferative disorders comprises a step of administering an effective amount of a compound represented by
24	7511061	Triazoles as farnesyl transferase inhibitors A prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L 1 and L 2 are R 1 —Y— wherein each (R 1 —Y)— substituent is defined independently...
25	7504415	Therapeutic agent for glomerular disease The present invention is directed to a preventive or therapeutic agent for a glomerular disease comprising as an active ingredient a compound represented by formula (1): or a salt thereof. The...
26	7504402	Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
27	7501517	Process for making montelukast and intermediates therefor A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (4) is provided.
28	7498343	Mycobacterial inhibitors The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or the general Formula (Ib) the pharmaceutically acceptable acid or base addition...
29	7491825	Basic non-peptide bradykinin antagonists and pharmaceutical compositions therefrom Non-peptide compounds of formula (I) having activity as specific antagonists of bradykinin (BK) B2 receptor. The compounds are chemically characterized by the presence of an alpha,...
30	7482362	Substituted-4-quinolones Substituted-4-quinolones of the formula (I): wherein R 1 is a straight or branched chain, saturated or ethylenically-unsaturated aliphatic hydrocarbyl group containing 1 to 18 carbon atoms which...
31	7479498	Treatments for viral infections The present invention relates to improved methods and compositions for treating viral infections and other diseases and conditions that induce a cytokine storm. More particularly, the present...
32	7479497	Use of quinoline derivatives with anti-integrase effect and applications thereof The invention relates to the use of 8-hydroxyquinoline 7-carboxylic acid derivatives in order to produce integrase-inhibiting medicaments, capable of blocking viral replication in the stages...
33	7476763	Oxo-substituted cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I: methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
34	7476748	Process for making montelukast and intermediates therefor A process for making montelukast, a pharmaceutically useful compound of the following formula and salts thereof: using a compound of formula (11) is provided.
35	7476680	Substituted heterocyclic compounds for treating multidrug resistance Compounds suitable for treating multidrug resistance and methods for their preparation and use are disclosed. The compounds are represented by the following formula: or an optical isomer,...
36	7462637	Derivatives of [6,7-dihydro-5H-imidazo[1,2--a]imidazole-3-sulfonyl]-pyrrolidine-2-carboxylic acid amide Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonyl]-pyrrolidi ne-2-carboxylic acid amide which exhibit good inhibitory effect upon the interaction of CAMs and Leukointegrins and are...
37	7459564	Substituted biaryl compounds as factor XIa inhibitors The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R 3 , and ring B...
38	7459447	Method for treating hyperlipidemia Provided is a method for treating hyperlipidemia or hypercholesterolemia, which comprises administering effective doses of ezetimibe and pitavastatin or a salt or lactone derivative thereof.
39	7456196	Bicyclic-substituted amines as histamine-3 receptor ligands Compounds of formula (I) are useful in treating conditions or disorders prevented by or ameliorated by histamine-3 receptor ligands. Also disclosed are pharmaceutical compositions comprising...
40	7452905	Phenylalanine derivatives Specific phenylalanine derivatives or pharmaceutically acceptable salts thereof have an antagonistic effect on the α 4 integrins and, therefore, are usable as therapeutic agents or preventive...
41	7446116	Montelukast amantadine salt An amantadine salt of montelukast is useful in purification of montelukast or its salts and as a pharmaceutical active ingredient.
42	7446103	Bicyclic benzamide compound as histamine H3 receptor ligand useful in the treatment of neurological diseases The present invention relates to novel bicyclic benzamide derivatives having pharmacological activity, processes for their preparation, to compositions containing them and to their use in the...
43	7442710	Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X 1 and X 2 are each independently N or C—R″ and R 1 , R 2 ,R 3 , R 4 , R 5 , and R 6 are as defined in...
44	RE40558	Therapeutic uses of di-aryl acid derivatives The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and...
45	7429666	Pyridine analogs as C5a antagonists The present invention provides novel compounds of Formula I which are antagonists of the C5a receptor. Compounds of the present invention are useful for the treatment of various C5a-mediated...
46	7429592	Cyanoanthranilamide derivatives and the use thereof as medicaments Substituted cyanoanthranilamide derivatives, their production and use as pharmaceutical agents for treating diseases that are triggered by persistent angiogenesis are described. The compounds...
47	7414056	Pyrazole-amide compounds useful as kinase inhibitors The present invention provides pyrazole derived compounds of formula (I) useful for treating p38 kinase-associated conditions, where G, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and m are as...
48	7407989	Compounds useful for modulating abnormal cell proliferation There is described compounds of Formula I, and salts, solvates and hydrates thereof: wherein: R 1 , R 2 and R 3 are each independently selected from OH, C 1-6 alkyl, OC 1-6 alkyl, OC(O)C 1-6...
49	7402597	Activator of peroxisome proliferator-activated receptor δ A compound represented by the formula (I) or a salt of the compound, and a PPAR-δ activator which contains the compound or salt as the active ingredient: (wherein A represents O or S; B 1 ...
50	RE40418	Treatment of neoplasms with CCI-779/EKB-569 combination This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.

Matches 1 - 50 out of 908

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