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6924295 |
Tetrahydroquinoline derivative compound and drug containing the compound as active ingredient
A compound of formula (I)
(wherein all symbols are as defined in the specification) and salt thereof, and peroxisome proliferator activated receptor regulator comprising thereof as active...
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6919353 |
Substituted 8-arylquinolune PDE4 inhibitors
8-arylquinolines of formula (I) wherein the aryl group at the 8-position contains a meta two atom bridge to an optionally substituted phenyl or pyridyl group, are PDE4 inhibitors useful to treat...
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6903114 |
Derivatives of naphthalene with COMT inhibiting activity
Compounds of formula (I′), wherein A, R 1 to R 3 and t are as defined in the disclosure, exhibit COMT enzyme inhibiting activity so that they are useful as COMT inhibitors.
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6884784 |
Diagnosis and management of infection caused by chlamydia
The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae . The invention is based, in part, upon the...
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6884821 |
Carboxylic acid derivatives and drugs containing the same
Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the...
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6884808 |
Heterocycle-containing carboxylic acid derivative and drug containing the same
Described is a heterocycle-containing carboxylic acid derivative represented by the following formula (I):
wherein A represents, for example, a heteroaryl group which contains at least one...
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6878720 |
VEGF receptor tyrosine kinase inhibitors
Described are compunds of formula (I), wherein W is O or S; X is NR 8 ; Y is CR 9 R 10 —(CH 2 )n wherein R 9 and R 10 are independently of each other hydrogen or lower alkyl, and n is an...
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6875765 |
Arylsulfonamide ethers, and methods of use thereof
The novel arylsulfonamide ether compounds, pharmaceutical compositions and uses thereof as inhibitors of interleukin-1β converting enzyme and other cysteine proteases in the ICE family are...
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6875769 |
Substituted6,6-hetero-bicyclicderivatives
This invention relates to compounds of the formula
wherein A, B, D, E, K, G, R 3 and R 5 are defined as in the specification, and to the pharmaceutically acceptable salts of such compounds.
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6867218 |
Compounds, their preparation and use
The present invention relates to compounds of the general formula (I)
The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the...
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6867217 |
Substituted polycyclic aryl and heteroaryl pyridones useful for selective inhibition of the coagulation cascade
The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods...
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6864254 |
Inhibitor for 20-hete-yielding enzyme
An inhibitor for 20-hydroxyeicosatetraenoic acid production which comprises as the active ingredient a specific hydroxyformamidine derivative or a pharmacologically acceptable salt thereof. It is...
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6861442 |
PYK2 and inflammation
The present invention relates generally to the fields of immunology and medicine, and more specifically to the field of cellular signal transduction. The present invention relates, inter alia, to...
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6855711 |
Pharmaceutical compositions comprising iron chelators for the treatment of neurodegenerative disorders and some novel iron chelators
Use of a compound of formula (I), wherein R 1 is H or hydrocarbyl; R 2 is a hydrophobic radical; R 3 is 3-(C 2 -C 6 )acyl-4-hydroxyphenyl, 3-hydroxyimino (C 2 -C 6 )-alkyl-4-hydroxyphenyl, or...
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6849636 |
Triazole derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase-1
Triazole derivatives of structural formula I are selective inhibitors of the 11β-hydroxysteroid dehydrogenase-1. The compounds are useful for the treatment of diabetes, such as...
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6844357 |
Substituted quinolin-2-one derivatives useful as antiproliferative agents
The present invention relates to compounds of formulas 1 and 2
wherein R 1 , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , R 10 and Z are as defined herein. The present invention also relates to...
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6841555 |
Lavendamycin analogs, quinoline-5,8-diones and methods of using them
The invention provides novel lavendamycin analogs having the following general formula:
and quinoline-5,8-diones having the following formula:
Methods of making and using and compositions...
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6841561 |
Dihydroorotate dehydrogenase inhibitors for the treatment of viral-mediated diseases
Flavivirus, rhabdovirus and paramyxovirus infections may be treated by administering an inhibitor of the enzyme dihydroorotate dehydrogenase such as...
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6833389 |
Use of thiamphenicol and derivatives thereof for the preparation of pharmaceutical compositions useful in the treatment of Chlamydia pneumoniae infections
Use of thiamphenicol and derivatives thereof for the preparation of pharmaceutical compositions useful for the treatment Chlamydia pneumoniae infections is described.
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6831080 |
Cinnamide derivatives as KCNQ potassium channel modulators
There is provided novel cinnamide derivatives of Formula I: wherein R is C 1-4 alkyl or trifluoromethyl; R 1 is selected from the group consisting of pyridinyl, quinolinyl, thienyl, furanyl,...
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6821986 |
Amino acid derivatives and their use as medicines
Novel compounds of formula wherein the substituents are defined as in the specification and are useful for inhibiting neuronal NO synthase or inducible NO synthase as well as inhibiting lipidic...
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6821988 |
3-cyanoquinolines as inhibitors of EGF-R and HER2 kinases
This invention provides compounds of Formula (I), represented by the structure wherein G 1 , G 2 , G 3 , G 4 , Z, X and n are defined herein, or a pharmaceutically acceptable salt thereof which...
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6812229 |
Carbamate derivative and agricultural/horticultural fungicide
It is to provide a novel fungicide having high controlling effects on plant diseases particularly on wheat powdery mildew and cucumber gray mold, without ill effects on crops. A carbamate...
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6809093 |
2-substituted heterocyclic compounds
Compounds, compositions, and methods for treating multidrug resistance are disclosed. Suitable compounds are 2-substituted heterocyclic compounds. An example compound has the formula:
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6809106 |
Quinoline derivatives as inhibitors of MEK enzymes
A compound of formula (I) or a pharmaceutically acceptable salt thereof; for use as a medicament wherein: n is 0-1; Y is selected from —NH—, —O—, —S—, or —NR 7 — where R 7 is...
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6809097 |
Quinoline derivatives inhibiting the effect of growth factors such as VEGF
Compounds of the formula (I): wherein: R 2 represents hydroxy, halogeno, C 1-3 alkyl, C 1-3 alkoxy, C 1-3 alkanoyloxy, trifluoromethyl, cyano, amino or nitro; n is an integer from 0 to 5; Z...
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6806277 |
Quinolylpropylpiperidine derivatives, preparation process and intermediates, and compositions including them
Quinolylpropylpiperidine derivatives of general formula (I) in which: R 1 is NH 2 , alkylamino, dialkylamino, hydroxyamino, alkyl(alkyloxy)amino or alkyloxyamino, R 2 is a carboxyl,...
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6803369 |
Compounds and methods for the treatment of neoplastic disease
A method of modulating the activity of a aberrant cell topoisomerase enzyme involving contacting the enzyme with a compound that inhibits enzyme-mediated cleavage of a polynucleotide substrate with...
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6803376 |
Method of use of quinolone compounds against pneumococcal and haemophilus bacteria
This invention relates, in part, to newly identified methods of using quinolone antibiotics, particularly a gemifloxacin compound against certain pathogenic bacteria, particularly quinolone...
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6800652 |
Diaryl compounds
The invention relates to compounds of formula I
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6787534 |
Sulfonamide-containing heterocyclic compounds
The present invention provides a sulfonamide- or sulfonylurea-containing heterocyclic compounds. Specifically, it provides a heterocyclic compound represented by the formula (I), a...
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6787552 |
PPAR delta activators
Compounds of the general formula (I) or salts thereof and activators of PPARδ (peroxisome proliferator activated receptor δ) containing the compounds or the salts as the active ingredient:...
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6787556 |
Benzoic acid derivatives for the treatment of diabetes mellitus
The present invention relates to the use of certain benzoic acid derivatives of formula (I), as disclosed in the specification, which act as peroxisome proliferator activated receptor (PPAR)...
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6780875 |
Quinoline-4-carboxamide derivatives as NK-3 and NK-2 receptor antagonists
A compound, or a solvate or a salt thereof, of formula (I): wherein, Ar is an optionally substituted aryl or a C 5-7 cycloalkdienyl group, or an optionally substituted C 5-7 cycloalkyl group,...
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6777427 |
Tetrahydroquinoline compounds
Tetrahydroquinoline compounds of general formula (I) or pharmacologically acceptable salts thereof, which have a specific and strong binding affinity for AR, exhibit AR agonism or antagonism, have...
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6770648 |
Compounds for the modulation of PPAR&ggr activity
Modulators of PPARγ activity are provided which are useful in pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes and obesity.
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6762193 |
Method of treating hair loss
A method of treating inflammatory skin diseases and/or hair loss, comprising administering to a patient in need of such treatment a therapeutically effective amount of a leukotriene receptor...
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6747053 |
Heteroaryl nitriles
The present invention relates to compound of formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and n are as defined in the description and claims and pharmaceutically acceptable salts and/or...
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6747041 |
Heterocyclic dicarboxylic acid diamide derivatives, agricultural/horticultural insecticides and method of using the same
Heterocyclic dicarboxylic acid diamide derivative represented by the general formula (I): wherein R 1 , R 2 and R 3 represent each H, optionally halogenated C 3-6 cycloalkyl, etc.; Het...
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6743804 |
Quinoline derivatives as NK3 antagonists
The present invention relates to a novel use, in particular a novel pharmaceutical use for a series of quinoline derivatives.
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6740664 |
Methods for treating otic and ophthalmic infections
Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents. The...
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6740654 |
Squaric acid derivatives
Squaric acid derivatives of formula (1) are described: wherein Het is an optionally substituted bicyclic fused ring heteroaromatic group; L 2 is a covalent bond or an atom or group —O—,...
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6740649 |
Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)
The present application describes novel cyclic hydroxamic acids of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from...
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6734192 |
Treatment of viral infections
A pharmaceutical composition comprising therapeutically effective quantities of calcium channel blockers in combination with quinolines. In preferred embodiments, the invention further comprises...
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6734193 |
(1,2,3,4-tetrahydroquinolin-8-yl)-heptatrienoic acid derivatives having serum glucose reducing activity
Compounds of the formula where the variables have the meaning defined in the specification are capable of reducing serum glucose levels in diabetic mammals without the undesirable side effects...
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6734182 |
Aryl sulfonamides and sulfamide derivatives and uses thereof
This invention is directed to novel aryl sulfonamide and sulfamide compounds which bind selectively to and inhibit the activity of the human Y5 receptor. This invention is also related to uses of...
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6723753 |
Substituted n-benzyl-n-phenyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer...
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6713489 |
7-&lsqb (4′-trifluoromethyl-biphenyl-2-carbonyl)amino&rsqb -quinoline-3-carboxylic acid amides, and methods of inhibiting the secretion of apolipoprotein B
This invention relates to compounds of Formula I: that inhibit the secretion of apolipoprotein B, to pharmaceutical compositions comprising the compounds, and to methods of treating and/or...
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6710056 |
Amidinophenylpyruvic acid derivatives
An amidinophenylpyruvic acid derivative of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an excellent antagonistic effect against activated blood...
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6710033 |
Methods and treatment of multiple sclerosis
The invention features methods and reagents for the diagnosis, monitoring, and treatment of multiple sclerosis. The invention is based in part on the discovery that Chlamydia is present in patients...
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