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5366972 |
5,11-dihydro-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepines and their use in the prevention or treatment of HIV infection
Disclosed are novel 5,11-dihydro-6H-dipyrido[3,2-b; 2',3'-e][1,4]diazepines. These are useful in the prevention or treatment of HIV infection.
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5358955 |
Aryl and heteroarylmethoxyphenyl inhibitors of leukotriene biosynthesis
The present invention relates to a compound of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein W is selected from optionally substituted pyridyl, naphthyl, and quinolyl;...
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5356903 |
1-cyclopropyl-4-pyridyl-quinolines
Compounds of formula ##STR1## wherein; R 1 is hydrogen, lower-alkyl, or trifluoromethyl; R 2 is lower-alkyl, trifluoromethyl or CH 2 X where X is hydroxy, chloro, lower-alkylamino or...
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5350754 |
Heterocyclic cycloalkanes
The invention concerns a heterocyclic cycloalkane of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one...
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5348976 |
Condensed heterocyclic derivatives and agricultural or horticultural fungicides containing the same
The present invention provides a condensed heterocyclic derivative represented by a formula: ##STR1## wherein R 1 represents a lower alkyl group, an alkenyl group, or the like, R 2 , R 3 , R 4 , R...
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5346914 |
(4-alkoxypyran-4-yl) substituted arylalkylaryl-, arylalkenylaryl-, and arylalkynylarylurea inhibitors of 5-lipoxygenase
Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R 6 and R 7 are hydrogen or alkyl, or R 6 and R 7 , together with the nitrogen atoms to which...
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5340811 |
Isoquinoline-or quinoline-sulfonamide derivative and a pharmaceutical composition comprising the same
Disclosed is a sulfonamide derivative represented by following formula (I) and a medicine for the treatment of asthma comprising the sulfonamide derivative as an active ingredient which exhibits...
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5324747 |
N-substituted anilines, inhibitors of phospholipases A.sub.2
Compounds of the formula ##STR1## wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , n, m, o, p and q are as hereinafter set forth, and, when R 2 is hydrogen, pharmaceutically acceptable...
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5318979 |
Method of inhibiting the activity of cryptosporidium parvum
A method for inhibiting the activity of cryptosporidium parvum in vivo comprises administering to a human host an antimalarial drug, which is capable of exhibiting a protective effect, a curative...
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5310744 |
Quinolylmethoxyphenyl-acetamides
Quinolylmethoxyphenyl-acetamides of the formula: ##STR1## in which A, B, D, E, G, L and M are hydrogen, hydroxyl, halogen, cyano, carboxyl, nitro, trifluoromethyl, trifluoromethoxy, alkyl, alkoxy...
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5304563 |
2-substituted quinolines, and their use in medicaments
The title compounds are prepared either by reacting the corresponding halogenomethylquinolines with substituted phenols, optionally subsequently alkylating these or hydrolysing esters to acids, or...
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5302613 |
Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
This invention relates to compounds of Formula I ##STR1## which are useful as antiatherosclerotic agents and inhibitors of cell proliferation for the treatment of proliferative diseases. In...
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5298512 |
Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
Substituted chromans which by inhibiting 5-lipoxygenase enzyme are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction, stroke and related disease...
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5298511 |
Alkanoic acid derivatives
The invention concerns alkanoic acid derivatives of the formula I ##STR1## wherein Ar 1 is optionally-substituted phenyl or naphthyl, or a 10-membered bicyclic heterocyclic moiety containing one...
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5296484 |
Quinoline derivatives
The compounds of the formula: ##STR1## wherein the substituents are herein below defined; are plant fungicides, insecticides, and miticides.
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5294622 |
Substituted quinolines and cinnolines
The compounds of the formula: ##STR1## where the substituents are herein below defined, are fungicides, insecticides, and miticides.
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5292771 |
Substituted β-diketones and their use
Compound of formula ##STR1## wherein n is 0 or 1, R 1 and R 2 are independently methyl, ethyl or cyclopropyl and R is an optionally substituted phenyl or heteroaryl group or salt or ester thereof...
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5292755 |
USPA benzolyguanidines
Benzoylguanidines of the formula I ##STR1## where R(1) or R(2) is equal to R(6)--S(O) n -- or R(7)R(8)N--O 2 S-- and the other substituent R(1) or R(2) is in each case equal to H, F, Cl, Br,...
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5292769 |
Substituted mandelic acid derivatives and their use in medicaments
Substituted mandelic acid derivatives can be prepared by reaction of glyoxylic esters with Grignard compounds. The substituted mandelic acid derivatives are suitable as active compounds in...
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5288761 |
Open chain enediyne dihydroperoxides having DNA cleaving properties
Open chain enediyne dihydroperoxides having eight carbons between the hydroperoxide groups that cleave DNA are disclosed, as are methods of making and using the same.
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5288750 |
Substituted β-diketones
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5288733 |
Quinolylmethoxyphenylacetic acid acylamides and ureas
Quinolylmethoxyphenylacetic acid acylamides and ureas can be prepared either by reacting corresponding carboxylic acids with amides or reacting corresponding amides with isocyanates or ureas. The...
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5283250 |
Quinolinyl/quinolinylalkyl-N-terminal amino hydroxy
Non-peptidyl compounds characterized generally as quinolinyl/quinolinylalkyl-N-terminal amino hydroxy β-amino acid derivatives are useful as renin inhibitors for treatment of hypertension....
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5283245 |
Heterocyclic thiazole derivatives and pharmaceutical compositions comprising said derivatives
The invention concerns a thiazole of the formula I, ##STR1## wherein Q 1 is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two...
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5281600 |
Cyclic anthranilic acid derivatives
An antirheumatoid pharmaceutical composition containing a cyclic anthranilic acid derivative of the following formula, ##STR1## wherein R 1 , and R 2 and R 3 each independently indicate a...
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5281597 |
Heterocyclic and aromatic thiosemicarbazones useful in the treatment of filariasis
This invention is directed to heterocyclic and aromatic thiosemicarbazones seful in the treatment of filariasis and in an animal, including humans.
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5278166 |
4-amino-3-heteroaryl butyric acid compounds, compositions, and their use for treating disorders involving a dysfunction of GABA.sub.B receptors
A compound of formula (I): ##STR1## and medicinal products containing the same which are useful in treating disorders connected to a dysfunction of GABA B receptors, are disclosed.
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5273993 |
Compounds having one or more aminosulfonyloxy radicals useful as pharmaceuticals
Methods of treating chronic arthritis and osteoporosis which utilize both known and novel compounds which would fall under the general formula: (HO)p--A--[--OS(O) 2 NR 1 R 2 ] z wherein A...
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5270324 |
Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
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5266568 |
Hydroxyalkylquinoline ether acids as leukotriene antagonists
Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
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5256789 |
Antiinflammatory hydroxamic acids and N-hydroxyureas
Compounds having the structure ##STR1## wherein X is nitrogen, oxygen, sulfur or a bond and Z is oxygen or sulfur have been synthesized. These compounds are lipoxygenase inhibitors and are useful...
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5256661 |
Substituted 2-aminotetralins and pharmaceutical use
Certain novel compounds having the structural formula ##STR1## where R 2 , R 3 and R 4 are each selected from the group consisting of H and OA; A is H or is selected from the group consisting of...
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5254595 |
Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them
Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group,...
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5248685 |
Substituted 1-[3-(heteroarylmethoxy)phenyl]alkanols and related compounds in the treatment of asthma
Substituted 1-[3-(heteroarylmethoxy)phenyl]-alkanols and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or...
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5234932 |
Substituted quinolines and leucotriene antagonism treatment therewith
The present invention relates to hitherto unknown compounds of formula, in which m and n stand for an integer from 0-5, p stands for 0 or 1, and q stands for an integer from 0-4, R 1 and R 2 are...
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5232916 |
Quinoline ether alkanoic acids
Compounds having the formula: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
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5231102 |
Tetrahydroquinoline derivatives useful for neurodegenerative disorders
A class of 1,2,3,4-tetrahydroquinolines possessing at least one substituent, or a spirocyclic moiety, at the 4-position, and an acidic group or a group convertible thereto in vivo at the...
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5227387 |
Quinoline nematicidal method
A method of inhibiting a nematode population which comprises applying to the locus of a nematode, a nematode inactivating amount of a compound of the formula (1): Het--X--CH 2 --CH 2 --Ar ...
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5223517 |
Heterocyclically substituted cycloalkano[b]-indolesulphonamides
Heterocyclically substituted cycloalkano[b]-indolesulphonamides can be prepared by reaction of appropriate N-unsubstituted indoles with acrylonitrile, followed by hydrolysis, esterification or...
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5221678 |
(Quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
Compounds having the Formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They...
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5215989 |
Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
Compounds of structural formula: ##STR1## wherein Ar is an aromatic ring, B is a cyclic moiety fused to Ar of 5-7 members, X and Y are bridging groups, Q is a nitrogen containing heterocycle, R 2 ...
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5215998 |
Alkylphosphonothioate insecticides
Compounds and compositions containing alkylphosphonothioates, for insecticidal control, particularly for use as soil and/or foliar insecticides, having the formula. ##STR1## in which R is C 1 -C 3...
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5212182 |
Substituted quinolinyl- and naphthalenylbenzamides or benzylamines and related compounds useful as analgesics
This invention relates to novel quinolinyl- and naphthalenylbenzamides or benylamines and related disclosed compounds of the formula ##STR1## wherein X is nitrogen, NO or CR 1 ; Y is C(R 1 )(R 2...
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5212180 |
Quinoline-containing ketoacids as leukotriene antagonists
Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents....
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5204329 |
Treatment of organ transplantation rejection
4-Quinoline-carboxylic acid derivatives, such as 2-(2'-fluoro-1,1'-biphenyl-4-yl)-6-fluoro-3-methyl-4-quinoli
ne carboxylic acid, in combination with other immunosuppressive agents are useful for...
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5204358 |
Hetaryl styryl quinolines as leukotriene inhibitors
Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and...
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5204348 |
Heterocyclic compounds and anticancer-drug potentiaters conaining them as effective components
Novel heterocyclic compounds, which are represented by the following general formula, useful as anticancer drug potentiaters having a potentiating effect on the incorporation of anticancer drugs...
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5202336 |
Antiflammatory quinolin methoxy phenylsulphonamides
New phenylsulphonamide of the formula in which ##STR1## R 1 represents a pyridyl, quinolyl or isoquinolyl radical which is unsubstituted or substituted by halogen, alkyl, cycloalkyl, alkoxy,...
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5202326 |
Heterocyclic ethers
The invention concerns a heterocyclic ether of the formula I ##STR1## wherein Q is an optionally substituted 6-membered monocyclic or 10-membered bicyclic heterocyclic moiety containing one or two...
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5202349 |
Substituted phenylacetylenes, pharmaceutical compositions containing these compounds and processes for the preparation of these compounds and compositions
Substituted phenylacetylenes of the formula ##STR1## wherein one of the groups R 1 is a hydrogen atom and the other represents the group of the formula ##STR2## in which R 3 is hydrogen, methyl...
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