Patents in Class 514/310

Matches 1 - 50 out of 296

1 2 3 4 5 6 >

Match	Document	Document Title
1	7612089	Tetrahydroisoquinolines as factor Xa inhibitors The present invention is directed to compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof which are inhibitors of Factor Xa. The...
2	7601740	Selective serotonin 2A/2C receptor inverse agonists as therapeutics for neurodegenerative diseases Behavioral pharmacological data with the compound of formula (I), a novel and selective 5HT2A/2C receptor inverse agonist, demonstrate in vivo efficacy in models of psychosis and dyskinesias. This...
3	7589105	Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound Pharmaceutical compositions and methods of treatment are provided for treating amyloidosis, containing, as an active ingredient, at least one nitrogen-containing heteroaryl compound represented by...
4	7582638	Pyrazole-isoquinoline urea derivatives as p38 kinase inhibitors The present invention provides kinase inhibitors of Formula (I) wherein R1, R2, and X are as described herein, or a pharmaceutically acceptable salt thereof.
5	7572806	PPAR active compounds Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
6	7550481	Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease The present invention is directed to phenylamide and pyridylamide derivative compounds of which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which...
7	7538121	Vanilloid receptor modulators Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R 1 , R 2 , R 3 , P, X, Y, q, r ans s are as defined in the specification, a process for...
8	7528151	Heterocyclic urea derivatives for the treatment of pain Compounds of formula (I): or a pharmaceutically acceptable salt thereof, or a solvate thereof, wherein: P, P′, R 1 , R 2 , n, p, q, r, and s are as defined in the specification, processes for...
9	7528150	Urea derivatives having vanilloid receptor antagonist activity According to the invention there are provided compounds of formula (I) wherein R 1 , p, P, n, s, r, W, P′, t, R 2 and q are as defined in the specification, processes for preparing them and...
10	7524861	Process for the preparation of a hydrate of an anthranilic acid derivative A hydrate of an acid addition bis-salt of an anthranilic acid derivative is produced by a process which comprises: (a) combining, in any order, the anthranalic acid derivative, a...
11	7507748	Substituted aryl-amine derivatives and methods of use Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds of Formula I and II wherein R, R 1 ...
12	7504228	Integrin linked kinase modulation of monocyte activation Methods are provided to specifically modulate the activation of monocytes and/or macrophages. Administration of integrin linked kinase (ILK) blocking agents; compounds that otherwise prevent the...
13	7495011	Anti-coronavirus drug The present invention provides an anti-coronavirus agent including as an active ingredient as exemplified by nelfinavir and salts thereof, an anti-SARS agent including the anti-coronavirus agent,...
14	7482361	Crystalline form for quinapril hydrochloride and process for preparing the same A novel crystalline form of quinapril hydrochloride of formula (I) An amorphous form of quinapril hydrochloride substantially free of impurities, specially diketopiperazine compound, and...
15	7482342	Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors Compound corresponding to general formula (I): in which, R 1 represents a hydrogen or halogen atom, an NH 2 , NHR 2 , NHCOR 2 , NO 2 , CN, CH 2 NH 2 and CH 2 NHR 2 ; or alternatively R 1 ...
16	7476763	Oxo-substituted cyclohexyl-1,4-diamine compounds Novel cyclohexyl-1,4-diamine compounds corresponding to formula I: methods for their production, pharmaceutical formulations containing these compounds, methods of producing such pharmaceutical...
17	7456195	Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein...
18	7452887	Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof Quinoline- and isoquinoline-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, methods of using compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions...
19	7442710	Substituted phenyl methanones The present invention relates to compounds of general formula IA or IB wherein X 1 and X 2 are each independently N or C—R″ and R 1 , R 2 ,R 3 , R 4 , R 5 , and R 6 are as defined in...
20	7425563	4-(Substituted aryl)-5-hydroxyisoquinolinone derivative The invention provides 4-substituted aryl-5-hydroxyisoquinolinone derivatives and their pharmacologically acceptable addition salts with excellent inhibitory effect on poly (ADP-ribose) synthetase....
21	7423049	Inhibitors of p38 The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods...
22	7417056	5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents Compounds of general formula (IIa) or (IIb) and their use as pharmaceutical agents.
23	7396838	Use of 1H-indol-3-yl-2-oxoacetamide compounds A method of treating cancer including administering to a subject in need thereof an effective amount of a compound of the formula 1: wherein R 1 , R 2 , R 3 , R 4 , and n are as defined herein.
24	7371763	Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas The invention relates to a group of quinolyl, isoquinolyl and pyridyl ureas, their the use in treating raf mediated diseases, and pharmaceutical compositions which contain these ureas for use in...
25	7371762	3-substituted 6,7-dihydroxytetrahydroisoquinoline derivatives for use as antibacterial agents The invention relates to novel tetrahydroisoquinoline derivatives of general formula I and theirs use as active ingredients in the preparation of pharmaceutical compositions. The invention also...
26	7361687	Arylsulphonamide derivatives and methods of preparing The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic use
27	7361663	N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor Xa This invention is directed to N-acylpyrrolidin-2-ylalkylbenzamidine derivatives which useful for inhibiting the activity of Factor Xa, by contacting said derivatives with a composition containing...
28	7351716	Dermatological preparations The present invention relates to a dermatologic preparation containing a diamide derivative represented by the following formula (1): (wherein, R 1 represents a linear or branched hydrocarbon...
29	7351715	Unit dosage forms for the treatment of herpes simplex The components of this invention are chosen because of their complementarity for the prevention or treatment of diseases caused by the herpes simplex virus. L-Lysine favorably increases the...
30	7323475	Nitrogen-containing heteroaryl compounds and methods of use thereof The present invention relates to compounds suitable for use in mediating hypoxia inducible factor and for treating erythropoietin-associated conditions by increasing endogenous erythropoietin in...
31	7307088	Substituted anthranilic amide derivatives and methods of use Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically...
32	7307086	3-(4-heteroarylcyclohexylamino)cyclopentanecarboxamides as modulators of chemokine receptors The present invention is directed to compounds of Formula I: which are modulators of chemokine receptors. The compounds of the invention, and compositions thereof, are useful in the treatment...
33	7285563	Heteroaromatic urea derivatives as VR-1 receptor modulators for treating pain The present invention provides compounds of formula (I); pharmaceutically acceptable salts and N-oxides thereof in which A, B, D and E are C or N with the proviso that one or more are N, R 1 , R 2...
34	7268135	Biaryl sulfonamides and methods for using same The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
35	7241775	Composition, process of making, and medical use of substituted 4-phenyltetrahydroisoquinolines Substituted 4-phenyltetrahydroisoquinolines of formula I, process for their preparation, their use as a medicament and medicaments containing them. The compounds of formula I can be used, among...
36	7238707	Substituted pentanols, a process for their production and their use as anti-inflammatory agents The invention relates to substituted pentanols, a process for their production and their use as anti-inflammatory agents.
37	7211586	Substituted tetrahydroisoquinolines The invention is directed to physiologically active compounds of formula (I): wherein: R 1 represents optionally substituted aryl, optionally substituted heteroaryl, R 3 NH—Ar 1 —L 2 —...
38	7202253	Cycloalkyl inhibitors of potassium channel function Novel cycloalkyl compounds useful as inhibitors of potassium channel function (especially inhibitors of the K v 1 subfamily of voltage gated K + channels, especially inhibitors K v 1.5 which has...
39	7199133	Derivatives of phenoxy-n-′4-(isothiazolindin-1, 1-dioxid-2yl)phenyll-valerian-acid amide and other compounds as inhibitors of the coagulation factor xa in the treatment of thromboembolic diseases and tumors Novel compounds of formula (I), wherein D, W, X, Y, T and R 1 have the meanings cited in claim 1 , are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of...
40	7169768	Method of decreasing atherosclerosis and its complications A method of decreasing atherosclerosis and its complications including but not limited to myocardial infarction, stroke and peripheral vascular disease wherein the method involves administering to...
41	7169767	Ophthalmic compositions containing galactomannan polymers and borate The present invention is directed to ophthalmic compositions containing a gelling amount of a combination of galactomannan polysaccharides and borates. The compositions gel or partially gel upon...
42	7163949	4-phenyl substituted tetrahydroisoquinolines and use thereof Provided herein are compounds of the formulae IA–IF. These compounds are tetrahydroisoquinolines of the following structure: wherein R 1 –R 8 for compounds of each of the formulae IA, IB,...
43	7144895	Benzene acetamide compounds useful as serine protease inhibitors Compounds having the formula (I), and pharmaceutically-acceptable salts, hydrates, or prodrugs thereof, are useful as serine protease inhibitors, wherein X is —OH, —O(alkyl), —O(aryl),...
44	7125891	Tripeptidyl peptidase inhibitors The present invention is concerned with novel compounds of formula (I) which are inhibitors of a membrane tripeptidyl peptidase responsible for the inactivation of endogenous neuropeptides such as...
45	7122559	Phenylglycine derivatives useful as serine protease inhibitors Compounds having the formula (I), or a stereoisomer or pharmaceutically-acceptable salt, or hydrate thereof, are useful as factor VIIa inhibitors, wherein X is —NR 6 S(O) p R 16 ; W is...
46	7115646	Cyclic diamines and derivatives as factor Xa inhibitors The present application describes cyclic diamino compounds, derivatives thereof, and pharmaceutically acceptable salt forms thereof, which are useful as inhibitors of factor Xa.
47	7109212	Quinoline and isoquinoline derivatives, a process for their production and their use as inflammation inhibitors The invention relates to quinoline and isoquinoline derivatives of general formula I and a process for their production, and their use as inflammation inhibitors.
48	7105536	Compounds The invention relates to novel isoquinolines and their use as anticonvulsants and in the treatment of a variety of disorders.
49	7094789	5-substituted isoquinoline derivatives A compound represented by the following formula (1) or a salt thereof: wherein R 1 represents hydrogen atom, a halogen atom and the like; R 2 represents hydrogen atom, a halogen atom, a C 1-6...
50	7091249	Drugs for spinal anesthesia Spinal anesthetics for intrathecal administration to produce spinal anesthesia are provided with use of 6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahydroisoquinolone-3-car boxylic acid or a...

Matches 1 - 50 out of 296

1 2 3 4 5 6 >